CyPPA, a positive SK3/SK2 modulator, reduces activity of dopaminergic neurons, inhibits dopamine release, and counteracts hyperdopaminergic behaviors induced by methylphenidate

Frontiers in Pharmacology

Volumn 3 FEB, Issue , 2012, Pages

  Herrik, Kjartan F ^a   Redrobe, John P ^a   Holst, Dorte ^b   Hougaard, Charlotte ^b   Sandager Nielsen, Karin ^b   Nielsen, Alexander N ^b   Ji, Huifang ^c   Holst, Nina M ^d   Rasmussen, Hanne B ^d   Nielsen, Elsebet Ø ^b   Strøbæk, Dorte ^b   Shepard, Paul D ^c   Christophersen, Palle ^b  

^a H LUNDBECK A S   (Denmark)

^b NEUROSEARCH A S   (Denmark)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Apamin; Dopamine release; Immunocytochemistry; KCa2+; KCNN; MAHP; NS8593; Substantia nigra compacta

Indexed keywords

APAMIN; CYCLOHEXYL [2 (3,5 DIMETHYLPYRAZOL 1 YL) 6 METHYL PYRIMIDIN 4 YL]AMINE; DOPAMINE; METHYLPHENIDATE; QUINPIROLE; SMALL CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; UNCLASSIFIED DRUG;

AFTERHYPERPOLARIZATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDROMIC STIMULATION; ARTICLE; BRAIN ELECTROPHYSIOLOGY; BRAIN SLICE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOPAMINE RELEASE; DOPAMINERGIC NERVE CELL; DRUG EFFICACY; DRUG MECHANISM; EVOKED RESPONSE; HYPERACTIVITY; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MOLECULAR DYNAMICS; MOTOR DYSFUNCTION; MOUSE; NONHUMAN; RAT; SENSITIVITY ANALYSIS;

EID: 84866237553     PISSN: None     EISSN: 16639812     Source Type: Journal    
DOI: 10.3389/fphar.2012.00011     Document Type: Article

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