The generation R study: A review of design, findings to date, and a study of the 5-HTTLPR by environmental interaction from fetal life onward

Journal of the American Academy of Child and Adolescent Psychiatry

Volumn 51, Issue 11, 2012, Pages

  Tiemeier, Henning ^a,b   Velders, Fleur P ^a,b   Szekely, Eszter ^a,b   Roza, Sabine J ^a   Dieleman, Gwen ^a   Jaddoe, Vincent W V ^a,b   Uitterlinden, Andre G ^b   White, Tonya J H ^a   Bakermans Kranenburg, Marian J ^c   Hofman, Albert ^b   Van Ijzendoorn, Marinus H ^c   Hudziak, James J ^b,d   Verhulst, Frank C ^a  

^a SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c LEIDEN UNIVERSITY   (Netherlands)

^d VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

5 HTTLPR; emotional problems; gene environment interaction; Generation R; maternal anxiety

Indexed keywords

SEROTONIN TRANSPORTER;

ALLELE; ANXIETY DISORDER; CHILD; CHILD BEHAVIOR CHECKLIST; CHRONIC DISEASE; COHORT ANALYSIS; CONTROLLED STUDY; EMOTIONAL DISORDER; EUROPE; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; HUMAN TISSUE; MALE; MATERNAL DISEASE; PERINATAL PERIOD; PRENATAL PERIOD; PRESCHOOL CHILD; PRIORITY JOURNAL; PSYCHOLOGIC ASSESSMENT; RECOGNITION; REVIEW; SECOND TRIMESTER PREGNANCY;

EID: 84867897980     PISSN: 08908567     EISSN: 15275418     Source Type: Journal    
DOI: 10.1016/j.jaac.2012.08.021     Document Type: Article

References (73)

1. V.W. Jaddoe, C.M. van Duijn, A.J. van der Heijden The Generation R Study: design and cohort update 2010 Eur J Epidemiol 25 2010 823 841
2. J. Henrichs, J.J. Schenk, S.J. Roza Maternal psychological distress and fetal growth trajectories: the Generation R Study Psychol Med 40 2010 633 643
3. S.J. Roza, F.C. Verhulst, V.W. Jaddoe Maternal smoking during pregnancy and child behaviour problems: the Generation R Study Int J Epidemiol 38 2009 680 689
4. H. El Marroun, V.W. Jaddoe, J.J. Hudziak Maternal use of selective serotonin reuptake inhibitors, fetal growth, and risk of adverse birth outcomes Arch Gen Psychiatry 69 2012 706 714
5. H. El Marroun, H. Tiemeier, E.A. Steegers Intrauterine cannabis exposure affects fetal growth trajectories: the Generation R Study J Am Acad Child Adolesc Psychiatry 48 2009 1173 1181
6. S.J. Roza, P.A. van Lier, V.W. Jaddoe Intrauterine growth and infant temperamental difficulties: the Generation R Study J Am Acad Child Adolesc Psychiatry 47 2008 264 272
7. T. van Batenburg-Eddes, L. de Groot, E.A.P. Steegers Fetal programming of infant neuromotor development: the Generation R Study Pediatr Res 67 2010 132 137
8. N.J. Wiles, T.J. Peters, J. Heron, D. Gunnell, A. Emond, G. Lewis Fetal growth and childhood behavioral problems: results from the ALSPAC cohort Am J Epidemiol 163 2006 829 837
9. H. El Marroun, J.J. Hudziak, H. Tiemeier Intrauterine cannabis exposure leads to more aggressive behavior and attention problems in 18-month-old girls Drug Alcohol Depend 118 2011 470 474
10. A. Ghassabian, J.J. Bongers-Schokking, J. Henrichs Maternal thyroid function during pregnancy and behavioral problems in the offspring: the Generation R Study Pediatr Res 69 2011 454 459
11. J. Steenweg-de Graaff, S.J. Roza, E.A. Steegers Maternal folate status in early pregnancy and child emotional and behavioral problems: the Generation R Study Am J Clin Nutr 95 2012 1413 1421
12. M.J. Brion, M. Zeegers, V. Jaddoe Intrauterine effects of maternal prepregnancy overweight on child cognition and behavior in 2 cohorts Pediatrics 127 2011 e202 e211
13. F.P. Velders, G. Dieleman, J. Henrichs Prenatal and postnatal psychological symptoms of parents and family functioning: the impact on child emotional and behavioural problems Eur Child Adolesc Psychiatry 20 2011 341 350
14. J. Rijlaarsdam, G.W.J.M. Stevens, J.V.D. Ende A brief observational instrument for the assessment of infant home environment: development and psychometric testing Int J Method Psychiat Res 21 2012 195 204
15. R.M. Freathy, D.O. Mook-Kanamori, U. Sovio Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight Nat Genet 42 2010 430 435
16. M.P. Luijk, G.I. Roisman, J.D. Haltigan Dopaminergic, serotonergic, and oxytonergic candidate genes associated with infant attachment security and disorganization? In search of main and interaction effects J Child Psychol Psychiatry 52 2011 1295 1307
17. M.P. Luijk, F.P. Velders, A. Tharner FKBP5 and resistant attachment predict cortisol reactivity in infants: gene-environment interaction Psychoneuroendocrinology 35 2010 1454 1461
18. M. Pluess, F.P. Velders, J. Belsky Serotonin transporter polymorphism moderates effects of prenatal maternal anxiety on infant negative emotionality Biol Psychiatry 69 2011 520 525
19. S.J. Roza, P.P. Govaert, M.H. Lequin et al. Cerebral ventricular volume and temperamental difficulties in infancy The Generation R Study J Psychiatry Neurosci 33 2008 431 439
20. C.M. Herba, S.J. Roza, P. Govaert Infant brain development and vulnerability to later internalizing difficulties: the Generation R Study J Am Acad Child Adolesc Psychiatry 49 2010 1053 1063
21. Langeslag, Schmidt, Ghassabian Functional connectivity between parietal and frontal brain regions and intelligence in young children: the Generation R study [published online September 24, 2012] Hum Brain Mapp 2012 10.1002/hbm.22143
22. A. Tharner, M.P. Luijk, M.H. van Ijzendoorn Maternal lifetime history of depression and depressive symptoms in the prenatal and early postnatal period do not predict infant-mother attachment quality in a large, population-based Dutch cohort study Attach Hum Dev 14 2012 63 81
23. M.P. Luijk, N. Saridjan, A. Tharner Attachment, depression, and cortisol: deviant patterns in insecure-resistant and disorganized infants Dev Psychobiol 52 2010 441 452
24. T.L. Bale, T.Z. Baram, A.S. Brown Early life programming and neurodevelopmental disorders Biol Psychiatry 68 2010 314 319
25. P.W. Jansen, H. Raat, J.P. Mackenbach National origin and behavioural problems of toddlers: the role of family risk factors and maternal immigration characteristics J Abnorm Child Psychol 38 2010 1151 1164
26. J. Henrichs, L. Rescorla, J.J. Schenk Examining continuity of early expressive vocabulary development: the Generation R Study J Speech Lang Hear Res 54 2011 854 869
27. K.S. Kendler Toward a philosophical structure for psychiatry Am J Psychiatry 162 2005 433 440
28. R. Plomin, D. Daniels Why are children in the same family so different from one another? Int J Epidemiol 40 2011 563 582
29. A. Caspi, K. Sugden, T.E. Moffitt Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene Science 301 2003 386 389
30. M.R. Munafo, C. Durrant, G. Lewis, J. Flint Gene X environment interactions at the serotonin transporter locus Biol Psychiatry 65 2009 211 219
31. N. Risch, R. Herrell, T. Lehner Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis JAMA 301 2009 2462 2471
32. K. Karg, M. Burmeister, K. Shedden, S. Sen The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation Arch Gen Psychiatry 68 2011 444 454
33. L.E. Duncan, M.C. Keller A critical review of the first 10 years of candidate gene-by-environment interaction research in psychiatry Am J Psychiatry 168 2011 1041 1049
34. M. Rutter, A. Thapar, A. Pickles Gene-environment interactions: biologically valid pathway or artifact? Arch Gen Psychiatry 66 2009 1287 1289
35. R. Uher, P. McGuffin The moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: 2009 update Mol Psychiatry 15 2010 18 22
36. A. Caspi, A.R. Hariri, A. Holmes, R. Uher, T.E. Moffitt Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits Am J Psychiatry 167 2010 509 527
37. R. Uher, A. Caspi, R. Houts Serotonin transporter gene moderates childhood maltreatment's effects on persistent but not single-episode depression: replications and implications for resolving inconsistent results J Affect Disord 135 2011 56 65
38. K.P. Lesch, D. Bengel, A. Heils Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region Science 274 1996 1527 1531
39. A.R. Hariri, V.S. Mattay, A. Tessitore Serotonin transporter genetic variation and the response of the human amygdala Science 297 2002 400 403
40. J.Y. Lau, D. Goldman, B. Buzas Amygdala function and 5-HTT gene variants in adolescent anxiety and major depressive disorder Biol Psychiatry 65 2009 349 355
41. A.J. Bennett, K.P. Lesch, A. Heils Early experience and serotonin transporter gene variation interact to influence primate CNS function Mol Psychiatry 7 2002 118 122
42. G.W. Brown, T.O. Harris Depression and the serotonin transporter 5-HTTLPR polymorphism: a review and a hypothesis concerning gene-environment interaction J Affect Disord 111 2008 1 12
43. S.J. Lupien, B.S. McEwen, M.R. Gunnar, C. Heim Effects of stress throughout the lifespan on the brain, behaviour and cognition Nat Rev Neurosci 10 2009 434 445
44. M.L. Phillips, W.C. Drevets, S.L. Rauch, R. Lane Neurobiology of emotion perception I: the neural basis of normal emotion perception Biol Psychiatry 54 2003 504 514
45. C.S. Monk The development of emotion-related neural circuitry in health and psychopathology Dev Psychopathol 20 2008 1231 1250
46. J.Y. Lau, M. Burt, E. Leibenluft Individual differences in children's facial expression recognition ability: the role of nature and nurture Dev Neuropsychol 34 2009 37 51
47. E.B. McClure A meta-analytic review of sex differences in facial expression processing and their development in infants, children, and adolescents Psychol Bull 126 2000 424 453
48. T. Canli, K.P. Lesch Long story short: the serotonin transporter in emotion regulation and social cognition Nat Neurosci 10 2007 1103 1109
49. V.W. Jaddoe, R. Bakker, C.M. van Duijn The Generation R Study Biobank: a resource for epidemiological studies in children and their parents Eur J Epidemiol 22 2007 917 923
50. V.W. Jaddoe, C.M. van Duijn, A.J. van der Heijden The Generation R Study: design and cohort update until the age of 4 years Eur J Epidemiol 23 2008 801 811
51. X.Z. Hu, R.H. Lipsky, G. Zhu Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder Am J Hum Genet 78 2006 815 826
52. J.R. Wendland, B.J. Martin, M.R. Kruse, K.P. Lesch, D.L. Murphy Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531 Mol Psychiatry 11 2006 224 226
53. A.O.J. Hendriks, G.V.D. Willige [Long lasting difficultied measured with a self-assessment questionnaire and semi-structured interview: a theoretical and emperical comparison] (in Dutch) Gedrag Gezondheid 18 1990 273 282
54. Beurs D. Brief Symptom Inventory, handleiding. Leiden, the Netherlands; 2004
55. L.R. Derogatis Brief Symptom Inventory (BSI): Administration, Scoring and Procedures. Manual Third Edition 1993 National Computer Systems Minneapolis, MN
56. T.M. Achenbach, L.M. Rescorla Manual for the ASEBA Preschool Form & Profiles 2000 Youth & Families Burlington, VT: University of Vermont, Research Center for Children
57. E. Szekely, C.M. Herba, P.P. Arp Recognition of scared faces and the serotonin transporter gene in young children: the Generation R Study J Child Psychol Psychiatry 52 2011 1279 1286
58. A.R. Hariri, S.Y. Bookheimer, J.C. Mazziotta Modulating emotional responses: effects of a neocortical network on the limbic system Neuroreport 11 2000 43 48
59. J.M. Gauderman WM Quanto 1.1: a computer program for power and sample size calculations for genetic-epidemiologic studies http://hydra.usc.edu/gxe Accessed on May 31, 2012
60. M.J. Bakermans-Kranenburg, M.H. van Ijzendoorn Differential susceptibility to rearing environment depending on dopamine-related genes: new evidence and a meta-analysis Dev Psychopathol 23 2011 39 52
61. J. Kim-Cohen, A. Caspi, A. Taylor MAOA, maltreatment, and gene-environment interaction predicting children's mental health: new evidence and a meta-analysis Mol Psychiatry 11 2006 903 913
62. SPSS Inc. SPSS Statistics for Windows, Version 17.0. Chicago: SPSS Inc; 2008.
63. R. Uher, N. Perroud, M.Y. Ng Genome-wide pharmacogenetics of antidepressant response in the GENDEP project Am J Psychiatry 167 2010 555 564
64. J.A. Luan, M.Y. Wong, N.E. Day, N.J. Wareham Sample size determination for studies of gene-environment interaction Int J Epidemiol 30 2001 1035 1040
65. vM.H. IJzendoorn, K. Caspers, M.J. Bakermans-Kranenburg, S.R. Beach, R. Philibert Methylation matters: interaction between methylation density and serotonin transporter genotype predicts unresolved loss or trauma Biol Psychiatry 68 2010 405 407
66. H. Belay, C.L. Burton, V. Lovic, M.J. Meaney, M. Sokolowski, A.S. Fleming Early adversity and serotonin transporter genotype interact with hippocampal glucocorticoid receptor mRNA expression, corticosterone, and behavior in adult male rats Behav Neurosci 125 2011 150 160
67. E. Kistner-Griffin, C.W. Brune, L.K. Davis, J.S. Sutcliffe, N.J. Cox, E.H. Cook Jr Parent-of-origin effects of the serotonin transporter gene associated with autism Am J Med Genet B Neuropsychiatr Genet 156 2011 139 144
68. A. Bonnin, P. Levitt Fetal, maternal, and placental sources of serotonin and new implications for developmental programming of the brain Neuroscience 197 2011 1 7
69. S.J. Suomi Risk, resilience, and gene x environment interactions in rhesus monkeys Ann N Y Acad Sci 1094 2006 52 62
70. J.R. Homberg, K.P. Lesch Looking on the bright side of serotonin transporter gene variation Biol Psychiatry 69 2011 513 519 15
71. J. Belsky, M. Pluess Beyond diathesis stress: differential susceptibility to environmental influences Psychol Bull 135 2009 885 908
72. B.J. Ellis, W.T. Boyce, J. Belsky, M.J. Bakermans-Kranenburg, M.H. van Ijzendoorn Differential susceptibility to the environment: an evolutionary-neurodevelopmental theory Dev Psychopathol 23 2011 7 28
73. J. Hardy, N.C. Low Genes and environment in psychiatry: winner's curse or cure? Arch Gen Psychiatry 68 2011 455 456