Ankaflavin: A natural novel PPARγ agonist upregulates Nrf2 to attenuate methylglyoxal-induced diabetes in vivo

Free Radical Biology and Medicine

Volumn 53, Issue 11, 2012, Pages 2008-2016

  Lee, Bao Hong ^a   Hsu, Wei Hsuan ^a   Chang, Yu Ying ^a   Kuo, Hsuan Fu ^a   Hsu, Ya Wen ^a   Pan, Tzu Ming ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Advanced glycation end products; Ankaflavin; Free radicals; Methylglyoxal; Nuclear factor erythroid related factor 2; Peroxisome proliferator activated receptor

Indexed keywords

ADVANCED GLYCATION END PRODUCT; ANKAFLAVIN; ANTIDIABETIC AGENT; GLUCOSE; GLUCOSE TRANSPORTER 2; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; HEME OXYGENASE 1; INTERLEUKIN 1BETA; MESSENGER RNA; METHYLGLYOXAL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PROTEIN TYROSINE PHOSPHATASE 1B; ROSIGLITAZONE; TRANSCRIPTION FACTOR MAF; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; GLUCOSE BLOOD LEVEL; GLUCOSE TRANSPORT; GLYCATION; IN VITRO STUDY; IN VIVO STUDY; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; LIVER FUNCTION; MALE; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

ANILIDES; ANIMALS; ANTI-INFLAMMATORY AGENTS; BLOOD GLUCOSE; CYTOKINES; DIABETES MELLITUS, EXPERIMENTAL; FLAVINS; GENE EXPRESSION; GENE EXPRESSION REGULATION; GLYCOSYLATION END PRODUCTS, ADVANCED; HEME OXYGENASE-1; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN RESISTANCE; LEUKOCYTES, MONONUCLEAR; LIVER; MALE; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PANCREAS; PHOSPHORYLATION; PPAR GAMMA; PROTEIN PROCESSING, POST-TRANSLATIONAL; PYRUVALDEHYDE; RATS; RATS, WISTAR; RECEPTORS, IMMUNOLOGIC; UP-REGULATION;

RATTUS; RATTUS NORVEGICUS;

EID: 84868541248     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2012.09.025     Document Type: Article

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