Contextual memory deficits observed in mice overexpressing small conductance Ca2+-activated K+ type 2 (KCa2.2, SK2) channels are caused by an encoding deficit

Learning and Memory

Volumn 15, Issue 4, 2008, Pages 208-213

  Stackman Jr , Robert W ^a   Bond, Chris T ^b   Adelman, John P ^b  

^a FLORIDA ATLANTIC UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ACTIVATED POTASSIUM CHANNEL;

ARTICLE; BRAIN FUNCTION; HIPPOCAMPUS; LEARNING; LOCOMOTION; MEMORY; MEMORY DISORDER; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE;

ANIMALS; FEAR; GENE EXPRESSION REGULATION; GENOTYPE; HIPPOCAMPUS; MEMORY DISORDERS; MICE; SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; SYNAPSES;

EID: 42149154880     PISSN: 10720502     EISSN: 15495485     Source Type: Journal    
DOI: 10.1101/lm.906808     Document Type: Article

References (31)

1. Bannerman, D.M., Good, M.A., Butcher, S.P., Ramsay, M., and Morris, R.G. 1995. Distinct components of spatial learning revealed by prior training and NMDA receptor blockade. Nature 378: 182-186.
2. Behnisch, T. and Reymann, K.G. 1998. Inhibition of apamin-sensitive calcium dependent potassium channels facilitate the induction of long-term potentiation in the CA1 region of rat hippocampus in vitro. Neurosci. Lett. 253: 91-94.
3. + channel SK3 generates age-related memory and LTP deficits. Nat. Neurosci. 6: 911-912.
4. Butcher, S.P., Davis, S., and Morris, R.G. 1990. A dose-related impairment of spatial learning by the NMDA receptor antagonist, 2-amino-5-phosphonovalerate (AP5). Eur. Neuropsychopharmacol. 1: 15-20.
5. Cravens, C.J., Vargas-Pinto, N., Christian, K.M., and Nakazawa, K. 2006. CA3 NMDA receptors are crucial for rapid and automatic representation of context memory. Eur. J. Neurosci. 24: 1771-1780.
6. Davis, S., Butcher, S.P., and Morris, R.G. 1992. The NMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitro. J. Neurosci. 12: 21-34.
7. Eichenbaum, H. 2000. A cortical-hippocampal system for declarative memory. Nat. Rev. Neurosci. 1: 41-50.
8. Faber, E.S., Delaney, A.J., and Sah, P. 2005. SK channels regulate excitatory synaptic transmission and plasticity in the lateral amygdala. Nat. Neurosci. 8: 635-641.
9. Hammond, R.S., Bond, C.T., Strassmaier, T., Ngo-Anh, T.J., Adelman, J.P., Maylie, J., and Stackman, R.W. 2006. Small-conductance Ca2+-activated K+ channel type 2 (SK2) modulates hippocampal learning, memory, and synaptic plasticity. J. Neurosci. 26: 1844-1853.
10. Kohler, M., Hirschberg, B., Bond, C.T., Kinzie, J.M., Marrion, N.V., Maylie, J., and Adelman, J.P. 1996. Small-conductance, calcium-activated potassium channels from mammalian brain. Science 273: 1709-1714.
11. Kramar, E.A., Lin, B., Lin, C.Y., Arai, A.C., Gall, C.M., and Lynch, G. 2004. A novel mechanism for the facilitation of θ-induced long-term potentiation by brain-derived neurotrophic factor. J. Neurosci. 24: 5151-5161.
12. Maison, S.F., Parker, L.L., Young, L., Adelman, J.P., Zuo, J., and Liberman, M.C. 2007. Overexpression of SK2 channels enhances efferent suppression of cochlear responses without enhancing noise resistance. J. Neurophysiol. 97: 2930-2936.
13. Malenka, R.C. and Nicoll, R.A. 1999. Long-term potentiation - a decade of progress? Science 285: 1870-1874.
14. Maren, S. 1998. Overtraining does not mitigate contextual fear conditioning deficits produced by neurotoxic lesions of the basolateral amygdala. J. Neurosci. 18: 3088-3097.
15. Maren, S., Aharonov, G., and Fanselow, M.S. 1997. Neurotoxic lesions of the dorsal hippocampus and Pavlovian fear conditioning in rats. Behav. Brain Res. 88: 261-274.
16. Matus-Amat, P., Higgins, E.A., Barrientos, R.M., and Rudy, J.W. 2004. The role of the dorsal hippocampus in the acquisition and retrieval of context memory representations. J. Neurosci. 24: 2431-2439.
17. Muller, J., Corodimas, K.P., Fridel, Z., and LeDoux, J.E. 1997. Functional inactivation of the lateral and basal nuclei of the amygdala by muscimol infusion prevents fear conditioning to an explicit conditioned stimulus and to contextual stimuli. Behav. Neurosci. 111: 683-691.
18. 2+- mediated feedback loop in dendritic spines. Nat. Neurosci. 8: 642-649.
19. Niewoehner, B., Single, F.N., Hvalby, O., Jensen, V., Meyer Zum Alten Borgloh, S., Seeburg, P.H., Rawlins, J.N., Sprengel, R., and Bannerman, D.M. 2007. Impaired spatial working memory but spared spatial reference memory following functional loss of NMDA receptors in the dentate gyrus. Eur. J. Neurosci. 25: 837-846.
20. 2+ channels. J. Neurosci. 18: 3171-3179.
21. Phillips, R.G. and LeDoux, J.E. 1992. Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behav. Neurosci. 106: 274-285.
22. Ponnusamy, R., Poulos, A.M., and Fanselow, M.S. 2007. Amygdala-dependent and amygdala-independent pathways for contextual fear conditioning. Neuroscience 147: 919-927.
23. Ris, L., Capron, B., Sclavons, C., Liegeois, J.F., Seutin, V., and Godaux, E. 2007. Metaplastic effect of apamin on LTP and paired-pulse facilitation. Learn. Mem. 14: 390-399.
24. Rudy, J.W., Barrientos, R.M., and O'Reilly, R.C. 2002. Hippocampal formation supports conditioning to memory of a context. Behav. Neurosci. 116: 530-538.
25. + channels in rat brain. J. Neurosci. 22: 9698-9707.
26. 2+-activated potassium channel subunits, SK1, SK2, and SK3 in mouse brain. Mol. Cell. Neurosci. 26: 458-469.
27. + channels modulate synaptic plasticity and memory encoding. J. Neurosci. 22: 10163-10171.
28. + channel subunits, SK1, SK2, and SK3, in the adult rat central nervous system. Mol. Cell. Neurosci. 15: 476-493.
29. + current in hippocampal pyramidal neurons. Proc. Natl. Acad. Sci. 96: 4662-4667.
30. + channels. Neuroscientist. 9: 434-439.
31. Wiltgen, B.J., Sanders, M.J., Anagnostaras, S.G., Sage, J.R., and Fanselow, M.S. 2006. Context fear learning in the absence of the hippocampus. J. Neurosci. 26: 5484-5491.