TCR-redirected human T cells inhibit hepatitis C virus replication: Hepatotoxic potential is linked to antigen specificity and functional avidity

Journal of Immunology

Volumn 189, Issue 9, 2012, Pages 4510-4519

  Pasetto, Anna ^a   Frelin, Lars ^a   Aleman, Soo ^a   Holmström, Fredrik ^a   Brass, Anette ^a   Ahlén, Gustaf ^a   Brenndörfer, Erwin D ^a   Lohmann, Volker ^b   Bartenschlager, Ralf ^b   Sällberg, Matti ^a   Bertoletti, Antonio ^c   Chen, Margaret ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c AGENCY FOR SCIENCE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTATE AMINOTRANSFERASE; GAMMA INTERFERON; HLA A2 ANTIGEN; INTERLEUKIN 2; NONSTRUCTURAL PROTEIN 5A; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; VIRUS RNA;

ANIMAL EXPERIMENT; ANTIGEN SPECIFICITY; APOPTOSIS; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DEGRANULATION; ENZYME RELEASE; FEMALE; FLOW CYTOMETRY; GENE TRANSFER; HEPATITIS C; HEPATITIS C VIRUS; HEPATOMA CELL; HUMAN; HUMAN CELL; LYMPHOCYTE FUNCTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; VIRUS INHIBITION; VIRUS REPLICATION;

AMINO ACID SEQUENCE; ANIMALS; ANTIVIRAL AGENTS; CELL LINE; CELL LINE, TUMOR; CYTOTOXICITY, IMMUNOLOGIC; EPITOPES, T-LYMPHOCYTE; FEMALE; GENE TRANSFER TECHNIQUES; HEPACIVIRUS; HUMANS; LEUKOCYTES, MONONUCLEAR; MALE; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; RECEPTORS, ANTIGEN, T-CELL; TRANSDUCTION, GENETIC; VIRUS REPLICATION;

EID: 84867912743     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1201613     Document Type: Article

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