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Volumn 954, Issue , 2012, Pages 357-363

Small molecule screening for inhibitors of the YopH phosphatase of Yersinia pseudotuberculosis

Author keywords

[No Author keywords available]

Indexed keywords

OUTER MEMBRANE PROTEIN; PROTEIN TYROSINE PHOSPHATASE; YOPH PROTEIN, YERSINIA;

EID: 84868160251     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4614-3561-7_43     Document Type: Conference Paper
Times cited : (4)

References (31)
  • 1
    • 79955438388 scopus 로고    scopus 로고
    • Utilization of nitrophenylphosphates and oxime-based ligation for the development of nanomolar af fi nity inhibitors of the Yersinia pestis outer protein H (YopH) phosphatase
    • Bahta M, Lountos GT, Dyas B et al (2011) Utilization of nitrophenylphosphates and oxime-based ligation for the development of nanomolar af fi nity inhibitors of the Yersinia pestis outer protein H (YopH) phosphatase. J Med Chem 54:2933-2943
    • (2011) J Med Chem , vol.54 , pp. 2933-2943
    • Bahta, M.1    Lountos, G.T.2    Dyas, B.3
  • 2
    • 75249090304 scopus 로고    scopus 로고
    • Antivirulence drugs to target bacterial secretion systems
    • Baron C (2009) Antivirulence drugs to target bacterial secretion systems. Curr Opin Microbiol 13:1-6
    • (2009) Curr Opin Microbiol , vol.13 , pp. 1-6
    • Baron, C.1
  • 3
    • 0023969046 scopus 로고
    • The plasmid-encoded Yop2b protein of Yersinia pseudotuberculosis is a virulence determinant regulated by calcium and temperature at the level of transcription
    • Bölin I, Wolf-Watz H (1988) The plasmid-encoded Yop2b protein of Yersinia pseudotuberculosis is a virulence determinant regulated by calcium and temperature at the level of transcription. Mol Microbiol 2:237-245
    • (1988) Mol Microbiol , vol.2 , pp. 237-245
    • Bölin, I.1    Wolf-Watz, H.2
  • 4
    • 47749106894 scopus 로고    scopus 로고
    • Stoichiometry and physical chemistry of promiscous aggregate-based inhibitors
    • Coan KE, Shoichet BK (2008) Stoichiometry and physical chemistry of promiscous aggregate-based inhibitors. J Am Chem Soc 130:9606-9612
    • (2008) J Am Chem Soc , vol.130 , pp. 9606-9612
    • Coan, K.E.1    Shoichet, B.K.2
  • 5
    • 77956747889 scopus 로고    scopus 로고
    • A focused library of protein tyrosine phosphatase inhibitors
    • Comeau AB, Critton DA, Page R et al (2010) A focused library of protein tyrosine phosphatase inhibitors. J Med Chem 53:6768-6772
    • (2010) J Med Chem , vol.53 , pp. 6768-6772
    • Comeau, A.B.1    Critton, D.A.2    Page, R.3
  • 6
    • 37849049329 scopus 로고    scopus 로고
    • Design, syn thesis, and multivariate quantitative structure-activity relationship of salicylanilides, potent inhibitors of type III secretion in Yersinia
    • Dahlgren MK, Kauppi AM, Olsson IM et al (2007) Design, synthesis, and multivariate quantitative structure-activity relationship of salicylanilides, potent inhibitors of type III secretion in Yersinia. J Med Chem 50:6177-6188
    • (2007) J Med Chem , vol.50 , pp. 6177-6188
    • Dahlgren, M.K.1    Kauppi, A.M.2    Olsson, I.M.3
  • 7
    • 77954268482 scopus 로고    scopus 로고
    • Synthesis of 2-(2-aminopyrimidine)-2,2-difluoroethanols as potential bioisosters of salicylidene acylhydrazides
    • Dahlgren MK, Öberg CT, Wallin EA et al (2010a) Synthesis of 2-(2-aminopyrimidine)-2,2-difluoroethanols as potential bioisosters of salicylidene acylhydrazides. Molecules 15:4423-4438
    • (2010) Molecules , vol.15 , pp. 4423-4438
    • Dahlgren, M.K.1    Öberg, C.T.2    Wallin, E.A.3
  • 8
    • 77950058871 scopus 로고    scopus 로고
    • Statistical molecular design of a focused salicylidene acylhydrazide library and multivariate QSAR of inhibition of type III secretion in the Gramnegative bacterium Yersinia
    • Dahlgren MK, Zetterström CE, Gylfe Å et al (2010b) Statistical molecular design of a focused salicylidene acylhydrazide library and multivariate QSAR of inhibition of type III secretion in the Gramnegative bacterium Yersinia. Bioorg Med Chem 18: 2686-2703
    • (2010) Bioorg Med Chem , vol.18 , pp. 2686-2703
    • Dahlgren, M.K.1    Zetterström, C.E.2    Gylfe, Å.3
  • 9
    • 33845249292 scopus 로고    scopus 로고
    • Protein delivery into eukaryotic cells by type III secretion machines
    • Galan JE, Wolf-Watz H (2006) Protein delivery into eukaryotic cells by type III secretion machines. Nature 444:567-573
    • (2006) Nature , vol.444 , pp. 567-573
    • Galan, J.E.1    Wolf-Watz, H.2
  • 10
    • 0033566587 scopus 로고    scopus 로고
    • Fluorogenic substrates based on fl uorinated umbelliferones for continuous assays of phosphatases and beta-galactosidases
    • Gee KR, Sun WC, Bhalgat MK et al (1999) Fluorogenic substrates based on fl uorinated umbelliferones for continuous assays of phosphatases and beta-galactosidases. Anal Biochem 273:41-48
    • (1999) Anal Biochem , vol.273 , pp. 41-48
    • Gee, K.R.1    Sun, W.C.2    Bhalgat, M.K.3
  • 11
    • 77957313061 scopus 로고    scopus 로고
    • Synthesis of [4-(2-hydroxyphenyl)thiazol-2-yl]methanones as potential bioisosteres of salicylidene acylhydrazides
    • Hillgren JM, Dahlgren MK, To TM et al (2010) Synthesis of [4-(2-hydroxyphenyl)thiazol-2-yl]methanones as potential bioisosteres of salicylidene acylhydrazides. Molecules 15:6019-6034
    • (2010) Molecules , vol.15 , pp. 6019-6034
    • Hillgren, J.M.1    Dahlgren, M.K.2    To, T.M.3
  • 12
    • 77954378388 scopus 로고    scopus 로고
    • Derivatives of salicylic acid as inhibitors of YopH in Yersinia pestis
    • Huang Z, He Y, Zhang X et al (2010) Derivatives of salicylic acid as inhibitors of YopH in Yersinia pestis. Chem Biol Drug Des 76:85-99
    • (2010) Chem Biol Drug Des , vol.76 , pp. 85-99
    • Huang, Z.1    He, Y.2    Zhang, X.3
  • 13
    • 0031864184 scopus 로고    scopus 로고
    • Type III protein secretion systems in bacterial pathogens of animals and plants
    • Hueck CJ (1998) Type III protein secretion systems in bacterial pathogens of animals and plants. Microbiol Mol Biol Rev 62:379-433
    • (1998) Microbiol Mol Biol Rev , vol.62 , pp. 379-433
    • Hueck, C.J.1
  • 14
    • 0036228931 scopus 로고    scopus 로고
    • Yersinia effectors target mammalian signalling pathways
    • Juris SJ, Shao F, Dixon JE (2002) Yersinia effectors target mammalian signalling pathways. Cell Microbiol 4: 201-211
    • (2002) Cell Microbiol , vol.4 , pp. 201-211
    • Juris, S.J.1    Shao, F.2    Dixon, J.E.3
  • 15
    • 0038130714 scopus 로고    scopus 로고
    • Salicylanilides are potent inhibitors of type III secretion in Yersinia
    • Kauppi AM, Nordfelth R, Hägglund U et al (2003a) Salicylanilides are potent inhibitors of type III secretion in Yersinia. Adv Exp Med Biol 529:97-100
    • (2003) Adv Exp Med Biol , vol.529 , pp. 97-100
    • Kauppi, A.M.1    Nordfelth, R.2    Hägglund, U.3
  • 16
    • 0037350267 scopus 로고    scopus 로고
    • Targeting bacterial virulence: Inhibitors of type III secretion in Yersinia
    • Kauppi AM, Nordfelth R, Uvell H et al (2003b) Targeting bacterial virulence: inhibitors of type III secretion in Yersinia. Chem Biol 10:241-249
    • (2003) Chem Biol , vol.10 , pp. 241-249
    • Kauppi, A.M.1    Nordfelth, R.2    Uvell, H.3
  • 17
    • 34748881946 scopus 로고    scopus 로고
    • Inhibitors of type III secretion in Yersinia: Design, synthesis and multivariate QSAR of 2-arylsulfonylaminobenzanilides
    • Kauppi AM, Andersson CD, Norberg HA et al (2007) Inhibitors of type III secretion in Yersinia: design, synthesis and multivariate QSAR of 2-arylsulfonylaminobenzanilides. Bioorg Med Chem 15:6994-7011
    • (2007) Bioorg Med Chem , vol.15 , pp. 6994-7011
    • Kauppi, A.M.1    Andersson, C.D.2    Norberg, H.A.3
  • 18
    • 44949215750 scopus 로고    scopus 로고
    • Virulence blockers as alternatives to antibiotics: Type III secretion inhibitors against Gram-negative bacteria
    • Keyser P, Elofsson M, Rosell S et al (2008) Virulence blockers as alternatives to antibiotics: type III secretion inhibitors against Gram-negative bacteria. J Intern Med 264:17-29
    • (2008) J Intern Med , vol.264 , pp. 17-29
    • Keyser, P.1    Elofsson, M.2    Rosell, S.3
  • 19
    • 23644432990 scopus 로고    scopus 로고
    • Synthesis of tripeptides as potent Yersinia protein tyrosine phosphatase inhibitors
    • Lee K, Boovanahalli SK, Nam KY et al (2005) Synthesis of tripeptides as potent Yersinia protein tyrosine phosphatase inhibitors. Bioorg Med Chem Lett 15: 4037-4042
    • (2005) Bioorg Med Chem Lett , vol.15 , pp. 4037-4042
    • Lee, K.1    Boovanahalli, S.K.2    Nam, K.Y.3
  • 20
    • 77952976580 scopus 로고    scopus 로고
    • NMR-based design and evaluation of novel bidentate inhibitors of the protein tyrosine phosphatase YopH
    • Leone M, Barile E, Vazquez J et al (2010) NMR-based design and evaluation of novel bidentate inhibitors of the protein tyrosine phosphatase YopH. Chem Biol Drug Des 76:10-16
    • (2010) Chem Biol Drug Des , vol.76 , pp. 10-16
    • Leone, M.1    Barile, E.2    Vazquez, J.3
  • 21
    • 0142180154 scopus 로고    scopus 로고
    • Aurintricarboxylic acid blocks in vitro and in vivo activity of YopH, an essential virulent factor of Yersinia pestis, the agent of plague
    • Liang F, Huang Z, Lee SY (2003) Aurintricarboxylic acid blocks in vitro and in vivo activity of YopH, an essential virulent factor of Yersinia pestis, the agent of plague. J Biol Chem 278:41734-41741
    • (2003) J Biol Chem , vol.278 , pp. 41734-41741
    • Liang, F.1    Huang, Z.2    Lee, S.Y.3
  • 22
    • 77950934522 scopus 로고    scopus 로고
    • A rapid oxime linker-based library approach to identi fi cation of bivalent inhibitors of the Yersinia pestis protein-tyrosine phosphatase
    • Liu F, Hakami RM, Dyas B et al (2010) A rapid oxime linker-based library approach to identi fi cation of bivalent inhibitors of the Yersinia pestis protein-tyrosine phosphatase, YopH. Bioorg Med Chem Lett 20:2813-2816
    • (2010) YopH. Bioorg Med Chem Lett , vol.20 , pp. 2813-2816
    • Liu, F.1    Hakami, R.M.2    Dyas, B.3
  • 23
    • 2442609929 scopus 로고    scopus 로고
    • Suramin derivatives as inhibitors and activators of protein-tyrosine phosphatases
    • McCain DF, Wu L, Nickel P et al (2004) Suramin derivatives as inhibitors and activators of protein-tyrosine phosphatases. J Biol Chem 279:14713-14725
    • (2004) J Biol Chem , vol.279 , pp. 14713-14725
    • McCain, D.F.1    Wu, L.2    Nickel, P.3
  • 24
    • 0024216207 scopus 로고
    • Nucleotide sequence and transcription analysis of yop51 from Yersinia enterocolitica W22703
    • Michiels T, Cornelis G (1988) Nucleotide sequence and transcription analysis of yop51 from Yersinia enterocolitica W22703. Microb Pathog 5:449-459
    • (1988) Microb Pathog , vol.5 , pp. 449-459
    • Michiels, T.1    Cornelis, G.2
  • 25
    • 17644371042 scopus 로고    scopus 로고
    • Smallmolecule inhibitors speci fi cally targeting type III secretion
    • Nordfelth R, Kauppi AM, Norberg HA et al (2005) Smallmolecule inhibitors speci fi cally targeting type III secretion. Infect Immun 73:3104-3114
    • (2005) Infect Immun , vol.73 , pp. 3104-3114
    • Nordfelth, R.1    Kauppi, A.M.2    Norberg, H.A.3
  • 26
    • 0023711836 scopus 로고
    • Inhibition of phagocytosis in Yersinia pseudotuberculosis: A virulence plasmid-encoded ability involving the Yop2b protein
    • Rosqvist R, Bölin I, Wolf-Watz H (1988) Inhibition of phagocytosis in Yersinia pseudotuberculosis: a virulence plasmid-encoded ability involving the Yop2b protein. Infect Immun 56:2139-2143
    • (1988) Infect Immun , vol.56 , pp. 2139-2143
    • Rosqvist, R.1    Bölin, I.2    Wolf-Watz, H.3
  • 27
    • 0022629859 scopus 로고
    • Virulence genes regulated at the transcriptional level by Ca 2+ in Yersinia pestis include structural genes for outer membrane proteins
    • Straley CS, Bowmer WS (1986) Virulence genes regulated at the transcriptional level by Ca 2+ in Yersinia pestis include structural genes for outer membrane proteins. Infect Immun 51:445-454
    • (1986) Infect Immun , vol.51 , pp. 445-454
    • Straley, C.S.1    Bowmer, W.S.2
  • 28
    • 15744388307 scopus 로고    scopus 로고
    • Inhibition of Yersinia tyrosine phosphatase by furanyl salicylate compounds
    • Tautz L, Bruckner S, Sareth S et al (2005) Inhibition of Yersinia tyrosine phosphatase by furanyl salicylate compounds. J Biol Chem 280:9400-9408
    • (2005) J Biol Chem , vol.280 , pp. 9400-9408
    • Tautz, L.1    Bruckner, S.2    Sareth, S.3
  • 29
    • 34250198598 scopus 로고    scopus 로고
    • Development and optimization of high-throughput in vitro protein phosphatase screening assays
    • Tierno MB, Johnston PA, Foster C et al (2007) Development and optimization of high-throughput in vitro protein phosphatase screening assays. Nat Protoc 2:1134-1144
    • (2007) Nat Protoc , vol.2 , pp. 1134-1144
    • Tierno, M.B.1    Johnston, P.A.2    Foster, C.3
  • 30
    • 34247592309 scopus 로고    scopus 로고
    • Development of molecular probes for second-site screening and design of protein tyrosine phosphatase inhibitors
    • Vazquez J, Tautz L, Ryan JJ et al (2007) Development of molecular probes for second-site screening and design of protein tyrosine phosphatase inhibitors. J Med Chem 50:2137-2143
    • (2007) J Med Chem , vol.50 , pp. 2137-2143
    • Vazquez, J.1    Tautz, L.2    Ryan, J.J.3
  • 31
    • 0033003760 scopus 로고    scopus 로고
    • A simple statistical parameter for use in evaluation and validation of high throughput screening assays
    • Zhang JH, Chung TDY, Oldenburg KR (1999) A simple statistical parameter for use in evaluation and validation of high throughput screening assays. J Biomol Screen 4:67-73
    • (1999) J Biomol Screen , vol.4 , pp. 67-73
    • Zhang, J.H.1    Chung, T.D.Y.2    Oldenburg, K.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.