Genome-wide pharmacogenetics of antidepressant response in the GENDEP project

American Journal of Psychiatry

Volumn 167, Issue 5, 2010, Pages 555-564

  Uher, Rudolf ^a   Perroud, Nader ^a   Ng, Mandy Y M ^a   Hauser, Joanna ^a   Henigsberg, Neven ^a   Maier, Wolfgang ^a   Mors, Ole ^a   Placentino, Anna ^a   Rietschel, Marcella ^a   Souery, Daniel ^a   Žagar, Tina ^a   Czerski, Piotr M ^a   Jerman, Borut ^a   Larsen, Erik Roj ^a   Schulze, Thomas G ^a   Zobel, Astrid ^a   Cohen Woods, Sarah ^a   Pirlo, Katrina ^a   Butler, Amy W ^a   Muglia, Pierandrea ^a   Barnes, Michael R ^a   Lathrop, Mark ^a   Farmer, Anne ^a   Breen, Gerome ^a   Aitchison, Katherine J ^a   Craig, Ian ^a   Lewis, Cathryn M ^a   McGuffin, Peter ^a   more..

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ESCITALOPRAM; INTERLEUKIN 1; INTERLEUKIN 11; INTERLEUKIN 6; NORTRIPTYLINE;

ADULT; ARTICLE; CHROMOSOME 1; CHROMOSOME 10; CLINICAL TRIAL; DISEASE SEVERITY; FEMALE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOME; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; MARKER GENE; PHARMACOGENETICS; PRIORITY JOURNAL; RANDOMIZATION; SINGLE NUCLEOTIDE POLYMORPHISM; TREATMENT DURATION; TREATMENT OUTCOME; TREATMENT RESPONSE;

ANTIDEPRESSIVE AGENTS; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; CITALOPRAM; DEPRESSIVE DISORDER; DEPRESSIVE DISORDER, MAJOR; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; INTERLEUKIN-11; INTERLEUKIN-6; NORTRIPTYLINE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHARMACOGENETICS; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; PSYCHIATRIC STATUS RATING SCALES; SULFOTRANSFERASES; TREATMENT OUTCOME;

EID: 77951779878     PISSN: 0002953X     EISSN: 15357228     Source Type: Journal    
DOI: 10.1176/appi.ajp.2009.09070932     Document Type: Article

References (41)

1. Franchini L, Serretti A, Gasperini M, Smeraldi E: Familial concordance of fluvoxamine response as a tool for differentiating mood disorder pedigrees. J Psychiatr Res 1998; 32:255-259 (Pubitemid 28410114)
2. Kato M, Serretti A: Review and meta-analysis of antidepressant pharmacogenetic findings in major depressive disorder. Mol Psychiatry (Epub ahead of print, Nov 4, 2008)
3. Uher R, Huezo-Diaz P, Perroud N, Smith R, Rietschel M, Mors O, Hauser J, Maier W, Kozel D, Henigsberg N, Barreto M, Placentino A, Dernovsek MZ, Schulze T, Kalember P, Zobel A, Czerski P, Larsen ER, Souery D, Govannini C, Gray JM, Lewis CM, Farmer A, Aitchison KJ, McGuffin P, Craig I: Genetic predictors of antidepressant response in the GENDEP project. Pharmacogenomics J 2009; 9:225-233
4. Uher R, Maier W, Hauser J, Marusic A, Schmael C, Mors O, Henigsberg N, Souery D, Placentino A, Rietschel M, Zobel A, Dmitrzak-Weglarz M, Petrovic A, Jorgensen L, Kalember P, Giovannini C, Barreto M, Elkin A, Landau S, Farmer A, Aitchison KJ, McGuffin P: Differential efficacy of escitalopram and nortriptyline on dimensional measures of depression. Br J Psychiatry 2009; 194:252-259
5. Wing JK, Sartorius N, Ustin TB: Diagnosis and Clinical Measurement in Psychiatry: A Reference Manual for SCAN. Geneva, World Health Organization, 1998
6. Sanchez C, Bergqvist PB, Brennum LT, Gupta S, Hogg S, Larsen A, Wiborg O: Escitalopram, the S-(+)-enantiomer of citalopram, is a selective serotonin reuptake inhibitor with potent effects in animal models predictive of antidepressant and anxiolytic activities. Psychopharmacology (Berl) 2003; 167:353-362
7. Sanchez C, Hyttel J: Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding. Cell Mol Neurobiol 1999; 19:467-489 (Pubitemid 29283825)
8. Uher R, Farmer A, Maier W, Rietschel M, Hauser J, Marusic A, Mors O, Elkin A, Williamson RJ, Schmael C, Henigsberg N, Perez J, Mendlewicz J, Janzing JG, Zobel A, Skibinska M, Kozel D, Stamp AS, Bajs M, Placentino A, Barreto M, McGuffin P, Aitchison KJ: Measuring depression: comparison and integration of three scales in the GENDEP study. Psychol Med 2008; 38:289-300 (Pubitemid 351156595)
9. Huezo-Diaz P, Uher R, Smith R, Rietschel M, Henigsberg N, Marusic A, Mors O, Maier W, Hauser J, Souery D, Placentino A, Zobel A, Larsen EJ, Czerski PM, Gupta G, Hoda F, Perroud N, Farmer A, Craig I, Aitchison KJ, McGuffin P: Moderation of antidepressant response by the serotonin transporter gene. Br J Psychiatry 2009; 195:30-38
10. Perroud N, Aitchison KJ, Uher R, Smith R, Huezo-Diaz P, Marusic A, Maier W, Mors O, Placentino A, Henigsberg N, Rietschel M, Hauser J, Souery D, Kapelski P, Bonvicini C, Zobel A, Jorgensen L, Petrovic A, Kalember P, Schulze TG, Gupta B, Gray JM, Lewis CM, Farmer AE, McGuffin P, Craig I: Genetic predictors of increase in suicidal ideation during antidepressant treatment in the GENDEP project. Neuropsychopharmacology 2009; 34:2517-2528
11. Montgomery SA, Asberg M: A new depression scale designed to be sensitive to change. Br J Psychiatry 1979; 134:382-389
12. Mulder RT, Joyce PR, Frampton C: Relationships among measures of treatment outcome in depressed patients. J Affect Disord 2003; 76:127-135 (Pubitemid 37013364)
13. Uher R, Muthen B, Souery D, Mors O, Jaracz J, Placentino A, Petrovic A, Zobel A, Henigsberg N, Rietschel M, Aitchison KJ, Farmer A, McGuffin P: Trajectories of change in depression severity during treatment with antidepressants. Psychol Med (Epub ahead of print, Oct 29, 2009)
14. Streiner DL: Breaking up is hard to do: the heartbreak of dichotomizing continuous data. Can J Psychiatry 2002; 47:262-266
15. Leucht S, Kane JM, Etschel E, Kissling W, Hamann J, Engel RR: Linking the PANSS, BPRS, and CGI: clinical implications. Neuropsychopharmacology 2006; 31:2318-2325
16. Lane P: Handling drop-out in longitudinal clinical trials: a comparison of the LOCF and MMRM approaches. Pharm Stat 2008; 7:93-106
17. Freeman B, Smith N, Curtis C, Huckett L, Mill J, Craig IW: DNA from buccal swabs recruited by mail: evaluation of storage effects on long-term stability and suitability for multiplex polymerase chain reaction genotyping. Behav Genet 2003; 33:67-72 (Pubitemid 36176783)
18. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, Maller J, Sklar P, De Bakker PI, Daly MJ, Sham PC: PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007; 81:559-575 (Pubitemid 47330214)
19. Bacanu SA, Devlin B, Roeder K: Association studies for quantitative traits in structured populations. Genet Epidemiol 2002; 22:78-93 (Pubitemid 34019893)
20. Dudbridge F, Gusnanto A: Estimation of significance thresholds for genomewide association scans. Genet Epidemiol 2008; 32:227-234 (Pubitemid 351550369)
21. Pe'er I, Yelensky R, Altshuler D, Daly MJ: Estimation of the multiple testing burden for genomewide association studies of nearly all common variants. Genet Epidemiol 2008; 32:381-385
22. Benjamini Y, Hochberg Y: Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Ser B 1995; 57:289-300
23. Storey JD, Tibshirani R: Statistical significance for genomewide studies. Proc Natl Acad Sci U S A 2003; 100:9440-9445
24. Redon R, Ishikawa S, Fitch KR, Feuk L, Perry GH, Andrews TD, Fiegler H, Shapero MH, Carson AR, Chen W, Cho EK, Dallaire S, Freeman JL, Gonzalez JR, Gratacos M, Huang J, Kalaitzopoulos D, Komura D, MacDonald JR, Marshall CR, Mei R, Montgomery L, Nishimura K, Okamura K, Shen F, Somerville MJ, Tchinda J, Valsesia A, Woodwark C, Yang F, Zhang J, Zerjal T, Zhang J, Armengol L, Conrad DF, Estivill X, Tyler-Smith C, Carter NP, Aburatani H, Lee C, Jones KW, Scherer SW, Hurles ME: Global variation in copy number in the human genome. Nature 2006; 444:444-454 (Pubitemid 44809057)
25. Cartegni L, Wang J, Zhu Z, Zhang MQ, Krainer AR: ESEfinder: a web resource to identify exonic splicing enhancers. Nucleic Acids Res 2003; 31:3568-3571 (Pubitemid 37442199)
26. Muglia P, Tozzi F, Galwey NW, Francks C, Upmanyu R, Kong XQ, Antoniades A, Domenici E, Perry J, Rothen S, Vandeleur CL, Mooser V, Waeber G, Vollenweider P, Preisig M, Lucae S, Muller-Myhsok B, Holsboer F, Middleton LT, Roses AD: Genome-wide association study of recurrent major depressive disorder in two European case-control cohorts. Mol Psychiatry (Epub ahead of print, Dec 23, 2008)
27. Sullivan PF, de Geus EJ, Willemsen G, James MR, Smit JH, Zandbelt T, Arolt V, Baune BT, Blackwood D, Cichon S, Coventry WL, Domschke K, Farmer A, Fava M, Gordon SD, He Q, Heath AC, Heutink P, Holsboer F, Hoogendijk WJ, Hottenga JJ, Hu Y, Kohli M, Lin D, Lucae S, Macintyre DJ, Maier W, McGhee KA, McGuffin P, Montgomery GW, Muir WJ, Nolen WA, Nothen MM, Perlis RH, Pirlo K, Posthuma D, Rietschel M, Rizzu P, Schosser A, Smit AB, Smoller JW, Tzeng JY, van Dyck R, Verhage M, Zitman FG, Martin NG, Wray NR, Boomsma DI, Penninx BW: Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo. Mol Psychiatry 2009; 14:359-375
28. Ising M, Lucae S, Binder EB, Bettecken T, Uhr M, Ripke S, Kohli MA, Hennings JM, Horstmann S, Kloiber S, Menke A, Bondy B, Rupprecht R, Domschke K, Baune BT, Arolt V, Rush AJ, Holsboer F, Muller-Myhsok B: A genomewide association study points to multiple loci that predict antidepressant drug treatment outcome in depression. Arch Gen Psychiatry 2009; 66:966-975
29. Akita K, von Holst A, Furukawa Y, Mikami T, Sugahara K, Faissner A: Expression of multiple chondroitin/dermatan sulfotransferases in the neurogenic regions of the embryonic and adult central nervous system implies that complex chondroitin sulfates have a role in neural stem cell maintenance. Stem Cells 2008; 26:798-809
30. Ishii M, Maeda N: Oversulfated chondroitin sulfate plays critical roles in the neuronal migration in the cerebral cortex. J Biol Chem 2008; 283:32610-32620
31. Duman RS, Monteggia LM: A neurotrophic model for stress-related mood disorders. Biol Psychiatry 2006; 59:1116-1127 (Pubitemid 43912554)
32. Goi T, Rusanescu G, Urano T, Feig LA: Ral-specific guanine nucleotide exchange factor activity opposes other Ras effectors in PC12 cells by inhibiting neurite outgrowth. Mol Cell Biol 1999; 19:1731-1741 (Pubitemid 29098231)
33. Anney RJ, Lasky-Su J, O'Dushlaine C, Kenny E, Neale BM, Mulligan A, Franke B, Zhou K, Chen W, Christiansen H, Rias-Vasquez A, Banaschewski T, Buitelaar J, Ebstein R, Miranda A, Mulas F, Oades RD, Roeyers H, Rothenberger A, Sergeant J, Sonuga-Barke E, Steinhausen H, Asherson P, Faraone SV, Gill M: Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the International Multicentre ADHD Genetics Study. Am J Med Genet B Neuropsychiatr Genet 2008; 147B:1369-1378
34. Bull SJ, Huezo-Diaz P, Binder EB, Cubells JF, Ranjith G, Maddock C, Miyazaki C, Alexander N, Hotopf M, Cleare AJ, Norris S, Cassidy E, Aitchison KJ, Miller AH, Pariante CM: Functional polymorphisms in the interleukin-6 and serotonin transporter genes, and depression and fatigue induced by interferon-alpha and ribavirin treatment. Mol Psychiatry 2009; 14:1095-1104
35. Watanabe D, Yoshimura R, Khalil M, Yoshida K, Kishimoto T, Taga T, Kiyama H: Characteristic localization of gp130 (the signal-transducing receptor component used in common for IL-6/IL-11/CNTF/LIF/OSM) in the rat brain. Eur J Neurosci 1996; 8:1630-1640 (Pubitemid 26289681)
36. Rudge JS, Eaton MJ, Mather P, Lindsay RM, Whittemore SR: CNTF induces raphe neuronal precursors to switch from a serotonergic to a cholinergic phenotype in vitro. Mol Cell Neurosci 1996; 7:204-221 (Pubitemid 26171284)
37. Danese A, Moffitt TE, Pariante CM, Ambler A, Poulton R, Caspi A: Elevated inflammation levels in depressed adults with a history of childhood maltreatment. Arch Gen Psychiatry 2008; 65:409-415 (Pubitemid 351519890)
38. Uher R: The implications of gene-environment interactions in depression: Will cause inform cure? Mol Psychiatry 2008; 13:1070-1078
39. Miller AH, Maletic V, Raison CL: Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol Psychiatry 2009; 65:732-741
40. 3) receptor. Mol Psychiatry 2003; 8:994-1007
41. 3 receptors in raft-like domains. J Neurosci 2005; 25:10198-10206