Chronic methylglyoxal infusion by minipump causes pancreatic β-cell dysfunction and induces type 2 diabetes in Sprague-Dawley rats

Diabetes

Volumn 60, Issue 3, 2011, Pages 899-908

  Dhar, Arti ^a   Dhar, Indu ^a   Jiang, Bo ^a   Desai, Kaushik M ^a   Wu, Lingyun ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

6 N CARBOXYMETHYLLYSINE; ADVANCED GLYCATION END PRODUCT; CCAAT ENHANCER BINDING PROTEIN BETA; GLUCOKINASE; GLUCOSE TRANSPORTER 2; GLUCOSE TRANSPORTER 4; GLUTATHIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; METHYLGLYOXAL; PHOSPHATIDYLINOSITOL 3 KINASE; TRANSCRIPTION FACTOR MAFA;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GLUCOSE TOLERANCE; GLUCOSE TRANSPORT; IMPAIRED GLUCOSE TOLERANCE; INSULIN RELEASE; MALE; MINIPUMP; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS INSUFFICIENCY; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT; TISSUE DISTRIBUTION;

ADIPOSE TISSUE; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; DIABETES MELLITUS, TYPE 2; GLUCOSE; GLUCOSE TOLERANCE TEST; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; INFUSION PUMPS; INSULIN; INSULIN-SECRETING CELLS; MALE; MUSCLE, SKELETAL; PANCREAS; PYRUVALDEHYDE; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 79952403213     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db10-0627     Document Type: Article

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