Acute hyperglycemia causes intracellular formation of CML and activation of ras, p42/44 MAPK, and nuclear factor κB in PBMCs

Diabetes

Volumn 52, Issue 3, 2003, Pages 621-633

  Schiekofer, Stephan ^a   Andrassy, Martin ^a   Chen, Jiang ^a   Rudofsky, Gottfried ^a   Schneider, Jochen ^a   Wendt, Thoralf ^a   Stefan, Norbert ^b   Humpert, Per ^a   Fritsche, Andreas ^b   Stumvoll, Michael ^b   Schleicher, Erwin ^b   Häring, Hans Ulrich ^b   Nawroth, Peter P ^a   Bierhaus, Angelika ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

CML, carboxymethyllysine; DMEM, Dulbecco's modified Eagle's medium; DTT, diothiothreitol; EMSA, electrophoretic mobility shift assay; MAPK, mitogen activated protein kinase; NF, nuclear factor; PBMC, peripheral blood mononuclear cell; PKC, protein kinase C

Indexed keywords

CARBOXYMETHYLLYSINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; LUCIFERASE; MITOGEN ACTIVATED PROTEIN KINASE; PEPTIDE; PROTEIN KINASE C; PROTEIN P42; PROTEIN P44; RAS PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID COMPOSITION; AMINO ACID SYNTHESIS; ARTICLE; BINDING AFFINITY; CELL ACTIVATION; CELL ISOLATION; CONTROLLED STUDY; GENE ACTIVATION; GENETIC TRANSCRIPTION; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; GLUCOSE INFUSION; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HYPERGLYCEMIA; MONONUCLEAR CELL; NUCLEOCYTOPLASMIC TRANSPORT; PLASMID; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; TRANSCRIPTION REGULATION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CATTLE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENDOTHELIUM, VASCULAR; GLUCOSE CLAMP TECHNIQUE; HUMANS; HYPERGLYCEMIA; LEUKOCYTES, MONONUCLEAR; LYSINE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS P21(RAS); SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 0037339603     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.52.3.621     Document Type: Article

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