-
1
-
-
84859169877
-
The cancer cell line encyclopedia enables predictive modelling of anticancer drug sensitivity
-
Barretina J, Caponigro G, Stransky N, et al. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature. 2012;483(7391):603-607.
-
(2012)
Nature
, vol.483
, Issue.7391
, pp. 603-607
-
-
Barretina, J.1
Caponigro, G.2
Stransky, N.3
-
2
-
-
73949083834
-
MEK1 mutations confer resistance to MEK and B-RAF inhibition
-
Emery CM, Vijayendran KG, Zipser MC, et al. MEK1 mutations confer resistance to MEK and B-RAF inhibition. Proc Natl Acad Sci USA. 2009;106(48): 20411-20416.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, Issue.48
, pp. 20411-20416
-
-
Emery, C.M.1
Vijayendran, K.G.2
Zipser, M.C.3
-
3
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
Lynch TJ, Bell DW, Sordella R, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med. 2004;350(21):2129-2139.
-
(2004)
N Engl J Med
, vol.350
, Issue.21
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
-
4
-
-
2342624080
-
EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy
-
Paez JG, Janne PA, Lee JC, et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science. 2004;304(5676):1497-1500.
-
(2004)
Science
, vol.304
, Issue.5676
, pp. 1497-1500
-
-
Paez, J.G.1
Janne, P.A.2
Lee, J.C.3
-
5
-
-
4444344330
-
EGF receptor gene mutations are common in lung cancers from never smokers and are associated with sensitivity of tumors to gefitinib and erlotinib
-
Pao W, Miller V, Zakowski M, et al. EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci USA. 2004; 101(36):13306-13311.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, Issue.36
, pp. 13306-13311
-
-
Pao, W.1
Miller, V.2
Zakowski, M.3
-
6
-
-
0037025173
-
Cancer: Addiction to oncogenes-The Achilles heal of cancer
-
Weinstein IB. Cancer: addiction to oncogenes-the Achilles heal of cancer. Science. 2002;297(5578):63-64.
-
(2002)
Science
, vol.297
, Issue.5578
, pp. 63-64
-
-
Weinstein, I.B.1
-
7
-
-
40049100818
-
Prognostic and therapeutic implications of EGFR and KRAS mutations in resected lung adenocarcinoma
-
Marks JL, Broderick S, Zhou Q, et al. Prognostic and therapeutic implications of EGFR and KRAS mutations in resected lung adenocarcinoma. J Thorac Oncol. 2008;3(2):111-116.
-
(2008)
J Thorac Oncol
, vol.3
, Issue.2
, pp. 111-116
-
-
Marks, J.L.1
Broderick, S.2
Zhou, Q.3
-
8
-
-
77958478674
-
Rational, biologically based treatment of EGFRmutant non-small-cell lung cancer
-
Pao W, Chmielecki J. Rational, biologically based treatment of EGFRmutant non-small-cell lung cancer. Nat Rev Cancer. 2010;10(11):760-774.
-
(2010)
Nat Rev Cancer
, vol.10
, Issue.11
, pp. 760-774
-
-
Pao, W.1
Chmielecki, J.2
-
9
-
-
80155150303
-
Personalized medicine in lung cancer: What we need to know
-
Mok TS. Personalized medicine in lung cancer: what we need to know. Nat Rev Clin Oncol. 2011;8(11):661-668.
-
(2011)
Nat Rev Clin Oncol
, Issue.11
, pp. 661-668
-
-
Mok, T.S.1
-
10
-
-
0023271954
-
Mutational activation of the K-ras oncogene: A possible pathogenetic factor in adenocarcinoma of the lung
-
Rodenhuis S, van de Wetering ML, Mooi WJ, Evers SG, van Zandwijk N, Bos JL. Mutational activation of the K-ras oncogene: a possible pathogenetic factor in adenocarcinoma of the lung. N Engl J Med. 1987;317(15):929-935.
-
(1987)
N Engl J Med
, vol.317
, Issue.15
, pp. 929-935
-
-
Rodenhuis, S.1
Van De Wetering, M.L.2
Mooi, W.J.3
Evers, S.G.4
Van Zandwijk, N.5
Bos, J.L.6
-
11
-
-
65349107082
-
KRAS mutations in non-small cell lung cancer
-
Riely GJ, Marks J, Pao W. KRAS mutations in non-small cell lung cancer. Proc Am Thorac Soc. 2009;6(2):201-205.
-
(2009)
Proc Am Thorac Soc
, vol.6
, Issue.2
, pp. 201-205
-
-
Riely, G.J.1
Marks, J.2
Pao, W.3
-
12
-
-
34547638047
-
Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer
-
Soda M, Choi YL, Enomoto M, et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature. 2007;448(7153): 561-566.
-
(2007)
Nature
, vol.448
, Issue.7153
, pp. 561-566
-
-
Soda, M.1
Choi, Y.L.2
Enomoto, M.3
-
13
-
-
48549098388
-
Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer
-
Choi YL, Takeuchi K, Soda M, et al. Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer. Cancer Res. 2008; 68(13):4971-4976.
-
(2008)
Cancer Res
, vol.68
, Issue.13
, pp. 4971-4976
-
-
Choi, Y.L.1
Takeuchi, K.2
Soda, M.3
-
14
-
-
70349342712
-
EML4-ALK: Honing in on a new target in non-small-cell lung cancer
-
Horn L, Pao W. EML4-ALK: honing in on a new target in non-small-cell lung cancer. J Clin Oncol. 2009;27(26):4232-4235.
-
(2009)
J Clin Oncol
, vol.27
, Issue.26
, pp. 4232-4235
-
-
Horn, L.1
Pao, W.2
-
15
-
-
48249114422
-
EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer
-
Koivunen JP, Mermel C, Zejnullahu K, et al. EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer. Clin Cancer Res. 2008;14(13): 4275-4283.
-
(2008)
Clin Cancer Res
, vol.14
, Issue.13
, pp. 4275-4283
-
-
Koivunen, J.P.1
Mermel, C.2
Zejnullahu, K.3
-
16
-
-
78049425319
-
Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer
-
Kwak EL, Bang YJ, Camidge DR, et al. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med. 2010;363(18):1693- 1703.
-
(2010)
N Engl J Med
, vol.363
, Issue.18
, pp. 1693-1703
-
-
Kwak, E.L.1
Bang, Y.J.2
Camidge, D.R.3
-
17
-
-
0242442020
-
HER2 status in non-small cell lung cancer: Results from patient screening for enrollment to a phase II study of herceptin
-
Heinmoller P, Gross C, Beyser K, et al. HER2 status in non-small cell lung cancer: results from patient screening for enrollment to a phase II study of herceptin. Clin Cancer Res. 2003;9(14):5238-5243.
-
(2003)
Clin Cancer Res
, vol.9
, Issue.14
, pp. 5238-5243
-
-
Heinmoller, P.1
Gross, C.2
Beyser, K.3
-
18
-
-
4944232647
-
Lung cancer: Intragenic ERBB2 kinase mutations in tumours
-
Stephens P, Hunter C, Bignell G, et al. Lung cancer: intragenic ERBB2 kinase mutations in tumours. Nature. 2004;431(7008):525-526.
-
(2004)
Nature
, vol.431
, Issue.7008
, pp. 525-526
-
-
Stephens, P.1
Hunter, C.2
Bignell, G.3
-
19
-
-
20144386787
-
Somatic mutations of the HER2 kinase domain in lung adenocarcinomas
-
Shigematsu H, Takahashi T, Nomura M, et al. Somatic mutations of the HER2 kinase domain in lung adenocarcinomas. Cancer Res. 2005;65(5):1642- 1646.
-
(2005)
Cancer Res
, vol.65
, Issue.5
, pp. 1642-1646
-
-
Shigematsu, H.1
Takahashi, T.2
Nomura, M.3
-
20
-
-
33750627353
-
Mutational analysis of the HER2 gene in lung tumors from Caucasian patients: Mutations are mainly present in adenocarcinomas with bronchioloalveolar features
-
Buttitta F, Barassi F, Fresu G, et al. Mutational analysis of the HER2 gene in lung tumors from Caucasian patients: mutations are mainly present in adenocarcinomas with bronchioloalveolar features. Int J Cancer. 2006;119(11): 2586-2591.
-
(2006)
Int J Cancer
, vol.119
, Issue.11
, pp. 2586-2591
-
-
Buttitta, F.1
Barassi, F.2
Fresu, G.3
-
21
-
-
33745727112
-
HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors
-
Wang SE, Narasanna A, Perez-Torres M, et al. HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors. Cancer Cell. 2006;10(1): 25-38.
-
(2006)
Cancer Cell
, vol.10
, Issue.1
, pp. 25-38
-
-
Wang, S.E.1
Narasanna, A.2
Perez-Torres, M.3
-
22
-
-
11144358645
-
High frequency of mutations of the PIK3CA gene in human cancers
-
Samuels Y, Wang Z, Bardelli A, et al. High frequency of mutations of the PIK3CA gene in human cancers. Science. 2004;304(5670):554.
-
(2004)
Science
, vol.304
, Issue.5670
, pp. 554
-
-
Samuels, Y.1
Wang, Z.2
Bardelli, A.3
-
23
-
-
33751084640
-
PIK3CA mutation status in Japanese lung cancer patients
-
Kawano O, Sasaki H, Endo K, et al. PIK3CA mutation status in Japanese lung cancer patients. Lung Cancer. 2006;54(2):209-215.
-
(2006)
Lung Cancer
, vol.54
, Issue.2
, pp. 209-215
-
-
Kawano, O.1
Sasaki, H.2
Endo, K.3
-
24
-
-
54549094903
-
Somatic mutations affect key pathways in lung adenocarcinoma
-
Ding L, Getz G, Wheeler DA, et al. Somatic mutations affect key pathways in lung adenocarcinoma. Nature. 2008;455(7216):1069-1075.
-
(2008)
Nature
, vol.455
, Issue.7216
, pp. 1069-1075
-
-
Ding, L.1
Getz, G.2
Wheeler, D.A.3
-
25
-
-
48649107410
-
Novel MEK1 mutation identified by mutational analysis of epidermal growth factor receptor signaling pathway genes in lung adenocarcinoma
-
Marks JL, Gong Y, Chitale D, et al. Novel MEK1 mutation identified by mutational analysis of epidermal growth factor receptor signaling pathway genes in lung adenocarcinoma. Cancer Res. 2008;68(14):5524-5528.
-
(2008)
Cancer Res
, vol.68
, Issue.14
, pp. 5524-5528
-
-
Marks, J.L.1
Gong, Y.2
Chitale, D.3
-
26
-
-
61549138135
-
Activation of MET by gene amplification or by splice mutations deleting the juxtamembrane domain in primary resected lung cancers
-
Onozato R, Kosaka T, Kuwano H, Sekido Y, Yatabe Y, Mitsudomi T. Activation of MET by gene amplification or by splice mutations deleting the juxtamembrane domain in primary resected lung cancers. J Thorac Oncol. 2009; 4(1):5-11.
-
(2009)
J Thorac Oncol
, vol.4
, Issue.1
, pp. 5-11
-
-
Onozato, R.1
Kosaka, T.2
Kuwano, H.3
Sekido, Y.4
Yatabe, Y.5
Mitsudomi, T.6
-
27
-
-
79251490374
-
New driver mutations in non-small-cell lung cancer
-
Pao W, Girard N. New driver mutations in non-small-cell lung cancer. Lancet Oncol. 2011;12(2):175-180.
-
(2011)
Lancet Oncol
, vol.12
, Issue.2
, pp. 175-180
-
-
Pao, W.1
Girard, N.2
-
28
-
-
34249075147
-
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
-
Engelman JA, Zejnullahu K, Mitsudomi T, et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science. 2007; 316(5827):1039-1043.
-
(2007)
Science
, vol.316
, Issue.5827
, pp. 1039-1043
-
-
Engelman, J.A.1
Zejnullahu, K.2
Mitsudomi, T.3
-
29
-
-
38049150665
-
MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
-
Bean J, Brennan C, Shih JY, et al. MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proc Natl Acad Sci USA. 2007;104(52):20932-20937.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, Issue.52
, pp. 20932-20937
-
-
Bean, J.1
Brennan, C.2
Shih, J.Y.3
-
30
-
-
46249096082
-
Lung adenocarcinoma: Modification of the 2004 WHO mixed subtype to include the major histologic subtype suggests correlations between papillary and micropapillary adenocarcinoma subtypes, EGFR mutations and gene expression analysis
-
Motoi N, Szoke J, Riely GJ, et al. Lung adenocarcinoma: modification of the 2004 WHO mixed subtype to include the major histologic subtype suggests correlations between papillary and micropapillary adenocarcinoma subtypes, EGFR mutations and gene expression analysis. Am J Surg Pathol. 2008;32(6):810- 827.
-
(2008)
Am J Surg Pathol
, vol.32
, Issue.6
, pp. 810-827
-
-
Motoi, N.1
Szoke, J.2
Riely, G.J.3
-
31
-
-
36248980204
-
Characterizing the cancer genome in lung adenocarcinoma
-
Weir BA, Woo MS, Getz G, et al. Characterizing the cancer genome in lung adenocarcinoma. Nature. 2007;450(7171):893-898.
-
(2007)
Nature
, vol.450
, Issue.7171
, pp. 893-898
-
-
Weir, B.A.1
Woo, M.S.2
Getz, G.3
-
32
-
-
36849065315
-
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer
-
Rikova K, Guo A, Zeng Q, et al. Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell. 2007;131(6):1190- 1203.
-
(2007)
Cell
, vol.131
, Issue.6
, pp. 1190-1203
-
-
Rikova, K.1
Guo, A.2
Zeng, Q.3
-
33
-
-
84655163371
-
Combination epigenetic therapy has efficacy in patients with refractory advanced non-small cell lung cancer
-
Juergens RA, Wrangle J, Vendetti FP, et al. Combination epigenetic therapy has efficacy in patients with refractory advanced non-small cell lung cancer. Cancer Discov. 2011;1(7):598-607.
-
(2011)
Cancer Discov
, vol.1
, Issue.7
, pp. 598-607
-
-
Juergens, R.A.1
Wrangle, J.2
Vendetti, F.P.3
-
34
-
-
77953000554
-
EGFR mutation is a better predictor of response to tyrosine kinase inhibitors in non-small cell lung carcinoma than FISH, CISH, and immunohistochemistry
-
Sholl LM, Xiao Y, Joshi V, et al. EGFR mutation is a better predictor of response to tyrosine kinase inhibitors in non-small cell lung carcinoma than FISH, CISH, and immunohistochemistry. Am J Clin Pathol. 2010;133(6):922-934.
-
(2010)
Am J Clin Pathol
, vol.133
, Issue.6
, pp. 922-934
-
-
Sholl, L.M.1
Xiao, Y.2
Joshi, V.3
-
35
-
-
33847293670
-
High-throughput oncogene mutation profiling in human cancer
-
Thomas RK, Baker AC, Debiasi RM, et al. High-throughput oncogene mutation profiling in human cancer. Nat Genet. 2007;39(3):347-351.
-
(2007)
Nat Genet
, vol.39
, Issue.3
, pp. 347-351
-
-
Thomas, R.K.1
Baker, A.C.2
Debiasi, R.M.3
-
36
-
-
70849116358
-
Profiling critical cancer gene mutations in clinical tumor samples
-
MacConaill LE, Campbell CD, Kehoe SM, et al. Profiling critical cancer gene mutations in clinical tumor samples. PLoS One. 2009;4(11):e7887.
-
(2009)
PLoS One
, vol.4
, Issue.11
-
-
MacConaill, L.E.1
Campbell, C.D.2
Kehoe, S.M.3
-
37
-
-
84859374349
-
Critical oncogenic mutations in newly diagnosed pediatric diffuse intrinsic pontine glioma
-
Grill J, Puget S, Andreiuolo F, Philippe C, MacConaill L, Kieran MW. Critical oncogenic mutations in newly diagnosed pediatric diffuse intrinsic pontine glioma. Pediatr Blood Cancer. 2012;58(4):489-491.
-
(2012)
Pediatr Blood Cancer
, vol.58
, Issue.4
, pp. 489-491
-
-
Grill, J.1
Puget, S.2
Andreiuolo, F.3
Philippe, C.4
MacConaill, L.5
Kieran, M.W.6
-
38
-
-
84861333261
-
-
published online ahead of print October 17, 2011, Cancer
-
Choy E, Hornicek F, Macconaill L, et al. High-throughput genotyping in osteosarcoma identifies multiple mutations in phosphoinositide-3-kinase and other oncogenes [published online ahead of print October 17, 2011]. Cancer. 2012;118(11):2905-2914.
-
High-throughput Genotyping in Osteosarcoma Identifies Multiple Mutations in Phosphoinositide-3-Kinase and Other Oncogenes
, vol.118
, Issue.11
, pp. 2905-2914
-
-
Choy, E.1
Hornicek, F.2
Macconaill, L.3
-
39
-
-
80052526766
-
High throughput interrogation of somatic mutations in high grade serous cancer of the ovary
-
Matulonis UA, Hirsch M, Palescandolo E, et al. High throughput interrogation of somatic mutations in high grade serous cancer of the ovary. PLoS One. 2011;6(9):e24433.
-
(2011)
PLoS One
, vol.6
, Issue.9
-
-
Matulonis, U.A.1
Hirsch, M.2
Palescandolo, E.3
-
40
-
-
77956904045
-
Recurrent BRAF mutations in Langerhans cell histiocytosis
-
Badalian-Very G, Vergilio JA, Degar BA, et al. Recurrent BRAF mutations in Langerhans cell histiocytosis. Blood. 2010;116(11):1919-1923.
-
(2010)
Blood
, vol.116
, Issue.11
, pp. 1919-1923
-
-
Badalian-Very, G.1
Vergilio, J.A.2
Degar, B.A.3
-
41
-
-
84866695504
-
Comprehensive analysis for clinically relevant oncogenic driver mutations in 1131 consecutive lung adenocarcinomas
-
Arcila M, Lau CY, Jhanwar SC, Zakowski MF, Kris MG, Ladanyi M. . Comprehensive analysis for clinically relevant oncogenic driver mutations in 1131 consecutive lung adenocarcinomas. Mod Pathol 2011;24(suppl 1):404a.
-
(2011)
Mod Pathol
, vol.24
, Issue.SUPPL.. 1
-
-
Arcila, M.1
Lau, C.Y.2
Jhanwar, S.C.3
Zakowski, M.F.4
Kris, M.G.5
Ladanyi, M.6
-
42
-
-
78651071913
-
Detection of KRAS and BRAF mutations in colorectal carcinoma roles for high-sensitivity locked nucleic acid- PCR sequencing and broad-spectrum mass spectrometry genotyping
-
Arcila M, Lau C, Nafa K, Ladanyi M. Detection of KRAS and BRAF mutations in colorectal carcinoma roles for high-sensitivity locked nucleic acid- PCR sequencing and broad-spectrum mass spectrometry genotyping. J Mol Diagn. 2011;13(1):64-73.
-
(2011)
J Mol Diagn
, vol.13
, Issue.1
, pp. 64-73
-
-
Arcila, M.1
Lau, C.2
Nafa, K.3
Ladanyi, M.4
-
43
-
-
82655176916
-
Multiplex mutation screening by mass spectrometry: Evaluation of 820 cases from a personalized cancer medicine registry
-
published online ahead of print July 2, 2001
-
Beadling CHM, Warrick A, Forbes EM, et al. Multiplex mutation screening by mass spectrometry: evaluation of 820 cases from a personalized cancer medicine registry [published online ahead of print July 2, 2011]. J Mol Diagn. 2011;13(5):504-513.
-
(2011)
J Mol Diagn
, vol.13
, Issue.5
, pp. 504-513
-
-
Beadling, C.H.M.1
Warrick, A.2
Forbes, E.M.3
-
44
-
-
77954566882
-
Rapid targeted mutational analysis of human tumours: A clinical platform to guide personalized cancer medicine
-
Dias-Santagata D, Akhavanfard S, David SS, et al. Rapid targeted mutational analysis of human tumours: a clinical platform to guide personalized cancer medicine. EMBO Mol Med. 2010;2(5):146-158.
-
(2010)
EMBO Mol Med
, vol.2
, Issue.5
, pp. 146-158
-
-
Dias-Santagata, D.1
Akhavanfard, S.2
David, S.S.3
-
45
-
-
77954938591
-
Future of personalized medicine in oncology: A systems biology approach
-
Gonzalez-Angulo AM, Hennessy BT, Mills GB. Future of personalized medicine in oncology: a systems biology approach. J Clin Oncol. 2010;28(16): 2777-2783.
-
(2010)
J Clin Oncol
, vol.28
, Issue.16
, pp. 2777-2783
-
-
Gonzalez-Angulo, A.M.1
Hennessy, B.T.2
Mills, G.B.3
-
46
-
-
84866684546
-
LC-MAP: A pilot study of prospective profiling of clinical tumor specimens for the presence of key mutations in targetable pathways in patients with lung adenocarcinoma and metastatic colorectal cancer using Sequenom genotyping
-
Lau C, Ang D, Brzostowski EB, et al. LC-MAP: a pilot study of prospective profiling of clinical tumor specimens for the presence of key mutations in targetable pathways in patients with lung adenocarcinoma and metastatic colorectal cancer using Sequenom genotyping. J Mol Diagn 2010;12:910.
-
(2010)
J Mol Diagn
, vol.12
, pp. 910
-
-
Lau, C.1
Ang, D.2
Brzostowski, E.B.3
-
47
-
-
78651079558
-
A platform for rapid detection of multiple oncogenic mutations with relevance to targeted therapy in non-smallcell lung cancer
-
Su Z, Dias-Santagata D, Duke M, et al. A platform for rapid detection of multiple oncogenic mutations with relevance to targeted therapy in non-smallcell lung cancer. J Mol Diagn. 2011;13(1):74-84.
-
(2011)
J Mol Diagn
, vol.13
, Issue.1
, pp. 74-84
-
-
Su, Z.1
Dias-Santagata, D.2
Duke, M.3
-
48
-
-
53649106195
-
Next-generation DNA sequencing
-
Shendure J, Ji H. Next-generation DNA sequencing. Nat Biotechnol. 2008; 26(10):1135 -1145.
-
(2008)
Nat Biotechnol
, vol.26
, Issue.10
, pp. 1135-1145
-
-
Shendure, J.1
Ji, H.2
-
49
-
-
77956838065
-
Advances in understanding cancer genomes through second-generation sequencing
-
Meyerson M, Gabriel S, Getz G. Advances in understanding cancer genomes through second-generation sequencing. Nat Rev Genet. 2010;11(10): 685-696.
-
(2010)
Nat Rev Genet
, vol.11
, Issue.10
, pp. 685-696
-
-
Meyerson, M.1
Gabriel, S.2
Getz, G.3
-
50
-
-
84865833740
-
High-throughput detection of actionable genomic alterations in clinical tumor samples by targeted, massively parallel sequencing
-
Wagle N, Berger MF, Davis MJ, et al. High-throughput detection of actionable genomic alterations in clinical tumor samples by targeted, massively parallel sequencing. Cancer Discov. 2012;2(1):82-93.
-
(2012)
Cancer Discov
, vol.2
, Issue.1
, pp. 82-93
-
-
Wagle, N.1
Berger, M.F.2
Davis, M.J.3
-
51
-
-
75349100601
-
Targeted next-generation sequencing of a cancer transcriptome enhances detection of sequence variants and novel fusion transcripts
-
Levin JZ, Berger MF, Adiconis X, et al. Targeted next-generation sequencing of a cancer transcriptome enhances detection of sequence variants and novel fusion transcripts. Genome Biol. 2009;10(10):R115.
-
(2009)
Genome Biol
, vol.10
, Issue.10
-
-
Levin, J.Z.1
Berger, M.F.2
Adiconis, X.3
-
52
-
-
77953006634
-
The mutation spectrum revealed by paired genome sequences from a lung cancer patient
-
Lee W, Jiang Z, Liu J, et al. The mutation spectrum revealed by paired genome sequences from a lung cancer patient. Nature. 2010;465(7297):473- 477.
-
(2010)
Nature
, vol.465
, Issue.7297
, pp. 473-477
-
-
Lee, W.1
Jiang, Z.2
Liu, J.3
-
53
-
-
74449085934
-
A small-cell lung cancer genome with complex signatures of tobacco exposure
-
463
-
Pleasance ED, Stephens PJ, O'Meara S, et al. A small-cell lung cancer genome with complex signatures of tobacco exposure. Nature. 14;463(7278): 184-190.
-
Nature
, vol.14
, Issue.7278
, pp. 184-190
-
-
Pleasance, E.D.1
Stephens, P.J.2
O'Meara, S.3
-
54
-
-
79958112619
-
Inhibitor-sensitive FGFR1 amplification in human non-small cell lung cancer
-
Dutt A, Ramos AH, Hammerman PS, et al. Inhibitor-sensitive FGFR1 amplification in human non-small cell lung cancer. PLoS One. 2011;6(6):e20351.
-
(2011)
PLoS One
, vol.6
, Issue.6
-
-
Dutt, A.1
Ramos, A.H.2
Hammerman, P.S.3
-
55
-
-
84866709500
-
Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer
-
Hammerman PS, Sos ML, Ramos AH, et al. Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer. Cancer Discov. 2011;1(1):78-89.
-
(2011)
Cancer Discov
, vol.1
, Issue.1
, pp. 78-89
-
-
Hammerman, P.S.1
Sos, M.L.2
Ramos, A.H.3
-
56
-
-
84862776857
-
Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies
-
Lipson D, Capelletti M, Yelensky R, et al. Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies. Nat Med. 2012;18(3): 382-384.
-
(2012)
Nat Med
, vol.18
, Issue.3
, pp. 382-384
-
-
Lipson, D.1
Capelletti, M.2
Yelensky, R.3
-
57
-
-
84857985225
-
RET, ROS1 and ALK fusions in lung cancer
-
Takeuchi K, Soda M, Togashi Y, et al. RET, ROS1 and ALK fusions in lung cancer. Nat Med. 2012;18(3):378-381.
-
(2012)
Nat Med
, vol.18
, Issue.3
, pp. 378-381
-
-
Takeuchi, K.1
Soda, M.2
Togashi, Y.3
-
58
-
-
84857929267
-
KIF5B-RET fusions in lung adenocarcinoma
-
Kohno T, Ichikawa H, Totoki Y, et al. KIF5B-RET fusions in lung adenocarcinoma. Nat Med. 2012;18(3):375-377.
-
(2012)
Nat Med
, vol.18
, Issue.3
, pp. 375-377
-
-
Kohno, T.1
Ichikawa, H.2
Totoki, Y.3
-
59
-
-
84863230117
-
A transforming KIF5B and RET gene fusion in lung adenocarcinoma revealed from whole-genome and transcriptome sequencing
-
Ju YS, Lee WC, Shin JY, et al. A transforming KIF5B and RET gene fusion in lung adenocarcinoma revealed from whole-genome and transcriptome sequencing. Genome Res. 2012;22(3):436-445.
-
(2012)
Genome Res
, vol.22
, Issue.3
, pp. 436-445
-
-
Ju, Y.S.1
Lee, W.C.2
Shin, J.Y.3
-
60
-
-
82655184653
-
Personalized oncology through integrative high-throughput sequencing: A pilot study
-
Roychowdhury S, Iyer MK, Robinson DR, et al. Personalized oncology through integrative high-throughput sequencing: a pilot study. Sci Transl Med. 2011;3(111):111ra121.
-
(2011)
Sci Transl Med
, vol.3
, Issue.111
-
-
Roychowdhury, S.1
Iyer, M.K.2
Robinson, D.R.3
-
61
-
-
84857042170
-
Clinical implementation of comprehensive strategies to characterize cancer genomes: Opportunities and challenges
-
MacConaill LE, Van Hummelen P, Meyerson M, Hahn WC. Clinical implementation of comprehensive strategies to characterize cancer genomes: opportunities and challenges. Cancer Discov. 2011;1(4):297.
-
(2011)
Cancer Discov
, vol.1
, Issue.4
, pp. 297
-
-
MacConaill, L.E.1
Van Hummelen, P.2
Meyerson, M.3
Hahn, W.C.4
-
62
-
-
84856555469
-
An emerging toolkit for targeted cancer therapies
-
Mills GB. An emerging toolkit for targeted cancer therapies. Genome Res. 2012;22(2):177-182.
-
(2012)
Genome Res
, vol.22
, Issue.2
, pp. 177-182
-
-
Mills, G.B.1
-
63
-
-
47949114668
-
Detection of mutations in EGFR in circulating lung-cancer cells
-
Maheswaran S, Sequist LV, Nagrath S, et al. Detection of mutations in EGFR in circulating lung-cancer cells. N Engl J Med. 2008;359(4):366-377.
-
(2008)
N Engl J Med
, vol.359
, Issue.4
, pp. 366-377
-
-
Maheswaran, S.1
Sequist, L.V.2
Nagrath, S.3
-
64
-
-
37549002543
-
Isolation of rare circulating tumour cells in cancer patients by microchip technology
-
Nagrath S, Sequist LV, Maheswaran S, et al. Isolation of rare circulating tumour cells in cancer patients by microchip technology. Nature. 2007; 450(7173):1235-1239.
-
(2007)
Nature
, vol.450
, Issue.7173
, pp. 1235-1239
-
-
Nagrath, S.1
Sequist, L.V.2
Maheswaran, S.3
-
65
-
-
34347353063
-
Circulating tumor cells (CTC) detection: Clinical impact and future directions
-
Paterlini-Brechot P, Benali NL. Circulating tumor cells (CTC) detection: clinical impact and future directions. Cancer Lett. 2007;253(2):180-204.
-
(2007)
Cancer Lett
, vol.253
, Issue.2
, pp. 180-204
-
-
Paterlini-Brechot, P.1
Benali, N.L.2
-
66
-
-
84870911765
-
Detection of EGFR mutations in plasma DNA from lung cancer patients by mass spectrometry genotyping is predictive of tumor EGFR status and response to EGFR inhibitors
-
Brevet M, Johnson ML, Azzoli CG, Ladanyi M. Detection of EGFR mutations in plasma DNA from lung cancer patients by mass spectrometry genotyping is predictive of tumor EGFR status and response to EGFR inhibitors. Lung Cancer. 2010.
-
(2010)
Lung Cancer
-
-
Brevet, M.1
Johnson, M.L.2
Azzoli, C.G.3
Ladanyi, M.4
-
67
-
-
77952962769
-
Development of personalized tumor biomarkers using massively parallel sequencing
-
Leary RJ, Kinde I, Diehl F, et al. Development of personalized tumor biomarkers using massively parallel sequencing. Sci Transl Med. 2010;2(20): 20ra14.
-
(2010)
Sci Transl Med
, vol.2
, Issue.20
-
-
Leary, R.J.1
Kinde, I.2
Diehl, F.3
-
68
-
-
84863011201
-
Genomic analysis of circulating cell-free DNA infers breast cancer dormancy
-
Shaw JA, Page K, Blighe K, et al. Genomic analysis of circulating cell-free DNA infers breast cancer dormancy. Genome Res. 2012;22(2):220-231.
-
(2012)
Genome Res
, vol.22
, Issue.2
, pp. 220-231
-
-
Shaw, J.A.1
Page, K.2
Blighe, K.3
-
69
-
-
79958728268
-
PI3K pathway mutations and PTEN levels in primary and metastatic breast cancer
-
Gonzalez-Angulo AM, Ferrer-Lozano J, Stemke-Hale K, et al. PI3K pathway mutations and PTEN levels in primary and metastatic breast cancer. Mol Cancer Ther. 2011;10(6):1093-1101.
-
(2011)
Mol Cancer Ther
, vol.10
, Issue.6
, pp. 1093-1101
-
-
Gonzalez-Angulo, A.M.1
Ferrer-Lozano, J.2
Stemke-Hale, K.3
-
70
-
-
79951834210
-
PIK3CA mutations may be discordant between primary and corresponding metastatic disease in breast cancer
-
Dupont Jensen J, Laenkholm AV, Knoop A, et al. PIK3CA mutations may be discordant between primary and corresponding metastatic disease in breast cancer. Clin Cancer Res. 2011;17(4):667-677.
-
(2011)
Clin Cancer Res
, vol.17
, Issue.4
, pp. 667-677
-
-
Dupont Jensen, J.1
Laenkholm, A.V.2
Knoop, A.3
-
71
-
-
84863393080
-
Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
-
Gerlinger M, Rowan AJ, Horswell S, et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med. 2012; 366(10):883-892.
-
(2012)
N Engl J Med
, vol.366
, Issue.10
, pp. 883-892
-
-
Gerlinger, M.1
Rowan, A.J.2
Horswell, S.3
-
72
-
-
61449259809
-
Epidermal growth factor receptor abnormalities in the pathogenesis and progression of lung adenocarcinomas
-
Tang X, Varella-Garcia M, Xavier AC, et al. Epidermal growth factor receptor abnormalities in the pathogenesis and progression of lung adenocarcinomas. Cancer Prev Res (Phila). 2008;1(3):192-200.
-
(2008)
Cancer Prev Res (Phila)
, vol.1
, Issue.3
, pp. 192-200
-
-
Tang, X.1
Varella-Garcia, M.2
Xavier, A.C.3
-
73
-
-
42049094628
-
Epidermal growth factor receptor gene amplification is acquired in association with tumor progression of EGFR-mutated lung cancer
-
Yatabe Y, Takahashi T, Mitsudomi T. Epidermal growth factor receptor gene amplification is acquired in association with tumor progression of EGFR-mutated lung cancer. Cancer Res. 2008;68(7):2106-2111.
-
(2008)
Cancer Res
, vol.68
, Issue.7
, pp. 2106-2111
-
-
Yatabe, Y.1
Takahashi, T.2
Mitsudomi, T.3
-
74
-
-
84863393305
-
Estimation of rearrangement phylogeny for cancer genomes
-
Greenman CD, Pleasance ED, Newman S, et al. Estimation of rearrangement phylogeny for cancer genomes. Genome Res. 2012;22(2):346-361.
-
(2012)
Genome Res
, vol.22
, Issue.2
, pp. 346-361
-
-
Greenman, C.D.1
Pleasance, E.D.2
Newman, S.3
-
75
-
-
33746420974
-
Detection of oncogenic mutations in the EGFR gene in lung adenocarcinoma with differential sensitivity to EGFR tyrosine kinase inhibitors
-
Spring Harb Symp Quant Biol
-
Thomas RK, Greulich H, Yuza Y, et al. Detection of oncogenic mutations in the EGFR gene in lung adenocarcinoma with differential sensitivity to EGFR tyrosine kinase inhibitors. Cold Spring Harb Symp Quant Biol. 2005;70:73-81.
-
(2005)
Cold
, vol.70
, pp. 73-81
-
-
Thomas, R.K.1
Greulich, H.2
Yuza, Y.3
-
76
-
-
84869497627
-
Genetic insight and therapeutic targets in squamouscell lung cancer
-
Jan 23
-
Sos ML, Thomas RK. Genetic insight and therapeutic targets in squamouscell lung cancer. Oncogene. Jan 23 2012.
-
Oncogene
, pp. 2012
-
-
Sos, M.L.1
Thomas, R.K.2
|