Evolutionarily conserved substrate substructures for automated annotation of enzyme superfamilies

PLoS Computational Biology

Volumn 4, Issue 8, 2008, Pages

  Chiang, Ranyee A ^a   Sali, Andrej ^a   Babbitt, Patricia C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYMES; ORTHOGONAL FUNCTIONS; PRECISION ENGINEERING;

ENVIRONMENTAL CONDITIONS; ENZYME ENGINEERING; ENZYME EVOLUTIONS; ENZYME FUNCTIONS; ENZYME SEQUENCE; ENZYME STRUCTURES; ENZYME SUPERFAMILIES; GRAPH ISOMORPHISM; MOLECULAR FUNCTION; MULTIPLE CONTEXTS;

SUBSTRATES;

ALKALINE PHOSPHATASE; AMINOPEPTIDASE; ARGINASE; ASPARAGINASE; BETA LACTAMASE; CARBOHYDRATE PHOSPHATASE; CASPASE; CHELATE; COBALAMIN; CYTIDINE DEAMINASE; DEOXYURIDINE TRIPHOSPHATE PYROPHOSPHATASE; ENOLASE; ENZYME; EPIMERASE; EXOPEPTIDASE; FRUCTOSE BISPHOSPHATE ALDOLASE; GAMMA GLUTAMYLTRANSFERASE; GLUTAMINASE; HYDROLASE; LAMININ; LIGASE; NUDIX HYDROLASE; OXIDOREDUCTASE; PHOSPHATASE; PHOSPHOGLYCERATE MUTASE; SUBTILISIN; THIOL ESTER HYDROLASE; XYLOSE;

AMINO ACID SEQUENCE; ARTICLE; AUTOMATION; ENZYME SUBSTRATE COMPLEX; GENOMICS; MOLECULAR EVOLUTION; PROTEIN ENGINEERING; PROTEIN FUNCTION; PROTEIN STRUCTURE; ANIMAL; AUTOMATED PATTERN RECOGNITION; BIOLOGY; CATALYSIS; CHEMISTRY; CLUSTER ANALYSIS; ENZYME SPECIFICITY; GENETICS; HUMAN; METABOLISM; METHODOLOGY; NUCLEOTIDE SEQUENCE; PROTEIN BINDING; PROTEIN DATABASE; PROTEIN DOMAIN; SEQUENCE ALIGNMENT; STRUCTURAL HOMOLOGY; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; CATALYSIS; CLUSTER ANALYSIS; COMPUTATIONAL BIOLOGY; CONSERVED SEQUENCE; DATABASES, PROTEIN; ENZYMES; EVOLUTION, MOLECULAR; HUMANS; PATTERN RECOGNITION, AUTOMATED; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; SEQUENCE ALIGNMENT; STRUCTURAL HOMOLOGY, PROTEIN; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 50949084090     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1000142     Document Type: Article

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