Resurgent sodium current and action potential formation in dissociated cerebellar Purkinje neurons

Journal of Neuroscience

Volumn 17, Issue 12, 1997, Pages 4517-4526

  Raman, Indira M ^a   Bean, Bruce P ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b NONE

Author keywords

Action potential; Afterdepolarization; Cerebellum; Complex spike; Pacemaking; Purkinje neuron; Single channel; Sodium channel; Tetrodotoxin

Indexed keywords

SODIUM CHANNEL; TETRODOTOXIN;

ACTION POTENTIAL; ANIMAL CELL; ARTICLE; CHANNEL GATING; HYPERPOLARIZATION; MEMBRANE DEPOLARIZATION; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PURKINJE CELL; PYRAMIDAL NERVE CELL; RAT; REPOLARIZATION; SODIUM CURRENT; SPIKE; VOLTAGE CLAMP;

EID: 0031010957     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.17-12-04517.1997     Document Type: Article

References (18)

1. Bell CC, Grimm RJ (1969) Discharge properties of Purkinje cells recorded on single and double microelectrodes. J Neurophysiol 32:1044-1055.
2. + channels. J Neurophysiol 71:2562-2565.
3. B receptors. J Neurophysiol 74:1137-1148.
4. + conductance in medium-sized neostriatal neurons: characterization using infrared videomicroscopy and whole-cell patch-clamp recordings. J Neurophysiol 74:1343-1348.
5. Crill WE (1996) Persistent sodium current in mammalian central neurons. Annu Rev Physiol 58:349-362.
6. + channel behaves like an open channel blocker. Neuron 7:743-753.
7. Eccles JC, Llinás R, Sasaki K (1966) The excitatory synaptic action of climbing fibers on the Purkinje neurons of the cerebellum. J Physiol (Lond) 182:268-296.
8. Eccles JC, Ito M, Szentagothai J (1967) The cerebellum as a neuronal machine. Berlin: Springer.
9. French CR, Sah P, Buckett KJ, Gage PW (1990) A voltage-dependent persistent sodium current in mammalian hippocampal neurons. J Gen Physiol 95:1139-1157.
10. Fujita Y (1967) Activity of dendrites of single Purkinje cells and its relationship to so-called inactivation response in rabbit cerebellum. J Neurophysiol 31:131-141.
11. + conductances in somatic membranes of rat Purkinje cells from organotypic cerebellar cultures. J Physiol (Lond) 417:105-122.
12. Gruol DL, Franklin CL (1987) Morphological and physiological differentiation of Purkinje neurons in cultures of rat cerebellum. J Neurosci 7:1271-1293.
13. Gruol DL, Deal CR, Franklin CL (1992) Developmental changes in calcium conductances contribute to the physiological maturation of cerebellar Purkinje neurons in culture. J Neurosci 12:2838-2848.
14. Hodgkin AL, Huxley AF (1952) A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol (Lond) 117:500-544.
15. Hotson JR, Prince DA, Schwartzkroin PA (1979) Anomalous inward rectification in hippocampal neurons. J Neurophysiol 42:889-895.
16. Hounsgaard J (1979) Pacemaker properties of mammalian Purkinje neurons. Acta Physiol Scand 106:91-92.
17. Latham A, Paul DH (1971) Spontaneous activity of cerebellar Purkinje cells and their responses to impulses in climbing fibres. J Physiol (Lond) 213:135-156.
18. Llinás R (1988) The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function. Science 242:1654-1164.