Expression of toll-like receptors in the pancreas of recent-onset fulminant type 1 diabetes

Endocrine Journal

Volumn 57, Issue 3, 2010, Pages 211-219

  Shibasaki, Saeko ^a   Imagawa, Akihisa ^a,b   Tauriainen, Sisko ^c   Iino, Morio ^d   Oikarinen, Maarit ^c   Hitoshi, Abiru ^d   Tamaki, Keiji ^d   Seino, Hiroaki ^e   Nishi, Katsuhiro ^f   Takase, Izumi ^f   Okada, Yoshikatsu ^a   Uno, Sae ^b   Murase Mishiba, Yuko ^a   Terasaki, Jungo ^a   Makino, Hideichi ^g   Shimomura, Iichiro ^b   Hyöty, Heikki ^c,h   Hanafusa, Toshiaki ^a  

^a OSAKA MEDICAL COLLEGE   (Japan)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^d KYOTO UNIVERSITY   (Japan)

^e Diabetic Center   (Japan)

^f SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^g Takanoko Hospital   (Japan)

^h TAMPERE UNIVERSITY HOSPITAL   (Finland)

Author keywords

Enterovirus; Insulitis; Toll like receptor

Indexed keywords

CD3 ANTIGEN; CD68 ANTIGEN; GLUCAGON; INSULIN; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; VIRUS RNA;

ADULT; ARTICLE; AUTOPSY; CASE REPORT; ENTEROVIRUS INFECTION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOPATHOGENESIS; IN SITU HYBRIDIZATION; INSULIN DEPENDENT DIABETES MELLITUS; MACROPHAGE; MALE; PANCREAS ISLET BETA CELL; T LYMPHOCYTE;

EID: 77953648887     PISSN: 09188959     EISSN: 13484540     Source Type: Journal    
DOI: 10.1507/endocrj.K09E-291     Document Type: Article

References (29)

1. A merican Diabetes Association (2008) Diagnosis and classification of diabetes mellitus. Diabetes Care 31: S55-60.
2. Imagawa A, Hanafusa T, Miyagawa J, Matsuzawa Y for the Osaka IDDM Study Group. (2000) A novel subtype of type 1 diabetes mellitus characterized by a rapid onset and an absence of diabetes-related antibodies. N Engl J Med 342: 301-307.
3. Imagawa A, Hanafusa T, Uchigata Y, Kanatsuka A, Kawasaki E, Kobayashi T, Shimada A, Shimizu I, Toyoda T, Maruyama T, Makino H (2003) Fulminant type 1 diabetes: a nationwide survey in Japan. Diabetes Care 26: 2345-2352.
4. Hanafusa T, Imagawa A (2007) Fulminant type 1 diabetes: a novel clinical entity requiring special attention by all medical practitioners. Nat Clin Pract Endocrinol Metab 3: 36-45.
5. Cho YM, Kim JT, Ko KS, Koo BK, Yang SW, Park MH, Lee HK, Park KS (2007) Fulminant type 1 diabetes in Korea: high prevalence among patients with adult-onset type 1 diabetes. Diabetologia 50: 2276-2279.
6. Chiou CC, Chung WH, Hung SI, Yang LC, Hong HS (2006) Fulminant type 1 diabetes mellitus caused by drug hypersensitivity syndrome with human herpesvirus 6 infection. J Am Acad Dermatol 54: S14-S17.
7. Moreau C, Drui D, Arnault-Ouary G, Charbonnel B, Chaillous L, Cariou B (2008) Fulminant type 1 diabetes in Caucasians: a report of three cases. Diabetes Metab 34: 529-532.
8. Sayama K, Imagawa A, Okita K, Uno S, Moriwaki M, Kozawa J, Iwahashi H, Yamagata K, Tamura S, Matsuzawa Y, Hanafusa T, Miyagawa J, Shimomura I (2005) Pancreatic beta and alpha cells are both decreased in patients with fulminant type 1 diabetes: a morphometrical assessment. Diabetologia 48: 1560-1564.
9. Tanaka S, Kobayashi T, Momotsu T (2000) A novel subtype of type 1 diabetes mellitus. N Engl J Med 342: 1835-1838.
10. Yamazaki M, Hayashi T (2002) Rapid-onset type 1 diabetes mellitus without pancreatic exocrine dysfunction. Ann Intern Med 137: 145-146.
11. Imagawa A, Hanafusa T, Uchigata Y, kanatsuka A, Kawasaki E, Kobayashi T, Shimada A, Shimizu I, Maruyama T, Makino H (2005) Different contribution of class II HLA in fulminant and typical autoimmune type 1 diabetes mellitus. Diabetologia 48: 294-300.
12. Erratum in: Diabetologia (2008) 51: 524-526.
13. Kawasaki E, Imagawa A, Makino H, Uga M, Abiru N, Hanafusa T, Uchigata Y, Eguchi K (2008) Differences in the contribution of CTLA4 gene to susceptibility to fulminant and type 1A diabetes in Japanese patients. Diabetes Care 31: 1608-1610.
14. Imagawa A. Hanafusa T, Makino H, Miyagawa J, Juto P (2005) High titres of IgA antibodies to enterovirus in fulminant type-1 diabetes. Diabetologia 48: 290-293.
15. Sano H, Terasaki J, Tsutsumi C, Imagawa A, Hanafusa T (2008) A case of fulminant type 1 diabetes mellitus after influenza B infection. Diabetes Res Clin Pract 79: e8-9.
16. Goto A, Takahashi Y, Kishimoto M, Nakajima Y, Nakanishi K, Kajio H, Noda M (2008) A case of fulminant type 1 diabetes associated with significant elevation of mumps titers. Endocr J 55: 561-564.
17. Hanafusa T, Imagawa A, Iwahashi H, Uchigata Y, Kanatsuka A, Kawasaki E, Kobayashi T, Shimada A, Shimizu I, Maruyama T, Makino H (2008) Report of the Japan Diabetes Society's committee on research on fulminant type 1 diabetes mellitus: Analysis of antiviral antibodies at disease onset. J Japan Diab Soc 51:531-536.
18. Itoh N, Hanafusa T, Miyazaki A, Miyagawa J, Yamagata K, Yamamoto K, Waguri M, Imagawa A, Tamura S, Inada M, Kawata S, Tarui S, Kono N, Matsuzawa Y (1993) Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulindependent diabetes mellitus patients. J Clin Invest 92: 2313-2322.
19. Oikarinen M, Tauriainen S, Honkanen T, Oikarinen S, Vuori K, Kaukinen K, Rantala I, Mäki M, Hyöty H (2008) Detection of enteroviruses in the intestine of type 1 diabetic patients. Clin Exp Immunol 151: 71-75.
20. Oikarinen M, Tauriainen S, Honkanen T, Vuori K, Karhunen P, Vasama-Nolvi C, Oikarinen S, Verbeke C, Blair GE, Rantala I, Ilonen J, Simell O, Knip M, Hyöty H (2008) Analysis of pancreas tissue in a child positive for islet cell antibodies. Diabetologia 51: 1796-1802.
21. Hohenadl, C, Klingel, K, Mertsching, J, Hofschneider PH, Kandolf R (1991) Strand-specific detection of enteroviral RNA in myocardial tissue by in situ hybridization. Mol Cell Probes 5: 11-20.
22. Ylipaasto P, Kutlu B, Rasilainen S, Passchaert J, Salmera K, Teerijoki H, Korsgren O, Lahesmaa R, Hovi T, Eizirik DL, Otonkoski T, Roivainen M (2005) Global profiling of coxsackievirus- and cytokine-induced gene expression in human pancreatic islets Diabetologia 48: 1510-1522.
23. Hultcrantz M, Hühn MH, Wolf M, Olsson A, Jacobson S, Williams BR, Korsgren O, Flodström-Tullberg M (2007) Interferons induce an antiviral state in human pancreatic islet cells. Virology 367: 92-101.
24. Komatsuda A, Wakui H, Iwamoto K, Ozawa M, Togashi M, Masai R, Maki N, Hatakeyama T, Sawada K (2008) Up-regulated expression of Toll-like receptors mRNAs in peripheral blood mononuclear cells from patients with systemic lupus erythematosus. Clin Exp Immunol 152: 482-487.
25. Ylipaasto P, Klingel K, Lindberg AM, Otonkoski T, Kandolf R, Hovi T, Roivainen M (2004) Enterovirus infection in human pancreatic islet cells, islet tropism in vivo and receptor involvement in cultured islet beta cells. Diabetologia 47: 225-239
26. Eisenbarth GS (2007) Update in type 1 diabetes. J Clin Endocrinol Metab 92: 2403-2407.
27. Moriwaki M, Itoh N, Miyagawa J, Yamamoto K, Imagawa A, Yamagata K, Iwahashi H, Nakajima H, Namba M, Nagata S, Hanafusa T, Matsuzawa Y (1999) Fas and Fas ligand expression in inflamed islets in pancreas sections of patients with recent-onset Type I diabetes mellitus. Diabetologia 42: 1332-40.
28. Akira S, Uematsu S, Takeuchi O (2006) Pathogen recognition and innate immunity. Cell 124: 783-801.
29. Ihm SH, Lee KU, Rhee BD, Min HK (1990) Initial role of macrophage in the development of anti-beta cell cellular autoimmunity in multiple low-dose streptozotocin-induced diabetes in mice. Diabetes Res Clin Pract 10: 123-126.