Role of oxidative metabolism in the effect of valproic acid on markers of cell viability, necrosis, and oxidative stress in sandwich-cultured rat hepatocytes

Toxicological Sciences

Volumn 118, Issue 2, 2010, Pages 501-509

  Kiang, Tony K L ^a   Teng, Xiao Wei ^a   Karagiozov, Stoyan ^a   Surendradoss, Jayakumar ^a   Chang, Thomas K H ^a   Abbott, Frank S ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Cytotoxicity; Hepatocytes; Metabolism; Oxidative stress; Reactive metabolites; Valproic acid

Indexed keywords

1 AMINOBENZOTRIAZOLE; 2 (4 IODOPHENYL) 3 (4 NITROPHENYL) 5 (2,4 DISULFOPHENYL) 2H TETRAZOLIUM; 2 FLUORO 2 PROPYLPENTANOIC ACID; 2 PROPYL 4 PENTENOIC ACID; 3 HYDROXYVALPROIC ACID; 4 HYDROXY 4 PROPYLPENTANOIC ACID; 5 HYDROXYVALPROIC ACID; DICHLORODIHYDROFLUORESCEIN; LACTATE DEHYDROGENASE; TERT BUTYL HYDROPEROXIDE; TETRAZOLIUM; UNCLASSIFIED DRUG; VALERIC ACID DERIVATIVE; VALPROIC ACID;

AEROBIC METABOLISM; ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; LIVER CELL; LIVER TOXICITY; MALE; METABOLITE; NONHUMAN; OXIDATIVE STRESS; RAT;

ANIMALS; BIOLOGICAL MARKERS; CELL CULTURE TECHNIQUES; CELL SURVIVAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENERGY METABOLISM; ENZYME INHIBITORS; HEPATOCYTES; L-LACTATE DEHYDROGENASE; MALE; NECROSIS; OXIDATION-REDUCTION; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; TERT-BUTYLHYDROPEROXIDE; VALPROIC ACID;

RATTUS;

EID: 78549249819     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq294     Document Type: Article

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