Inhibitors of type III secretion in Yersinia: Design, synthesis and multivariate QSAR of 2-arylsulfonylamino-benzanilides

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 22, 2007, Pages 6994-7011

  Kauppi, Anna M ^a   Andersson, C David ^a   Norberg, Henrik A ^b   Sundin, Charlotta ^b   Linusson, Anna ^a   Elofsson, Mikael ^a  

^a UMEÅ UNIVERSITY   (Sweden)

^b Innate Pharmaceuticals AB   (Sweden)

Author keywords

Inhibitors; Statistical molecular design: multivariate QSAR; Type III secretion; Virulence; Yersinia

Indexed keywords

2 (3,5 DICHLORO 2 HYDROXY BENZENESULFONYLAMINO) N (3,4 DICHLOROPHENYL) 4,5 DIFLUOROBENZAMIDE; 2 (4 ACETYLBENZENESULFONYLAMINO) 4 CHLORO N (3 CHLORO 4 FLUOROPHENYL)BENZAMIDE; 2 (BENZO[1,2,5]THIADIAZOLE 4 SULFONYLAMINO) 4 CHLORO N (3,4 DICHLOROPHENYL)BENZAMIDE; 2 (BENZO[1,2,5]THIADIAZOLE 4 SULFONYLAMINO) 4 CHLORO N (3,4 DIFLUOROPHENYL)BENZAMIDE; 2 (BENZO[1,2,5]THIADIAZOLE 4 SULFONYLAMINO) 5 CHLORO N (3 CHLOROPHENYL)BENZAMIDE; 2 (BENZO[1,2,5]THIADIAZOLE 4 SULFONYLAMINO) 5 CHLORO N (3,4 DICHLOROPHENYL)BENZAMIDE; 2 (BENZO[1,2,5]THIADIAZOLE 4 SULFONYLAMINO) 5 CHLORO N PHENYLBENZAMIDE; 2 (BENZO[1,2,5]THIADIAZOLE 4 SULFONYLAMINO) N (3,4 DICHLOROPHENYL) 4,5 DIFLUOROBENZAMIDE; 2 (BENZO[1,2,5]THIADIAZOLE 4 SULFONYLAMINO) N (3,4 DICHLOROPHENYL)BENZAMIDE; 2 (BENZO[1,2,5]THIADIAZOLE 4 SULFONYLAMINO) N (4 CHLOROPHENYL)BENZAMIDE; 2 BENZENESULFONYLAMINO 5 CHLORO N (3,4 DICHLOROPHENYL)BENZAMIDE; 2 BENZENESULFONYLAMINO 5 CHLORO N (4 DIMETHYLAMINOPHENYL)BENZAMIDE; 2 BENZENESULFONYLAMINO 5 CHLORO N QUINOLIN 7 YL BENZAMIDE; 2 BENZENESULFONYLAMINO N BENZO[1,3]DIOXOL 5 YL 4 CHLOROBENZAMIDE; 4 CHLORO 2 (3 FLUOROBENZENESULFONYLAMINO) N (4 METHOXYPHENYL)BENZAMIDE; 4 CHLORO 2 (3,4 DICHLOROBENZENESULFONYLAMINO) N (4 FLUOROPHENYL)BENZAMIDE; 4 CHLORO 2 (3,4 DICHLOROBENZENESULFONYLAMINO) N (4 METHOXYPHENYL)BENZAMIDE; 4 CHLORO 2 (3,5 DICHLORO 2 HYDROXYBENZENESULFONYLAMINO) N (3,4 DIFLUOROPHENYL)BENZAMIDE; 4,5 DIFLUORO 2 (3 FLUOROBENZENESULFONYLAMINO) N (4 FLUOROPHENYL)BENZAMIDE; 5 CHLORO 2 (3,4 DICHLOROBENZENESULFONYLAMINO) N QUINOLIN 7 YL BENZAMIDE; 5 CHLORO 2 (3,5 DICHLORO 2 HYDROXYBENZENESULFONYLAMINO) N (4 FLUOROPHENYL)BENZAMIDE; 5 CHLORO N (3 CHLORO 4 FLUOROPHENYL) 2 (3,4 DICHLOROBENZENESULFONYLAMINO)BENZAMIDE; 5 CHLORO N (4 DIMETHYLAMINOPHENYL) 2 (3 NITROBENZENESULFONYLAMINO)BENZAMIDE; ANILIDE; N (3,4 DICHLOROPHENYL) 4,5 DIFLUORO 2 (3 NITROBENZENESULFONYLAMINO)BENZAMIDE; N (3,4 DICHLOROPHENYL) 4,5 DIFLUORO 2 (TOLUENE 4 SULFONYLAMINO)BENZAMIDE; N (3,4 DIFLUOROPHENYL) 4,5 DIFLUORO 2 (3 NITROBENZENESULFONYLAMINO)BENZAMIDE; N BENZO[1,3]DIOXOL 5 YL 4 CHLORO 2 (3,4 DICHLOROBENZENESULFONYLAMINO)BENZAMIDE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL INFECTION; CALCULATION; CORRELATION ANALYSIS; DRUG DESIGN; DRUG SYNTHESIS; ENZYME RELEASE; INHIBITION KINETICS; MULTIVARIATE ANALYSIS; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REPORTER GENE; SIGNAL TRANSDUCTION; STATISTICAL ANALYSIS; YERSINIA;

ANILIDES; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; DRUG DESIGN; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; MULTIVARIATE ANALYSIS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; STEREOISOMERISM; YERSINIA PSEUDOTUBERCULOSIS;

BACTERIA (MICROORGANISMS); YERSINIA;

EID: 34748881946     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.07.047     Document Type: Article

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