Utilization of nitrophenylphosphates and oxime-based ligation for the development of nanomolar affinity inhibitors of the Yersinia pestis outer protein H (YopH) phosphatase

Journal of Medicinal Chemistry

Volumn 54, Issue 8, 2011, Pages 2933-2943

  Bahta, Medhanit ^a   Lountos, George T ^a   Dyas, Beverly ^b   Kim, Sung Eun ^a   Ulrich, Robert G ^b   Waugh, David S ^a   Burke, Terrence R ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NITROPHENYLPHOSPHATE DERIVATIVE; OUTER MEMBRANE PROTEIN; OXIME DERIVATIVE; PHENYL GROUP; PHOSPHATASE; PHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL GROWTH; BINDING AFFINITY; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG STRUCTURE; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME SUBSTRATE; NONHUMAN; YERSINIA PESTIS;

ANIMALS; BACTERIA; BACTERIAL OUTER MEMBRANE PROTEINS; CELL LINE; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; INHIBITORY CONCENTRATION 50; MICE; MODELS, MOLECULAR; OXIMES; PHOSPHATES; PROTEIN TYROSINE PHOSPHATASES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; YERSINIA PESTIS;

EID: 79955438388     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200022g     Document Type: Article

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