Induction of oxidative stress and inhibition of superoxide dismutase expression in rat cerebral cortex and cerebellum by PTU-induced hypothyroidism and its reversal by curcumin

Neurological Sciences

Volumn 33, Issue 4, 2012, Pages 869-873

  Jena, Srikanta ^a   Anand, Chinmay ^a   Chainy, Gagan Bihari Nityananda ^b   Dandapat, Jagneshwar ^a  

^a UTKAL UNIVERSITY   (India)

^b Imgenex India Pvt Ltd   (India)

Author keywords

Antioxidant enzymes; Cerebellum; Cerebral cortex; Curcumin; Hypothyroidism; Oxidative stress

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; CURCUMIN; MANGANESE SUPEROXIDE DISMUTASE; PROPYLTHIOURACIL; SUPEROXIDE DISMUTASE;

ADULT ANIMAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CEREBELLUM; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVITY; HYPOTHYROIDISM; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING;

ANALYSIS OF VARIANCE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTITHYROID AGENTS; CEREBELLUM; CEREBRAL CORTEX; CURCUMIN; DISEASE MODELS, ANIMAL; HYPOTHYROIDISM; LIPID PEROXIDATION; MALE; OXIDATIVE STRESS; PROPYLTHIOURACIL; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 84863986274     PISSN: 15901874     EISSN: 15903478     Source Type: Journal    
DOI: 10.1007/s10072-011-0853-4     Document Type: Article

References (24)

1. Oppenheimer JH, Schwartz HL (1997) Molecular basis of thyroid hormone-dependent brain development. Endocr Rev 18:462-475 (Pubitemid 27349552)
2. Bhanja S, Chainy GBN (2010) PTU-induced hypothyroidism modulates antioxidant defence status in the developing cerebellum. Int J Dev Neurosci 28:251-262
3. de Souza ME, Dora JM, Wagner MS, Maia AL (2005) Decreased type 1 iodothyronine deiodinase expression might be an early and discrete event in thyroid cell dedifferentiation towards papillary carcinoma. Clin Endocrinol 62:672-678 (Pubitemid 40825936)
4. Diez D, Grijota-Martinez C, Agretti P, De Marco G, Tonacchera M, Pinchera A, de Escobar GM, Bernal J, Morte B (2008) Thyroid hormone action in the adult brain: gene expression profiling of the effects of single and multiple doses of triiodo-L-thyronine in the rat striatum. Endocrinol 149:3989-4000
5. Sarkar PK, Morris JJ, Martin JV (2011) Non-genomic effect of L-triiodothyronine on calmodulin-dependent synaptosomal protein phosphorylation in adult rat brain cortex. Indian J Exp Biol 49:169-176
6. Das K, Chainy GBN (2004) Thyroid hormone influences antioxidant defense system in adult rat brain. Neurochem Res 29:1755-1766 (Pubitemid 39070067)
7. Boelaert K, Franklyn JA (2005) Thyroid hormone in health and disease. J Endocrinol 187:1-15 (Pubitemid 41556396)
8. Torun AN, Kulaksizoglu S, Kulaksizoglu M, Pamuk BO, Isbilen E, Tutuncu NB (2009) Serum total antioxidant status and lipid peroxidation marker malondialdehyde levels in overt and subclinical hypothyroidism. Clin Endocrinol (Oxf). 70:469-474
9. Jena S, Chainy GBN, Dandapat J (2011) Expression of antioxidant genes in renal cortex of PTU-induced hypothyroid rats: effect of vitamin E and curcumin. Mol Biol Rep doi: 10.1007/ s11033-011-0849-4
10. Mogulkoc R, Baltaci AK, Aydin L, Oztekin E, Sivrikaya A (2005) The effect of thyroxine administration on lipid peroxidation in different tissues of rats with hypothyroidism. Acta Physiol Hung 92:39-46 (Pubitemid 40803896)
11. Subudhi U, Das K, Paital B, Bhanja S, Chainy GBN (2009) Supplementation of curcumin and vitamin E enhances oxidative stress, but restores hepatic histoarchitechture in hypothyroid rats. Life Sci 84:372-379
12. Jena S, Chainy GBN (2011) Regulation of expression of antioxidant enzymes by vitamin E and curcumin in L-thyroxine induced oxidative stress in rat renal cortex. Mol Biol Rep 38:1047-1054. doi:10.1007/s11033-010-0201-4
13. Duvoix A, Blasius R, Delhalle S, Schnekenburger M, Morceau F, Henry E, Dicato M, Diederich M (2005) Chemoprotective and therapeutic effects of Curcumin. Cancer Lett 223:181-190
14. Ringman JM, Frautschy SA, Cole GM, Masterman DL, Cummings JL (2005) A potential role of the curry spice curcumin in Alzheimer's disease. Curr Alzheimer Res 2:131-136 (Pubitemid 40862872)
15. Ladenson PW, Kieffer JD, Farewell AP, Ridgway C (1986) Modulation of myocardial L-triidothyronine receptors in normal hypothyroid and hyperthyroid rats. Metabolism 35:5-12 (Pubitemid 16162841)
16. Reddy AC, Lokesh BR (1996) Effect of curcumin and eugenol on iron-induced hepatic toxicity in rats. Toxicol 107:39-45 (Pubitemid 26061925)
17. Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxide s in animal tissue by thiobarbituric acid reaction. Anal Biochem 95:352-358
18. Das K, Samanta L, Chainy GBN (2000) A modified spectrophotometric assay of superoxide dismutase using nitrite formation of superoxide radicals. Indian J Biochem Biophys 37:201-204
19. Constantinou C, Margarity M, Valcana T (2005) Region-specific effects of hypothyroidism on the relative expression of thyroid hormone receptors in adult rat brain. Mol Cell Biochem 278:93-100 (Pubitemid 41418924)
20. Cano-Europa E, Pérez-Severiano F, Vergara P, Ortiz-Butrón R, Ríos C, Segovia J, Pacheco-Rosado J (2008) Hypothyroidism induces selective oxidative stress in amygdala and hippocampus of rat. Metab Brain Dis 23:275-287
21. Jiang J, Wang W, Sun YJ, Hu M, Li F, Zhu DY (2007) Neuroprotective effect of curcumin on focal cerebral ischemic rats by preventing blood-brain barrier damage. Eur J Pharmacol 30:54-62 (Pubitemid 46435844)
22. Iqball A, Jorde R, Figenschau Y (2006) Serum lipid levels in relation to serum thyroid-stimulating hormone and the effect of thyroxine treatment on serum lipid levels in subjects with subclinical hypothyroidism: the Tromso Study. J Intern Med 260:53-61 (Pubitemid 43894070)
23. Miranda S, Opazo C, Larrondo LF, Munoz FJ, Ruiz F, Leighton F, Inestrosa NC (2000) The role of oxidative stress in the toxicity induced by amyloid beta-peptide in Alzheimer's disease. Prog Neurobiol 62:633-648 (Pubitemid 30407138)
24. Halliwell B, Gutteridge JMC (2001) Free radicals in biology and medicine, 3rd edn. New York, Oxford University Press