Genomics of the periinfarction cortex after focal cerebral ischemia

Journal of Cerebral Blood Flow and Metabolism

Volumn 23, Issue 7, 2003, Pages 786-810

  Lu, Aigang ^a   Tang, Yang ^a   Ran, Ruiqiong ^a   Clark, Joseph F ^a   Aronow, Bruce J ^b   Sharp, Frank R ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b CINCINNATI CHILDREN S HOSPITAL RESEARCH FOUNDATION   (United States)

Author keywords

Cathepsins; Cerebral ischemia; DNA microarrays; Egr 1; Functional genomics; Gene expression; Glycerol 3 phosphate dehydrogenase

Indexed keywords

AGRIN; CALPAIN; CATHEPSIN; CELL ADHESION MOLECULE; CHEMOKINE; CYSTATIN B; CYSTEINE PROTEINASE; CYTOKINE; GLYCEROL 3 PHOSPHATE DEHYDROGENASE; GUANINE NUCLEOTIDE BINDING PROTEIN; HEAT SHOCK PROTEIN; IMMUNOGLOBULIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1; JANUS KINASE 2; LIPOPOLYSACCHARIDE BINDING PROTEIN; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; METALLOPROTEINASE INHIBITOR; PROTEIN CELF; PROTEIN CPG21; PROTEIN DAF; PROTEIN DERIVATIVE; PROTEIN NARP; PROTEIN RAD; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; RNA; TENASCIN; TRANSCRIPTION FACTOR EGR 1; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN INFARCTION; BRAIN ISCHEMIA; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; CONVALESCENCE; DNA MICROARRAY; DOWN REGULATION; GENE CONTROL; GENOMICS; GLYCOLYSIS; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MITOCHONDRIAL RESPIRATION; NERVE CELL PLASTICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; QUANTITATIVE ANALYSIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STROKE; TISSUE REPAIR; TRANSCRIPTION REGULATION; UNINDEXED SEQUENCE; UPREGULATION;

EID: 0038354467     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.WCB.0000062340.80057.06     Document Type: Article

References (70)

1. Albers GW, Goldstein LB, Hall D, Lesko LM (2001) Aptiganel hydrochloride in acute ischemic stroke: a randomized controlled trial. JAMA 286:2673-2682
2. Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, Harris MA, Hill DP, Issel-Tarver L, Kasarskis A, Lewis S, Matese JC, Richardson JE, Ringwald M, Rubin GM, Sherlock G (2000) Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet 25:25-29
3. Ashwal S, Tone B, Tian HR, Cole DJ, Pearce WJ (1998) Core and penumbral nitric oxide synthase activity during cerebral ischemia and reperfusion. Stroke 29:1037-1046
4. Barber PA, Auer RN, Buchan AM, Sutherland GR (2001) Understanding and managing ischemic stroke. Can J Physiol Pharmacol 79:283-296
5. Benchoua A, Guegan C, Couriaud C, Hosseini H, Sampaio N, Morin D, Onteniente B (2001) Specific caspase pathways are activated in the two stages of cerebral infarction. J Neurosci 21:7127-7134
6. Berthou C, Michel L, Soulie A, Jean-Louis F, Flageul B, Dubertret L, Sigaux F, Zhang Y, Sasportes M (1997) Acquisition of granzyme B and Fas ligand proteins by human keratinocytes contributes to epidermal cell defense. J Immunol 159:5293-5300
7. Butler D (2002) Piecing it all together. Nature 420:460
8. Chen XP, Losman JA, Rothman P (2000) SOCS proteins, regulators of intracellular signaling. Immunity 13:287-290
9. Chen XP, Losman JA, Cowan S, Donahue E, Fay S, Vuong BQ, Nawijn MC, Capece D, Cohan VL, Rothman P (2002) Pim serine/threonine kinases regulate the stability of Socs-1 protein. Proc Natl Acad Sci U S A 99:2175-2180
10. Chuquet J, Benchenane K, Liot G, Fernandez-Monreal M, Toutain J, Blanchet S, Eveno E, Auffray C, Pietu G, Buisson A, Touzani O, MacKenzie ET, Vivien D (2002) Matching gene expression with hypometabolism after cerebral ischemia in the nonhuman primate. J Cereb Blood Flow Metab 22:1165-1169
11. Cimerman N, Mesko Brguljan P, Krasovec M, Suskovic S, Kos J (2001) Serum concentration and circadian profiles of cathepsins B, H and L, and their inhibitors, stefins A and B, in asthma. Clin Chim Acta 310:113-122
12. Cote J, Dupuis S, Wu JY (2001) Polypyrimidine track-binding protein binding downstream of caspase-2 alternative exon 9 represses its inclusion. J Biol Chem 276:8535-8543
13. De Keyser J, Sulter G, Luiten PG (1999) Clinical trials with neuroprotective drugs in acute ischemic stroke: are we doing the right thing? Trends Neurosci 22:535-540
14. Dirnagl U, Iadecola C, Moskowitz MA (1999) Pathobiology of ischemic stroke: an integrated view. Trends Neurosci 22:391-397
15. Encinas M, Iglesias M, Llecha N, Comella JX (1999) Extracellular-regulated kinases and phosphatidylinositol 3-kinase are involved in brain-derived neurotrophic factor-mediated survival and neuritogenesis of the neuroblastoma cell line SH-SY5Y. J Neurochem 73:1409-1421
16. Fisher M, Schaebitz W (2000) An overview of acute stroke therapy: past, present, and future. Arch Intern Med 160:3196-3206
17. Fong DK, Craig AM (1999) The Narp hypothesis? Neuron 23:195-197
18. Gill R, Soriano M, Blomgren K, Hagberg H, Wybrecht R, Miss MT, Hoefer S, Adam G, Niederhauser O, Kemp JA, Loetscher H (2002) Role of caspase-3 activation in cerebral ischemia-induced neuro-degeneration in adult and neonatal brain. J Cereb Blood Flow Metab 22:420-430
19. Grant ER, Errico MA, Emanuel SL, Benjamin D, McMillian MK, Wadsworth SA, Zivin RA, Zhong Z (2001) Protection against glutamate toxicity through inhibition of the p44/42 mitogen-activated protein kinase pathway in neuronally differentiated P19 cells. Biochem Pharmacol 62:283-296
20. Greenbaum LE, Li W, Cressman DE, Peng Y, Ciliberto G, Poli V, Taub R (1998) CCAAT enhancer-binding protein β is required for normal hepatocyte proliferation in mice after partial hepatectomy. J Clin Invest 102:996-1007
21. Gutsmann T, Muller M, Carroll SF, MacKenzie RC, Wiese A, Seydel U (2001) Dual role of lipopolysaccharide (LPS)-binding protein in neutralization of LPS and enhancement of LPS-induced activation of mononuclear cells. Infect Immun 69:6942-6950
22. Han BH, Holtzman DM (2000) BDNF protects the neonatal brain from hypoxic-ischemic injury in vivo via the ERK pathway. J Neurosci 20:5775-5781
23. Heinrich PC, Behrmann I, Muller-Newen G, Schaper F, Graeve L (1998) Interleukin-6-type cytokine signaling through the gp 130/Jak/STAT pathway. Biochem J 334:297-314
24. Hengartner MO (2000) The biochemistry of apoptosis. Nature 407:770-776
25. Herbert TP, Fahraeus R, Prescott A, Lane DP, Proud CG (2000) Rapid induction of apoptosis mediated by peptides that bind initiation factor eIF4E. Curr Biol 10:793-796
26. Hoeppner DJ, Hengartner MO, Schnabel R (2001) Engulfment genes cooperate with ced-3 to promote cell death in Caenorhabditis elegans. Nature 412:202-206
27. Huang Y, Wang KK (2001) The calpain family and human disease. Trends Mol Med 7:355-362
28. Hwang K, Jeong DW, Lee JW, Kim IH, Chang HI, Kim HJ, Kim IY (1999) Alteration of the NAD+/NADH ratio in CHO cells by stable transfection with human cytosolic glycerol-3-phosphate dehydrogenase: resistance to oxidative stress. Mol Cells 9:429-435
29. Ikari Y, Mulvihill E, Schwartz SM (2001) Alpha 1-Proteinase inhibitor, alpha 1-antichymotrypsin, and alpha 2-macroglobulin are the antiapoptotic factors of vascular smooth muscle cells. J Biol Chem 276:11798-11803
30. Ishibashi T, Bottaro DP, Michieli P, Kelley CA, Aaronson SA (1994) A novel dual specificity phosphatase induced by serum stimulation and heat shock. J Biol Chem 269:29897-29902
31. Islekel H, Islekel S, Guner G, Ozdamar N (1999) Evaluation of lipid peroxidation, cathepsin L and acid phosphatase activities in experimental brain ischemia-reperfusion. Brain Res 843:18-24
32. Jander S, Kraemer M, Schroeter M, Witte OW, Stoll G (1995) Lymphocytic infiltration and expression of intercellular adhesion molecule-1 in photochemically induced ischemia of the rat cortex. J Cereb Blood Flow Metab 15:42-51
33. Jin K, Mao XO, Eshoo MW, Nagayama T, Minami M, Simon RP, Greenberg DA (2001) Microarray analysis of hippocampal gene expression in global cerebral ischemia. Ann Neurol 50:93-103
34. Juan TS, McNiece IK, Jenkins NA, Gilbert DJ, Copeland NG, Fletcher FA (1996) Molecular characterization of mouse and rat CPP32 β gene encoding a cysteine protease resembling interleukin-1β converting enzyme and CED-3. Oncogene 13:749-755
35. Keyvani K, Witte OW, Paulus W (2002) Gene expression profiling in perilesional and contralateral areas after ischemia in rat brain. J Cereb Blood Flow Metab 22:153-160
36. Kim YD, Sohn NW, Kang C, Soh Y (2002) DNA array reveals altered gene expression in response to focal cerebral ischemia. Brain Res Bull 58:491-498
37. Lieuallen K, Pennacchio LA, Park M, Myers RM, Lennon GG (2001) Cystatin B-deficient mice have increased expression of apoptosis and glial activation genes. Hum Mol Genet 10:1867-1871
38. Lilly M, Sandholm J, Cooper JJ, Koskinen PJ, Kraft A (1999) The PIM-1 serine kinase prolongs survival and inhibits apoptosis-related mitochondrial dysfunction in part through a bcl-2-dependent pathway. Oncogene 18:4022-4031
39. Lipton P (1999) Ischemic cell death in brain neurons. Physiol Rev 79:1431-1568
40. Loddick SA, Turnbull AV, Rothwell NJ (1998) Cerebral interleukin-6 is neuroprotective during permanent focal cerebral ischemia in the rat. J Cereb Blood Flow Metab 18:176-179
41. Loetscher H, Niederhauser O, Kemp J, Gill R (2001) Is caspase-3 inhibition a valid therapeutic strategy in cerebral ischemia? Drug Discov Today 6:671-680
42. Martin de la Vega C, Burda J, Nemethova M, Quevedo C, Alcazar A, Martin ME, Danielisova V, Fando JL, Salinas M (2001) Possible mechanisms involved in the down-regulation of translation during transient global ischemia in the rat brain. Biochem J 357:819-826
43. Matsuda S, Wen TC, Morita F, Otsuka H, Igase K, Yoshimura H, Sakanaka M (1996) Interleukin-6 prevents ischemia-induced learning disability and neuronal and synaptic loss in gerbils. Neurosci Lett 204:109-112
44. Mitchell SA, Brown EC, Coldwell MJ, Jackson RJ, Willis AE (2001) Protein factor requirements of the Apaf-1 internal ribosome entry segment: roles of polypyrimidine tract binding protein and upstream of N-ras. Mol Cell Biol 21:3364-3374
45. Namura S, Zhu J, Fink K, Endres M, Srinivasan A, Tomaselli KJ, Yuan J, Moskowitz MA (1998) Activation and cleavage of caspase-3 in apoptosis induced by experimental cerebral ischemia. J Neurosci 18:3659-3668
46. Neumar RW, Meng FH, Mills AM, Xu YA, Zhang C, Welsh FA, Siman R (2001) Calpain activity in the rat brain after transient forebrain ischemia. Exp Neurol 170:27-35
47. Noordewier MO, Warren PV (2001) Gene expression microarrays and the integration of biological knowledge. Trends Biotechnol 19:412-415
48. O'Brien RJ, Xu D, Petralia RS, Steward O, Huganir RL, Worley P (1999) Synaptic clustering of AMPA receptors by the extracellular immediate-early gene product Narp. Neuron 23:309-323
49. Ohkubo K, Ogata S, Misumi Y, Takami N, Ikehara Y (1991) Molecular cloning and characterization of rat contrapsin-like protease inhibitor and related proteins. J Biochem (Tokyo) 109:243-250
50. Oka K, Sawamura T, Kikuta K, Itokawa S, Kume N, Kita T, Masaki T (1998) Lectin-like oxidized low-density lipoprotein receptor 1 mediates phagocytosis of aged/apoptotic cells in endothelial cells. Proc Natl Acad Sci U S A 95:9535-9540
51. Pause A, Belsham GJ, Gingras AC, Donze O, Lin TA, Lawrence JC Jr, Sonenberg N (1994) Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function. Nature 371:762-767
52. Phan TG, Wright PM, Markus R, Howells DW, Davis SM, Donnan GA (2002) Salvaging the ischemic penumbra: more than just reperfusion? Clin Exp Pharmacol Physiol 29:1-10
53. Podack ER (1999) How to induce involuntary suicide: the need for dipeptidyl peptidase I. Proc Natl Acad Sci U S A 96:8312-8314
54. Rajdev S, Hara K, Kokubo Y, Mestril R, Dillmann W, Weinstein PR, Sharp FR (2000) Mice overexpressing rat heat shock protein 70 are protected against cerebral infarction. Ann Neurol 47:782-791
55. Sato T, Aoki J, Nagai Y, Dohmae N, Takio K, Doi T, Arai H, Inoue K (1997) Serine phospholipid-specific phospholipase A that is secreted from activated platelets: a new member of the lipase family. J Biol Chem 272:2192-2198
56. Savill J, Fadok V (2000) Corpse clearance defines the meaning of cell death. Nature 407:784-788
57. Schwarz DA, Barry G, Mackay KB, Manu F, Naeve GS, Vana AM, Verge G, Conlon PJ, Foster AC, Maki RA (2002) Identification of differentially expressed genes induced by transient ischemic stroke. Brain Res Mol Brain Res 101:12-22
58. Sharp FR, Lu A, Tang Y, Millhorn DE (2000) Multiple molecular penumbras after focal cerebral ischemia. J Cereb Blood Flow Metab 20:1011-1032
59. Soriano MA, Tessier M, Certa U, Gill R (2000) Parallel gene expression monitoring using oligonucleotide probe arrays of multiple transcripts with an animal model of focal ischemia. J Cereb Blood Flow Metab 20:1045-1055
60. Stevens SL, Bao J, Hollis J, Lessov NS, Clark WM, Stenzel-Poore MP (2002) The use of flow cytometry to evaluate temporal changes in inflammatory cells following focal cerebral ischemia in mice. Brain Res 932:110-119
61. Stoll G, Jander S, Schroeter M (1998) Inflammation and glial responses in ischemic brain lesions. Prog Neurobiol 56:149-171
62. Tang Y, Lu A, Aronow BJ, Sharp FR (2001) Blood genomic responses differ after stroke, seizures, hypoglycemia, and hypoxia: blood genomic fingerprints of disease. Ann Neurol 50:699-707
63. Tang Y, Lu A, Aronow BJ, Wagner KR, Sharp FR (2002) Genomic responses of the brain to ischemic stroke, intracerebral hemorrhage, kainate seizures, hypoglycemia, and hypoxia. Eur J Neurosci 15:1937-1952
64. Tee AR, Proud CG (2002) Caspase cleavage of initiation factor 4E-binding protein 1 yields a dominant inhibitor of cap-dependent translation and reveals a novel regulatory motif. Mol Cell Biol 22:1674-1683
65. Wang KK (2000) Calpain and caspase: can you tell the difference? Trends Neurosci 23:20-26
66. White BC, Sullivan JM, DeGracia DJ, O'Neil BJ, Neumar RW, Grossman LI, Rafols JA, Krause GS (2000) Brain ischemia and reperfusion: molecular mechanisms of neuronal injury. J Neurol Sci 179:1-33
67. Yamashima T (2000) Implication of cysteine proteases calpain, cathepsin and caspase in ischemic neuronal death of primates. Prog Neurobiol 62:273-295
68. Yan SF, Fujita T, Lu J, Okada K, Shan Zou Y, Mackman N, Pinsky DJ, Stern DM (2000) Egr-1, a master switch coordinating upregulation of divergent gene families underlying ischemic stress. Nat Med 6:1355-1361
69. Yoshida M, Yamashima T, Zhao L, Tsuchiya K, Kohda Y, Tonchev AB, Matsuda M, Kominami E (2002) Primate neurons show different vulnerability to transient ischemia and response to cathepsin inhibition. Acta Neuropathol (Berl) 104:267-272
70. Yrjanheikki J, Keinanen R, Pellikka M, Hokfelt T, Koistinaho J (1998) Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia. Proc Natl Acad Sci U S A 95:15769-15774