Tetracycline Inhibits Local Inflammation Induced by Cerebral Ischemia via Modulating Autophagy

PLoS ONE

Volumn 7, Issue 11, 2012, Pages

  Jiang, Yongjun ^a   Zhu, Juehua ^a   Wu, Li ^a   Xu, Gelin ^a   Dai, Jianwu ^b   Liu, Xinfeng ^a  

^a MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

^b INSTITUTE OF GENETICS AND DEVELOPMENTAL BIOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYLADENINE; BECLIN 1; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MEMBRANE PROTEIN; MESSENGER RNA; PROTEIN LC3; SYNAPTOTAGMIN I; TETRACYCLINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; BINDING AFFINITY; BRAIN ISCHEMIA; CONTROLLED STUDY; DOWN REGULATION; DRUG ACTIVITY; DRUG EFFICACY; ENZYME ACTIVATION; ENZYME INHIBITION; GENE EXPRESSION; INFLAMMATION; MALE; MICROGLIA; NEUROPROTECTION; NONHUMAN; PROTEIN BINDING; PROTEIN BLOOD LEVEL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; WESTERN BLOTTING;

ADENINE; ANIMALS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; BRAIN ISCHEMIA; INFLAMMATION; INTERLEUKIN-6; MALE; MICROGLIA; MICROTUBULE-ASSOCIATED PROTEINS; NEUROPROTECTIVE AGENTS; NF-KAPPA B; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TETRACYCLINE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84868709247     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0048672     Document Type: Article

References (47)

1. Jin R, Yang G, Li G, (2010) Inflammatory mechanisms in ischemic stroke: role of inflammatory cells. J Leukoc Biol 87: 779-789.
2. Hill WD, Hess DC, Carroll JE, Wakade CG, Howard EF, et al. (2001) The NF-kappaB inhibitor diethyldithiocarbamate (DDTC) increases brain cell death in a transient middle cerebral artery occlusion model of ischemia. Brain Res Bull 55: 375-386.
3. McCoy MK, Tansey MG, (2008) TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease. J Neuroinflammation 5: 45.
4. Xia W, Han J, Huang G, Ying W, (2010) Inflammation in ischaemic brain injury: current advances and future perspectives. Clin Exp Pharmacol Physiol 37: 253-258.
5. Kleinig TJ, Vink R, (2009) Suppression of inflammation in ischemic and hemorrhagic stroke: therapeutic options. Current Opinion in Neurology 22: 294-301.
6. Sun Q, Fan W, Zhong Q, (2009) Regulation of Beclin 1 in autophagy. Autophagy 5: 713-716.
7. Mizushima N, Komatsu M, (2011) Autophagy: renovation of cells and tissues. Cell 147: 728-741.
8. Viscomi MT, D'Amelio M, Cavallucci V, Latini L, Bisicchia E, et al. (2012) Stimulation of autophagy by rapamycin protects neurons from remote degeneration after acute focal brain damage. Autophagy 8: 222-235.
9. Mizushima N, Levine B, Cuervo AM, Klionsky DJ, (2008) Autophagy fights disease through cellular self-digestion. Nature 451: 1069-1075.
10. Puyal J, Clarke PG, (2009) Targeting autophagy to prevent neonatal stroke damage. Autophagy 5: 1060-1061.
11. Rami A, Langhagen A, Steiger S, (2008) Focal cerebral ischemia induces upregulation of Beclin 1 and autophagy-like cell death. Neurobiol Dis 29: 132-141.
12. Wen YD, Sheng R, Zhang LS, Han R, Zhang X, et al. (2008) Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways. Autophagy 4: 762-769.
13. Meng Q, Cai D, (2011) Defective hypothalamic autophagy directs the central pathogenesis of obesity via the IkappaB kinase beta (IKKbeta)/NF-kappaB pathway. J Biol Chem 286: 32324-32332.
14. Yrjanheikki J, Tikka T, Keinanen R, Goldsteins G, Chan PH, et al. (1999) A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window. Proc Natl Acad Sci U S A 96: 13496-13500.
15. Liu Z, Fan Y, Won SJ, Neumann M, Hu D, et al. (2007) Chronic treatment with minocycline preserves adult new neurons and reduces functional impairment after focal cerebral ischemia. Stroke 38: 146-152.
16. Kim HS, Suh YH, (2009) Minocycline and neurodegenerative diseases. Behav Brain Res 196: 168-179.
17. Jiang Y, Wei N, Lu T, Zhu J, Xu G, et al. (2011) Intranasal brain-derived neurotrophic factor protects brain from ischemic insult via modulating local inflammation in rats. Neuroscience 172: 398-405.
18. Basic Kes V, Simundic AM, Nikolac N, Topic E, Demarin V, (2008) Pro-inflammatory and anti-inflammatory cytokines in acute ischemic stroke and their relation to early neurological deficit and stroke outcome. Clin Biochem 41: 1330-1334.
19. Smith CJ, Emsley HC, Gavin CM, Georgiou RF, Vail A, et al. (2004) Peak plasma interleukin-6 and other peripheral markers of inflammation in the first week of ischaemic stroke correlate with brain infarct volume, stroke severity and long-term outcome. BMC Neurol 4: 2.
20. Lindeman JH, Abdul-Hussien H, van Bockel JH, Wolterbeek R, Kleemann R, (2009) Clinical trial of doxycycline for matrix metalloproteinase-9 inhibition in patients with an abdominal aneurysm: doxycycline selectively depletes aortic wall neutrophils and cytotoxic T cells. Circulation 119: 2209-2216.
21. Bostanci N, Akgul B, Tsakanika V, Allaker RP, Hughes FJ, et al. (2011) Effects of low-dose doxycycline on cytokine secretion in human monocytes stimulated with Aggregatibacter actinomycetemcomitans. Cytokine 56: 656-661.
22. Jantzie LL, Cheung PY, Todd KG, (2005) Doxycycline reduces cleaved caspase-3 and microglial activation in an animal model of neonatal hypoxia-ischemia. J Cereb Blood Flow Metab 25: 314-324.
23. Wideroe M, Havnes MB, Morken TS, Skranes J, Goa PE, et al. (2012) Doxycycline treatment in a neonatal rat model of hypoxia-ischemia reduces cerebral tissue and white matter injury: a longitudinal magnetic resonance imaging study. Eur J Neurosci.
24. Denes A, Vidyasagar R, Feng J, Narvainen J, McColl BW, et al. (2007) Proliferating resident microglia after focal cerebral ischaemia in mice. J Cereb Blood Flow Metab 27: 1941-1953.
25. Piras A, Gianetto D, Conte D, Bosone A, Vercelli A, (2011) Activation of autophagy in a rat model of retinal ischemia following high intraocular pressure. PLoS One 6: e22514.
26. Buschini E, Piras A, Nuzzi R, Vercelli A, (2011) Age related macular degeneration and drusen: neuroinflammation in the retina. Prog Neurobiol 95: 14-25.
27. Karin M, (2008) The IkappaB kinase- a bridge between inflammation and cancer. Cell Res 18: 334-342.
28. Wang Q, Tang XN, Yenari MA, (2007) The inflammatory response in stroke. J Neuroimmunol 184: 53-68.
29. Hayden MS, Ghosh S, (2008) Shared principles in NF-kappaB signaling. Cell 132: 344-362.
30. Herrmann O, Baumann B, de Lorenzi R, Muhammad S, Zhang W, et al. (2005) IKK mediates ischemia-induced neuronal death. Nat Med 11: 1322-1329.
31. Hallenbeck JM, (2002) The many faces of tumor necrosis factor in stroke. Nat Med 8: 1363-1368.
32. Cai Z, Zhao Y, Yao S, Bin Zhao B, (2011) Increases in beta-amyloid protein in the hippocampus caused by diabetic metabolic disorder are blocked by minocycline through inhibition of NF-kappaB pathway activation. Pharmacol Rep 63: 381-391.
33. Ci X, Chu X, Chen C, Li X, Yan S, et al. (2011) Oxytetracycline attenuates allergic airway inflammation in mice via inhibition of the NF-kappaB pathway. J Clin Immunol 31: 216-227.
34. Hoyt JC, Ballering J, Numanami H, Hayden JM, Robbins RA, (2006) Doxycycline modulates nitric oxide production in murine lung epithelial cells. J Immunol 176: 567-572.
35. Huang Y, Li R, Chen X, Zhuo Y, Jin R, et al. (2011) Doxycycline up-regulates the expression of IL-6 and GM-CSF via MAPK/ERK and NF-kappaB pathways in mouse thymic epithelial cells. Int Immunopharmacol 11: 1143-1149.
36. Seglen PO, Gordon PB, (1982) 3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes. Proc Natl Acad Sci U S A 79: 1889-1892.
37. Wu YT, Tan HL, Shui G, Bauvy C, Huang Q, et al. (2010) Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase. J Biol Chem 285: 10850-10861.
38. Colleran A, Ryan A, O'Gorman A, Mureau C, Liptrot C, et al. (2011) Autophagosomal IkappaB alpha degradation plays a role in the long term control of tumor necrosis factor-alpha-induced nuclear factor-kappaB (NF-kappaB) activity. J Biol Chem 286: 22886-22893.
39. Liu B, Tan W, Barsoum A, Gu X, Chen K, et al. (2010) IL-17 is a potent synergistic factor with GM-CSF in mice in stimulating myelopoiesis, dendritic cell expansion, proliferation, and functional enhancement. Exp Hematol 38: 877-884 e871.
40. Sperti C, Beltrame V, Milanetto AC, Moro M, Pedrazzoli S, (2010) Parenchyma-sparing pancreatectomies for benign or border-line tumors of the pancreas. World J Gastrointest Oncol 2: 272-281.
41. Wang J, (2008) Beclin 1 bridges autophagy, apoptosis and differentiation. Autophagy 4: 947-948.
42. Mizushima N, Yoshimori T, (2007) How to interpret LC3 immunoblotting. Autophagy 3: 542-545.
43. Yao JS, Chen Y, Zhai W, Xu K, Young WL, et al. (2004) Minocycline exerts multiple inhibitory effects on vascular endothelial growth factor-induced smooth muscle cell migration: the role of ERK1/2, PI3K, and matrix metalloproteinases. Circ Res 95: 364-371.
44. Yao JS, Shen F, Young WL, Yang GY, (2007) Comparison of doxycycline and minocycline in the inhibition of VEGF-induced smooth muscle cell migration. Neurochem Int 50: 524-530.
45. Liu WT, Lin CH, Hsiao M, Gean PW, (2011) Minocycline inhibits the growth of glioma by inducing autophagy. Autophagy 7: 166-175.
46. Jiang Y, Wei N, Zhu J, Zhai D, Wu L, et al. (2011) A new approach with less damage: intranasal delivery of tetracycline-inducible replication-defective herpes simplex virus type-1 vector to brain. Neuroscience.
47. Jiang Y, Wei N, Zhu J, Lu T, Chen Z, et al. (2010) Effects of brain-derived neurotrophic factor on local inflammation in experimental stroke of rat. Mediators Inflamm 2010: 372423.