High Ca2+ load promotes Hydrogen peroxide generation via activation of α-glycerophosphate dehydrogenase in brain mitochondria

Free Radical Biology and Medicine

Volumn 53, Issue 11, 2012, Pages 2119-2130

  Tretter, Laszlo ^a,b   Adam Vizi, Vera ^a,b  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

Glycerophosphate dehydrogenase; Glycerophosphate shuttle; Calcium; Free radicals; Hydrogen peroxide; Mitochondria; Myxothiazol; Permeability transition pore; Reactive oxygen species; Reverse electron transport

Indexed keywords

ALAMETHICIN; CALCIUM ION; GLYCEROL 3 PHOSPHATE DEHYDROGENASE; HYDROGEN PEROXIDE; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; MYXOTHIAZOL; REACTIVE OXYGEN METABOLITE; ADENOSINE DIPHOSPHATE; ALPHA-GLYCEROPHOSPHORIC ACID; CALCIUM; GLYCEROPHOSPHATE; METHACRYLIC ACID DERIVATIVE; THIAZOLE DERIVATIVE; UBIQUINOL CYTOCHROME C REDUCTASE; UNCOUPLING PROTEIN;

ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVATION; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; ANIMAL; BRAIN; DRUG ANTAGONISM; DRUG EFFECT; ENERGY METABOLISM; ENZYMOLOGY; GUINEA PIG; METABOLISM; OXYGEN CONSUMPTION; PHYSIOLOGY;

CAVIA;

ADENOSINE DIPHOSPHATE; ALAMETHICIN; ANIMALS; BRAIN; CALCIUM; ELECTRON TRANSPORT COMPLEX III; ENERGY METABOLISM; ENZYME ACTIVATION; GLYCEROLPHOSPHATE DEHYDROGENASE; GLYCEROPHOSPHATES; GUINEA PIGS; HYDROGEN PEROXIDE; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; METHACRYLATES; MITOCHONDRIA; OXYGEN CONSUMPTION; THIAZOLES; UNCOUPLING AGENTS;

EID: 84868662354     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2012.09.029     Document Type: Article

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