Structural and mechanistic basis behind the inhibitory interaction of PcTS on α-synuclein amyloid fibril formation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 50, 2009, Pages 21057-21062

  Lamberto, Gonzalo R ^a   Binolfi, Andrés ^a   Orcellet, María L ^a   Bertoncini, Carlos W ^b   Zweckstetter, Markus ^c,d   Griesinger, Christian ^c   Fernández, Claudio O ^a,c  

^a UNIVERSIDAD NACIONAL DE ROSARIO   (Argentina)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^d Deutsche Forschungsgemeinschaft   (Germany)

Author keywords

Aggregation inhibitor; Misfolding; Parkinson's disease

Indexed keywords

ALPHA SYNUCLEIN; AMYLOID; PHTHALOCYANINE; PHTHALOCYANINE TETRASULFONATE; SULFONIC ACID DERIVATIVE; TYROSINE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CONTROLLED STUDY; DEGENERATIVE DISEASE; DRUG BINDING; DRUG INHIBITION; DRUG STRUCTURE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL;

ALPHA-SYNUCLEIN; AMYLOID; BINDING SITES; HUMANS; INDOLES; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR PROBES; PROTEIN MULTIMERIZATION;

EID: 75849152230     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0902603106     Document Type: Article

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