A Single Infusion of Brain-Derived Neurotrophic Factor into the Ventral Tegmental Area Induces Long-Lasting Potentiation of Cocaine Seeking after Withdrawal

Journal of Neuroscience

Volumn 24, Issue 7, 2004, Pages 1604-1611

  Lu, Lin ^a   Dempsey, Jack ^a   Liu, Shirley Y ^a   Bossert, Jennifer M ^a   Shaham, Yavin ^a  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

Brain derived nerve growth factor; Drug self administration; Extinction; Growth factors; MAP kinase; Reinstatement; Relapse; Substantia nigra

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; BRAIN DERIVED NEUROTROPHIC FACTOR; COCAINE; DOPAMINE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; NERVE GROWTH FACTOR;

ADAPTATION; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASSOCIATION; BRAIN LEVEL; COCAINE DEPENDENCE; CONTROLLED STUDY; CORRELATION ANALYSIS; DOPAMINERGIC NERVE CELL; DRUG SELF ADMINISTRATION; DRUG WITHDRAWAL; ENZYME ACTIVITY; EXPERIMENTAL MODEL; INFUSION; INSTRUMENTAL CONDITIONING; LIMBIC CORTEX; LONG TERM POTENTIATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; REINFORCEMENT; RELAPSE; SUBSTANTIA NIGRA; TASK PERFORMANCE; VENTRAL TEGMENTUM;

ANIMALS; BEHAVIOR, ANIMAL; BRAIN-DERIVED NEUROTROPHIC FACTOR; COCAINE; COCAINE-RELATED DISORDERS; CONDITIONING, OPERANT; CUES; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; EXTINCTION, PSYCHOLOGICAL; INFUSIONS, PARENTERAL; MALE; NERVE GROWTH FACTOR; RATS; RATS, LONG-EVANS; SUBSTANCE WITHDRAWAL SYNDROME; SUBSTANTIA NIGRA; TIME FACTORS; VENTRAL TEGMENTAL AREA;

EID: 1242319311     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5124-03.2004     Document Type: Article

References (40)

1. Altar CA, DiStefano PS (1998) Neurotrophin trafficking by anterograde transport. Trends Neurosci 21:433-437.
2. Baker DA, McFarland K, Lake RW, Shen H, Tang XC, Toda S, Kalivas PW (2003) Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse. Nat Neurosci 6:743-749.
3. Balleine BW, Dickinson A (1998) Goal-directed instrumental action: contingency and incentive learning and their cortical substrates. Neuropharmacology 37:407-419.
4. Berhow MT, Russell DS, Terwilliger RZ, Beitner-Johnson D, Self DW, Lindsay RM, Nestler EJ (1995) Influence of neurotrophic factors on morphine- and cocaine-induced biochemical changes in the mesolimbic dopamine system. Neuroscience 68:969-979.
5. Bonci A, Bernardi G, Grillner P, Mercuri NB (2003) The dopamine-containing neuron: maestro or simple musician in the orchestra of addiction? Trends Pharmacol Sci 24:172-177.
6. Ciccocioppo R, Sanna PP, Weiss F (2001) Cocaine-predictive stimulus induces drug-seeking behavior and neural activation in limbic brain regions after multiple months of abstinence: reversal by D(1) antagonists. Proc Natl Acad Sci USA 98:1976-1981.
7. Everitt BJ, Wolf ME (2002) Psychomotor stimulant addiction: a neural systems perspective. J Neurosci 22:3312-3320.
8. Grimm JW, Hope BT, Wise RA, Shaham Y (2001) Incubation of cocaine craving after withdrawal. Nature 412:141-142.
9. Grimm JW, Shaham Y, Hope BT (2002) Effect of the cocaine and sucrose withdrawal period on extinction behavior, cue-induced reinstatement and protein levels of the dopamine transporter and tyrosine hydroxylase in limbic and cortical areas in rats. Behav Pharmacol 13:379-388.
10. Grimm JW, Lu L, Hayashi T, Hope BT, Su TP, Shaham Y (2003) Time-dependent increases in brain-derived neurotrophic factor protein levels within the mesolimbic dopamine system after withdrawal from cocaine: implications for incubation of cocaine craving. J Neurosci 23:742-747.
11. Horger BA, Iyasere CA, Berhow MT, Messer CJ, Nestler EJ, Taylor JR (1999) Enhancement of locomotor activity and conditioned reward to cocaine by brain-derived neurotrophic factor. J Neurosci 19:4110-4122.
12. Hyman C, Hofer M, Barde YA, Juhasz M, Yancopoulos GD, Squinto SP, Lindsay RM (1991) BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra. Nature 350:230-232.
13. Kalivas PW, McFarland K (2003) Brain circuitry and the reinstatement of cocaine seeking behavior. Psychopharmacology 168:44-56.
14. Kalivas PW, Toda S, Bowers MS, Baker DA, Ghasemzadeh MB (2003) The temporal sequence of changes in gene expression by drugs of abuse. Methods Mol Med 79:3-11.
15. Lu L, Grimm JW, Shaham Y, Hope BT (2003) Molecular neuroadaptations in the accumbens and ventral tegmental area during the first 90 days of forced abstinence from cocaine self-administration in rats. J Neurochem 85:1604-1613.
16. Martin-Iverson MT, Altar CA (1996) Spontaneous behaviours of rats are differentially affected by substantia nigra infusions of brain-derived neurotrophic factor and neurotrophin-3. Eur J Neurosci 8:1696-1706.
17. McFarlane S (2000) Dendritic morphogenesis: building an arbor. Mol Neurobiol 22:1-9.
18. Meredith GE, Callen S, Scheuer DA (2002) Brain-derived neurotrophic factor expression is increased in the rat amygdala, piriform cortex and hypothalamus following repeated amphetamine administration. Brain Res 949:218-227.
19. Nestler EJ (2001) Molecular basis of long-term plasticity underlying addiction. Nat Rev Neurosci 2:119-128.
20. O'Brien CP (1997) A range of research-based pharmacotherapies for addiction. Science 278:66-70.
21. Paxinos G, Watson C (1998) The rat brain in stereotaxic coordinates, Ed 4. San Diego: Academic.
22. Phillips GD, Howes SR, Whitelaw RB, Wilkinson LS, Robbins TW, Everitt BJ (1994) Isolation rearing enhances the locomotor response to cocaine and a novel environment, but impairs the intravenous self-administration of cocaine. Psychopharmacology 115:407-418.
23. Pierce RC, Bari AA (2001) The role of neurotrophic factors in psychostimulant-induced behavioral and neuronal plasticity. Rev Neurosci 12:95-110.
24. Pierce RC, Pierce-Bancroft AF, Prasad BM (1999) Neurotrophin-3 contributes to the initiation of behavioral sensitization to cocaine by activating the Ras/Mitogen-activated protein kinase signal transduction cascade. J Neurosci 19:8685-8995.
25. Poo MM (2001) Neurotrophins as synaptic modulators. Nat Rev Neurosci 2:24-32.
26. Riccio DC, Ackil J, Burch-Vernon A (1992) Forgetting of stimulus attributes: methodological implications for assessing associative phenomena. Psychol Bull 112:433-445.
27. Schafe GE, Atkins CM, Swank MW, Bauer EP, Sweatt JD, LeDoux JE (2000) Activation of ERK/MAP kinase in the amygdala is required for memory consolidation of Pavlovian fear conditioning. J Neurosci 20:8177-8187.
28. Seroogy KB, Lundgren KH, Tran TM, Guthrie KM, Isackson PJ, Gall CM (1994) Dopaminergic neurons in rat ventral midbrain express brain-derived neurotrophic factor and neurotrophin-3 mRNAs. J Comp Neurol 342:321-334.
29. Shaham Y (2002) The drug withdrawal period and susceptibility to relapse to heroin and cocaine seeking. Behav Pharmacol 13:503.
30. Shaham Y, Shalev U, Lu L, De Wit H, Stewart J (2003) The reinstatement model of drug relapse: history, methodology and major findings. Psychopharmacology 168:3-20.
31. Shalev U, Morales M, Hope B, Yap J, Shaham Y (2001) Time-dependent changes in extinction behavior and stress-induced reinstatement of drug seeking following withdrawal from heroin in rats. Psychopharmacology 156:98-107.
32. Shalev U, Grimm JW, Shaham Y (2002) Neurobiology of relapse to heroin and cocaine seeking: a review. Pharmacol Rev 54:1-42.
33. Shen RY, Altar CA, Chiodo LA (1994) Brain-derived neurotrophic factor increases the electrical activity of pars compacta dopamine neurons in vivo. Proc Natl Acad Sci USA 91:8920-8924.
34. Shirayama Y, Chen AC, Nakagawa S, Russell DS, Duman RS (2002) Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression. J Neurosci 22:3251-3261.
35. Swanson LW (1982) The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat. Brain Res Bull 9:321-353.
36. Sweatt JD (2001) The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory. J Neurochem 76:1-10.
37. Thoenen H (1995) Neurotrophins and neuronal plasticity. Science 270:593-598.
38. Tran-Nguyen TL, Fuchs RA, Coffey GP, O'Dell LE, Baker DA, Neisewander JL (1998) Time-dependent changes in cocaine seeking behavior and dopamine overflow in the amygdala during cocaine withdrawal. Neuropsychopharmacology 19:48-59.
39. White FJ, Kalivas PW (1998) Neuroadaptations involved in amphetamine and cocaine addiction. Drug Alcohol Depend 51:141-153.
40. Wise RA, Hoffman DC (1992) Localization of drug reward mechanisms by intracranial injections. Synapse 10:247-263.