A rapid oxime linker-based library approach to identification of bivalent inhibitors of the Yersinia pestis protein-tyrosine phosphatase, YopH

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 9, 2010, Pages 2813-2816

  Liu, Fa ^a   Hakami, Ramin Mollaaghababa ^b,c   Dyas, Beverly ^c   Bahta, Medhanit ^a   Lountos, George T ^a   Waugh, David S ^a   Ulrich, Robert G ^c   Burke Jr , Terrence R ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b OAK RIDGE ASSOCIATED UNIVERSITIES   (United States)

^c UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

Author keywords

Inhibitor; Protein tyrosine phosphatase; Yersinia pestis; YopH

Indexed keywords

ALDEHYDE; ANTIINFECTIVE AGENT; OXIME; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; PROTEIN YOPH; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG IDENTIFICATION; DRUG SYNTHESIS; HYDROLYSIS; MOLECULAR DOCKING; MOLECULAR LIBRARY; YERSINIA PESTIS;

ALDEHYDES; BACTERIAL OUTER MEMBRANE PROTEINS; BINDING SITES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; OXIMES; PROTEIN TYROSINE PHOSPHATASES; SMALL MOLECULE LIBRARIES; YERSINIA PESTIS;

YERSINIA PESTIS;

EID: 77950934522     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.03.058     Document Type: Article

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