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Volumn 9, Issue 11, 2009, Pages 1615-1621

All-trans retinoic acid as a novel therapeutic strategy for Alzheimer's disease

Author keywords

Alzheimer's disease; Cell cycle; Oxidative stress; Retinoic acid; Therapeutics

Indexed keywords

AMYLOID BETA PROTEIN; BETA CAROTENE; CYCLIN B; RETINOIC ACID; RETINOIC ACID RECEPTOR ALPHA; RETINOIC ACID RECEPTOR BETA; RETINOIC ACID RECEPTOR GAMMA; RETINOL;

EID: 70849097441     PISSN: 14737175     EISSN: 17448360     Source Type: Journal    
DOI: 10.1586/ern.09.86     Document Type: Review
Times cited : (101)

References (102)
  • 3
    • 0033956665 scopus 로고    scopus 로고
    • Pharmacokinetics of all-trans retinoic acid, 13-cis retinoic acid, and fenretinide in plasma and brain of rat
    • Le Doze F, Debruyne D, Albessard F, Barre L, Defer GL. Pharmacokinetics of all-trans retinoic acid, 13-cis retinoic acid, and fenretinide in plasma and brain of rat. Drug Metab. Dispos. 28, 205-208 (2000). (Pubitemid 30069005)
    • (2000) Drug Metabolism and Disposition , vol.28 , Issue.2 , pp. 205-208
    • Le Doze, F.1    Debruyne, D.2    Albessard, F.3    Barre, L.4    Defer, G.L.5
  • 4
    • 0037081796 scopus 로고    scopus 로고
    • Influence of isomerisation on the growth inhibitory effects and cellular activity of 13-cis and all-trans retinoic acid in neuroblastoma cells
    • DOI 10.1016/S0006-2952(01)00844-9, PII S0006295201008449
    • Veal GJ, Errington J, Redfern CP, Pearson AD, Boddy AV. Influence of isomerisation on the growth inhibitory effects and cellular activity of 13-cis and all-trans retinoic acid in neuroblastoma cells. Biochem. Pharmacol. 63, 207-215 (2002). (Pubitemid 34158821)
    • (2002) Biochemical Pharmacology , vol.63 , Issue.2 , pp. 207-215
    • Veal, G.J.1    Errington, J.2    Redfern, C.P.F.3    Pearson, A.D.J.4    Boddy, A.V.5
  • 5
    • 0029562554 scopus 로고
    • The RXR heterodimers and orphan receptors
    • Mangelsdorf DJ, Evans RM. The RXR heterodimers and orphan receptors. Cell 83, 841-850 (1995).
    • (1995) Cell , vol.83 , pp. 841-850
    • Mangelsdorf, D.J.1    Evans, R.M.2
  • 6
    • 63049130472 scopus 로고    scopus 로고
    • Induction of apoptosis by the retinoid inducible growth regulator RIG1 depends on the NC motif in HtTA cervical cancer cells
    • Tsai FM, Shyu RY, Lin SC, Wu CC, Jiang SY. Induction of apoptosis by the retinoid inducible growth regulator RIG1 depends on the NC motif in HtTA cervical cancer cells. BMC Cell Biol. 10, 15 (2009).
    • (2009) BMC Cell Biol. , vol.10 , pp. 15
    • Tsai, F.M.1    Shyu, R.Y.2    Lin, S.C.3    Wu, C.C.4    Jiang, S.Y.5
  • 7
    • 71849090358 scopus 로고    scopus 로고
    • Retinoic acids are potent inhibitors of spontaneous human eosinophil apoptosis
    • Ueki S, Mahemuti G, Oyamada H et al. Retinoic acids are potent inhibitors of spontaneous human eosinophil apoptosis. J. Immunol. 181, 7689-7698 (2008).
    • (2008) J. Immunol. , vol.181 , pp. 7689-7698
    • Ueki, S.1    Mahemuti, G.2    Oyamada, H.3
  • 8
    • 27944432591 scopus 로고    scopus 로고
    • RARβ1': Primed to fight retinoid resistance in lung carcinogenesis
    • DOI 10.1093/jnci/dji413
    • Sabichi AL, Xu X, Lippman SM. RARβ1': primed to fight retinoid resistance in lung carcinogenesis. J. Natl Cancer Inst. 97, 1632-1633 (2005). (Pubitemid 41672222)
    • (2005) Journal of the National Cancer Institute , vol.97 , Issue.22 , pp. 1632-1633
    • Sabichi, A.L.1    Xu, X.2    Lippman, S.M.3
  • 9
    • 62549125005 scopus 로고    scopus 로고
    • The novel RARβ isoform (β5) is a potential target of retinoids in breast cancer
    • Christov K. The novel RARβ isoform (β5) is a potential target of retinoids in breast cancer. Curr. Cancer Drug Targets 9, 142-147 (2009).
    • (2009) Curr. Cancer Drug Targets , vol.9 , pp. 142-147
    • Christov, K.1
  • 10
    • 45549091579 scopus 로고    scopus 로고
    • Distinct functions of retinoic acid receptor β isoforms: Implications for targeted therapy
    • Swift CB, Hays JL, Petty WJ. Distinct functions of retinoic acid receptor β isoforms: implications for targeted therapy. Endocr. Metab. Immune Disord. Drug Targets 8, 47-50 (2008).
    • (2008) Endocr. Metab. Immune Disord. Drug Targets , vol.8 , pp. 47-50
    • Swift, C.B.1    Hays, J.L.2    Petty, W.J.3
  • 12
    • 3042649475 scopus 로고    scopus 로고
    • 2 signaling in the nucleus
    • DOI 10.1016/j.brainresrev.2004.03.002, PII S0165017304000359
    • Farooqui AA, Antony P, Ong WY, Horrocks LA, Freysz L. Retinoic acid-mediated phospholipase A2 signaling in the nucleus. Brain Res. Brain Res. Rev. 45, 179-195 (2004). (Pubitemid 38802870)
    • (2004) Brain Research Reviews , vol.45 , Issue.3 , pp. 179-195
    • Farooqui, A.A.1    Antony, P.2    Ong, W.-Y.3    Horrocks, L.A.4    Freysz, L.5
  • 14
    • 84880190029 scopus 로고    scopus 로고
    • Oxidative stress and iron imbalance in Alzheimer disease: How rust became the fuss!
    • Smith MA. Oxidative stress and iron imbalance in Alzheimer disease: how rust became the fuss! J. Alzheimers Dis. 9, 305-308 (2006).
    • (2006) J. Alzheimers Dis. , vol.9 , pp. 305-308
    • Smith, M.A.1
  • 15
    • 62549138762 scopus 로고    scopus 로고
    • Free radical damage to cerebral cortex in Alzheimer's disease, microvascular brain injury, and smoking
    • Sonnen JA, Larson EB, Gray SL et al. Free radical damage to cerebral cortex in Alzheimer's disease, microvascular brain injury, and smoking. Ann. Neurol. 65, 226-229 (2009).
    • (2009) Ann. Neurol. , vol.65 , pp. 226-229
    • Sonnen, J.A.1    Larson, E.B.2    Gray, S.L.3
  • 16
    • 62549117802 scopus 로고    scopus 로고
    • Altered redox balance in disease: Can we change the new equilibria?
    • Perry G, Zhu X, Moreira PI, Smith MA. Altered redox balance in disease: can we change the new equilibria? Ann. Neurol. 65, 121-123 (2009).
    • (2009) Ann. Neurol. , vol.65 , pp. 121-123
    • Perry, G.1    Zhu, X.2    Moreira, P.I.3    Smith, M.A.4
  • 17
    • 67650921433 scopus 로고    scopus 로고
    • Vitamin e paradox in Alzheimer's disease: It does not prevent loss of cognition and may even be detrimental
    • Lloret A, Badia MC, Mora NJ, Pallardo FV, Alonso MD, Vina J. Vitamin E paradox in Alzheimer's disease: it does not prevent loss of cognition and may even be detrimental. J. Alzheimers Dis. 17(1), 143-149 (2009).
    • (2009) J. Alzheimers Dis. , vol.17 , Issue.1 , pp. 143-149
    • Lloret, A.1    Badia, M.C.2    Mora, N.J.3    Pallardo, F.V.4    Alonso, M.D.5    Vina, J.6
  • 18
    • 9544248763 scopus 로고    scopus 로고
    • Dietary antioxidants and cognitive function in a population-based sample of older persons. The Rotterdam Study
    • Jama JW, Launer LJ, Witteman JC et al. Dietary antioxidants and cognitive function in a population-based sample of older persons. The Rotterdam Study. Am. J. Epidemiol. 144, 275-280 (1996).
    • (1996) Am. J. Epidemiol. , vol.144 , pp. 275-280
    • Jama, J.W.1    Launer, L.J.2    Witteman, J.C.3
  • 19
  • 20
    • 0032921546 scopus 로고    scopus 로고
    • Plasma chain-breaking antioxidants in Alzheimer's disease, vascular dementia and Parkinson's disease
    • Foy CJ, Passmore AP, Vahidassr MD, Young IS, Lawson JT. Plasma chain-breaking antioxidants in Alzheimer's disease, vascular dementia and Parkinson's disease. QJM 92, 39-45 (1999).
    • (1999) QJM , vol.92 , pp. 39-45
    • Foy, C.J.1    Passmore, A.P.2    Vahidassr, M.D.3    Young, I.S.4    Lawson, J.T.5
  • 21
    • 9844235930 scopus 로고    scopus 로고
    • Cerebrospinal fluid levels of a-tocopherol (vitamin E) in Alzheimer's disease
    • Jimenez-Jimenez FJ, de Bustos F, Molina JA et al. Cerebrospinal fluid levels of a-tocopherol (vitamin E) in Alzheimer's disease. J. Neural Transm. 104, 703-710 (1997).
    • (1997) J. Neural Transm. , vol.104 , pp. 703-710
    • Jimenez-Jimenez, F.J.1    De Bustos, F.2    Molina, J.A.3
  • 22
    • 0032799243 scopus 로고    scopus 로고
    • Serum levels of β-carotene, α-carotene and vitamin a in patients with Alzheimer's disease
    • Jimenez-Jimenez FJ, Molina JA, de Bustos F et al. Serum levels of β-carotene, α-carotene and vitamin A in patients with Alzheimer's disease. Eur. J. Neurol. 6, 495-497 (1999).
    • (1999) Eur. J. Neurol. , vol.6 , pp. 495-497
    • Jimenez-Jimenez, F.J.1    Molina, J.A.2    De Bustos, F.3
  • 25
    • 0033301784 scopus 로고    scopus 로고
    • Dietary links to Alzheimer's disease: 1999 update
    • Grant WB. Dietary links to Alzheimer's disease: 1999 update. J. Alzheimers Dis. 1, 197-201 (1999).
    • (1999) J. Alzheimers Dis. , vol.1 , pp. 197-201
    • Grant, W.B.1
  • 26
    • 0033301717 scopus 로고    scopus 로고
    • Diet and oxidative stress: A novel synthesis of epidemiological data on Alzheimer's disease
    • Smith MA, Petot GJ, Perry G. Diet and oxidative stress: a novel synthesis of epidemiological data on Alzheimer's disease. J. Alzheimers Dis. 1, 203-206 (1999). (Pubitemid 30829139)
    • (1999) Journal of Alzheimer's Disease , vol.1 , Issue.4-5 , pp. 203-206
    • Smith, M.A.1    Petot, G.J.2    Perry, G.3
  • 27
    • 0033048004 scopus 로고    scopus 로고
    • Antioxidant potentials of vitamin a and carotenoids and their relevance to heart disease
    • DOI 10.1016/S0891-5849(98)00266-4, PII S0891584998002664
    • Palace VP, Khaper N, Qin Q, Singal PK. Antioxidant potentials of vitamin A and carotenoids and their relevance to heart disease. Free Radic. Biol. Med. 26, 746-761 (1999). (Pubitemid 29146279)
    • (1999) Free Radical Biology and Medicine , vol.26 , Issue.5-6 , pp. 746-761
    • Palace, V.P.1    Khaper, N.2    Qin, Q.3    Singal, P.K.4
  • 28
    • 0024557736 scopus 로고
    • Effects of vitamin a and its analogs on nonenzymatic lipid peroxidation in rat brain mitochondria
    • Das NP. Effects of vitamin A and its analogs on nonenzymatic lipid peroxidation in rat brain mitochondria. J. Neurochem. 52, 585-588 (1989).
    • (1989) J. Neurochem. , vol.52 , pp. 585-588
    • Das, N.P.1
  • 29
    • 0342748723 scopus 로고    scopus 로고
    • Cellular redox state and its relationship to the inhibition of clonal cell growth and the induction of apoptosis during all-trans retinoic acid exposure in acute myeloblastic leukemia cells
    • Mantymaa P, Guttorm T, Siitonen T et al. Cellular redox state and its relationship to the inhibition of clonal cell growth and the induction of apoptosis during all-trans retinoic acid exposure in acute myeloblastic leukemia cells. Haematologica 85, 238-245 (2000). (Pubitemid 30340138)
    • (2000) Haematologica , vol.85 , Issue.3 , pp. 238-245
    • Mantymaa, P.1    Guttorm, T.2    Siitonen, T.3    Saily, M.4    Savolainen, E.-R.5    Levonen, A.-L.6    Kinnula, V.7    Koistinen, P.8
  • 30
    • 46649108164 scopus 로고    scopus 로고
    • Xanthine oxidase-dependent ROS production mediates vitamin a pro-oxidant effects in cultured Sertoli cells
    • DOI 10.1080/10715760802144422, PII 794011882
    • Zanotto-Filho A, Schroder R, Moreira JC. Xanthine oxidase-dependent ROS production mediates vitamin A pro-oxidant effects in cultured Sertoli cells. Free Radic. Res. 42, 593-601 (2008). (Pubitemid 351935152)
    • (2008) Free Radical Research , vol.42 , Issue.6 , pp. 593-601
    • Zanotto-Filho, A.1    Schroder, R.2    Moreira, J.C.F.3
  • 31
    • 41149179991 scopus 로고    scopus 로고
    • All-trans-retinoic acid induces manganese superoxide dismutase in human neuroblastoma through NF-κB
    • Kiningham KK, Cardozo ZA, Cook C et al. All-trans-retinoic acid induces manganese superoxide dismutase in human neuroblastoma through NF-κB. Free Radic. Biol. Med. 44, 1610-1616 (2008).
    • (2008) Free Radic. Biol. Med. , vol.44 , pp. 1610-1616
    • Kiningham, K.K.1    Cardozo, Z.A.2    Cook, C.3
  • 32
    • 0033992544 scopus 로고    scopus 로고
    • Inhibition of glutathione depletion by retinoic acid and tocopherol protects cultured neurons from staurosporine-induced oxidative stress and apoptosis
    • DOI 10.1016/S0197-0186(99)00101-1, PII S0197018699001011
    • Ahlemeyer B, Krieglstein J. Inhibition of glutathione depletion by retinoic acid and tocopherol protects cultured neurons from staurosporine- induced oxidative stress and apoptosis. Neurochem. Int. 36, 1-5 (2000). (Pubitemid 29481778)
    • (2000) Neurochemistry International , vol.36 , Issue.1 , pp. 1-5
    • Ahlemeyer, B.1    Krieglstein, J.2
  • 34
    • 0343293791 scopus 로고    scopus 로고
    • Retinoic acid potentiated the protective effect of NGF against staurosporine-induced apoptosis in cultured chick neurons by increasing the trkA protein expression
    • Ahlemeyer B, Huhne R, Krieglstein J. Retinoic acid potentiated the protective effect of NGF against staurosporine-induced apoptosis in cultured chick neurons by increasing the trkA protein expression. J. Neurosci. Res. 60, 767-778 (2000). (Pubitemid 30399548)
    • (2000) Journal of Neuroscience Research , vol.60 , Issue.6 , pp. 767-778
    • Ahlemeyer, B.1    Huhne, R.2    Krieglstein, J.3
  • 36
    • 0030610491 scopus 로고    scopus 로고
    • Involvement of phospholipase A2 in neurodegeneration
    • Farooqui AA, Yang HC, Horrocks L. Involvement of phospholipase A2 in neurodegeneration. Neurochem. Int. 30, 517-522 (1997).
    • (1997) Neurochem. Int. , vol.30 , pp. 517-522
    • Farooqui, A.A.1    Yang, H.C.2    Horrocks, L.3
  • 38
    • 0034997561 scopus 로고    scopus 로고
    • Plasmalogens: Workhorse lipids of membranes in normal and injured neurons and glia
    • Farooqui AA, Horrocks LA. Plasmalogens: workhorse lipids of membranes in normal and injured neurons and glia. Neuroscientist 7, 232-245 (2001).
    • (2001) Neuroscientist , vol.7 , pp. 232-245
    • Farooqui, A.A.1    Horrocks, L.A.2
  • 39
    • 0343362701 scopus 로고    scopus 로고
    • 2: Localization, role, and involvement in neurological diseases
    • Farooqui AA, Ong WY, Horrocks LA, Farooqui T. Brain cytosolic phospholipase A2: localization, role, and involvement in neurological diseases. Neuroscientist 6, 169-180 (2000). (Pubitemid 30366361)
    • (2000) Neuroscientist , vol.6 , Issue.3 , pp. 169-180
    • Farooqui, A.A.1    Ong, W.Y.2    Horrocks, L.A.3    Farooqui, T.4
  • 40
    • 0030893109 scopus 로고    scopus 로고
    • Membrane phospholipid alterations in Alzheimer's disease: Deficiency of ethanolamine plasmalogens
    • Farooqui AA, Rapoport SI, Horrocks LA. Membrane phospholipid alterations in Alzheimer's disease: deficiency of ethanolamine plasmalogens. Neurochem. Res. 22, 523-527 (1997).
    • (1997) Neurochem. Res. , vol.22 , pp. 523-527
    • Farooqui, A.A.1    Rapoport, S.I.2    Horrocks, L.A.3
  • 41
    • 1842861720 scopus 로고    scopus 로고
    • Effect of retinoids on LPS-induced COX-2 expression and COX-2 associated PGE(2) release from mouse peritoneal macrophages and TNF-α release from rat peripheral blood mononuclear cells
    • Kim BH, Kang KS, Lee YS. Effect of retinoids on LPS-induced COX-2 expression and COX-2 associated PGE(2) release from mouse peritoneal macrophages and TNF-α release from rat peripheral blood mononuclear cells. Toxicol. Lett. 150, 191-201 (2004).
    • (2004) Toxicol. Lett. , vol.150 , pp. 191-201
    • Kim, B.H.1    Kang, K.S.2    Lee, Y.S.3
  • 43
    • 63849221643 scopus 로고    scopus 로고
    • Specific loss of brain ABCA1 increases brain cholesterol uptake and influences neuronal structure and function
    • Karasinska JM, Rinninger F, Lutjohann D et al. Specific loss of brain ABCA1 increases brain cholesterol uptake and influences neuronal structure and function. J. Neurosci. 29, 3579-3589 (2009).
    • (2009) J. Neurosci. , vol.29 , pp. 3579-3589
    • Karasinska, J.M.1    Rinninger, F.2    Lutjohann, D.3
  • 44
    • 0037969631 scopus 로고    scopus 로고
    • 22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid β secretion
    • Koldamova RP, Lefterov IM, Ikonomovic MD et al. 22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid β secretion. J. Biol. Chem. 278, 13244-13256 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 13244-13256
    • Koldamova, R.P.1    Lefterov, I.M.2    Ikonomovic, M.D.3
  • 45
    • 41149098547 scopus 로고    scopus 로고
    • Quantitative profiling of endogenous retinoic acid in vivo and in vitro by tandem mass spectrometry
    • Kane MA, Folias AE, Wang C, Napoli JL. Quantitative profiling of endogenous retinoic acid in vivo and in vitro by tandem mass spectrometry. Anal. Chem. 80, 1702-1708 (2008).
    • (2008) Anal. Chem. , vol.80 , pp. 1702-1708
    • Kane, M.A.1    Folias, A.E.2    Wang, C.3    Napoli, J.L.4
  • 46
    • 33750530367 scopus 로고    scopus 로고
    • Retinoid receptors, transporters, and metabolizers as therapeutic targets in late onset Alzheimer disease
    • Goodman AB. Retinoid receptors, transporters, and metabolizers as therapeutic targets in late onset Alzheimer disease. J. Cell Physiol. 209, 598-603 (2006).
    • (2006) J. Cell Physiol. , vol.209 , pp. 598-603
    • Goodman, A.B.1
  • 47
    • 37149054466 scopus 로고    scopus 로고
    • Functional implication of the vitamin a signaling pathway in the brain
    • DOI 10.1001/archneur.64.12.1706
    • Tafti M, Ghyselinck NB. Functional implication of the vitamin A signaling pathway in the brain. Arch. Neurol. 64, 1706-1711 (2007). (Pubitemid 350254931)
    • (2007) Archives of Neurology , vol.64 , Issue.12 , pp. 1706-1711
    • Tafti, M.1    Ghyselinck, N.B.2
  • 48
    • 2342459231 scopus 로고    scopus 로고
    • All-trans retinoic acid induces apoptosis in acute myeloblastic leukaemia cells
    • Zheng A, Savolainen ER, Koistinen P. All-trans retinoic acid induces apoptosis in acute myeloblastic leukaemia cells. Apoptosis 2, 319-329 (1997). (Pubitemid 127504717)
    • (1997) Apoptosis , vol.2 , Issue.3 , pp. 319-329
    • Zheng, A.1    Savolainen, E.-R.2    Koistinen, P.3
  • 49
    • 0031972626 scopus 로고    scopus 로고
    • Retinoic acid induces apoptosis-associated neural differentiation of a murine teratocarcinoma cell line
    • Herget T, Specht H, Esdar C, Oehrlein SA, Maelicke A. Retinoic acid induces apoptosis-associated neural differentiation of a murine teratocarcinoma cell line. J. Neurochem. 70, 47-58 (1998). (Pubitemid 28020827)
    • (1998) Journal of Neurochemistry , vol.70 , Issue.1 , pp. 47-58
    • Herget, T.1    Specht, H.2    Esdar, C.3    Oehrlein, S.A.4    Maelicke, A.5
  • 50
    • 33748675072 scopus 로고    scopus 로고
    • The effects of all-trans-retinoic acid on cell cycle and alkaline phosphatase activity in pancreatic cancer cells
    • Guo JM, Xiao BX, Lou YR et al. The effects of all-trans-retinoic acid on cell cycle and alkaline phosphatase activity in pancreatic cancer cells. Med. Chem. 2, 457-461 (2006).
    • (2006) Med. Chem. , vol.2 , pp. 457-461
    • Guo, J.M.1    Xiao, B.X.2    Lou, Y.R.3
  • 51
    • 48049118647 scopus 로고    scopus 로고
    • ATRA-inhibited proliferation in glioma cells is associated with subcellular redistribution of β-catenin via up-regulation of Axin
    • Lu J, Zhang F, Zhao D et al. ATRA-inhibited proliferation in glioma cells is associated with subcellular redistribution of β-catenin via up-regulation of Axin. J. Neurooncol. 87, 271-277 (2008).
    • (2008) J. Neurooncol. , vol.87 , pp. 271-277
    • Lu, J.1    Zhang, F.2    Zhao, D.3
  • 52
    • 0030921323 scopus 로고    scopus 로고
    • Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease
    • McShea A, Harris PL, Webster KR, Wahl AF, Smith MA. Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease. Am. J. Pathol. 150, 1933-1939 (1997).
    • (1997) Am. J. Pathol. , vol.150 , pp. 1933-1939
    • McShea, A.1    Harris, P.L.2    Webster, K.R.3    Wahl, A.F.4    Smith, M.A.5
  • 53
    • 0033537306 scopus 로고    scopus 로고
    • Signal transduction abnormalities in Alzheimer's disease: Evidence of a pathogenic stimuli
    • DOI 10.1016/S0006-8993(98)01135-4, PII S0006899398011354
    • McShea A, Zelasko DA, Gerst JL, Smith MA. Signal transduction abnormalities in Alzheimer's disease: evidence of a pathogenic stimuli. Brain Res. 815, 237-242 (1999). (Pubitemid 29225270)
    • (1999) Brain Research , vol.815 , Issue.2 , pp. 237-242
    • McShea, A.1    Zelasko, D.A.2    Gerst, J.L.3    Smith, M.A.4
  • 55
    • 62549114846 scopus 로고    scopus 로고
    • The neuronal expression of MYC causes a neurodegenerative phenotype in a novel transgenic mouse
    • Lee HG, Casadesus G, Nunomura A et al. The neuronal expression of MYC causes a neurodegenerative phenotype in a novel transgenic mouse. Am. J. Pathol. 174, 891-897 (2009).
    • (2009) Am. J. Pathol. , vol.174 , pp. 891-897
    • Lee, H.G.1    Casadesus, G.2    Nunomura, A.3
  • 56
    • 49549083587 scopus 로고    scopus 로고
    • Neuronal binucleation in Alzheimer disease hippocampus
    • Zhu X, Siedlak SL, Wang Y et al. Neuronal binucleation in Alzheimer disease hippocampus. Neuropathol. Appl. Neurobiol. 34, 457-465 (2008).
    • (2008) Neuropathol. Appl. Neurobiol. , vol.34 , pp. 457-465
    • Zhu, X.1    Siedlak, S.L.2    Wang, Y.3
  • 57
    • 0031006939 scopus 로고    scopus 로고
    • Aberrant expression of mitotic cdc2/cyclin B1 kinase in degenerating neurons of Alzheimer's disease brain
    • Vincent I, Jicha G, Rosado M, Dickson DW. Aberrant expression of mitotic cdc2/cyclin B1 kinase in degenerating neurons of Alzheimer's disease brain. J. Neurosci. 17, 3588-3598 (1997). (Pubitemid 27200586)
    • (1997) Journal of Neuroscience , vol.17 , Issue.10 , pp. 3588-3598
    • Vincent, I.1    Jicha, G.2    Rosado, M.3    Dickson, D.W.4
  • 58
    • 0030742818 scopus 로고    scopus 로고
    • Cell cycle markers in the hippocampus in Alzheimer's disease
    • DOI 10.1007/s004010050665
    • Nagy Z, Esiri MM, Cato AM, Smith AD. Cell cycle markers in the hippocampus in Alzheimer's disease. Acta Neuropathol. (Berl.) 94, 6-15 (1997). (Pubitemid 27289096)
    • (1997) Acta Neuropathologica , vol.94 , Issue.1 , pp. 6-15
    • Nagy, Zs.1    Esiri, M.M.2    Cato, A.-M.3    Smith, A.D.4
  • 59
    • 0027426029 scopus 로고
    • A cdc2-related kinase PSSALRE/cdk5 is homologous with the 30 kDa subunit of tau protein kinase II, a proline-directed protein kinase associated with microtubule
    • DOI 10.1016/0014-5793(93)80723-8
    • Kobayashi S, Ishiguro K, Omori A et al. A cdc2-related kinase PSSALRE/cdk5 is homologous with the 30 kDa subunit of tau protein kinase II, a proline-directed protein kinase associated with microtubule. FEBS Lett. 335, 171-175 (1993). (Pubitemid 23350401)
    • (1993) FEBS Letters , vol.335 , Issue.2 , pp. 171-175
    • Kobayashi, S.1    Ishiguro, K.2    Omori, A.3    Takamatsu, M.4    Arioka, M.5    Imahori, K.6    Uchida, T.7
  • 60
    • 0026694067 scopus 로고
    • Implication of brain cdc2 and MAP2 kinases in the phosphorylation of tau protein in Alzheimer's disease
    • Ledesma MD, Correas I, Avila J, Diaz-Nido J. Implication of brain cdc2 and MAP2 kinases in the phosphorylation of tau protein in Alzheimer's disease. FEBS Lett. 308, 218-224 (1992).
    • (1992) FEBS Lett. , vol.308 , pp. 218-224
    • Ledesma, M.D.1    Correas, I.2    Avila, J.3    Diaz-Nido, J.4
  • 61
    • 0028295848 scopus 로고
    • Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein
    • Suzuki T, Oishi M, Marshak DR, Czernik AJ, Nairn AC, Greengard P. Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein. EMBO J. 13, 1114-1122 (1994). (Pubitemid 24074718)
    • (1994) EMBO Journal , vol.13 , Issue.5 , pp. 1114-1122
    • Suzuki, T.1    Oishi, M.2    Marshak, D.R.3    Czernik, A.J.4    Nairn, A.C.5    Greengard, P.6
  • 62
    • 43049119952 scopus 로고    scopus 로고
    • Phosphorylation of β-amyloid precursor protein (APP) cytoplasmic tail facilitates amyloidogenic processing during apoptosis
    • Sodhi CP, Perez RG, Gottardi-Littell NR. Phosphorylation of β-amyloid precursor protein (APP) cytoplasmic tail facilitates amyloidogenic processing during apoptosis. Brain Res. 1198, 204-212 (2008).
    • (2008) Brain Res. , vol.1198 , pp. 204-212
    • Sodhi, C.P.1    Perez, R.G.2    Gottardi-Littell, N.R.3
  • 63
    • 0036282745 scopus 로고    scopus 로고
    • Cdc2 phosphorylation of BAD links the cell cycle to the cell death machinery
    • DOI 10.1016/S1097-2765(02)00524-5
    • Konishi Y, Lehtinen M, Donovan N, Bonni A. Cdc2 phosphorylation of BAD links the cell cycle to the cell death machinery. Mol. Cell 9, 1005-1016 (2002). (Pubitemid 34626670)
    • (2002) Molecular Cell , vol.9 , Issue.5 , pp. 1005-1016
    • Konishi, Y.1    Lehtinen, M.2    Donovan, N.3    Bonni, A.4
  • 65
    • 0034495353 scopus 로고    scopus 로고
    • Amyloid precursor protein β-secretase (BACE) mRNA expression in human neural cell lines following induction of neuronal differentiation and exposure to cytokines and growth factors
    • DOI 10.1046/j.1440-1789.2000.00349.x
    • Satoh J, Kuroda Y. Amyloid precursor protein β-secretase (BACE) mRNA expression in human neural cell lines following induction of neuronal differentiation and exposure to cytokines and growth factors. Neuropathology 20, 289-296 (2000). (Pubitemid 32125545)
    • (2000) Neuropathology , vol.20 , Issue.4 , pp. 289-296
    • Satoh, J.-I.1    Kuroda, Y.2
  • 66
    • 0026767361 scopus 로고
    • Increased expression of β-amyloid precursor protein during neuronal differentiation is not accompanied by secretory cleavage
    • Hung AY, Koo EH, Haass C, Selkoe DJ. Increased expression of β-amyloid precursor protein during neuronal differentiation is not accompanied by secretory cleavage. Proc. Natl Acad. Sci. USA 89, 9439-9443 (1992).
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , pp. 9439-9443
    • Hung, A.Y.1    Koo, E.H.2    Haass, C.3    Selkoe, D.J.4
  • 67
    • 0027231768 scopus 로고
    • Altered levels and splicing of the amyloid precursor protein in the adult rat hippocampus after treatment with DMSO or retinoic acid
    • DOI 10.1016/0169-328X(93)90198-X
    • Pan JB, Monteggia LM, Giordano T. Altered levels and splicing of the amyloid precursor protein in the adult rat hippocampus after treatment with DMSO or retinoic acid. Brain Res. Mol Brain Res. 18, 259-266 (1993). (Pubitemid 23130613)
    • (1993) Molecular Brain Research , vol.18 , Issue.3 , pp. 259-266
    • Pan, J.B.1    Monteggia, L.M.2    Giordano, T.3
  • 68
    • 0032544526 scopus 로고    scopus 로고
    • Upregulation of amyloid precursor protein gene promoter in rat primary hippocampal neurons by phorbol ester, IL-1 and retinoic acid, but not by reactive oxygen species
    • DOI 10.1016/S0169-328X(98)00164-8, PII S0169328X98001648
    • Yang Y, Quitschke WW, Brewer GJ. Upregulation of amyloid precursor protein gene promoter in rat primary hippocampal neurons by phorbol ester, IL-1 and retinoic acid, but not by reactive oxygen species. Brain Rese. Mol. Brain Res. 60, 40-49 (1998). (Pubitemid 28433193)
    • (1998) Molecular Brain Research , vol.60 , Issue.1 , pp. 40-49
    • Yang, Y.1    Quitschke, W.W.2    Brewer, G.J.3
  • 69
    • 0037403038 scopus 로고    scopus 로고
    • Regulation of β-amyloid precursor protein and inositol 1,4,5-trisphosphate receptor gene expression during differentiation of a human neuronal cell line
    • Murray JN, Igwe OJ. Regulation of β-amyloid precursor protein and inositol 1,4,5-trisphosphate receptor gene expression during differentiation of a human neuronal cell line. Prog. Neuropsychopharmacol. Biol. Psychiatry 27, 351-363 (2003).
    • (2003) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.27 , pp. 351-363
    • Murray, J.N.1    Igwe, O.J.2
  • 70
  • 72
    • 33747132102 scopus 로고    scopus 로고
    • Retinoic acid normalizes nuclear receptor mediated hypo-expression of proteins involved in β-amyloid deposits in the cerebral cortex of vitamin a deprived rats
    • DOI 10.1016/j.nbd.2006.01.008, PII S0969996106000143
    • Husson M, Enderlin V, Delacourte A et al. Retinoic acid normalizes nuclear receptor mediated hypo-expression of proteins involved in β-amyloid deposits in the cerebral cortex of vitamin A deprived rats. Neurobiol. Dis. 23, 1-10 (2006). (Pubitemid 44218979)
    • (2006) Neurobiology of Disease , vol.23 , Issue.1 , pp. 1-10
    • Husson, M.1    Enderlin, V.2    Delacourte, A.3    Ghenimi, N.4    Alfos, S.5    Pallet, V.6    Higueret, P.7
  • 73
    • 4344628460 scopus 로고    scopus 로고
    • Disruption of the retinoid signalling pathway causes a deposition of amyloid β in the adult rat brain
    • DOI 10.1111/j.1460-9568.2004.03563.x
    • Corcoran JP, So PL, Maden M. Disruption of the retinoid signalling pathway causes a deposition of amyloid β in the adult rat brain. Eur. J. Neurosci. 20, 896-902 (2004). (Pubitemid 39141297)
    • (2004) European Journal of Neuroscience , vol.20 , Issue.4 , pp. 896-902
    • Corcoran, J.P.T.1    Po, L.S.2    Maden, M.3
  • 75
    • 0141645549 scopus 로고    scopus 로고
    • Vitamin a deficiency and relational memory deficit in adult mice: Relationships with changes in brain retinoid signalling
    • DOI 10.1016/S0166-4328(03)00099-8
    • Etchamendy N, Enderlin V, Marighetto A, Pallet V, Higueret P, Jaffard R. Vitamin A deficiency and relational memory deficit in adult mice: relationships with changes in brain retinoid signalling. Behav. Brain Res. 145, 37-49 (2003). (Pubitemid 37188631)
    • (2003) Behavioural Brain Research , vol.145 , Issue.1-2 , pp. 37-49
    • Etchamendy, N.1    Enderlin, V.2    Marighetto, A.3    Pallet, V.4    Higueret, P.5    Jaffard, R.6
  • 76
    • 84880187014 scopus 로고    scopus 로고
    • Alzheimer's disease: The amyloid cascade hypothesis - An update and reappraisal
    • Hardy J. Alzheimer's disease: the amyloid cascade hypothesis: an update and reappraisal. J. Alzheimers Dis. 9, 151-153 (2006). (Pubitemid 44253307)
    • (2006) Journal of Alzheimer's Disease , vol.9 , Issue.SUPPL. 3 , pp. 151-153
    • Hardy, J.1
  • 78
    • 33646855957 scopus 로고    scopus 로고
    • Neuropathology of Alzheimer disease: Pathognomonic but not pathogenic
    • DOI 10.1007/s00401-006-0071-y
    • Castellani RJ, Lee HG, Zhu X, Nunomura A, Perry G, Smith MA. Neuropathology of Alzheimer disease: pathognomonic but not pathogenic. Acta Neuropathol. (Berl.) 111, 503-509 (2006). (Pubitemid 43778954)
    • (2006) Acta Neuropathologica , vol.111 , Issue.6 , pp. 503-509
    • Castellani, R.J.1    Lee, H.-G.2    Zhu, X.3    Nunomura, A.4    Perry, G.5    Smith, M.A.6
  • 79
    • 38049098793 scopus 로고    scopus 로고
    • Oxidative stress activates a positive feedback between the γ- And β-secretase cleavages of the β-amyloid precursor protein
    • Tamagno E, Guglielmotto M, Aragno M et al. Oxidative stress activates a positive feedback between the γ- and β-secretase cleavages of the β-amyloid precursor protein. J. Neurochem. 104, 683-695 (2008).
    • (2008) J. Neurochem. , vol.104 , pp. 683-695
    • Tamagno, E.1    Guglielmotto, M.2    Aragno, M.3
  • 82
    • 0037418321 scopus 로고    scopus 로고
    • Evidence for defective retinoid transport and function in late onset Alzheimer's disease
    • Goodman AB, Pardee AB. Evidence for defective retinoid transport and function in late onset Alzheimer's disease. Proc. Natl Acad. Sci. USA 100, 2901-2905 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 2901-2905
    • Goodman, A.B.1    Pardee, A.B.2
  • 83
    • 4544227975 scopus 로고    scopus 로고
    • Vitamin a exhibits potent antiamyloidogenic and fibril-destabilizing effects in vitro
    • DOI 10.1016/j.expneurol.2004.05.035, PII S0014488604002183
    • Ono K, Yoshiike Y, Takashima A, Hasegawa K, Naiki H, Yamada M. Vitamin A exhibits potent antiamyloidogenic and fibril-destabilizing effects in vitro. Exp Neurol 189, 380-392 (2004). (Pubitemid 39221830)
    • (2004) Experimental Neurology , vol.189 , Issue.2 , pp. 380-392
    • Ono, K.1    Yoshiike, Y.2    Takashima, A.3    Hasegawa, K.4    Naiki, H.5    Yamada, M.6
  • 84
    • 58149268892 scopus 로고    scopus 로고
    • Retinoic acid attenuates β-amyloid deposition and rescues memory deficits in an Alzheimer's disease transgenic mouse model
    • Ding Y, Qiao A, Wang Z et al. Retinoic acid attenuates β-amyloid deposition and rescues memory deficits in an Alzheimer's disease transgenic mouse model. J. Neurosci. 28, 11622-11634 (2008).
    • (2008) J. Neurosci. , vol.28 , pp. 11622-11634
    • Ding, Y.1    Qiao, A.2    Wang, Z.3
  • 88
    • 33746036025 scopus 로고    scopus 로고
    • Parsing the genetic heterogeneity of chromosome 12q susceptibility genes for Alzheimer disease by family-based association analysis
    • Lin PI, Martin ER, Browning-Large CA et al. Parsing the genetic heterogeneity of chromosome 12q susceptibility genes for Alzheimer disease by family-based association analysis. Neurogenetics 7, 157-165 (2006).
    • (2006) Neurogenetics , vol.7 , pp. 157-165
    • Lin, P.I.1    Martin, E.R.2    Browning-Large, C.A.3
  • 89
    • 0023219013 scopus 로고
    • Immunodetection of protein composition in cerebral amyloid extracts in Alzheimer's disease: Enrichment of retinol-binding protein
    • Maury CP, Teppo AM. Immunodetection of protein composition in cerebral amyloid extracts in Alzheimer's disease: enrichment of retinol-binding protein. J. Neurol. Sci. 80, 221-228 (1987).
    • (1987) J. Neurol. Sci. , vol.80 , pp. 221-228
    • Maury, C.P.1    Teppo, A.M.2
  • 91
    • 24644483112 scopus 로고    scopus 로고
    • Genomic structure and functional characterization of the human ADAM10 promoter
    • DOI 10.1096/fj.04-3619fje
    • Prinzen C, Muller U, Endres K, Fahrenholz F, Postina R. Genomic structure and functional characterization of the human ADAM10 promoter. FASEB J. 19, 1522-1524 (2005). (Pubitemid 41279018)
    • (2005) FASEB Journal , vol.19 , Issue.11 , pp. 1522-1524
    • Prinzen, C.1    Muller, U.2    Endres, K.3    Fahrenholz, F.4    Postina, R.5
  • 92
    • 0029114162 scopus 로고
    • Promoter activity of the gene encoding the β-amyloid precursor protein is up-regulated by growth factors, phorbol ester, retinoic acid and interleukin-1
    • Lahiri DK, Nall C. Promoter activity of the gene encoding the β-amyloid precursor protein is up-regulated by growth factors, phorbol ester, retinoic acid and interleukin-1. Brain Res. Mol Brain Res. 32, 233-240 (1995).
    • (1995) Brain Res. Mol Brain Res. , vol.32 , pp. 233-240
    • Lahiri, D.K.1    Nall, C.2
  • 93
    • 0032544526 scopus 로고    scopus 로고
    • Upregulation of amyloid precursor protein gene promoter in rat primary hippocampal neurons by phorbol ester, IL-1 and retinoic acid, but not by reactive oxygen species
    • DOI 10.1016/S0169-328X(98)00164-8, PII S0169328X98001648
    • Yang Y, Quitschke WW, Brewer GJ. Upregulation of amyloid precursor protein gene promoter in rat primary hippocampal neurons by phorbol ester, IL-1 and retinoic acid, but not by reactive oxygen species. Brain Res. Mol Brain Res. 60, 40-49 (1998). (Pubitemid 28433193)
    • (1998) Molecular Brain Research , vol.60 , Issue.1 , pp. 40-49
    • Yang, Y.1    Quitschke, W.W.2    Brewer, G.J.3
  • 96
    • 0029827326 scopus 로고    scopus 로고
    • Regulation by retinoic acid of insulin-degrading enzyme and of a related endoprotease in human neuroblastoma cell lines
    • Melino G, Draoui M, Bernardini S, Bellincampi L, Reichert U, Cohen P. Regulation by retinoic acid of insulin-degrading enzyme and of a related endoprotease in human neuroblastoma cell lines. Cell Growth Differ. 7, 787-796 (1996). (Pubitemid 26360747)
    • (1996) Cell Growth and Differentiation , vol.7 , Issue.6 , pp. 787-796
    • Melino, G.1    Draoui, M.2    Bernardini, S.3    Bellincampi, L.4    Reichert, U.5    Cohen, P.6
  • 97
    • 0029795254 scopus 로고    scopus 로고
    • Amyloid β-protein reduces acetylcholine synthesis in a cell line derived from cholinergic neurons of the basal forebrain
    • Pedersen WA, Kloczewiak MA, Blusztajn JK. Amyloid β-protein reduces acetylcholine synthesis in a cell line derived from cholinergic neurons of the basal forebrain. Proc. Natl Acad. Sci. USA 93, 8068-8071 (1996).
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 8068-8071
    • Pedersen, W.A.1    Kloczewiak, M.A.2    Blusztajn, J.K.3
  • 98
    • 0029043420 scopus 로고
    • All-trans- And 9-cis-retinoic acid enhance the cholinergic properties of a murine septal cell line: Evidence that the effects are mediated by activation of retinoic acid receptor-α
    • Pedersen WA, Berse B, Schuler U, Wainer BH, Blusztajn JK. All-trans- and 9-cis-retinoic acid enhance the cholinergic properties of a murine septal cell line: evidence that the effects are mediated by activation of retinoic acid receptor-α. J. Neurochem. 65, 50-58 (1995).
    • (1995) J. Neurochem. , vol.65 , pp. 50-58
    • Pedersen, W.A.1    Berse, B.2    Schuler, U.3    Wainer, B.H.4    Blusztajn, J.K.5
  • 99
    • 0021745872 scopus 로고
    • Regulation of acetylcholinesterase activity by retinoic acid in a human neuroblastoma cell line
    • DOI 10.1016/0014-4827(84)90795-X
    • Sidell N, Lucas CA, Kreutzberg GW. Regulation of acetylcholinesterase activity by retinoic acid in a human neuroblastoma cell line. Exp. Cell Res 155, 305-309 (1984). (Pubitemid 15213294)
    • (1984) Experimental Cell Research , vol.155 , Issue.1 , pp. 305-309
    • Sidell, N.1    Lucas, C.A.2    Kreutzberg, G.W.3
  • 100
    • 21744440266 scopus 로고    scopus 로고
    • Retinoic acid isomers protect hippocampal neurons from amyloid-β induced neurodegeneration
    • Sahin M, Karauzum SB, Perry G, Smith MA, Aliciguzel Y. Retinoic acid isomers protect hippocampal neurons from amyloid-β induced neurodegeneration. Neurotox. Res. 7, 243-250 (2005).
    • (2005) Neurotox. Res. , vol.7 , pp. 243-250
    • Sahin, M.1    Karauzum, S.B.2    Perry, G.3    Smith, M.A.4    Aliciguzel, Y.5
  • 101
    • 33847126958 scopus 로고    scopus 로고
    • Retinoic acid activates human inducible nitric oxide synthase gene through binding of RARα/RXRα heterodimer to a novel retinoic acid response element in the promoter
    • DOI 10.1016/j.bbrc.2007.01.178, PII S0006291X07002628
    • Zou F, Liu Y, Liu L et al. Retinoic acid activates human inducible nitric oxide synthase gene through binding of RARα/RXRα heterodimer to a novel retinoic acid response element in the promoter. Biochem. Biophys. Res. Commun. 355, 494-500 (2007). (Pubitemid 46282655)
    • (2007) Biochemical and Biophysical Research Communications , vol.355 , Issue.2 , pp. 494-500
    • Zou, F.1    Liu, Y.2    Liu, L.3    Wu, K.4    Wei, W.5    Zhu, Y.6    Wu, J.7
  • 102
    • 54249100455 scopus 로고    scopus 로고
    • Alzheimer's disease: Cerebrovascular dysfunction, oxidative stress, and advanced clinical therapies
    • Marlatt MW, Lucassen PJ, Perry G, Smith MA, Zhu X. Alzheimer's disease: cerebrovascular dysfunction, oxidative stress, and advanced clinical therapies. J. Alzheimers Dis. 15, 199-210 (2008).
    • (2008) J. Alzheimers Dis. , vol.15 , pp. 199-210
    • Marlatt, M.W.1    Lucassen, P.J.2    Perry, G.3    Smith, M.A.4    Zhu, X.5


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