Self-renewal of stem cells

Biology of Blood and Marrow Transplantation

Volumn 3, Issue 4, 1997, Pages 171-178

  Lansdorp, Peter M ^a,b  

^a BRITISH COLUMBIA CANCER AGENCY   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Replicative potential; Stem cells; Telomeres

Indexed keywords

ANIMAL; BIOLOGICAL MODEL; CELL COUNT; CELL DIVISION; GENETICS; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; PHYSIOLOGY; REVIEW; TELOMERE;

ANIMALS; CELL COUNT; CELL DIVISION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; HUMANS; MODELS, BIOLOGICAL; TELOMERE;

EID: 0031241514     PISSN: 10838791     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (67)

1. McCulloch EA, Till JE: The radiation sensitivity of normal mouse bone marrow cells, determined by quantitative marrow transplantation into irradiated mice. Radiat Res 13:115, 1960.
2. Till JE, McCulloch EA, Siminovitch L: A stochastic model of stem cell proliferation, based on the growth of spleen colony-forming cells. Proc Natl Acad Sci USA 51:29, 1964.
3. Magli MC, Iscove NN, Odartchenko N: Transient nature of early haematopoietic spleen colonies. Nature 295:527, 1982.
4. Ploemacher RE, Brons RHC: Separation of CFU-S from primitive cells responsible for reconstitution of the bone marrow hemopoietic stem cell compartment following irradiation: evidence for a pre-CFU-S cell. Exp Hematol 17:263, 1989.
5. Jones RJ, Wagner JE, Celano P, Zicha MS, Sharkis SJ: Separation of pluripotent haematopoietic stem cells from spleen colony-forming cells. Nature 347:188, 1990.
6. Szilvassy SJ, Humphries RK, Lansdorp PM, Eaves AC, Eaves CJ: Quantitative assay for totipotent reconstituting hematopoietic stem cells by a competitive repopulation strategy. Proc Natl Acad Sci USA 87:8736, 1990.
7. Szilvassy SJ, Cory S: Phenotypic and functional characterization of competitive long-term repopulating hematopoietic stem cells enriched from 5-fluorouracil-treated murine marrow. Blood 81:2310, 1993.
8. Lansdorp PM, Dragowska W, Mayani H: Ontogeny-related changes in proliferative potential of human hematopoietic cells. J Exp Med 178:787, 1993.
9. Rebel VI, Miller CL, Thornbury GR, Dragowska WH, Eaves CJ, Lansdorp PM: A comparison of long-term repopulating hematopoietic stem cells in fetal liver and adult bone marrow from the mouse. Exp Hematol 24:638, 1996.
10. Rebel VI, Miller CL, Eaves CJ, Lansdorp PM: The repopulation potential of fetal liver hematopoietic stem cells in mice exceeds that of their adult bone marrow counterparts. Blood 87:3500, 1996.
11. Rebel VI, Miller CL, Spinelli JJ, Thomas TE, Eaves CJ, Lansdorp PM: Nonlinear effects of radiation dose on donor-cell reconstitution by limited numbers of purified stem cells. Biol Blood Marrow Transpl 1:32, 1995.
12. Lemischka IR, Raulet DH, Mulligan RC: Developmental potential and dynamic behavior of hematopoietic stem cells. Cell 45:917, 1986.
13. Fraser CC, Szilvassy SJ, Eaves CJ, Humphries RK: Proliferation of totipotent hematopoietic stem cells in vitro with retention of long-term competitive in vivo reconstituting ability. Proc Natl Acad Sci USA 89:1968, 1992.
14. Keller G, Snodgrass R: Life span of multipotential hematopoietic stem cells in vivo. J Exp Med 171:1407, 1990.
15. Lansdorp PM: Telomere length and proliferation potential of hematopoietic stem cells. J Cell Sci 108:1, 1995.
16. Lansdorp PM: Developmental changes in the function of hematopoietic stem cells. Exp Hematol 23:187, 1995.
17. Pawlink R, Eaves C, Humphries RK: Evidence of both ontogeny and transplant dose-regulated expansion of hematopoietic stem cells in vivo. Blood 88:2852, 1996.
18. Ogawa M: Differentiation and proliferation of hematopoietic stem cells. Blood 81:2844, 1993.
19. Dexter TM, Heyworth CM, Spooncer E, Ponting ILO: The role of growth factors in self-renewal and differentiation of haemopoietic stem cells. Philos Trans R Soc Lond Biol 327:85, 1990.
20. Metcalf D: Lineage commitment of hemopoietic progenitor cells in developing blast cell colonies: influence of colony-stimulating factors. Proc Natl Acad Sci USA 88:11310, 1991.
21. Mayani H, Dragowska W, Lansdorp PM: Lineage commitment in human hemopoiesis involves asymmetric cell division of multipotent progenitors and does not appear to be influenced by cytokines. J Cell Physiol 157:579, 1993.
22. Fairbairn LJ, Cowling GJ, Reipert BM, Dexter TM: Suppression of apoptosis allows differentiation and development of a multipotent hemopoietic cell line in the absence of added growth factors. Cell 74:823, 1993.
23. + subpopulations of human bone marrow cells. Proc Natl Acad Sci USA 91:12223, 1994.
24. Sauvageau G, Thorsteinsdottir U, Eaves CJ, Lawrence HJ, Largman C, Lansdorp PM, Humphries RK: Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo. Genes Dev 9:1753, 1995.
25. Harley CB: Telomeres and Aging. In: Telomeres. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 247, 1995.
26. Harley CB, Kim NW, Prowse KR, Weinrich SL, Hirsch KS, West MD, Bacchetti S, Hirte HW, Counter CM, Greider CW, Wright WE, Shay JW: Telomerase, cell immortality, and cancer. Cold Spring Harbor Symposia on Quantitative Biology. Cold Spring Harbor Laboratory Press, 307, 1994.
27. Blackburn EH: Telomeres: no end in sight. Cell 77:621, 1994.
28. Zakian VA: Telomeres: beginning to understand the end. Science 270:1601, 1995.
29. Vaziri H, Dragowska W, Allsopp RC, Thomas TE, Harley CB, Lansdorp PM: Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age. Proc Natl Acad Sci USA 91:9857, 1994.
30. Morrison SJ, Prowse KR, Ho P, Weissman IL: Telomerase activity in hematopoietic cells is associated with self-renewal potential. Immunity 5:207, 1996.
31. Holt SE, Shay JW, Wright WE: Refining the telomere-telomerase hypothesis of aging and cancer. Nat Biotechnol 14:834, 1996.
32. Autexier C, Greider CW: Telomerase and cancer: revisiting the telomere hypothesis. Trends Biochem Sei 21:387, 1996.
33. Hiyama K, Hirai Y, Kyoizumi S, Akiyama M, Hiyama E, Piatyszek MA, Shay JW, Ishioka S, Yamakido M: Activation of telomerase in human lymphocytes and hematopoietic progenitor cells. J Immunol 155:3711, 1995.
34. Chiu C-P, Dragowska W, Kim NW, Vaziri H, Yui J, Thomas TE, Harley CB, Lansdorp PM: Differential expression of telomerase activity in hematopoietic progenitors from adult human bone marrow. Stem Cells 14:239, 1996.
35. Weng N-P, Levine BL, June CH, Hodes RJ: Regulated expression of telomerase activity in human T lymphocyte development and activation. J Exp Med 183:2471, 1996.
36. Hastie ND, Dempster M, Dunlop MG, Thompson AM, Green DK, Allshire RC: Telomere reduction in human colorectal carcinoma and with ageing. Nature 346:866, 1990.
37. Harley CB, Futcher AB, Greider CW: Telomeres shorten during ageing of human fibroblasts. Nature 345:458, 1990.
38. Lansdorp PM, Verwoerd NP, van de Rijke FM, Dragowska V, Little M-T, Dirks RW, Raap AK, Tanke HJ: Heterogeneity in telomere length of human chromosomes. Hum Mol Genet 5:685, 1996.
39. Lansdorp PM, Poon S, Chavez E, Dragowska V, Zijlmans M, Bryan T, Reddel R, Egholm M, Bacchetti S, Martens U: Telomeres in the hematopoietic system. CIBA Foundation Symposium No. 211. Telomeres and Telomerase. Sussex, UK: John Wiley & Sons. In press.
40. Counter CM, Botelho FM, Wang P, Harley CB, Bacchetti S: Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes. J Virol 68:3410, 1994.
41. + counterparts. J Immunol 156:3587, 1996.
42. + T cell turnover. Science 274:1543, 1996.
43. Rosendaal M, Hodgson GS, Bradley TR: Organization of haemopoietic stem cells: the generation-age hypothesis. Cell Tissue Kinet 12:17, 1979.
44. Horvitz HR, Herskowitz I: Mechanisms of asymmetric cell division: Two Bs or not two Bs, that is the question. Cell 68:237, 1992.
45. Amon A: Mother and daughter are doing fine: asymmetric cell division in yeast. Cell 84:651, 1996.
46. Hirata J, Nakagoshi H, Nabeshima Y, Matsuzaki F: Asymmetric segregation of the homeodomain protein Prospero during Drosophila development. Nature 377:627, 1995.
47. Bradford GB, Williams B, Rossi R, Bertoncello I: Quiescence, cycling, and turnover in the primitive hematopoietic stem cell compartment. Exp Hematol 25:445, 1997.
48. Potten CS, Loeffler M: Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt. Development 10:1001, 1990.
49. Rebel VI, Lansdorp PM: Culture of purified stem cells from fetal liver results in loss of in vivo repopulating potential. J Hematother 5:25, 1996.
50. Slagboom PE, Droog S, Boomsma DI: Genetic determination of telomere size in humans: a twin study of three age groups. Am J Hum Genet 55:876, 1994.
51. Zakian VA: Structure, function, and replication of Saccharomyces cerevisiae telomeres. Annu Rev Genet 30:141, 1996.
52. Greider CW: Telomere length regulation. Annu Rev Biochem 65:337, 1996.
53. Chong L, van Steensel B, Broccoli D, Erdjument-Bromage H, Hanish J, Tempst P, de Lange T: A human telomeric protein. Science 270:1663, 1995.
54. van Steensel B, de Lange T: Control of telomere length by the human telomeric protein TRF1. Nature 385:740, 1997.
55. Mirabella A, Gartenberg MR: Yeast telomeric sequences function as chromosomal anchorage points in vivo. EMBO J 16:523, 1997.
56. Wotton D, Shore D: A novel Rap1p-interacting factor, Rif2p, cooperates with Riflp to regulate telomere length in Saccharomyces cerevisiae. Genes Dev 11:748, 1997.
57. Moretti P, Freeman K, Coodly L, Shore D: Evidence that a complex of SIR proteins interacts with the silencer and telomere-binding protein Rap1. Genes Dev 8:2257, 1994.
58. Marcand S, Buck SW, Moretti P, Gilson E, Shore D: Silencing of genes at nontelomeric sites in yeast is controlled by sequestration of silencing factors at telomeres by Rap1 protein. Genes Dev 10:1297, 1996.
59. Makarov VL, Hirose Y, Langmore JP: Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening. Cell 88:657, 1997.
60. Nugent CI, Hughes TR, Lue NF, Lundblad V: Cdc13p: a single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance. Science 274:249, 1996.
61. Fang G, Cech TR: Characterization of a G-quartet formation reaction promoted by the β-subunit of the Oxytricha telomere-binding protein. Biochemistry 32:11646, 1993.
62. Wellinger RJ, Ethier K, Labrecque P, Zakian VA: Evidence for a new step in telomere maintenance. Cell 85:423, 1996.
63. Feng J, Funk WD, Wang S-S, Weinrich SL, Avilion AA, Chiu C-P, Adams RR, Chang E, Allsopp RC, Yu J, Le S, West MD, Harley CB, Andrews WH, Greider CW, Villeponteau B: The RNA component of human telomerase. Science 269:1236, 1995.
64. Lingner J, Hughes TR, Shevchenko A, Mann M, Lundblad V, Cech TR: Reverse transcriptase motifs in the catalytic subunit of telomerase. Science 276:561, 1997.
65. Collins K, Kobayashi R, Greider CW: Purification of tetrahymena telomerase and cloning of genes encoding the two protein components of the enzyme. Cell 81:677, 1995.
66. Lingner J, Cech TR: Purification of telomerase from Euplotes aediculatus: requirement of a primer 3′ overhang. Proc Natl Acad Sci USA 93:10712, 1996.
67. Nakayama J, Saito M, Nakamura H, Matsuura A, Ishikawa F: TLP1: A gene encoding a protein component of mammalian telomerase is a novel member of WD repeats family. Cell 88:1, 1997.