Neurochemical evidence that phytanic acid induces oxidative damage and reduces the antioxidant defenses in cerebellum and cerebral cortex of rats

Life Sciences

Volumn 87, Issue 9-10, 2010, Pages 275-280

  Leipnitz, Guilhian ^a   Amaral, Alexandre U ^a   Zanatta, Ângela ^a   Seminotti, Bianca ^a   Fernandes, Carolina G ^a   Knebel, Lisiane A ^a   Vargas, Carmen R ^b   Wajner, Moacir ^a,b  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

Author keywords

Cerebellum; Cerebral cortex; Oxidative stress; Phytanic acid; Refsum disease

Indexed keywords

ALPHA TOCOPHEROL; CARBONYL DERIVATIVE; GLUTATHIONE; MELATONIN; PHYTANIC ACID; THIOBARBITURIC ACID REACTIVE SUBSTANCE; THIOL DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CEREBELLUM; CONTROLLED STUDY; DRUG ACTIVITY; IN VITRO STUDY; LIPID PEROXIDATION; MALE; NEUROCHEMISTRY; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PATHOPHYSIOLOGY; RAT; REFSUM DISEASE;

ANIMALS; ANTIOXIDANTS; BRAIN CHEMISTRY; CEREBELLUM; CEREBRAL CORTEX; GLUTATHIONE; LIPID PEROXIDATION; MALE; OXIDATIVE STRESS; PHYTANIC ACID; PROTEIN CARBONYLATION; RATS; RATS, WISTAR; REFSUM DISEASE; SULFHYDRYL COMPOUNDS; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

RATTUS;

EID: 77955775880     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2010.06.015     Document Type: Article

References (35)

1. Adam-Vizi V. Production of reactive oxygen species in brain mitochondria: contribution by electron transport chain and non-electron transport chain sources. Antioxidant & Redox Signaling 2005, 7:1140-1149.
2. Aksenov M.Y., Markesbery W.R. Changes in thiol content and expression of glutathione redox system genes in the hippocampus and cerebellum in Alzheimer's disease. Neuroscience Letters 2001, 302:141-145.
3. Bazan N.G., de Bazan H.E., Kennedy W.G., Joel C.D. Regional distribution and rate of production of free fatty acids in rat brain. Journal of Neurochemistry 1971, 18:1387-1393.
4. Brosius U., Gartner J. Cellular and molecular aspects of Zellweger syndrome and other peroxisome biogenesis disorders. Cellular and Molecular Life Sciences 2002, 59:1058-1069.
5. Browne R.W., Armstrong D. Reduced glutathione and glutathione disulfide. Methods in Molecular Biology 1998, 108:347-352.
6. Dalle-Donne I., Rossi R., Giustarini D., Milzani A., Colombo R. Protein carbonyl groups as biomarkers of oxidative stress. Clinica Chimica Acta: International Journal of Clinical Chemistry 2003, 329:23-38.
7. Delanty N., Dichter M.A. Oxidative injury in the nervous system. Acta Neurologica Scandinavica 1998, 98:145-153.
8. Eldjarn L., Try K., Stokke O., Munthe-Kaas A.W., Refsum S., Steinberg D., Avigan J., Mize C. Dietary effects on serum-phytanic-acid levels and on clinical manifestations in heredopathia atactica polyneuritiformis. Lancet 1966, 1:691-693.
9. Esterbauer H., Cheeseman K.H. Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. Methods in Enzymology 1990, 186:407-421.
10. Evelson P., Travacio M., Repetto M., Escobar J., Llesuy S., Lissi E.A. Evaluation of total reactive antioxidant potential (TRAP) of tissue homogenates and their cytosols. Archives of Biochemistry and Biophysics 2001, 388:261-266.
11. Ferdinandusse S., Zomer A.W., Komen J.C., van den Brink C.E., Thanos M., Hamers F.P., Wanders R.J., van der Saag P.T., Poll-The B.T., Brites P. Ataxia with loss of Purkinje cells in a mouse model for Refsum disease. Proceedings of the National Academy of Sciences of the United States of America 2008, 105:17712-17717.
12. Gibberd F.B., Billimoria J.D., Page N.G., Retsas S. Heredopathia atactica polyneuritiformis (Refsum's disease) treated by diet and plasma-exchange. Lancet 1979, 1:575-578.
13. Gould S.J., Raymond G.V., Valle D. The peroxisome biogenesis disorders. The Metabolic and Molecular Bases of Inherited Disease 2001, 3181-3217. McGraw-Hill, New York. C.R. Scriver, A.L. Beaudet, D. Valle (Eds.).
14. Halliwell B. Reactive oxygen species and the central nervous system. Journal of Neurochemistry 1992, 59:1609-1623.
15. Halliwell B., Gutteridge J.M.C. Free Radicals in Biology and Medicine. Cellular responses to oxidative stress: adaptation, damage, repair, senescence and death 2007, 187-267. Oxford University Press, Oxford. B. Halliwell, J.M.C. Gutteridge (Eds.).
16. Halliwell B., Whiteman M. Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean?. British Journal of Pharmacology 2004, 142:231-255.
17. Hungerbuhler J.P., Meier C., Rousselle L., Quadri P., Bogousslavsky J. Refsum's disease: management by diet and plasmapheresis. European Neurology 1985, 24:153-159.
18. Idel S., Ellinghaus P., Wolfrum C., Nofer J.R., Gloerich J., Assmann G., Spener F., Seedorf U. Branched chain fatty acids induce nitric oxide-dependent apoptosis in vascular smooth muscle cells. The Journal of Biological Chemistry 2002, 277:49319-49325.
19. Kahlert S., Schonfeld P., Reiser G. The Refsum disease marker phytanic acid, a branched chain fatty acid, affects Ca2+ homeostasis and mitochondria, and reduces cell viability in rat hippocampal astrocytes. Neurobiology of Disease 2005, 18:110-118.
20. Kolker S., Ahlemeyer B., Krieglstein J., Hoffmann G.F. Contribution of reactive oxygen species to 3-hydroxyglutarate neurotoxicity in primary neuronal cultures from chick embryo telencephalons. Pediatric Research 2001, 50:76-82.
21. Komen J.C., Distelmaier F., Koopman W.J., Wanders R.J., Smeitink J., Willems P.H. Phytanic acid impairs mitochondrial respiration through protonophoric action. Cellular and Molecular Life Sciences 2007, 64:3271-3281.
22. Kuhn D.M., Aretha C.W., Geddes T.J. Peroxynitrite inactivation of tyrosine hydroxylase: mediation by sulfhydryl oxidation, not tyrosine nitration. The Journal of Neuroscience 1999, 19:10289-10294.
23. Latini A., Scussiato K., Rosa R.B., Leipnitz G., Llesuy S., Bello-Klein A., Dutra-Filho C.S., Wajner M. Induction of oxidative stress by L-2-hydroxyglutaric acid in rat brain. Journal of Neuroscience Research 2003, 74:103-110.
24. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. The Journal of Biological Chemistry 1951, 193:265-275.
25. Masters-Thomas A., Bailes J., Billimoria J.D., Clemens M.E., Gibberd F.B., Page N.G. Heredopathia atactica polyneuritiformis (Refsum's disease): 1. Clinical features and dietary management. Journal of Human Nutrition 1980, 34:245-250.
26. Reiser G., Schonfeld P., Kahlert S. Mechanism of toxicity of the branched-chain fatty acid phytanic acid, a marker of Refsum disease, in astrocytes involves mitochondrial impairment. International Journal of Development Neuroscience 2006, 24:113-122.
27. Reznick A.Z., Packer L. Oxidative damage to proteins: spectrophotometric method for carbonyl assay. Methods in Enzymology 1994, 233:357-363.
28. Ronicke S., Kruska N., Kahlert S., Reiser G. The influence of the branched-chain fatty acids pristanic acid and Refsum disease-associated phytanic acid on mitochondrial functions and calcium regulation of hippocampal neurons, astrocytes, and oligodendrocytes. Neurobiology of Disease 2009, 36:401-410.
29. Schonfeld P., Reiser G. Comment concerning the article: 'Phytanic acid impairs mitochondrial respiration through protonophoric action' by Komen et al.: branched chain phytanic acid inhibits the activity of the mitochondrial respiratory chain. Cellular and Molecular Life Sciences 2008, 65:2266-2269.
30. Schonfeld P., Wojtczak L. Fatty acids decrease mitochondrial generation of reactive oxygen species at the reverse electron transport but increase it at the forward transport. Biochimica et Biophysica Acta 2007, 1767:1032-1040.
31. Schonfeld P., Kahlert S., Reiser G. In brain mitochondria the branched-chain fatty acid phytanic acid impairs energy transduction and sensitizes for permeability transition. The Biochemical Journal 2004, 383:121-128.
32. Wanders R.J., Schutgens R.B., Barth P.G., Tager J.M., van den Bosch H. Postnatal diagnosis of peroxisomal disorders: a biochemical approach. Biochimie 1993, 75:269-279.
33. Wanders R.J., Jakobs C., Skjeldal O.H. Refsum disease. The Metabolic and Molecular Bases of Inherited Disease 2001, 3303-3322. McGraw-Hill, New York. C.R. Scriver, A.L. Beaudet, W.S. Sly, D. Valle (Eds.).
34. Wierzbicki A.S., Mayne P.D., Lloyd M.D., Burston D., Mei G., Sidey M.C., Feher M.D., Gibberd F.B. Metabolism of phytanic acid and 3-methyl-adipic acid excretion in patients with adult Refsum disease. Journal of Lipid Research 2003, 44:1481-1488.
35. Zomer A.W., van Der Burg B., Jansen G.A., Wanders R.J., Poll-The B.T., van Der Saag P.T. Pristanic acid and phytanic acid: naturally occurring ligands for the nuclear receptor peroxisome proliferator-activated receptor alpha. Journal of Lipid Research 2000, 41:1801-1807.