The study on cognition and prognosis in the elderly (SCOPE): Principal results of a randomized double-blind intervention trial

Journal of Hypertension

Volumn 21, Issue 5, 2003, Pages 875-886

  Lithell, Hans ^a   Hansson, Lennart ^a   Skoog, Ingmar ^b   Elmfeldt, Dag ^a,c   Hofman, Albert ^d   Olofsson, Bertil ^c   Trenkwalder, Peter ^e   Zanchetti, Alberto ^f  

^a UPPSALA UNIVERSITY   (Sweden)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

^c ASTRAZENECA R AND D   (Sweden)

^d ERASMUS MEDICAL CENTER   (Netherlands)

^e UNIVERSITY OF MUNICH   (Germany)

^f UNIVERSITY OF MILAN   (Italy)

Author keywords

Angiotensin II type 1 receptor blockade; Candesartan; Cardiovascular events; Cognitive function; Elderly; Hypertension

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; CANDESARTAN; PLACEBO;

AGED; AGING; ANTIHYPERTENSIVE THERAPY; ARTICLE; BLOOD PRESSURE; BORDERLINE HYPERTENSION; CARDIOVASCULAR RISK; CLINICAL TRIAL; COGNITION; CONFIDENCE INTERVAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEMENTIA; DIASTOLIC BLOOD PRESSURE; DISEASE SEVERITY; FEMALE; FOLLOW UP; HEART DEATH; HEART INFARCTION; HUMAN; MAJOR CLINICAL STUDY; MALE; MINI MENTAL STATE EXAMINATION; MORTALITY; PRIORITY JOURNAL; PROGNOSIS; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; STROKE; SYSTOLIC BLOOD PRESSURE; TREATMENT OUTCOME; TYPES OF STUDY;

EID: 0037534905     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004872-200305000-00011     Document Type: Article

References (28)

1. Caird FI, Cargill D. Viewpoint. Chronic brain failure: the silent epidemic. NZ Med J 1987; 100:13-16.
2. Murray CJ, Lopez AD. Mortality by cause for eight regions of the world: Global Burden of Disease Study. Lancet 1997; 349:1269-1276.
3. MacMahon S, Peto R, Cutler J, Collins R, Sorlie P, Neaton J, et al. Blood pressure, stroke, and coronary heart disease. Part 1, prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution bias. Lancet 1990; 335:765-774.
4. Dannenberg AL, Garrison RJ, Kannel WB. Incidence of hypertension in the Framingham Study. Am J Public Health 1988; 78:676-679.
5. Skoog I, Lernfelt B, Landahl S, Palmertz B, Andreasson L-A, Nilsson L, et al. 15-year longitudinal study of blood pressure and dementia. Lancet 1996; 347:1141-1145.
6. Kilander L, Nyman H, Boberg M, Hansson L, Lithell H. Hypertension is related to cognitive impairment. A 20-year follow-up of 999 men. Hypertension 1998; 31:780-786.
7. Amery A, Birkenhäger W, Brixko P, Bulpitt C, Clement D, Deruyttere M, et al. Mortality and morbidity results from the European Working Party on High Blood Pressure in the Elderly trial. Lancet 1985; 1:1349-1354.
8. Coope J, Warrender TS. Randomised trial of treatment of hypertension in elderly patients in primary care. BMJ 1986; 293:1145-1151.
9. Dahlöf B, Lindholm LH, Hansson L, Scherstén B, Ekbom T, Wester P-O. Morbidity and mortality in the Swedish trial in Old Patients with Hypertension (STOP-Hypertension). Lancet 1991; 338:1281-1285.
10. SHEP Cooperative Research Group. Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension: Final results of the systolic hypertension in the elderly program. JAMA 1991; 265:3255-3264.
11. MRC Working Party. Medical Research Council trial of treatment of hypertension in older adults: principal results. BMJ 1992; 304:405-412.
12. Staessen JA, Fagard R, Thijs L, Celis H, Arabidze GG, Birkenhäger WH, et al. for the Systolic Hypertension in Europe (Syst-Eur) Trial Investigators. Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension. Lancet 1997; 350:757-764.
13. Bullpit CJ, Beokett NS, Cooke J, Dumitrascu DL, Gil-Extremera B, Nachev C, et al. on behalf of the HYVET-PILOT investigators. ISH/ESH meeting in Prague, June 2002. Abstract O016.
14. Hansson L, Lithell H, Skoog I, Baro F, Bánki CM, Breteler M, et al. Study on cognition and prognosis in the elderly (SCOPE). Blood Press 1999; 8:177-183.
15. Folstein MF, Folstein SE, McHugh PR. 'Mini-mental state': A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12:189-198.
16. World Health Organization. The ICD-10 Classification of Mental and Behavioural Disorders: Diagnostic Criteria for Research. Geneva: World Health Organization; 1993.
17. Dahlöf B, Devereaux RB, Kjeldsen SE, Julius S, Beevers G, de Faire U, et al. Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol. Lancet 2002; 359:995-1003.
18. Inada Y, Wada T, Ojima M, Sanada T, Shibouta Y, Kanagawa R, et al. Protective effects of candesartan cilexetil (TCV-116) against stroke, kidney dysfunction and cardiac hypertrophy in stroke-prone spontaneously hypertensive rats. Clin Exp Hypertens 1997; 19:1079-1099.
19. Mann J, Julius S for the VALUE Trial Group. The Valsartan Antihypertensive Long-term Use Evaluation (VALUE) trial of cardiovascular events in hypertension. Rationale and design. Blood Press 1998; 7:176-183.
20. Kjeldsen SE, Julius S, Brunner H, Hansson L, Henis M, Ekman S, et al. Characteristics of 15,314 hypertensive patients at high coronary risk. The VALUE trial. Blood Press 2001; 10:83-91.
21. Kjeldsen SE, Julius S, Hedner T, Hansson L. Stroke is more common than myocardial infarction in hypertension: analysis based on 11 major randomized intervention trials. Blood Press 2001; 10:190-192.
22. Forette F, Seux M-L, Staessen JA, Thijs L, Birkenhäger WH, Babarskiene M-R, et al. on behalf of the Syst-Eur Investigators. Prevention of dementia in randomised double-blind placebo-controlled Systolic Hypertension in Europe (Syst-Eur) trial. Lancet 1998; 352:1347-1351.
23. Forette F, Seux M-L, Staessen JA, Thijs L, Babarskiene M-R, Babeanu S, et al. The prevention of dementia with antihypertensive treatment. New evidence from the Systolic Hypertension in Europe (Syst-Eur) study. Arch Intern Med 2002; 162:2046-2052.
24. Jorm AF, Jolley D. The incidence of dementia: a meta-analysis. Neurology 1998; 51:728-733.
25. Gao S, Hendrie HC, Hall KS, Hui S. The relationships between age, sex, and the incidence of dementia and Alzheimer disease: a meta-analysis. Arch Gen Psychiatry 1998; 55:809-815.
26. Pollare T, Lithell H, Selinus I, Berne C. Sensitivity to insulin during treatment with atenolol and metoprolol: a randomised, double blind study of effects on carbohydrate and lipoprotein metabolism in hypertensive patients. BMJ 1989; 298:1152-1157.
27. Pollare T, Lithell H, Berne C. A comparison of the effects of hydrochlorothiazide and captopril on glucose and lipid metabolism in patients with hypertension. N Engl J Med 1989; 321:868-873.
28. Moan A, Hoieggen A, Seljeflot I, Risanger T, Arnesen H, Kjeldsen SE. The effect of angiotensin II receptor antagonism with losartan on glucose metabolism and insulin sensitivity. J Hypertens 1996; 14:1093-1097.