Genes and environment in psychiatry: Winner's curse or cure?

Archives of General Psychiatry

Volumn 68, Issue 5, 2011, Pages 455-456

  Hardy, John ^a   Low, Nancy C ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

SEROTONIN TRANSPORTER;

DEPRESSION; DNA POLYMORPHISM; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; MENTAL DISEASE; NOTE; STRESS;

ADULT; ALLELES; CHILD; DEPRESSIVE DISORDER; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOTYPE; HUMANS; LIFE CHANGE EVENTS; POLYMORPHISM, GENETIC; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SOCIAL ENVIRONMENT;

EID: 79955578449     PISSN: 0003990X     EISSN: 15383636     Source Type: Journal    
DOI: 10.1001/archgenpsychiatry.2011.35     Document Type: Note

References (9)

1. Hardy J, Low N, Singleton A. Whole genome association studies: deciding when persistence becomes perseveration. Am J Med Genet B Neuropsychiatr Genet. 2008;147B(2):131-133. (Pubitemid 351355274)
2. Tishler PV, Carey VJ. Can comparison of MZ- and DZ-twin concordance rates be used invariably to estimate heritability? Twin Res Hum Genet. 2007;10(5):712-717. (Pubitemid 47608004)
3. Karg K, Burmeister M, Shedden K, Sen S. The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation. Arch Gen Psych. 2011;68(5):444-454.
4. Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, McClay J, Mill J, Martin J, Braithwaite A, Poulton R. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science. 2003;301(5631):386-389. (Pubitemid 36877077)
5. Risch N, Herrell R, Lehner T, Liang K-Y, Eaves L, Hoh J, Griem A, Kovacs M, Ott J, Merikangas KR. Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis. JAMA. 2009;301(23):2462-2471.
6. Munafò MR, Durrant C, Lewis G, Flint J. Gene X environment interactions at the serotonin transporter locus. Biol Psychiatry. 2009;65(3):211-219.
7. Rutter M, Thapar A, Pickles A. Gene-environment interactions: biologically valid pathway or artifact? Arch Gen Psychiatry. 2009;66(12):1287-1289.
8. Zammit S, Owen MJ, Lewis G. Misconceptions about gene-environment interactions in psychiatry. Evid Based Ment Health. 2010;13(3):65-68.
9. Kraft P. Curses- winner's and otherwise- in genetic epidemiology. Epidemiology. 2008;19(5):649-658.