In brain mitochondria the branched-chain fatty acid phytanic acid impairs energy transduction and sensitizes for permeability transition

Biochemical Journal

Volumn 383, Issue 1, 2004, Pages 121-128

  Schönfeld, Peter ^a   Kahlert, Stefan ^a   Reiser, Georg ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

ADP ATP carrier; Branched chain fatty acid; Mitochondria; Neurodegeneration; Permeability transition; Respiratory chain; Synaptosome

Indexed keywords

ADENOSINETRIPHOSPHATE; DISEASES; FATTY ACIDS; GENETIC ENGINEERING; ORGANIC ACIDS;

BRAIN MITOCHONDRIA; GENTIC DISORDERS;

BRAIN;

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; CALCIUM ION; FATTY ACID; MITOCHONDRIAL PROTEIN; PALMITIC ACID; PHYTANIC ACID; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN MITOCHONDRION; BRAIN SYNAPTOSOME; CALCIUM TRANSPORT; CELL RESPIRATION; CONTROLLED STUDY; CYTOTOXICITY; DIFFUSION; DISORDERS OF PEROXISOMAL FUNCTIONS; ENERGY TRANSFER; MEMBRANE DEPOLARIZATION; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE; NERVE DEGENERATION; NERVOUS TISSUE; NONHUMAN; OXYGEN CONSUMPTION; PERMEABILITY TRANSITION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTON TRANSPORT; RAT; REDUCTION; REFSUM DISEASE; RESPIRATORY CHAIN;

ANIMALS; BRAIN; ELECTRON TRANSPORT; ENERGY METABOLISM; MEMBRANE POTENTIALS; MITOCHONDRIA; MITOCHONDRIAL ADP, ATP TRANSLOCASES; PERMEABILITY; PHYTANIC ACID; RATS; SYNAPTOSOMES; THERMODYNAMICS;

ANIMALIA;

EID: 6344243204     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20040583     Document Type: Article

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