Structural and sequence analysis of the human γd-crystallin amyloid fibril core using 2D IR spectroscopy, segmental 13C labeling, and mass spectrometry

Journal of the American Chemical Society

Volumn 134, Issue 44, 2012, Pages 18410-18416

  Moran, Sean D ^a,b   Decatur, Sean M ^b   Zanni, Martin T ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b OBERLIN COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDIC CONDITIONS; AMYLOID FIBRIL; C-TERMINAL DOMAINS; CONFORMATIONAL TRANSITIONS; CORE REGION; CRYSTALLIN; DRUG BINDING; EYE-LENS PROTEIN; ISOTOPE LABELING; MALDI MS/MS; N-TERMINAL DOMAINS; N-TERMINALS; NATIVE STATE; POTENTIAL DRUG; SEQUENCE ANALYSIS; STRUCTURAL CONTENT; STRUCTURE INFORMATION;

ISOTOPES; MASS SPECTROMETRY;

GLYCOPROTEINS;

AMYLOID; AMYLOID BETA PROTEIN; CARBON 13; GAMMA CRYSTALLIN;

ACIDITY; ALPHA HELIX; AMINO TERMINAL SEQUENCE; ANALYTIC METHOD; ARTICLE; BETA SHEET; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; INFRARED SPECTROSCOPY; ISOTOPE LABELING; MASS SPECTROMETRY; PROTEIN AGGREGATION; PROTEIN DOMAIN; SEQUENCE ANALYSIS; TANDEM MASS SPECTROMETRY;

AMINO ACID SEQUENCE; AMYLOID; CARBON ISOTOPES; GAMMA-CRYSTALLINS; HUMANS; ISOTOPE LABELING; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SPECTROPHOTOMETRY, INFRARED; TANDEM MASS SPECTROMETRY;

EID: 84868549643     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja307898g     Document Type: Article

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