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Volumn 225, Issue , 2012, Pages 258-268

An in vitro approach to assess the neurotoxicity of valproic acid-induced oxidative stress in cerebellum and cerebral cortex of young rats

Author keywords

Cerebellum; Cerebral cortex; Neurotoxicity; Oxidative stress; Valproic acid

Indexed keywords

ACETYLCHOLINESTERASE; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); AMINE OXIDASE (FLAVIN CONTAINING); CARBONYL DERIVATIVE; CATALASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; SUPEROXIDE DISMUTASE; THIOL PROTEINASE; XANTHINE OXIDASE;

EID: 84867881597     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2012.08.060     Document Type: Article
Times cited : (78)

References (59)
  • 4
    • 33845411261 scopus 로고    scopus 로고
    • Oxidative stress as a mechanism of valproic acid associated hepatotoxicity
    • Chang T.K., Abbott F.S. Oxidative stress as a mechanism of valproic acid associated hepatotoxicity. Drug Metab Rev 2006, 38:627-639.
    • (2006) Drug Metab Rev , vol.38 , pp. 627-639
    • Chang, T.K.1    Abbott, F.S.2
  • 8
    • 23744457490 scopus 로고    scopus 로고
    • Melatonin reduces oxidative stress and increases gene expression in the cerebral n cortex and cerebellum of aluminum-exposed rats
    • Esparza J.L., Gómez M., Rosa Nogués M., Paternain J.L., Mallol J., Domingo J.L. Melatonin reduces oxidative stress and increases gene expression in the cerebral n cortex and cerebellum of aluminum-exposed rats. J Pineal Res 2005, 39:129-136.
    • (2005) J Pineal Res , vol.39 , pp. 129-136
    • Esparza, J.L.1    Gómez, M.2    Rosa Nogués, M.3    Paternain, J.L.4    Mallol, J.5    Domingo, J.L.6
  • 9
    • 84862890285 scopus 로고    scopus 로고
    • FLZ, synthetic squamosamide cyclic derivative, attenuates memory deficit and pathological changes in mice with experimentally induced aging
    • Fang F., Wang Q.L., Liu G.T. FLZ, synthetic squamosamide cyclic derivative, attenuates memory deficit and pathological changes in mice with experimentally induced aging. Naunyn Schmiedebergs Arch Pharmacol 2012, 385:579-585.
    • (2012) Naunyn Schmiedebergs Arch Pharmacol , vol.385 , pp. 579-585
    • Fang, F.1    Wang, Q.L.2    Liu, G.T.3
  • 11
    • 0031962268 scopus 로고    scopus 로고
    • Increased protein oxidation in human substantia nigra pars compacta in comparison with basal ganglia and prefrontal cortex measured with an improved dinitrophenylhydrazine assay
    • Floor E., Wetzel M.G. Increased protein oxidation in human substantia nigra pars compacta in comparison with basal ganglia and prefrontal cortex measured with an improved dinitrophenylhydrazine assay. J Neurochem 1998, 70:268-275.
    • (1998) J Neurochem , vol.70 , pp. 268-275
    • Floor, E.1    Wetzel, M.G.2
  • 13
    • 3042777686 scopus 로고    scopus 로고
    • Catalase activity in cerebellum, hippocampus, frontal cortex and striatum after status epilepticus induced by pilocarpine in Wistar rats
    • Freitas R.M., Nascimento V.S., Vasconcelos S.M., Sousa F.C., Viana G.S., Fonteles M.M. Catalase activity in cerebellum, hippocampus, frontal cortex and striatum after status epilepticus induced by pilocarpine in Wistar rats. Neurosci Lett 2004, 365:102-105.
    • (2004) Neurosci Lett , vol.365 , pp. 102-105
    • Freitas, R.M.1    Nascimento, V.S.2    Vasconcelos, S.M.3    Sousa, F.C.4    Viana, G.S.5    Fonteles, M.M.6
  • 14
    • 77954643043 scopus 로고    scopus 로고
    • Autophagy induced by valproic acid is associated with oxidative stress in glioma cell lines
    • Fu J., Shao C.J., Chen F.R., Ng H.K., Chen Z.P. Autophagy induced by valproic acid is associated with oxidative stress in glioma cell lines. Neuro-oncol 2010, 12:328-340.
    • (2010) Neuro-oncol , vol.12 , pp. 328-340
    • Fu, J.1    Shao, C.J.2    Chen, F.R.3    Ng, H.K.4    Chen, Z.P.5
  • 16
    • 84862516912 scopus 로고    scopus 로고
    • Postnuclear supernatant: an in vitro model for assessing cadmium-induced neurotoxicity
    • Govil N., Chaudhary S., Waseem M., Parvez S. Postnuclear supernatant: an in vitro model for assessing cadmium-induced neurotoxicity. Biol Trace Elem Res 2012, 146:402-409.
    • (2012) Biol Trace Elem Res , vol.146 , pp. 402-409
    • Govil, N.1    Chaudhary, S.2    Waseem, M.3    Parvez, S.4
  • 17
    • 50349102186 scopus 로고    scopus 로고
    • Hydroxamic acid and fluorinated derivatives of valproic acid: anticonvulsant activity, neurotoxicity and teratogenicity
    • Gravemann U., Volland J., Nau H. Hydroxamic acid and fluorinated derivatives of valproic acid: anticonvulsant activity, neurotoxicity and teratogenicity. Neurotoxicol Teratol 2008, 30:390-394.
    • (2008) Neurotoxicol Teratol , vol.30 , pp. 390-394
    • Gravemann, U.1    Volland, J.2    Nau, H.3
  • 18
    • 0016275313 scopus 로고
    • Glutathione S-transferase: the first step in mercapturic acid formation
    • Habig W.H., Pabst M., Jaoby W.B. Glutathione S-transferase: the first step in mercapturic acid formation. J Biol Chem 1974, 249:7130-7139.
    • (1974) J Biol Chem , vol.249 , pp. 7130-7139
    • Habig, W.H.1    Pabst, M.2    Jaoby, W.B.3
  • 19
    • 0142011048 scopus 로고    scopus 로고
    • Aqueous extract of walnut (Juglans regia L.) protects mice against cyclophosphamide induced biochemical toxicity
    • Haque R., Bin-Hafeez B., Parvez S., Pandey S., Sayeed I., Ali M., Raisuddin S. Aqueous extract of walnut (Juglans regia L.) protects mice against cyclophosphamide induced biochemical toxicity. Hum Exp Toxicol 2003, 22:473-480.
    • (2003) Hum Exp Toxicol , vol.22 , pp. 473-480
    • Haque, R.1    Bin-Hafeez, B.2    Parvez, S.3    Pandey, S.4    Sayeed, I.5    Ali, M.6    Raisuddin, S.7
  • 20
    • 0031568289 scopus 로고    scopus 로고
    • A continuous spectrophotometric assay for monoamine oxidase and related enzymes in tissue homogenates
    • Holt A., Sharman D.F., Baker G.B., Palcic M.M. A continuous spectrophotometric assay for monoamine oxidase and related enzymes in tissue homogenates. Anal Biochem 1997, 244:384-392.
    • (1997) Anal Biochem , vol.244 , pp. 384-392
    • Holt, A.1    Sharman, D.F.2    Baker, G.B.3    Palcic, M.M.4
  • 21
    • 84863986274 scopus 로고    scopus 로고
    • Induction of oxidative stress and inhibition of superoxide dismutase expression in rat cerebral cortex and cerebellum by PTU-induced hypothyroidism and its reversal by curcumin
    • Jena S., Anand C., Chainy G.B., Dandapat J. Induction of oxidative stress and inhibition of superoxide dismutase expression in rat cerebral cortex and cerebellum by PTU-induced hypothyroidism and its reversal by curcumin. Neurol Sci 2012, 33:869-873.
    • (2012) Neurol Sci , vol.33 , pp. 869-873
    • Jena, S.1    Anand, C.2    Chainy, G.B.3    Dandapat, J.4
  • 22
    • 0016151122 scopus 로고
    • Bromobenzene induced liver necrosis; protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolites
    • Jollow D.J., Mitchell J.R., Zamppaglione Z., Gillette J.R. Bromobenzene induced liver necrosis; protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolites. Pharmacology 1974, 11:151-169.
    • (1974) Pharmacology , vol.11 , pp. 151-169
    • Jollow, D.J.1    Mitchell, J.R.2    Zamppaglione, Z.3    Gillette, J.R.4
  • 23
    • 0141427727 scopus 로고    scopus 로고
    • Tellurium-induced dose-dependent impairment of antioxidant status: differential effects in cerebrum, cerebellum, and brainstem of mice
    • Kaur P., Yousuf S., Ansari M.A., Siddiqui A., Ahmad A.S., Islam F. Tellurium-induced dose-dependent impairment of antioxidant status: differential effects in cerebrum, cerebellum, and brainstem of mice. Biol Trace Elem Res 2003, 94:247-258.
    • (2003) Biol Trace Elem Res , vol.94 , pp. 247-258
    • Kaur, P.1    Yousuf, S.2    Ansari, M.A.3    Siddiqui, A.4    Ahmad, A.S.5    Islam, F.6
  • 25
    • 78549249819 scopus 로고    scopus 로고
    • Role of oxidative metabolism in the effect of valproic acid on markers of cell viability, necrosis, and oxidative stress in sandwich-cultured rat hepatocytes
    • Kiang T.K., Teng X.W., Karagiozov S., Surendradoss J., Chang T.K., Abbott F.S. Role of oxidative metabolism in the effect of valproic acid on markers of cell viability, necrosis, and oxidative stress in sandwich-cultured rat hepatocytes. Toxicol Sci 2010, 118:501-509.
    • (2010) Toxicol Sci , vol.118 , pp. 501-509
    • Kiang, T.K.1    Teng, X.W.2    Karagiozov, S.3    Surendradoss, J.4    Chang, T.K.5    Abbott, F.S.6
  • 26
    • 79954629642 scopus 로고    scopus 로고
    • Glutathione depletion by valproic acid in sandwich-cultured rat hepatocytes: role of biotransformation and temporal relationship with onset of toxicity
    • Kiang T.K., Teng X.W., Surendradoss J., Karagiozov S., Abbott F.S., Chang T.K. Glutathione depletion by valproic acid in sandwich-cultured rat hepatocytes: role of biotransformation and temporal relationship with onset of toxicity. Toxicol Appl Pharmacol 2011, 252:318-324.
    • (2011) Toxicol Appl Pharmacol , vol.252 , pp. 318-324
    • Kiang, T.K.1    Teng, X.W.2    Surendradoss, J.3    Karagiozov, S.4    Abbott, F.S.5    Chang, T.K.6
  • 27
    • 77955775880 scopus 로고    scopus 로고
    • Neurochemical evidence that phytanic acid induces oxidative damage and reduces the antioxidant defenses in cerebellum and cerebral cortex of rats
    • Leipnitz G., Amaral A.U., Zanatta A., Seminotti B., Fernandes C.G., Knebel L.A., Vargas C.R., Wajner M. Neurochemical evidence that phytanic acid induces oxidative damage and reduces the antioxidant defenses in cerebellum and cerebral cortex of rats. Life Sci 2010, 87:275-280.
    • (2010) Life Sci , vol.87 , pp. 275-280
    • Leipnitz, G.1    Amaral, A.U.2    Zanatta, A.3    Seminotti, B.4    Fernandes, C.G.5    Knebel, L.A.6    Vargas, C.R.7    Wajner, M.8
  • 28
    • 79952539168 scopus 로고    scopus 로고
    • Pristanic acid promotes oxidative stress in brain cortex of young rats: a possible pathophysiological mechanism for brain damage in peroxisomal disorders
    • Leipnitz G., Amaral A.U., Fernandes C.G., Seminotti B., Zanatta A., Knebel L.A., Vargas C.R., Wajner M. Pristanic acid promotes oxidative stress in brain cortex of young rats: a possible pathophysiological mechanism for brain damage in peroxisomal disorders. Brain Res 2011, 1382:259-265.
    • (2011) Brain Res , vol.1382 , pp. 259-265
    • Leipnitz, G.1    Amaral, A.U.2    Fernandes, C.G.3    Seminotti, B.4    Zanatta, A.5    Knebel, L.A.6    Vargas, C.R.7    Wajner, M.8
  • 29
    • 27144539588 scopus 로고    scopus 로고
    • Science review: carnitine in the treatment of valproic acid-induced toxicity - what is the evidence?
    • Lheureux P.E., Penaloza A., Zahir S., Gris M. Science review: carnitine in the treatment of valproic acid-induced toxicity - what is the evidence?. Crit Care 2005, 9:431-440.
    • (2005) Crit Care , vol.9 , pp. 431-440
    • Lheureux, P.E.1    Penaloza, A.2    Zahir, S.3    Gris, M.4
  • 31
    • 4644297380 scopus 로고    scopus 로고
    • Plasma levels of total, free and protein bound thiols as well as sulfane sulfur in different age groups of rats
    • Malgorzata I., Grazyna C., Elzbieta L.K., Edward B., Lidia W. Plasma levels of total, free and protein bound thiols as well as sulfane sulfur in different age groups of rats. Acta Biochim Pol 2004, 51:815-824.
    • (2004) Acta Biochim Pol , vol.51 , pp. 815-824
    • Malgorzata, I.1    Grazyna, C.2    Elzbieta, L.K.3    Edward, B.4    Lidia, W.5
  • 32
    • 0015523099 scopus 로고
    • Role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase
    • Misra H.P., Fridovich I. Role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem 1972, 247:3170-3175.
    • (1972) J Biol Chem , vol.247 , pp. 3170-3175
    • Misra, H.P.1    Fridovich, I.2
  • 33
    • 0021752183 scopus 로고
    • Low activities of glutathione-related enzymes as factors in the genesis of urinary bladder cancer
    • Mohandas J., Marshall J.J., Duggin G.G., Horvath J.S., Tiller D.J. Low activities of glutathione-related enzymes as factors in the genesis of urinary bladder cancer. Cancer Res 1984, 44:5086-5091.
    • (1984) Cancer Res , vol.44 , pp. 5086-5091
    • Mohandas, J.1    Marshall, J.J.2    Duggin, G.G.3    Horvath, J.S.4    Tiller, D.J.5
  • 36
    • 84859764210 scopus 로고    scopus 로고
    • A new approach on valproic acid induced hepatotoxicity: involvement of lysosomal membrane leakiness and cellular proteolysis
    • Pourahmad J., Eskandari M.R., Kaghazi A., Shaki F., Shahraki J., Fard J.K. A new approach on valproic acid induced hepatotoxicity: involvement of lysosomal membrane leakiness and cellular proteolysis. Toxicol In Vitro 2012, 26:545-551.
    • (2012) Toxicol In Vitro , vol.26 , pp. 545-551
    • Pourahmad, J.1    Eskandari, M.R.2    Kaghazi, A.3    Shaki, F.4    Shahraki, J.5    Fard, J.K.6
  • 37
    • 57849159093 scopus 로고    scopus 로고
    • Branched chain fatty acids are constituents of the normal healthy newborn gastrointestinal tract
    • Ran-Ressler R.R., Devapatla S., Lawrence P., Brenna J.T. Branched chain fatty acids are constituents of the normal healthy newborn gastrointestinal tract. Pediatr Res 2008, 64:605-609.
    • (2008) Pediatr Res , vol.64 , pp. 605-609
    • Ran-Ressler, R.R.1    Devapatla, S.2    Lawrence, P.3    Brenna, J.T.4
  • 39
    • 70349783629 scopus 로고    scopus 로고
    • The influence of the branched-chain fatty acids pristanic acid and Refsum disease-associated phytanic acid on mitochondrial functions and calcium regulation of hippocampal neurons, astrocytes, and oligodendrocytes
    • Ronicke S., Kruska N., Kahlert S., Reiser G. The influence of the branched-chain fatty acids pristanic acid and Refsum disease-associated phytanic acid on mitochondrial functions and calcium regulation of hippocampal neurons, astrocytes, and oligodendrocytes. Neurobiol Dis 2009, 36:401-410.
    • (2009) Neurobiol Dis , vol.36 , pp. 401-410
    • Ronicke, S.1    Kruska, N.2    Kahlert, S.3    Reiser, G.4
  • 40
    • 33646594405 scopus 로고    scopus 로고
    • Differential acetylcholinesterase activity in rat cerebrum, cerebellum and hypothalamus
    • Roy R., Chaudhuri A.N. Differential acetylcholinesterase activity in rat cerebrum, cerebellum and hypothalamus. Indian J Exp Biol 2006, 44:381-386.
    • (2006) Indian J Exp Biol , vol.44 , pp. 381-386
    • Roy, R.1    Chaudhuri, A.N.2
  • 41
    • 33846195008 scopus 로고    scopus 로고
    • Behavioral and histologic neuroprotection of aqueous garlic extract after reversible focal cerebral ischemia
    • Saleem S., Ahmad M., Ahmad A.S., Yousuf S., Ansari M.A., Khan M.B., Ishrat T., Islam F. Behavioral and histologic neuroprotection of aqueous garlic extract after reversible focal cerebral ischemia. J Med Food 2006, 9:537-544.
    • (2006) J Med Food , vol.9 , pp. 537-544
    • Saleem, S.1    Ahmad, M.2    Ahmad, A.S.3    Yousuf, S.4    Ansari, M.A.5    Khan, M.B.6    Ishrat, T.7    Islam, F.8
  • 42
    • 84856113283 scopus 로고    scopus 로고
    • The inhibitory effect of manganese on acetylcholinesterase activity enhances oxidative stress and neuroinflammation in the rat brain
    • Santos D., Milatovic D., Andrade V., Batoreu M.C., Aschner M., Marreilha dos Santos A.P. The inhibitory effect of manganese on acetylcholinesterase activity enhances oxidative stress and neuroinflammation in the rat brain. Toxicology 2012, 292:90-98.
    • (2012) Toxicology , vol.292 , pp. 90-98
    • Santos, D.1    Milatovic, D.2    Andrade, V.3    Batoreu, M.C.4    Aschner, M.5    Marreilha dos Santos, A.P.6
  • 43
    • 6344243204 scopus 로고    scopus 로고
    • In brain mitochondria the branched-chain fatty acid phytanic acid impairs energy transduction and sensitizes for permeability transition
    • Schönfeld P., Kahlert S., Reiser G. In brain mitochondria the branched-chain fatty acid phytanic acid impairs energy transduction and sensitizes for permeability transition. Biochem J 2004, 383:121-128.
    • (2004) Biochem J , vol.383 , pp. 121-128
    • Schönfeld, P.1    Kahlert, S.2    Reiser, G.3
  • 44
    • 0014428865 scopus 로고
    • Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent
    • Sedlak J., Lindsay R.H. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal Biochem 1968, 25:192-205.
    • (1968) Anal Biochem , vol.25 , pp. 192-205
    • Sedlak, J.1    Lindsay, R.H.2
  • 45
    • 80054874386 scopus 로고    scopus 로고
    • Melatonin abrogates cadmium induced oxidative stress related neurotoxicity in rats
    • Shagirtha K., Muthumani M., Prabu S.M. Melatonin abrogates cadmium induced oxidative stress related neurotoxicity in rats. Eur Rev Med Pharmacol Sci 2011, 15:1039-1050.
    • (2011) Eur Rev Med Pharmacol Sci , vol.15 , pp. 1039-1050
    • Shagirtha, K.1    Muthumani, M.2    Prabu, S.M.3
  • 48
    • 0014690734 scopus 로고
    • The regulation of rat liver xanthine oxidase
    • Stripe F., Della Corte E. The regulation of rat liver xanthine oxidase. J Biol Chem 1969, 244:3855-3863.
    • (1969) J Biol Chem , vol.244 , pp. 3855-3863
    • Stripe, F.1    Della Corte, E.2
  • 49
    • 84862810515 scopus 로고    scopus 로고
    • Prenatal exposure to valproic acid enhances synaptic plasticity in the medial prefrontal cortex and fear memories
    • Sui L., Chen M. Prenatal exposure to valproic acid enhances synaptic plasticity in the medial prefrontal cortex and fear memories. Brain Res Bull 2012, 87:556-563.
    • (2012) Brain Res Bull , vol.87 , pp. 556-563
    • Sui, L.1    Chen, M.2
  • 50
    • 77953544509 scopus 로고    scopus 로고
    • Protective effect of lipoic acid against methotrexate-induced oxidative stress in liver mitochondria
    • Tabassum H., Parvez S., Pasha S.T., Banerjee B.D., Raisuddin S. Protective effect of lipoic acid against methotrexate-induced oxidative stress in liver mitochondria. Food Chem Toxicol 2010, 48:1973-1979.
    • (2010) Food Chem Toxicol , vol.48 , pp. 1973-1979
    • Tabassum, H.1    Parvez, S.2    Pasha, S.T.3    Banerjee, B.D.4    Raisuddin, S.5
  • 52
    • 26444592296 scopus 로고    scopus 로고
    • Valproic acid II: effects on oxidative stress, mitochondrial membrane potential, and cytotoxicity in glutathione-depleted rat hepatocytes
    • Tong V., Teng X.W., Chang T.K., Abbott F.S. Valproic acid II: effects on oxidative stress, mitochondrial membrane potential, and cytotoxicity in glutathione-depleted rat hepatocytes. Toxicol Sci 2005, 86:436-443.
    • (2005) Toxicol Sci , vol.86 , pp. 436-443
    • Tong, V.1    Teng, X.W.2    Chang, T.K.3    Abbott, F.S.4
  • 53
    • 26444467745 scopus 로고    scopus 로고
    • Valproic acid I: time course of lipid peroxidation biomarkers, liver toxicity, and valproic acid metabolite levels in rats
    • Tong V., Teng X.W., Chang T.K., Abbott F.S. Valproic acid I: time course of lipid peroxidation biomarkers, liver toxicity, and valproic acid metabolite levels in rats. Toxicol Sci 2005, 86:427-435.
    • (2005) Toxicol Sci , vol.86 , pp. 427-435
    • Tong, V.1    Teng, X.W.2    Chang, T.K.3    Abbott, F.S.4
  • 54
    • 81555195488 scopus 로고    scopus 로고
    • Valproic acid increases formation of reactive oxygen species and induces apoptosis in postimplantation embryos: a role for oxidative stress in valproic acid-induced neural tube defects
    • Tung E.W., Winn L.M. Valproic acid increases formation of reactive oxygen species and induces apoptosis in postimplantation embryos: a role for oxidative stress in valproic acid-induced neural tube defects. Mol Pharmacol 2011, 80:979-987.
    • (2011) Mol Pharmacol , vol.80 , pp. 979-987
    • Tung, E.W.1    Winn, L.M.2
  • 55
    • 0018069570 scopus 로고
    • Determination of malonaldehyde precursor in tissues by thiobarbituric acid test
    • Uchiyama M., Mihara M. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal Biochem 1978, 86:271-278.
    • (1978) Anal Biochem , vol.86 , pp. 271-278
    • Uchiyama, M.1    Mihara, M.2
  • 56
    • 79956322467 scopus 로고    scopus 로고
    • Valproic acid induces apoptosis in differentiating hippocampal neurons by the release of tumor necrosis factor-α from activated astrocytes
    • Wang C., Luan Z., Yang Y., Wang Z., Cui Y., Gu G. Valproic acid induces apoptosis in differentiating hippocampal neurons by the release of tumor necrosis factor-α from activated astrocytes. Neurosci Lett 2011, 497:122-127.
    • (2011) Neurosci Lett , vol.497 , pp. 122-127
    • Wang, C.1    Luan, Z.2    Yang, Y.3    Wang, Z.4    Cui, Y.5    Gu, G.6
  • 58
    • 76749126263 scopus 로고    scopus 로고
    • Ascorbic acid reverses valproic acid-induced inhibition of hoxa2 and maintains glutathione homeostasis in mouse embryos in culture
    • Zhang B., Wang X., Nazarali A.J. Ascorbic acid reverses valproic acid-induced inhibition of hoxa2 and maintains glutathione homeostasis in mouse embryos in culture. Cell Mol Neurobiol 2010, 30:137-148.
    • (2010) Cell Mol Neurobiol , vol.30 , pp. 137-148
    • Zhang, B.1    Wang, X.2    Nazarali, A.J.3
  • 59
    • 79960622483 scopus 로고    scopus 로고
    • Valproic acid inhibits neurosphere formation by adult subventricular cells by a lithium-sensitive mechanism
    • Zhou Q., Dalgard C.L., Wynder C., Doughty M.L. Valproic acid inhibits neurosphere formation by adult subventricular cells by a lithium-sensitive mechanism. Neurosci Lett 2011, 500:202-206.
    • (2011) Neurosci Lett , vol.500 , pp. 202-206
    • Zhou, Q.1    Dalgard, C.L.2    Wynder, C.3    Doughty, M.L.4


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