Asp664 cleavage of amyloid precursor protein induces tau phosphorylation by decreasing protein phosphatase 2A activity

Journal of Neurochemistry

Volumn 123, Issue 5, 2012, Pages 856-865

  Park, Seok Soon ^a   Jung, Hyun Jung ^a   Kim, Yoon Jeong ^a   Park, Tae Kwan ^a   Kim, Chaeyoung ^b   Choi, Heesun ^b   Mook Jung, In Hee ^b   Koo, Edward H ^c   Park, Sun Ah ^a  

^a Soonchunhyang University   (South Korea)

^b Seoul National University   (South Korea)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

amyloid precursor protein; caspase; phosphorylation; protein phosphatase 2; tau

Indexed keywords

AMYLOID PRECURSOR PROTEIN; ASPARAGINE; ASPARTIC ACID; ASPARTIC ACID 664; CASPASE; PHOSPHOPROTEIN PHOSPHATASE 2A; PROLINE; TAU PROTEIN; THREONINE; TYROSINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; BRAIN REGION; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; FETUS; HIPPOCAMPUS; MOLECULAR DYNAMICS; MOUSE; NERVE CELL; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RAT; WILD TYPE;

AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; ELECTROPHORESIS, POLYACRYLAMIDE GEL; IMMUNOHISTOCHEMISTRY; MICE; PHOSPHORYLATION; PROTEIN PHOSPHATASE 2; RATS; TAU PROTEINS; TRANSFECTION;

EID: 84868644922     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12032     Document Type: Article

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