-
1
-
-
77957329119
-
Isoprenoid pathway optimization for taxol precursor overproduction in Escherichia coli
-
Ajikumar PK, Xiao et al. 2010. Isoprenoid pathway optimization for taxol precursor overproduction in Escherichia coli. Science 330:70-74.
-
(2010)
Science
, vol.330
, pp. 70-74
-
-
Ajikumar, P.K.1
Xiao, W.H.2
-
3
-
-
0037151063
-
The kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase). A surprising lack of substrate channeling
-
Bulock KG, Beardsley GP, Anderson KS. 2002. The kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase). A surprising lack of substrate channeling. J. Biol. Chem. 277: 22168-22174.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 22168-22174
-
-
Bulock, K.G.1
Beardsley, G.P.2
Anderson, K.S.3
-
4
-
-
0242487787
-
OptKnock: a bilevel programming framework for identifying gene knockout strategies for microbial strain optimization
-
Burgard AP, Pharkya P, Maranas CD. 2003. OptKnock: a bilevel programming framework for identifying gene knockout strategies for microbial strain optimization. Biotechnol. Bioeng. 84:647-657.
-
(2003)
Biotechnol. Bioeng.
, vol.84
, pp. 647-657
-
-
Burgard, A.P.1
Pharkya, P.2
Maranas, C.D.3
-
5
-
-
33746922036
-
Evolutionary genomics of theHADsuperfamily: understanding the structural adaptations and catalytic diversity in a superfamily of phosphoesterases and allied enzymes
-
Burroughs AM, Allen KN, Dunaway-Mariano D, Aravind L. 2006. Evolutionary genomics of theHADsuperfamily: understanding the structural adaptations and catalytic diversity in a superfamily of phosphoesterases and allied enzymes. J. Mol. Biol. 361:1003-1034.
-
(2006)
J. Mol. Biol.
, vol.361
, pp. 1003-1034
-
-
Burroughs, A.M.1
Allen, K.N.2
Dunaway-Mariano, D.3
Aravind, L.4
-
6
-
-
0035177610
-
Enzyme engineering: rational redesign versus directed evolution
-
Chen R. 2001. Enzyme engineering: rational redesign versus directed evolution. Trends Biotechnol. 19:13-14.
-
(2001)
Trends Biotechnol
, vol.19
, pp. 13-14
-
-
Chen, R.1
-
7
-
-
50949084090
-
Evolutionarily conserved substrate substructures for automated annotation of enzyme superfamilies
-
Chiang RA, Sali A, Babbitt PC. 2008. Evolutionarily conserved substrate substructures for automated annotation of enzyme superfamilies. PLoS Comput. Biol. 4:e1000142.
-
(2008)
PLoS Comput. Biol.
, vol.4
-
-
Chiang, R.A.1
Sali, A.2
Babbitt, P.C.3
-
8
-
-
52649153633
-
Engineering of an Escherichia coli strain for the production of 3-methyl-1-Butanol
-
Connor MR, Liao JC. 2008. Engineering of an Escherichia coli strain for the production of 3-methyl-1-Butanol. Appl. Environ. Microbiol. 74: 5769-5775.
-
(2008)
Appl. Environ. Microbiol.
, vol.74
, pp. 5769-5775
-
-
Connor, M.R.1
Liao, J.C.2
-
9
-
-
68449088806
-
Synthetic protein scaffolds provide modular control over metabolic flux
-
Dueber JE, et al. 2009. Synthetic protein scaffolds provide modular control over metabolic flux. Nat. Biotechnol. 27:753-759.
-
(2009)
Nat. Biotechnol.
, vol.27
, pp. 753-759
-
-
Dueber, J.E.1
-
10
-
-
0025696050
-
Cloning and nucleotide sequence of the ispA gene responsible for farnesyl diphosphate synthase activity in Escherichia coli
-
Fujisaki S, Hara H, Nishimura Y, Horiuchi K, Nishino T. 1990. Cloning and nucleotide sequence of the ispA gene responsible for farnesyl diphosphate synthase activity in Escherichia coli. J. Biochem. 108:995-1000.
-
(1990)
J. Biochem.
, vol.108
, pp. 995-1000
-
-
Fujisaki, S.1
Hara, H.2
Nishimura, Y.3
Horiuchi, K.4
Nishino, T.5
-
12
-
-
0032811818
-
Escherichia coli open reading frame 696 is idi, a nonessential gene encoding isopentenyl diphosphate isomerase
-
Hahn FM, Hurlburt AP, Poulter CD. 1999. Escherichia coli open reading frame 696 is idi, a nonessential gene encoding isopentenyl diphosphate isomerase. J. Bacteriol. 181:4499-4504.
-
(1999)
J. Bacteriol.
, vol.181
, pp. 4499-4504
-
-
Hahn, F.M.1
Hurlburt, A.P.2
Poulter, C.D.3
-
13
-
-
36049014096
-
Real-time measurement of pyrophosphate release kinetics
-
Hanes JW, Johnson KA. 2008. Real-time measurement of pyrophosphate release kinetics. Anal. Biochem. 372:125-127.
-
(2008)
Anal. Biochem.
, vol.372
, pp. 125-127
-
-
Hanes, J.W.1
Johnson, K.A.2
-
14
-
-
42349106782
-
The Ehrlich pathway of fusel alcohol production: a century of research on Saccharomyces cerevisiae metabolism
-
Hazelwood LA, Daran J-M, van Maris AJA, Pronk JT, Dickinson JR. 2008. The Ehrlich pathway of fusel alcohol production: a century of research on Saccharomyces cerevisiae metabolism. Appl. Environ. Microbiol. 74:2259-2266.
-
(2008)
Appl. Environ. Microbiol.
, vol.74
, pp. 2259-2266
-
-
Hazelwood, L.A.1
Daran, J.-M.2
van Maris, A.J.A.3
Pronk, J.T.4
Dickinson, J.R.5
-
15
-
-
0032863699
-
Construction of environmentalDNAlibraries in Escherichia coli and screening for the presence of genes conferring utilization of 4-hydroxybutyrate
-
Henne A, Daniel R, Schmitz RA, Gottschalk G. 1999. Construction of environmentalDNAlibraries in Escherichia coli and screening for the presence of genes conferring utilization of 4-hydroxybutyrate. Appl. Environ. Microbiol. 65:3901-3907.
-
(1999)
Appl. Environ. Microbiol.
, vol.65
, pp. 3901-3907
-
-
Henne, A.1
Daniel, R.2
Schmitz, R.A.3
Gottschalk, G.4
-
16
-
-
0017272554
-
Enzyme recruitment in evolution of new function
-
Jensen RA. 1976. Enzyme recruitment in evolution of new function. Annu. Rev. Microbiol. 30:409-425.
-
(1976)
Annu. Rev. Microbiol.
, vol.30
, pp. 409-425
-
-
Jensen, R.A.1
-
18
-
-
78649716727
-
Manufacturing molecules through metabolic engineering
-
Keasling JD. 2010. Manufacturing molecules through metabolic engineering. Science 330:1355-1358.
-
(2010)
Science
, vol.330
, pp. 1355-1358
-
-
Keasling, J.D.1
-
19
-
-
77953623874
-
Enzyme promiscuity: a mechanistic and evolutionary perspective
-
Khersonsky O, Tawfik DS. 2010. Enzyme promiscuity: a mechanistic and evolutionary perspective. Annu. Rev. Biochem. 79:471-505.
-
(2010)
Annu. Rev. Biochem.
, vol.79
, pp. 471-505
-
-
Khersonsky, O.1
Tawfik, D.S.2
-
20
-
-
33846023053
-
Genome-wide analysis of substrate specificities of the Escherichia coli haloacid dehalogenase-like phosphatase family
-
Kuznetsova E, et al. 2006. Genome-wide analysis of substrate specificities of the Escherichia coli haloacid dehalogenase-like phosphatase family. J. Biol. Chem. 281:36149-36161.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 36149-36161
-
-
Kuznetsova, E.1
-
21
-
-
0034700150
-
Isoprenoid biosynthesis: the evolution of two ancient and distinct pathways across genomes
-
Lange BM, Rujan T, Martin W, Croteau R. 2000. Isoprenoid biosynthesis: the evolution of two ancient and distinct pathways across genomes. Proc. Natl. Acad. Sci. U. S. A. 97:13172-13177.
-
(2000)
Proc. Natl. Acad. Sci. U. S. A.
, vol.97
, pp. 13172-13177
-
-
Lange, B.M.1
Rujan, T.2
Martin, W.3
Croteau, R.4
-
22
-
-
50049109691
-
Heterologous protein production in Escherichia coli using the propionate-inducible pPro system by conventional and auto-induction methods
-
Lee SK, Keasling JD. 2008. Heterologous protein production in Escherichia coli using the propionate-inducible pPro system by conventional and auto-induction methods. Protein Expr. Purif. 61:197-203.
-
(2008)
Protein Expr. Purif.
, vol.61
, pp. 197-203
-
-
Lee, S.K.1
Keasling, J.D.2
-
23
-
-
0038391517
-
Engineering a mevalonate pathway in Escherichia coli for production of terpenoids
-
Martin VJ, Pitera DJ, Withers ST, Newman JD, Keasling JD. 2003. Engineering a mevalonate pathway in Escherichia coli for production of terpenoids. Nat. Biotechnol. 21:796-802.
-
(2003)
Nat. Biotechnol.
, vol.21
, pp. 796-802
-
-
Martin, V.J.1
Pitera, D.J.2
Withers, S.T.3
Newman, J.D.4
Keasling, J.D.5
-
24
-
-
30744470374
-
The Nudix hydrolase superfamily
-
McLennan AG. 2006. The Nudix hydrolase superfamily. Cell. Mol. Life Sci. 63:123-143.
-
(2006)
Cell. Mol. Life Sci.
, vol.63
, pp. 123-143
-
-
McLennan, A.G.1
-
25
-
-
36148932151
-
Tethering small molecules to a phage display library: discovery of a selective bivalent inhibitor or protein kinase A
-
Meyer SC, Shomin CD, Gaj T, Ghosh I. 2007. Tethering small molecules to a phage display library: discovery of a selective bivalent inhibitor or protein kinase A. J. Am. Chem. Soc. 129:13812-13813.
-
(2007)
J. Am. Chem. Soc.
, vol.129
, pp. 13812-13813
-
-
Meyer, S.C.1
Shomin, C.D.2
Gaj, T.3
Ghosh, I.4
-
26
-
-
9744224380
-
Structures and mechanisms of Nudix hydrolases
-
Mildvan AS, et al. 2005. Structures and mechanisms of Nudix hydrolases. Arch. Biochem. Biophys. 433:129-143.
-
(2005)
Arch. Biochem. Biophys.
, vol.433
, pp. 129-143
-
-
Mildvan, A.S.1
-
27
-
-
0034047474
-
Purification and characterization of bifunctional lysine-ketoglutarate reductase/saccharopine dehydrogenase from developing soybean seeds
-
Miron D, Ben-Yaacov S, Reches D, Schupper A, Galili G. 2000. Purification and characterization of bifunctional lysine-ketoglutarate reductase/saccharopine dehydrogenase from developing soybean seeds. Plant Physiol. 123:655-663.
-
(2000)
Plant Physiol
, vol.123
, pp. 655-663
-
-
Miron, D.1
Ben-Yaacov, S.2
Reches, D.3
Schupper, A.4
Galili, G.5
-
28
-
-
0031021921
-
Molecular cloning of the nemA gene encoding N-ethylmaleimide reductase from Escherichia coli
-
Miura K, et al. 1997. Molecular cloning of the nemA gene encoding N-ethylmaleimide reductase from Escherichia coli. Biol. Pharm. Bull. 20:110-112.
-
(1997)
Biol. Pharm. Bull.
, vol.20
, pp. 110-112
-
-
Miura, K.1
-
29
-
-
59649099262
-
Production of glucaric acid from a synthetic pathway in recombinant Escherichia coli
-
Moon TS, Yoon S-H, Lanza AM, Roy-Mayhew JD, Prather KLJ. 2009. Production of glucaric acid from a synthetic pathway in recombinant Escherichia coli. Appl. Environ. Microbiol. 75:589-595.
-
(2009)
Appl. Environ. Microbiol.
, vol.75
, pp. 589-595
-
-
Moon, T.S.1
Yoon, S.-H.2
Lanza, A.M.3
Roy-Mayhew, J.D.4
Prather, K.L.J.5
-
30
-
-
33846945701
-
Carbonyl reductases: the complex relationships of mammalian carbonyl- and quinone-reducing enzymes and their role in physiology
-
Oppermann U. 2007. Carbonyl reductases: the complex relationships of mammalian carbonyl- and quinone-reducing enzymes and their role in physiology. Annu. Rev. Pharmacol. Toxicol. 47:293-322.
-
(2007)
Annu. Rev. Pharmacol. Toxicol.
, vol.47
, pp. 293-322
-
-
Oppermann, U.1
-
31
-
-
0035913746
-
Bifunctional abietadiene synthase: free diffusive transfer of the (+)-copalyl diphosphate intermediate between two distinct active sites
-
Peters RJ, Ravn MM, Coates RM, Croteau RB. 2001. Bifunctional abietadiene synthase: free diffusive transfer of the (_)-copalyl diphosphate intermediate between two distinct active sites. J. Am. Chem. Soc. 123:8974-8978.
-
(2001)
J. Am. Chem. Soc.
, vol.123
, pp. 8974-8978
-
-
Peters, R.J.1
Ravn, M.M.2
Coates, R.M.3
Croteau, R.B.4
-
32
-
-
0024421881
-
Effect of evolution on the kinetic properties of enzymes
-
Pettersson G. 1989. Effect of evolution on the kinetic properties of enzymes. Eur. J. Biochem. 184:561-566.
-
(1989)
Eur. J. Biochem.
, vol.184
, pp. 561-566
-
-
Pettersson, G.1
-
33
-
-
33847309176
-
Balancing a heterologous mevalonate pathway for improved isoprenoid production in Escherichia coli
-
Pitera DJ, Paddon CJ, Newman JD, Keasling JD. 2007. Balancing a heterologous mevalonate pathway for improved isoprenoid production in Escherichia coli. Metab. Eng. 9:193-207.
-
(2007)
Metab. Eng.
, vol.9
, pp. 193-207
-
-
Pitera, D.J.1
Paddon, C.J.2
Newman, J.D.3
Keasling, J.D.4
-
34
-
-
0030817279
-
RNA-peptide fusions for the in vitro selection of peptides and proteins
-
Roberts RW, Szostak JW. 1997. RNA-peptide fusions for the in vitro selection of peptides and proteins. Proc. Natl. Acad. Sci. U. S. A. 94:12297-12302.
-
(1997)
Proc. Natl. Acad. Sci. U. S. A.
, vol.94
, pp. 12297-12302
-
-
Roberts, R.W.1
Szostak, J.W.2
-
35
-
-
0032568591
-
Optimizing the stability of single-chain proteins by linker length and composition mutagenesis
-
Robinson CR, Sauer RT. 1998. Optimizing the stability of single-chain proteins by linker length and composition mutagenesis. Proc. Natl. Acad. Sci. U. S. A. 95:5929-5934.
-
(1998)
Proc. Natl. Acad. Sci. U. S. A.
, vol.95
, pp. 5929-5934
-
-
Robinson, C.R.1
Sauer, R.T.2
-
36
-
-
79951633115
-
The evolution of new enzyme function: lessons from xenobiotic metabolizing bacteria versus insecticide-resistant insects
-
Russell RJ, et al. 2011. The evolution of new enzyme function: lessons from xenobiotic metabolizing bacteria versus insecticide-resistant insects. Evol. Appl. 4:225-248.
-
(2011)
Evol. Appl.
, vol.4
, pp. 225-248
-
-
Russell, R.J.1
-
37
-
-
70349964350
-
Automated design of synthetic ribosome binding sites to control protein expression
-
Salis HM, Mirsky EA, Voigt CA. 2009. Automated design of synthetic ribosome binding sites to control protein expression. Nat. Biotechnol. 27:946-950.
-
(2009)
Nat. Biotechnol.
, vol.27
, pp. 946-950
-
-
Salis, H.M.1
Mirsky, E.A.2
Voigt, C.A.3
-
38
-
-
34547958191
-
Selection and evolution of enzymes from a partially randomized non-catalytic scaffold
-
Seelig B, Szostak JW. 2007. Selection and evolution of enzymes from a partially randomized non-catalytic scaffold. Nature 448:828-831.
-
(2007)
Nature
, vol.448
, pp. 828-831
-
-
Seelig, B.1
Szostak, J.W.2
-
39
-
-
0021818675
-
Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface
-
Smith GP. 1985. Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface. Science 228:1315-1317.
-
(1985)
Science
, vol.228
, pp. 1315-1317
-
-
Smith, G.P.1
-
40
-
-
0025025784
-
Isopentenyl diphosphate: dimethylallyl diphosphate isomerase: construction of a high-level heterologous expression system for the gene from Saccharomyces cerevisiae and identification of an active-site nucleophile
-
Street IP, Poulter CD. 1990. Isopentenyl diphosphate:dimethylallyl diphosphate isomerase: construction of a high-level heterologous expression system for the gene from Saccharomyces cerevisiae and identification of an active-site nucleophile. Biochemistry 29:7531-7538.
-
(1990)
Biochemistry
, vol.29
, pp. 7531-7538
-
-
Street, I.P.1
Poulter, C.D.2
-
41
-
-
77949495880
-
Predicting metabolic engineering knockout strategies for chemical production: accounting for competing pathways
-
Tepper N, Shlomi T. 2010. Predicting metabolic engineering knockout strategies for chemical production: accounting for competing pathways. Bioinformatics 26:536-543.
-
(2010)
Bioinformatics
, vol.26
, pp. 536-543
-
-
Tepper, N.1
Shlomi, T.2
-
42
-
-
0035815113
-
Evolution of function in protein superfamilies, from a structural perspective
-
Todd AE, Orengo CA, Thorton JM. 2001. Evolution of function in protein superfamilies, from a structural perspective. J. Mol. Biol. 307: 1113-1143.
-
(2001)
J. Mol. Biol.
, vol.307
, pp. 1113-1143
-
-
Todd, A.E.1
Orengo, C.A.2
Thorton, J.M.3
-
43
-
-
0004068410
-
-
3rd ed Springer Verlag, New York, NY
-
Villadsen J, Nielsen J, Liden G. 2011. Bioreaction engineering principles, 3rd ed, p 7-62. Springer Verlag, New York, NY.
-
(2011)
Bioreaction engineering principles
, pp. 7-62
-
-
Villadsen, J.1
Nielsen, J.2
Liden, G.3
-
44
-
-
0035987236
-
'New uses for an old enzyme'-the old yellow enzyme family of flavoenzymes
-
Williams RE, Bruce NC. 2002. 'New uses for an old enzyme'-the old yellow enzyme family of flavoenzymes. Microbiology 148:1607-1614.
-
(2002)
Microbiology
, vol.148
, pp. 1607-1614
-
-
Williams, R.E.1
Bruce, N.C.2
-
46
-
-
35148889024
-
Identification of isopentenol biosynthesis genes from Bacillus subtilis by a screening method based on isoprenoid precursor toxicity
-
Withers ST, Gottlieb SS, Lieu B, Newman JD, Keasling JD. 2007. Identification of isopentenol biosynthesis genes from Bacillus subtilis by a screening method based on isoprenoid precursor toxicity. Appl. Environ. Microbiol. 73:6277-6283.
-
(2007)
Appl. Environ. Microbiol.
, vol.73
, pp. 6277-6283
-
-
Withers, S.T.1
Gottlieb, S.S.2
Lieu, B.3
Newman, J.D.4
Keasling, J.D.5
-
47
-
-
33144464467
-
Control of protein functional dynamics by peptide linkers
-
Wriggers W, Chakravarty S, Jennings PA. 2005. Control of protein functional dynamics by peptide linkers. Biopolymers 80:736-746.
-
(2005)
Biopolymers
, vol.80
, pp. 736-746
-
-
Wriggers, W.1
Chakravarty, S.2
Jennings, P.A.3
-
50
-
-
0037147307
-
The activity of the Arabidopsis bifunctional lysine-ketoglutarate reductase/saccharopine dehydrogenase enzyme of lysine catabolism is regulated by functional interaction between its two enzyme domains
-
Zhu X, Tang G, Galili G. 2002. The activity of the Arabidopsis bifunctional lysine-ketoglutarate reductase/saccharopine dehydrogenase enzyme of lysine catabolism is regulated by functional interaction between its two enzyme domains. J. Biol. Chem. 277:49655-49661.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 49655-49661
-
-
Zhu, X.1
Tang, G.2
Galili, G.3
|