Recognition of scared faces and the serotonin transporter gene in young children: The Generation R Study

Journal of Child Psychology and Psychiatry and Allied Disciplines

Volumn 52, Issue 12, 2011, Pages 1279-1286

  Székely, Eszter ^a,b   Herba, Catherine M ^b,c   Arp, Pascal P ^a   Uitterlinden, André G ^a   Jaddoe, Vincent W V ^a,b   Hofman, Albert ^a   Verhulst, Frank C ^b   Hudziak, James J ^d   Tiemeier, Henning ^a,b  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^c UNIVERSITY OF MONTREAL   (Canada)

^d UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

Author keywords

children; emotion processing; facial expression; fear; Serotonin transporter gene

Indexed keywords

SEROTONIN TRANSPORTER; SLC6A4 PROTEIN, HUMAN;

ALLELE; ARTICLE; EMOTION; FACIAL EXPRESSION; FEAR; FEMALE; GENETIC POLYMORPHISM; GENETICS; GENOTYPE; HUMAN; MALE; NEUROPSYCHOLOGICAL TEST; PATTERN RECOGNITION; PRESCHOOL CHILD; PSYCHOLOGICAL ASPECT; RECOGNITION;

ALLELES; CHILD, PRESCHOOL; EMOTIONS; FACIAL EXPRESSION; FEAR; FEMALE; GENOTYPE; HUMANS; MALE; NEUROPSYCHOLOGICAL TESTS; PATTERN RECOGNITION, VISUAL; POLYMORPHISM, GENETIC; RECOGNITION (PSYCHOLOGY); SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 80054996330     PISSN: 00219630     EISSN: 14697610     Source Type: Journal    
DOI: 10.1111/j.1469-7610.2011.02423.x     Document Type: Article

References (58)

1. Achenbach, T.M., &, Rescorla, L.A., (2000). Manual for the ASEBA preschool forms & profiles. Burlington: University of Vermont Research Center for Children, Youth, and Families.
2. Adolphs, R., Gosselin, F., Buchanan, T.W., Tranel, D., Schyns, P., &, Damasio, A.R., (2005). A mechanism for impaired fear recognition after amygdala damage. Nature, 433, 68-72. (Pubitemid 40101144)
3. Battaglia, M., Ogliari, A., Zanoni, A., Citterio, A., Pozzoli, U., Giorda, R., &, Marino, C., (2005). Influence of the serotonin transporter promoter gene and shyness on children's cerebral responses to facial expressions. Archives of General Psychiatry, 62, 85-94. (Pubitemid 40096074)
4. Belsky, J., Jonassaint, C., Pluess, M., Stanton, M., Brummett, B., &, Williams, R., (2009). Vulnerability genes or plasticity genes? Molecular Psychiatry, 14, 746-754.
5. Bennett, A.J., Lesch, K.P., Heils, A., Long, J.C., Lorenz, J.G., Shoaf, S.E., &, Higley, J.D., (2002). Early experience and serotonin transporter gene variation interact to influence primate CNS function. Molecular Psychiatry, 7, 118-122. (Pubitemid 34087891)
6. Bhagwagar, Z., Cowen, P.J., Goodwin, G.M., &, Harmer, C.J., (2004). Normalization of enhanced fear recognition by acute SSRI treatment in subjects with a previous history of depression. American Journal of Psychiatry, 161, 166-168. (Pubitemid 38419325)
7. Brown, G.W., &, Harris, T.O., (2008). Depression and the serotonin transporter 5-HTTLPR polymorphism: A review and a hypothesis concerning gene-environment interaction. Journal of Affective Disorders, 111, 1-12.
8. Buznikov, G.A., Shmukler, Y.B., &, Lauder, J.M., (1996). From oocyte to neuron: Do neurotransmitters function in the same way throughout development? Cellular and Molecular Neurobiology, 16, 537-559.
9. Canli, T., &, Lesch, K.P., (2007). Long story short: The serotonin transporter in emotion regulation and social cognition. Nature Neuroscience, 10, 1103-1109. (Pubitemid 47339957)
10. Caspi, A., Sugden, K., Moffitt, T.E., Taylor, A., Craig, I.W., Harrington, H., &, Poulton, R., (2003). Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science, 301, 386-389. (Pubitemid 36877077)
11. Davey Smith, G., &, Ebrahim, S., (2005). What can Mendelian randomisation tell us about modifiable behavioural and environmental exposures? British Medical Journal, 330, 1076-1079. (Pubitemid 40646565)
12. Davis, M., &, Whalen, P.J., (2001). The amygdala: Vigilance and emotion. Molecular Psychiatry, 6, 13-34. (Pubitemid 32096061)
13. Gardner, K.L., Thrivikraman, K.V., Lightman, S.L., Plotsky, P.M., &, Lowry, C.A., (2005). Early life experience alters behavior during social defeat: Focus on serotonergic systems. Neuroscience, 136, 181-191. (Pubitemid 41483846)
14. Gibb, B.E., Benas, J.S., Grassia, M., &, McGeary, J., (2009). Children's attentional biases and 5-HTTLPR genotype: Potential mechanisms linking mother and child depression. Journal of Clinical Child and Adolescent Psychology, 38, 415-426.
15. Glatt, C.E., DeYoung, J.A., Delgado, S., Service, S.K., Giacomini, K.M., Edwards, R.H., &, Freimer, N.B., (2001). Screening a large reference sample to identify very low frequency sequence variants: Comparisons between two genes. Nature Genetics, 27, 435-438. (Pubitemid 32268427)
16. Gotlib, I.H., Joormann, J., Minor, K.L., &, Hallmayer, J., (2008). HPA axis reactivity: A mechanism underlying the associations among 5-HTTLPR, stress, and depression. Biological Psychiatry, 63, 847-851. (Pubitemid 351458452)
17. Gotlib, I.H., Krasnoperova, E., Yue, D.N., &, Joormann, J., (2004). Attentional biases for negative interpersonal stimuli in clinical depression. Journal of Abnormal Psychology, 113, 121-135.
18. Guyer, A.E., Monk, C.S., McClure-Tone, E.B., Nelson, E.E., Roberson-Nay, R., Adler, A.D., &, Ernst, M., (2008). A developmental examination of amygdala response to facial expressions. Journal of Cognitive Neuroscience, 20, 1565-1582.
19. Hariri, A.R., Bookheimer, S.Y., &, Mazziotta, J.C., (2000). Modulating emotional responses: Effects of a neocortical network on the limbic system. Neuroreport, 11, 43-48. (Pubitemid 30053387)
20. Hariri, A.R., Drabant, E.M., &, Weinberger, D.R., (2006). Imaging genetics: Perspectives from studies of genetically driven variation in serotonin function and corticolimbic affective processing. Biological Psychiatry, 59, 888-897.
21. Hariri, A.R., &, Holmes, A., (2006). Genetics of emotional regulation: The role of the serotonin transporter in neural function. Trends in Cognitive Sciences, 10, 182-191.
22. Hariri, A.R., Mattay, V.S., Tessitore, A., Fera, F., &, Weinberger, D.R., (2003). Neocortical modulation of the amygdala response to fearful stimuli. Biological Psychiatry, 53, 494-501. (Pubitemid 36331888)
23. Hayden, E.P., Dougherty, L.R., Maloney, B., Emily Durbin, C., Olino, T.M., Nurnberger, J.I. Jr, &, Klein, D.N., (2007). Temperamental fearfulness in childhood and the serotonin transporter promoter region polymorphism: A multimethod association study. Psychiatric Genetics, 17, 135-142. (Pubitemid 46716205)
24. Heinz, A., Braus, D.F., Smolka, M.N., Wrase, J., Puls, I., Hermann, D., &, Buchel, C., (2005). Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter. Nature Neuroscience, 8, 20-21. (Pubitemid 41236725)
25. Heinz, A., Jones, D.W., Mazzanti, C., Goldman, D., Ragan, P., Hommer, D., &, Weinberger, D.R., (2000). A relationship between serotonin transporter genotype and in vivo protein expression and alcohol neurotoxicity. Biological Psychiatry, 47, 643-649. (Pubitemid 30169258)
26. Herba, C.M., Landau, S., Russell, T., Ecker, C., &, Phillips, M.L., (2006). The development of emotion-processing in children: Effects of age, emotion, and intensity. Journal of Child Psychology and Psychiatry, 47, 1098-1106. (Pubitemid 44660612)
27. Holmes, A., Lit, Q., Murphy, D.L., Gold, E., &, Crawley, J.N., (2003). Abnormal anxiety-related behavior in serotonin transporter null mutant mice: The influence of genetic background. Genes, Brain and Behavior, 2, 365-380. (Pubitemid 37463201)
28. Hu, X.Z., Lipsky, R.H., Zhu, G., Akhtar, L.A., Taubman, J., Greenberg, B.D., &, Goldman, D., (2006). Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. American Journal of Human Genetics, 78, 815-826.
29. Jacobs, R.H., Pine, D.S., Schoeny, M.E., Henry, D.B., Gollan, J.K., Moy, G., &, Walkschlag, L.S., (2011). Maternal depressive history, teen 5HTTLPR genotype, and the processing of emotional faces: Exploring mechanisms of risk. Behaviour Research and Therapy, 49, 80-84; doi:.
30. Jaddoe, V.W., Bakker, R., van Duijn, C.M., van der Heijden, A.J., Lindemans, J., Mackenbach, J.P., &, Hofman, A., (2007). The Generation R Study Biobank: A resource for epidemiological studies in children and their parents. European Journal of Epidemiology, 22, 917-923.
31. Jaddoe, V.W., van Duijn, C.M., van der Heijden, A.J., Mackenbach, J.P., Moll, H.A., Steegers, E.A., &, Hofman, A., (2008). The Generation R Study: Design and cohort update until the age of 4 years. European Journal of Epidemiology, 23, 801-811.
32. Jaddoe, V.W., van Duijn, C.M., van der Heijden, A.J., Mackenbach, J.P., Moll, H.A., Steegers, E.A., &, Hofman, A., (2010). The Generation R Study: Design and cohort update 2010. European Journal of Epidemiology, 25, 823-841.
33. Karg, K., Burmeister, M., Shedden, K., &, Sen, S., (2011) The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: Evidence of genetic moderation. Archives of General Psychiatry, 68, 444-454; doi:.
34. Kraft, J.B., Slager, S.L., McGrath, P.J., &, Hamilton, S.P., (2005). Sequence analysis of the serotonin transporter and associations with antidepressant response. Biological Psychiatry, 58, 374-381. (Pubitemid 41219705)
35. Lange, K., Williams, L.M., Young, A.W., Bullmore, E.T., Brammer, M.J., Williams, S.C., &, Phillips, M.L., (2003). Task instructions modulate neural responses to fearful facial expressions. Biological Psychiatry, 53, 226-232. (Pubitemid 36135933)
36. Lau, J.Y., Goldman, D., Buzas, B., Fromm, S.J., Guyer, A.E., Hodgkinson, C., &, Ernst, M., (2009). Amygdala function and 5-HTT gene variants in adolescent anxiety and major depressive disorder. Biological Psychiatry, 65, 349-355.
37. Lesch, K.P., Bengel, D., Heils, A., Sabol, S.Z., Greenberg, B.D., Petri, S., &, Muphy, D.L., (1996). Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science, 274, 1527-1531. (Pubitemid 26403928)
38. MacKenzie, A., &, Quinn, J., (1999). A serotonin transporter gene intron 2 polymorphic region, correlated with affective disorders, has allele-dependent differential enhancer-like properties in the mouse embryo. Proceedings of the National Academy of Sciences of the United States of America, 96, 15251-15255. (Pubitemid 30019798)
39. MacLeod, C., Mathews, A., &, Tata, P., (1986). Attentional bias in emotional disorders. Journal of Abnormal Psychology, 95, 15-20. (Pubitemid 17038587)
40. Monk, C.S., (2008). The development of emotion-related neural circuitry in health and psychopathology. Developmental Psychopathology, 20, 1231-1250.
41. Munafo, M.R., Brown, S.M., &, Hariri, A.R., (2008). Serotonin transporter (5-HTTLPR) genotype and amygdala activation: A meta-analysis. Biological Psychiatry, 63, 852-857. (Pubitemid 351458448)
42. Munafo, M.R., Freimer, N.B., Ng, W., Ophoff, R., Veijola, J., Miettunen, J., &, Flint, J., (2009). 5-HTTLPR genotype and anxiety-related personality traits: A meta-analysis and new data. American Journal of Medical Genetics, Part B, Neuropsychiatric Genetics, 150B, 271-281.
43. National Office for Statistics [Centraal Bureau voor de Statistiek] (2004-2006). Delivery, Length and Weight at Birth, and Breastfeeding. [Bevalling, lengte en gewicht bij geboorte en borstvoeding]. Den Haag/Heerlen: National Office for Statistics [Centraal Bureau voor de Statistiek]. [Cited February 2, 2001.].
44. Nordquist, N., &, Oreland, L., (2010). Serotonin, genetic variability, behaviour, and psychiatric disorders-A review. Upsala Journal of Medical Sciences, 115, 2-10.
45. Pacheco, J., Beevers, C.G., Benavides, C., McGeary, J., Stice, E., &, Schnyer, D.M., (2009). Frontal-limbic white matter pathway associations with the serotonin transporter gene promoter region (5-HTTLPR) polymorphism. Journal of Neuroscience, 29, 6229-6233.
46. Paton, J.J., Belova, M.A., Morrison, S.E., &, Salzman, C.D., (2006). The primate amygdala represents the positive and negative value of visual stimuli during learning. Nature, 439, 865-870. (Pubitemid 43255706)
47. Pauli-Pott, U., Friedel, S., Hinney, A., &, Hebebrand, J., (2009). Serotonin transporter gene polymorphism (5-HTTLPR), environmental conditions, and developing negative emotionality and fear in early childhood. Journal of Neural Transmission, 116, 503-512.
48. Perez-Edgar, K., Bar-Haim, Y., McDermott, J.M., Gorodetsky, E., Hodgkinson, C.A., Goldman, D., &, Fox, N.A., (2009). Variations in the serotonin-transporter gene are associated with attention bias patterns to positive and negative emotion faces. Biological Psychology, 83, 269-271; doi:.
49. Pezawas, L., Meyer-Lindenberg, A., Drabant, E.M., Verchinski, B.A., Munoz, K.E., Kolachana, B.S., &, Weinberger, D.R., (2005). 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: A genetic susceptibility mechanism for depression. Nature Neuroscience, 8, 828-834. (Pubitemid 43085851)
50. Phillips, M.L., Drevets, W.C., Rauch, S.L., &, Lane, R., (2003). Neurobiology of emotion perception I: The neural basis of normal emotion perception. Biological Psychiatry, 54, 504-514. (Pubitemid 37289437)
51. Schroeter, S., &, Blakely, R.D., (1996). Drug targets in the embryo. Studies on the cocaine- and antidepressant-sensitive serotonin transporter. Annals of the New York Academy of Sciences, 801, 239-255. (Pubitemid 27029013)
52. Surcinelli, P., Codispoti, M., Montebarocci, O., Rossi, N., &, Baldaro, B., (2006). Facial emotion recognition in trait anxiety. Journal of Anxiety Disorders, 20, 110-117. (Pubitemid 41735191)
53. Székely, E., Tiemeier, H., Arends, L.R., Jaddoe, V.W.V., Hofman, A., Verhulst, F.C., &, Herba, C.M., (in press). Recognition of facial expressions of emotions by three-year-olds. Emotion, 11, 425-435; doi:.
54. Thomas, K.M., Drevets, W.C., Whalen, P.J., Eccard, C.H., Dahl, R.E., Ryan, N.D., &, Casey, B.J., (2001). Amygdala response to facial expressions in children and adults. Biological Psychiatry, 49, 309-316. (Pubitemid 32182360)
55. Thomason, M.E., Henry, M.L., Paul Hamilton, J., Joormann, J., Pine, D.S., Ernst, M., &, Gotlib, I.H., (2010). Neural and behavioral responses to threatening emotion faces in children as a function of the short allele of the serotonin transporter gene. Biological Psychology, 85, 38-44; doi:.
56. Uher, R., &, McGuffin, P., (2008). The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: Review and methodological analysis. Molecular Psychiatry, 13, 131-146.
57. Uher, R., &, McGuffin, P., (2010). The moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: 2009 update. Molecular Psychiatry, 15, 18-22; doi:.
58. Vuilleumier, P., (2005). Cognitive science: Staring fear in the face. Nature, 433, 22-23. (Pubitemid 40101129)