Yersinia effectors target mammalian signalling pathways

Cellular Microbiology

Volumn 4, Issue 4, 2002, Pages 201-211

  Juris, Stephen J ^a   Shao, Feng ^a   Dixon, Jack E ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN;

ADAPTATION; BACTERIAL IMMUNITY; BACTERIAL SURVIVAL; BACTERIAL TRANSLOCATION; CELLULAR IMMUNITY; CONTROLLED STUDY; HOST CELL; HOST RESISTANCE; IMMUNE SYSTEM; INFECTION RESISTANCE; INFLAMMATION; MAMMAL; NONHUMAN; PATHOGENESIS; PHAGOCYTOSIS; PRIORITY JOURNAL; SHORT SURVEY; SIGNAL TRANSDUCTION; YERSINIA;

AMINO ACID SEQUENCE; BACTERIAL OUTER MEMBRANE PROTEINS; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, PROTEIN; SIGNAL TRANSDUCTION; YERSINIA; YERSINIA INFECTIONS;

ANIMALIA; BACTERIA (MICROORGANISMS); MAMMALIA; YERSINIA;

EID: 0036228931     PISSN: 14625814     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1462-5822.2002.00182.x     Document Type: Short Survey

References (102)

1. Molecular definition of distinct cytoskeletal structures involved in complement- and Fc receptor-mediated phagocytosis in macrophages
2. YopE of Yersinia, a GAP for Rho GTPases, selectively modulates Rac-dependent actin structures in endothelial cells
3. The Rho GTPases have multiple effects on the actin cytoskeleton
4. Effectors for the Rho GTPases
5. Penetration of M cells and destruction of Peyer's patches by Yersinia enterocolitica: An ultrastructural and histological study
6. The eukaryotic-like Ser/Thr protein kinases of Mycobacterium tuberculosis
7. The Yersinia Ser/Thr protein kinase YpkA/YopO directly interacts with the small GTPases RhoA and Rac-1
8. Bacterial evasion of host immune defense: Yersinia enterocolitica encodes a suppressor for tumor necrosis factor alpha expression
9. Identification of p130Cas as a substrate of Yersinia YopH (Yop51), a bacterial protein tyrosine phosphatase that translocates into mammalian cells and targets focal adhesions
10. The RhoGAP activity of the Yersinia pseudotuberculosis cytotoxin YopE is required for antiphagocytic function and virulence
11. Identification of an amino-terminal substrate-binding domain in the Yersinia tyrosine phosphatase that is required for efficient recognition of focal adhesion targets
12. Inhibition of the Fc receptor-mediated oxidative burst in macrophages by the Yersinia pseudotuberculosis tyrosine phosphatase
13. Tyrosine phosphate hydrolysis of host proteins by an essential Yersinia virulence determinant
14. The tripartite type III secretion of Shigella flexneri inserts IpaB and IpaC into host membranes
15. Role of YopP in suppression of tumor necrosis factor alpha release by macrophages during Yersinia infection
16. Status of YopM and YopN in the Yersinia Yop virulon: YopM of Y. enterocolitica is internalized inside the cytosol of PU5-1.8 macrophages by the YopB, D, N delivery apparatus
17. The plasmid-encoded Yop2b protein of Yersinia pseudotuberculosis is a virulence determinant regulated by calcium and temperature at the level of transcription
18. Yersinia enterocolitica can deliver Yop proteins into a wide range of cell types: Development of a delivery system for heterologous proteins
19. Function of Rho family proteins in actin dynamics during phagocytosis and engulfment
20. M-cell surface beta1 integrin expression and invasin-mediated targeting of Yersinia pseudotuberculosis to mouse Peyer's patch M cells
21. The Yersinia Yop virulon, a bacterial system to subvert cells of the primary host defense
22. Transcription of the yop regulon from Y. enterocolitica requires trans acting pYV and chromosomal genes
23. Yersinia enterocolitica YopP-induced apoptosis of macrophages involves the apoptotic signaling cascade upstream of bid
24. The Yersinia protein kinase A is a host factor inducible RhoA/Rac-binding virulence factor
25. Unusual molecular architecture of the Yersinia pestis cytotoxin YopM: A leucine-rich repeat protein with the shortest repeating unit
26. Yersinia pseudotuberculosis inhibits Fc receptor-mediated phagocytosis in J774 cells
27. The virulence protein Yop5 of Yersinia pseudotuberculosis is regulated at transcriptional level by plasmid-plB1-encoded trans-acting elements controlled by temperature and calcium
28. A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion
29. A secreted protein kinase of Yersinia pseudotuberculosis is an indispensable virulence determinant
30. Characterization of the operon encoding the YpkA Ser/Thr protein kinase and the YopJ protein of Yersinia pseudotuberculosis
31. The N-terminal domain of Pseudomonas aeruginosa exoenzyme S is a GTPase-activating protein for Rho GTPases
32. Role of YopH in the suppression of tyrosine phosphorylation and respiratory burst activity in murine macrophages infected with Yersinia enterocolitica
33. Colocalization of F-actin and talin during Fc receptor-mediated phagocytosis in mouse macrophages
34. Tyrosine phosphorylation is required for Fc receptor-mediated phagocytosis in mouse macrophages
35. Protein tyrosine phosphatase activity of an essential virulence determinant in Yersinia
36. The YopB protein of Yersinia pseudotuberculosis is essential for the translocation of Yop effector proteins across the target cell plasma membrane and displays a contact-dependent membrane disrupting activity
37. The Yersinia YpkA Ser/Thr kinase is translocated and subsequently targeted to the inner surface of the HeLa cell plasma membrane
38. Rho GTPases and the actin cytoskeleton
39. YopH dephosphorylates Cas and Fyn-binding protein in macrophages
40. Essential role of YopD in inhibition of the respiratory burst of macrophages by Yersinia enterocolitica
41. YopT, a new Yersinia Yop effector protein, affects the cytoskeleton of host cells
42. A distinctive role for the Yersinia protein kinase: Actin binding, kinase activation, and cytoskeleton disruption
43. A secreted protein tyrosine phosphatase with modular effector domains in the bacterial pathogen Salmonella typhimurium
44. The beginning of the end: IkappaB kinase (IKK) and NF-kappaB activation
45. Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich repeats
46. The leucine-rich repeat: A versatile binding motif
47. Molecular characterization and assembly of the needle complex of the Salmonella typhimurium type III protein secretion system
48. Novel families of putative protein kinases in bacteria and archaea: Evolution of the 'eukaryotic' protein kinase superfamily
49. YopM inhibits platelet aggregation and is necessary for virulence of Yersinia pestis in mice
50. A new protease required for cell-cycle progression in yeast
51. TNF-alpha gene expression in macrophages: Regulation by NF-kappa B is independent of c-Jun or C/EBP beta
52. Structure of the InIB leucine-rich repeats, a domain that triggers host cell invasion by the bacterial pathogen L. monocytogenes
53. Invasin-dependent and invasin-independent pathways for translocation of Yersinia pseudotuberculosis across the Peyer's patch intestinal epithelium
54. Phagocytosis and the actin cytoskeleton
55. The Yersinia Yops inhibit invasion of Listeria, Shigella and Edwardsiella but not Salmonella into epithelial cells
56. Innate immunity
57. Multiple signals converging on NF-kappaB
58. Yersinia enterocolitica induces apoptosis in macrophages by a process requiring functional type III secretion and translocation mechanisms and involving YopP, presumably acting as an effector protein
59. Yersinia signals macrophages to undergo apoptosis and YopJ is necessary for this cell death
60. Yersinia-induced apoptosis in vivo aids in the establishment of a systemic infection in mice
61. Association between virulence of Yersinia pestis and suppression of gamma interferon and tumor necrosis factor alpha
62. Insertion of a Yop translocation pore into the macrophage plasma membrane by Yersinia enterocolitica: Requirement for translocators YopB and YopD, but not LcrG
63. Inhibition of the mitogen-activated protein kinase kinase superfamily by a Yersinia effector
64. Disruption of signaling by Yersinia effector YopJ, a ubiquitin-like protein protease
65. Macrophages require constitutive NF-kappaB activation to maintain A1 expression and mitochondrial homeostasis
66. YopJ of Yersinia pseudotuberculosis is required for the inhibition of macrophage TNF-alpha production and downregulation of the MAP kinases p38 and JNK
67. YopJ of Yersinia spp. is sufficient to cause downregulation of multiple mitogen-activated protein kinases in eukaryotic cells
68. Genome sequence of Yersinia pestis, the causative agent of plague
69. Mitogen-activated protein (MAP) kinase pathways: Regulation and physiological functions
70. The PTPase YopH inhibits uptake of Yersinia, tyrosine phosphorylation of p130Cas and FAK, and the associated accumulation of these proteins in peripheral focal adhesions
71. Role of a plasmid in the pathogenicity of Yersinia species
72. Yersinia pestis YopM: Thrombin binding and overexpression
73. Regulation of interleukin-8 gene expression
74. Inhibition of phagocytosis in Yersinia pseudotuberculosis: A virulence plasmid-encoded ability involving the Yop2b protein
75. The cytotoxic protein YopE of Yersinia obstructs the primary host defence
76. Microinjection of the Yersinia YopE cytotoxin in mammalian cells induces actin microfilament disruption
77. Intracellular targeting of the Yersinia YopE cytotoxin in mammalian cells induces actin microfilament disruption
78. Differential contribution of Yersinia enterocolitica virulence factors to evasion of microbicidal action of neutrophils
79. Yersinia enterocolitica promotes deactivation of macrophage mitogen-activated protein kinases extracellular signal-regulated kinase-1/2, 38, and c-Jun NH2-terminal kinase. Correlation with its factor-alpha production
80. Interaction of Yersinia enterocolitica with macrophages leads to macro-phage cell death through apoptosis
81. Yersinia enterocolitica impairs activation of transcription factor NF-kappaB: Involvement in the induction of programmed cell death and in the suppression of the macrophage tumor necrosis factor alpha production
82. Yersinia outer protein P of Yersinia enterocolitica simultaneously blocks the nuclear factor-kappa B pathway and exploits lipopolysaccharide signaling to trigger apoptosis in macrophages
83. Delineation and mutational analysis of the Yersinia pseudotuberculosis YopE domains which mediate translocation across bacterial and eukaryotic cellular membranes
84. The yopJ locus is required for Yersinia-mediated inhibition of NF-kappaB activation and cytokine expression: YopJ contains a eukaryotic SH2-like domain that is essential for its repressive activity
85. The Salmonella YopJ-homologue AvrA does not possess YopJ-like activity
86. Bidirectional signaling between the cytoskeleton and integrins
87. Differential secretion of interleukin-8 by human epithelial cell lines upon entry of virulent or non-virulent Yersinia enterocolitica
88. Targeting of the Yersinia pestis YopM protein into HeLa cells and intracellular trafficking to the nucleus
89. Identification of the YopE and YopH domains required for secretion and internalization into the cytosol of macrophages, using the cyaA gene fusion approach
90. Modulation of host signaling by a bacterial mimic: Structure of the Salmonella effector SptP bound to Rac1
91. Virulence genes regulated at the transcriptional level by Ca2+ in Yersinia pestis include structural genes for outer membrane proteins
92. Crystal structure of Yersinia protein tyrosine phosphatase at 2.5 A and the complex with tungstate
93. Supramolecular structure of the Shigella type III secretion machinery: The needle part is changeable in length and essential for delivery of effectors
94. Yersinia enterocolitica type III secretion-translocation system: Channel formation by secreted Yops
95. A bacterial type III secretion system inhibits actin polymerization to prevent pore formation in host cell membranes
96. GAP activity of the Yersinia YopE cytotoxin specifically targets the Rho pathway: A mechanism for disruption of actin microfilament structure
97. A novel serine/threonine protein kinase homologue of Pseudomonas aeruginosa is specifically inducible within the host infection site and is required for full virulence in neutropenic mice
98. How the Pseudomonas aeruginosa ExoS toxin downregulates Rac
99. Respiratory burst and tyrosine phosphorylation by vanadate
100. Suppression of T and B lymphocyte activation by a Yersinia pseudotuberculosis virulence factor, yopH
101. Ubiquitin-like proteins: New wines in new bottles
102. The cytotoxin YopT of Yersinia enterocolitica induces modification and cellular redistribution of the small GTP-binding protein RhoA