Wnt3a regulates survival, expansion, and maintenance of neural progenitors derived from human embryonic stem cells

Molecular and Cellular Neuroscience

Volumn 36, Issue 3, 2007, Pages 408-415

  Davidson, Kathryn C ^a,b   Jamshidi, Pegah ^b   Daly, Rachel ^a   Hearn, Milton T W ^a   Pera, Martin F ^a   Dottori, Mirella ^a  

^a MONASH UNIVERSITY   (Australia)

^b Australian Stem Cell Center   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

WNT3A PROTEIN;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; EMBRYO; EMBRYONIC STEM CELL; HUMAN; HUMAN CELL; NERVE CELL; PRIORITY JOURNAL; UPREGULATION;

ANIMALS; APOPTOSIS; CARRIER PROTEINS; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; EMBRYONIC STEM CELLS; HUMANS; MICE; NEURONS; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; SPHEROIDS, CELLULAR; STEM CELLS; UP-REGULATION; WNT PROTEINS;

EID: 35448972941     PISSN: 10447431     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mcn.2007.07.013     Document Type: Article

References (28)

1. Almeida M., Han L., Bellido T., Manolagas S.C., and Kousteni S. Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT. J. Biol. Chem. 280 (2005) 41342-41351
2. Ben-Hur T., Idelson M., Khaner H., Pera M., Reinhartz E., Itzik A., and Reubinoff B.E. Transplantation of human embryonic stem cell-derived neural progenitors improves behavioral deficit in Parkinsonian rats. Stem. Cells 22 (2004) 1246-1255
3. Boland G.M., Perkins G., Hall D.J., and Tuan R.S. Wnt 3a promotes proliferation and suppresses osteogenic differentiation of adult human mesenchymal stem cells. J. Cell. Biochem. 93 (2004) 1210-1230
4. Carpenter M.K., Inokuma M.S., Denham J., Mujtaba T., Chiu C.P., and Rao M.S. Enrichment of neurons and neural precursors from human embryonic stem cells. Exp. Neurol. 172 (2001) 383-397
5. Chesnutt C., Burrus L.W., Brown A.M., and Niswander L. Coordinate regulation of neural tube patterning and proliferation by TGFbeta and WNT activity. Dev. Biol. 274 (2004) 334-347
6. Ciani L., and Salinas P.C. WNTs in the vertebrate nervous system: from patterning to neuronal connectivity. Nat. Rev., Neurosci. 6 (2005) 351-362
7. Ding S., Wu T.Y., Brinker A., Peters E.C., Hur W., Gray N.S., and Schultz P.G. Synthetic small molecules that control stem cell fate. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 7632-7637
8. Dravid G., Ye Z., Hammond H., Chen G., Pyle A., Donovan P., Yu X., and Cheng L. Defining the role of Wnt/beta-catenin signaling in the survival, proliferation, and self-renewal of human embryonic stem cells. Stem. Cells 23 (2005) 1489-1501
9. Gunhaga L., Marklund M., Sjodal M., Hsieh J.C., Jessell T.M., and Edlund T. Specification of dorsal telencephalic character by sequential Wnt and FGF signaling. Nat. Neurosci. 6 (2003) 701-707
10. Inoue T., Kagawa T., Fukushima M., Shimizu T., Yoshinaga Y., Takada S., Tanihara H., and Taga T. Activation of canonical Wnt pathway promotes proliferation of retinal stem cells derived from adult mouse ciliary margin. Stem. Cells 24 (2006) 95-104
11. Logan C.Y., and Nusse R. The Wnt signaling pathway in development and disease. Annu. Rev. Cell Dev. Biol. 20 (2004) 781-810
12. Megason S.G., and McMahon A.P. A mitogen gradient of dorsal midline Wnts organizes growth in the CNS. Development 129 (2002) 2087-2098
13. Murashov A.K., Pak E.S., Hendricks W.A., Owensby J.P., Sierpinski P.L., Tatko L.M., and Fletcher P.L. Directed differentiation of embryonic stem cells into dorsal interneurons. FASEB J. 19 (2005) 252-254
14. Muroyama Y., Kondoh H., and Takada S. Wnt proteins promote neuronal differentiation in neural stem cell culture. Biochem. Biophys. Res. Commun. 313 (2004) 915-921
15. Otero J.J., Fu W., Kan L., Cuadra A.E., and Kessler J.A. Beta-catenin signaling is required for neural differentiation of embryonic stem cells. Development 131 (2004) 3545-3557
16. Pera M.F., Filipczyk A.A., Hawes S.M., and Laslett A.L. Isolation, characterization, and differentiation of human embryonic stem cells. Methods Enzymol. 365 (2003) 429-446
17. Pera M.F., Andrade J., Houssami S., Reubinoff B., Trounson A., Stanley E.G., Ward-van Oostwaard D., and Mummery C. Regulation of human embryonic stem cell differentiation by BMP-2 and its antagonist noggin. J. Cell Sci. 117 (2004) 1269-1280
18. Perrier A.L., Tabar V., Barberi T., Rubio M.E., Bruses J., Topf N., Harrison N.L., and Studer L. Derivation of midbrain dopamine neurons from human embryonic stem cells. Proc. Natl. Acad. Sci. U.S.A. 101 (2004) 12543-12548
19. Reubinoff B.E., Itsykson P., Turetsky T., Pera M.F., Reinhartz E., Itzik A., and Ben-Hur T. Neural progenitors from human embryonic stem cells. Nat. Biotechnol. 19 (2001) 1134-1140
20. Reynolds B.A., and Weiss S. Clonal and population analyses demonstrate that an EGF-responsive mammalian embryonic CNS precursor is a stem cell. Dev. Biol. 175 (1996) 1-13
21. Reynolds B.A., Tetzlaff W., and Weiss S. A multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes. J. Neurosci. 12 (1992) 4565-4574
22. Sato N., Meijer L., Skaltsounis L., Greengard P., and Brivanlou A.H. Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat. Med. 10 (2004) 55-63
23. Schuldiner M., Eiges R., Eden A., Yanuka O., Itskovitz-Eldor J., Goldstein R.S., and Benvenisty N. Induced neuronal differentiation of human embryonic stem cells. Brain Res. 913 (2001) 201-205
24. Thomson J.A., Itskovitz-Eldor J., Shapiro S.S., Waknitz M.A., Swiergiel J.J., Marshall V.S., and Jones J.M. Embryonic stem cell lines derived from human blastocysts. Science 282 (1998) 1145-1147
25. Watanabe K., Kamiya D., Nishiyama A., Katayama T., Nozaki S., Kawasaki H., Watanabe Y., Mizuseki K., and Sasai Y. Directed differentiation of telencephalic precursors from embryonic stem cells. Nat. Neurosci. 8 (2005) 288-296
26. Willert K., Brown J.D., Danenberg E., Duncan A.W., Weissman I.L., Reya T., Yates Jr. J.R., and Nusse R. Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature 423 (2003) 448-452
27. Wodarz A., and Nusse R. Mechanisms of Wnt signaling in development. Annu. Rev. Cell. Dev. Biol. 14 (1998) 59-88
28. Yun M.S., Kim S.E., Jeon S.H., Lee J.S., and Choi K.Y. Both ERK and Wnt/beta-catenin pathways are involved in Wnt3a-induced proliferation. J. Cell Sci. 118 (2005) 313-322