Enterovirus-induced gene expression profile is critical for human pancreatic islet destruction

Diabetologia

Volumn 55, Issue 12, 2012, Pages 3273-3283

  Ylipaasto, P ^a   Smura, T ^a   Gopalacharyulu, P ^b   Paananen, A ^a   Seppanen Laakso T ^b   Kaijalainen, S ^a   Ahlfors, H ^c,d   Korsgren, O ^f   Lakey, J R T ^g   Lahesmaa, R ^d   Piemonti, L ^e   Oresic, M ^a   Galama, J ^h   Roivainen, M ^a  

^a NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^b VTT TECHNICAL RESEARCH CENTRE OF FINLAND   (Finland)

^c NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^d UNIVERSITY OF TURKU   (Finland)

^e SAN RAFFAELE HOSPITAL   (Italy)

^f UPPSALA UNIVERSITY   (Sweden)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Coxsackievirus; Echovirus; Enterovirus; Interleukin 1; Microarray analysis; Pancreatic beta cells; Pancreatic islets; Tumour necrosis factor; Type 1 diabetes

Indexed keywords

CHEMOKINE; CYTOKINE; DOUBLE STRANDED RNA; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; PATTERN RECOGNITION RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CLONE; CELL DAMAGE; CELL DESTRUCTION; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE RELEASE; DOWN REGULATION; ENTEROVIRUS; ENTEROVIRUS INFECTION; FEMALE; GENE EXPRESSION PROFILING; GLYCOLYSIS; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; IN VITRO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; MALE; MOUSE; NECROSIS; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREATIC ISLET DESTRUCTION; PRIORITY JOURNAL; VIRUS REPLICATION; VIRUS STRAIN;

ANIMALS; CELLS, CULTURED; CYTOPATHOGENIC EFFECT, VIRAL; DIABETES MELLITUS, TYPE 1; ENTEROVIRUS B, HUMAN; ENTEROVIRUS INFECTIONS; FEMALE; GENE EXPRESSION REGULATION; HUMANS; IMMUNITY, INNATE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INTERLEUKIN-1ALPHA; INTERLEUKIN-1BETA; MALE; MICE; MIDDLE AGED; NECROSIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84868199568     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-012-2713-z     Document Type: Article

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