SCOPUS 정보 검색 플랫폼

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 22, 2012, Pages 6794-6800

Future directions in phosphodiesterase drug discovery

(1) Deninno, Michael P a

a VERTEX PHARMACEUTICALS (United States)

Author keywords

cAMP; Catalytic domain; cGMP; Phosphodiesterase; Regulatory domain; Splice variants

Indexed keywords

PHOSPHODIESTERASE; PHOSPHODIESTERASE III INHIBITOR; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE IV INHIBITOR; PHOSPHODIESTERASE IX INHIBITOR; PHOSPHODIESTERASE V INHIBITOR; PHOSPHODIESTERASE VII INHIBITOR; PHOSPHODIESTERASE VIII INHIBITOR; PHOSPHODIESTERASE X INHIBITOR; ROFLUMILAST; ROLIPRAM; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CRYSTAL STRUCTURE; DEPRESSION; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME INACTIVATION; ENZYME REGULATION; ENZYME STRUCTURE; HUMAN; INFLAMMATION; NONHUMAN; PROTEIN FUNCTION; RESPIRATORY TRACT DISEASE; STRUCTURE ACTIVITY RELATION;

EID: 84867856446 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.09.028 Document Type: Review

Times cited : (28)

References (47)

1
- 0037705377
- P.R. Wielinga, I. van der Heijden, G. Reid, J.H. Beijnen, J. Wijnholds, and P. Borst J. Biol. Chem. 278 2003 17664
- (2003) J. Biol. Chem. , vol.278 , pp. 17664
- Wielinga, P.R.¹ Van Der Heijden, I.² Reid, G.³ Beijnen, J.H.⁴ Wijnholds, J.⁵ Borst, P.⁶

2
- 80053384655
- Springer Berlin
- S.H. Francis, M. Conti, and M.D. Houslay Phosphodiesterases as Drug Targets 2011 Springer Berlin
- (2011) Phosphodiesterases As Drug Targets
- Francis, S.H.¹ Conti, M.² Houslay, M.D.³

3
- 79955664087
- S.H. Francis, M.A. Blount, and J.D. Corbin Physiol. Rev. 91 2011 651
- (2011) Physiol. Rev. , vol.91 , pp. 651
- Francis, S.H.¹ Blount, M.A.² Corbin, J.D.³

4
- 33748686575
- A.T. Bender, and J.A. Beavo Pharmacol. Rev. 58 2006 488
- (2006) Pharmacol. Rev. , vol.58 , pp. 488
- Bender, A.T.¹ Beavo, J.A.²

5
- 77956925425
- V. Lakics, E.H. Karran, and F.G. Boess Neuropharmacology 59 2010 367
- (2010) Neuropharmacology , vol.59 , pp. 367
- Lakics, V.¹ Karran, E.H.² Boess, F.G.³

6
- 0036717930
- D. Rotella Nat. Rev. Drug Discov. 1 2002 674
- (2002) Nat. Rev. Drug Discov. , vol.1 , pp. 674
- Rotella, D.¹

7
- 0035216330
- A. Robichaud, C. Savoie, P.B. Stamatiou, F.D. Tattersall, and C.C. Chan Neuropharmacology 40 2001 262
- (2001) Neuropharmacology , vol.40 , pp. 262
- Robichaud, A.¹ Savoie, C.² Stamatiou, P.B.³ Tattersall, F.D.⁴ Chan, C.C.⁵

8
- 0031591662
- J.C. Parker, M.A. VanVolkenburg, N.A. Nardone, D.M. Hargrove, and K.M. Andrews Biochem. Biophys. Res. Commun. 236 1997 665
- (1997) Biochem. Biophys. Res. Commun. , vol.236 , pp. 665
- Parker, J.C.¹ Vanvolkenburg, M.A.² Nardone, N.A.³ Hargrove, D.M.⁴ Andrews, K.M.⁵

9
- 18644376713
- D.T. Manallack, R.A. Hughes, and P.E. Thompson J. Med. Chem. 48 2005 3449
- (2005) J. Med. Chem. , vol.48 , pp. 3449
- Manallack, D.T.¹ Hughes, R.A.² Thompson, P.E.³

10
- 84891746383
- From http://www.clinicaltrials.gov.

11
- 77957606223
- L.M. Fabbri, B. Beghé, U. Yasothan, and P. Kirkpatrick Nat. Rev. Drug. Discov. 9 2010 761
- (2010) Nat. Rev. Drug. Discov. , vol.9 , pp. 761
- Fabbri, L.M.¹ Beghé, B.² Yasothan, U.³ Kirkpatrick, P.⁴

12
- 0017120229
- U. Schwabe, M. Miyake, Y. Ohga, and J.M. Daly Mol. Pharmacol. 12 1976 900
- (1976) Mol. Pharmacol. , vol.12 , pp. 900
- Schwabe, U.¹ Miyake, M.² Ohga, Y.³ Daly, J.M.⁴

13
- 0034892150
- M. Aoki, M. Fukunaga, T. Sugimoto, Y. Hirano, M. Kobayashi, K. Honda, and T. Yamada J. Pharmacol. Exp. Ther. 298 2001 1142
- (2001) J. Pharmacol. Exp. Ther. , vol.298 , pp. 1142
- Aoki, M.¹ Fukunaga, M.² Sugimoto, T.³ Hirano, Y.⁴ Kobayashi, M.⁵ Honda, K.⁶ Yamada, T.⁷

14
- 23744451716
- K.F. Rabe, E.D. Bateman, D. O'Donnell, S. Witte, D. Bredenbröker, and T.D. Bethke Lancet 366 2005 563
- (2005) Lancet , vol.366 , pp. 563
- Rabe, K.F.¹ Bateman, E.D.² O'Donnell, D.³ Witte, S.⁴ Bredenbröker, D.⁵ Bethke, T.D.⁶

15
- 55949132109
- J.A. Siuciak CNS Drugs 22 2008 983
- (2008) CNS Drugs , vol.22 , pp. 983
- Siuciak, J.A.¹

16
- 69049103114
- P.R. Verhoest, D.S. Chapin, M. Corman, K. Fonseca, J.F. Harms, X. Hou, E.S. Marr, F.S. Menniti, F. Nelson, R. O'Connor, J. Pandit, C. Proulx-LaFrance, A.W. Schmidt, C.J. Schmidt, J.A. Suiciak, and S. Liras J. Med. Chem. 52 2009 5188
- (2009) J. Med. Chem. , vol.52 , pp. 5188
- Verhoest, P.R.¹ Chapin, D.S.² Corman, M.³ Fonseca, K.⁴ Harms, J.F.⁵ Hou, X.⁶ Marr, E.S.⁷ Menniti, F.S.⁸ Nelson, F.⁹ O'Connor, R.¹⁰ Pandit, J.¹¹ Proulx-Lafrance, C.¹² Schmidt, A.W.¹³ Schmidt, C.J.¹⁴ Suiciak, J.A.¹⁵ Liras, S.¹⁶

17
- 84655170136
- S.-W. Yang, J. Smotryski, W.T. McElroy, Z. Tan, G. Ho, D. Tulshian, W.J. Greenlee, M. Guzzi, X. Zhang, D. Mullins, L. Xiao, A. Hruza, T.-M. Chan, D. Rindgen, C. Bleickardt, and R. Hodgson Bioorg. Med. Chem. Lett. 22 2012 235
- (2012) Bioorg. Med. Chem. Lett. , vol.22 , pp. 235
- Yang, S.-W.¹ Smotryski, J.² McElroy, W.T.³ Tan, Z.⁴ Ho, G.⁵ Tulshian, D.⁶ Greenlee, W.J.⁷ Guzzi, M.⁸ Zhang, X.⁹ Mullins, D.¹⁰ Xiao, L.¹¹ Hruza, A.¹² Chan, T.-M.¹³ Rindgen, D.¹⁴ Bleickardt, C.¹⁵ Hodgson, R.¹⁶

18
- 84862811342
- E. Hu, R.K. Kunz, S. Rumfelt, N. Chen, R. Bürli, C. Li, K.L. Andrews, J. Zhang, S. Chmait, J. Kogan, M. Lindstrom, S.A. Hitchcock, and J. Treanor Bioorg. Med. Chem. Lett. 22 2012 2262
- (2012) Bioorg. Med. Chem. Lett. , vol.22 , pp. 2262
- Hu, E.¹ Kunz, R.K.² Rumfelt, S.³ Chen, N.⁴ Bürli, R.⁵ Li, C.⁶ Andrews, K.L.⁷ Zhang, J.⁸ Chmait, S.⁹ Kogan, J.¹⁰ Lindstrom, M.¹¹ Hitchcock, S.A.¹² Treanor, J.¹³

19
- 84857355907
- U. Bauer, F. Giordanetto, M. Bauer, G. O'Mahony, K.E. Johansson, W. Knecht, J. Hartleib-Geschwindner, E. Töppner Carlsson, and C. Enroth Bioorg. Med. Chem. Lett. 22 2012 1944
- (2012) Bioorg. Med. Chem. Lett. , vol.22 , pp. 1944
- Bauer, U.¹ Giordanetto, F.² Bauer, M.³ O'Mahony, G.⁴ Johansson, K.E.⁵ Knecht, W.⁶ Hartleib-Geschwindner, J.⁷ Töppner Carlsson, E.⁸ Enroth, C.⁹

20
- 80455140545
- M.S. Malamas, Y. Ni, J. Erdei, H. Stange, R. Schindler, H.-J. Lankau, C. Grunwald, K. Yi Fan, K. Parris, B. Langen, U. Egerland, T. Hage, K.L. Marquis, S. Grauer, J. Brennan, R. Navarra, R. Graf, B.L. Harrison, A. Robichaud, T. Kronbach, M.N. Pangalos, N. Hoefgen, and N.J. Brandon J. Med. Chem. 54 2011 7621
- (2011) J. Med. Chem. , vol.54 , pp. 7621
- Malamas, M.S.¹ Ni, Y.² Erdei, J.³ Stange, H.⁴ Schindler, R.⁵ Lankau, H.-J.⁶ Grunwald, C.⁷ Yi Fan, K.⁸ Parris, K.⁹ Langen, B.¹⁰ Egerland, U.¹¹ Hage, T.¹² Marquis, K.L.¹³ Grauer, S.¹⁴ Brennan, J.¹⁵ Navarra, R.¹⁶ Graf, R.¹⁷ Harrison, B.L.¹⁸ Robichaud, A.¹⁹ Kronbach, T.²⁰ more..

21
- 79957805368
- J. Kehler, A. Ritzen, M. Langgård, S.L. Petersen, M.M. Farah, C. Bundgaard, C.T. Christoffersen, J. Nielsen, and J.P. Kilburn Bioorg. Med. Chem. Lett. 21 2011 3738
- (2011) Bioorg. Med. Chem. Lett. , vol.21 , pp. 3738
- Kehler, J.¹ Ritzen, A.² Langgård, M.³ Petersen, S.L.⁴ Farah, M.M.⁵ Bundgaard, C.⁶ Christoffersen, C.T.⁷ Nielsen, J.⁸ Kilburn, J.P.⁹

22
- 61849162798
- K. Kadoshima-Yamaoka, M. Murakawa, M. Goto, Y. Tanaka, H. Inoue, H. Murafuji, A. Nagahira, Y. Hayashi, K. Nagahira, K. Miura, T. Nakatsuka, K. Chamoto, Y. Fukuda, and T. Nishimura Immunol. Lett. 122 2009 193
- (2009) Immunol. Lett. , vol.122 , pp. 193
- Kadoshima-Yamaoka, K.¹ Murakawa, M.² Goto, M.³ Tanaka, Y.⁴ Inoue, H.⁵ Murafuji, H.⁶ Nagahira, A.⁷ Hayashi, Y.⁸ Nagahira, K.⁹ Miura, K.¹⁰ Nakatsuka, T.¹¹ Chamoto, K.¹² Fukuda, Y.¹³ Nishimura, T.¹⁴

23
- 61849084263
- J. Guo, A. Watson, J. Kempson, M. Carlsen, J. Barbosa, K. Stebbins, D. Lee, J. Dodd, S.G. Nadler, M. McKinnon, J. Barrish, and W.J. Pitts Bioorg. Med. Chem. Lett. 19 2009 1935
- (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 1935
- Guo, J.¹ Watson, A.² Kempson, J.³ Carlsen, M.⁴ Barbosa, J.⁵ Stebbins, K.⁶ Lee, D.⁷ Dodd, J.⁸ Nadler, S.G.⁹ McKinnon, M.¹⁰ Barrish, J.¹¹ Pitts, W.J.¹²

24
- 80054760374
- R. Gewald, C. Rueger, C. Grunwald, U. Egerland, and N. Hoefgen Bioorg. Med. Chem. Lett. 21 2011 6652
- (2011) Bioorg. Med. Chem. Lett. , vol.21 , pp. 6652
- Gewald, R.¹ Rueger, C.² Grunwald, C.³ Egerland, U.⁴ Hoefgen, N.⁵

25
- 84859865682
- A. Banerjee, P.S. Yadav, M. Bajpai, R.R. Sangana, S. Gullapalli, G.S. Gudi, and L.A. Gharat Bioorg. Med. Chem. Lett. 22 2012 3223
- (2012) Bioorg. Med. Chem. Lett. , vol.22 , pp. 3223
- Banerjee, A.¹ Yadav, P.S.² Bajpai, M.³ Sangana, R.R.⁴ Gullapalli, S.⁵ Gudi, G.S.⁶ Gharat, L.A.⁷

26
- 79955559601
- M.P. DeNinno, S.W. Wright, M.S. Visser, J.B. Etienne, D.E. Moore, T.V. Olson, B.N. Rocke, M.P. Andrews, C. Zarbo, M. Millham, B.P. Boscoe, D.D. Boyer, S.D. Doran, and K.L. Houseknecht Bioorg. Med. Chem. Lett. 21 2011 3095
- (2011) Bioorg. Med. Chem. Lett. , vol.21 , pp. 3095
- Deninno, M.P.¹ Wright, S.W.² Visser, M.S.³ Etienne, J.B.⁴ Moore, D.E.⁵ Olson, T.V.⁶ Rocke, B.N.⁷ Andrews, M.P.⁸ Zarbo, C.⁹ Millham, M.¹⁰ Boscoe, B.P.¹¹ Boyer, D.D.¹² Doran, S.D.¹³ Houseknecht, K.L.¹⁴

27
- 84865149965
- M.P. DeNinno, S.W. Wright, J.B. Etienne, T.V. Olson, B.N. Rocke, J.W. Corbett, D.W. Kung, K.J. DiRico, K.M. Andrews, M.L. Millham, J.C. Parker, W. Esler, M. Van Volkenburg, D.D. Boyer, K.L. Houseknecht, and S.D. Doran Bioorg. Med. Chem. Lett. 22 2012 5721
- (2012) Bioorg. Med. Chem. Lett. , vol.22 , pp. 5721
- Deninno, M.P.¹ Wright, S.W.² Etienne, J.B.³ Olson, T.V.⁴ Rocke, B.N.⁵ Corbett, J.W.⁶ Kung, D.W.⁷ Dirico, K.J.⁸ Andrews, K.M.⁹ Millham, M.L.¹⁰ Parker, J.C.¹¹ Esler, W.¹² Van Volkenburg, M.¹³ Boyer, D.D.¹⁴ Houseknecht, K.L.¹⁵ Doran, S.D.¹⁶

28
- 27844464469
- F. Wunder, A. Tersteegen, A. Rebmann, C. Erb, T. Fahrig, and M. Hendrix Mol. Pharmacol. 68 2005 1775
- (2005) Mol. Pharmacol. , vol.68 , pp. 1775
- Wunder, F.¹ Tersteegen, A.² Rebmann, A.³ Erb, C.⁴ Fahrig, T.⁵ Hendrix, M.⁶

29
- 64249171797
- M.P. DeNinno, M. Andrews, A.S. Bell, Y. Chen, C. Eller-Zarbo, N. Eshelby, J.B. Etienne, D.E. Moore, M.J. Palmer, M.S. Visser, L.J. Yu, W.J. Zavadoski, and E.M. Gibbs Bioorg. Med. Chem. Lett. 19 2009 2537
- (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 2537
- Deninno, M.P.¹ Andrews, M.² Bell, A.S.³ Chen, Y.⁴ Eller-Zarbo, C.⁵ Eshelby, N.⁶ Etienne, J.B.⁷ Moore, D.E.⁸ Palmer, M.J.⁹ Visser, M.S.¹⁰ Yu, L.J.¹¹ Zavadoski, W.J.¹² Gibbs, E.M.¹³

30
- 77953675980
- T.T. Wager, X. Hou, P.R. Verhoest, and A. Villalobos ACS Chem. Neurosci. 1 2010 435
- (2010) ACS Chem. Neurosci. , vol.1 , pp. 435
- Wager, T.T.¹ Hou, X.² Verhoest, P.R.³ Villalobos, A.⁴

31
- 73249130591
- P.R. Verhoest, C. Proulx-Lafrance, M. Corman, L. Chenard, C.J. Helal, X. Hou, R. Kleiman, S. Liu, E. Marr, F.S. Menniti, C.J. Schmidt, M. Vanase-Frawley, A.W. Schmidt, R.D. Williams, F.R. Nelson, K.R. Fonseca, and S. Liras J. Med. Chem. 52 2009 7946
- (2009) J. Med. Chem. , vol.52 , pp. 7946
- Verhoest, P.R.¹ Proulx-Lafrance, C.² Corman, M.³ Chenard, L.⁴ Helal, C.J.⁵ Hou, X.⁶ Kleiman, R.⁷ Liu, S.⁸ Marr, E.⁹ Menniti, F.S.¹⁰ Schmidt, C.J.¹¹ Vanase-Frawley, M.¹² Schmidt, A.W.¹³ Williams, R.D.¹⁴ Nelson, F.R.¹⁵ Fonseca, K.R.¹⁶ Liras, S.¹⁷

32
- 33847068206
- K. Omori, and J. Kotera Circ. Res. 100 2007 309
- (2007) Circ. Res. , vol.100 , pp. 309
- Omori, K.¹ Kotera, J.²

33
- 33847689816
- H. Ke, and H. Wang Curr. Top. Med. Chem. 7 2007 391
- (2007) Curr. Top. Med. Chem. , vol.7 , pp. 391
- Ke, H.¹ Wang, H.²

34
- 71249129667
- C.C. Heikaus, J. Pandit, and R.E. Klevit Structure 17 2009 1551
- (2009) Structure , vol.17 , pp. 1551
- Heikaus, C.C.¹ Pandit, J.² Klevit, R.E.³

35
- 50349084137
- N. Handa, E. Mizohata, S. Kishishita, M. Toyama, S. Morita, T. Uchikubo-Kamo, R. Akasaka, K. Omori, J. Kotera, T. Terada, M. Shirouzu, and S. Yokoyama J. Biol. Chem. 283 2008 19657
- (2008) J. Biol. Chem. , vol.283 , pp. 19657
- Handa, N.¹ Mizohata, E.² Kishishita, S.³ Toyama, M.⁴ Morita, S.⁵ Uchikubo-Kamo, T.⁶ Akasaka, R.⁷ Omori, K.⁸ Kotera, J.⁹ Terada, T.¹⁰ Shirouzu, M.¹¹ Yokoyama, S.¹²

36
- 15744369740
- R. Zoraghi, E.P. Bessay, J.D. Corbin, and S.H. Francis J. Biol. Chem. 280 2005 12051
- (2005) J. Biol. Chem. , vol.280 , pp. 12051
- Zoraghi, R.¹ Bessay, E.P.² Corbin, J.D.³ Francis, S.H.⁴

37
- 0026316323
- S.D. Stroop, and J.A. Beavo J. Biol. Chem. 266 1991 23802
- (1991) J. Biol. Chem. , vol.266 , pp. 23802
- Stroop, S.D.¹ Beavo, J.A.²

38
- 0025041146
- M.K. Thomas, S.H. Francis, and J.D. Corbin J. Biol. Chem. 265 1990 14964
- (1990) J. Biol. Chem. , vol.265 , pp. 14964
- Thomas, M.K.¹ Francis, S.H.² Corbin, J.D.³

39
- 70849084890
- J. Pandit, M.D. Forman, K.F. Fennell, K.S. Dillman, and F.S. Menniti Proc. Natl. Acad. Sci. U.S.A. 106 2009 18225
- (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 18225
- Pandit, J.¹ Forman, M.D.² Fennell, K.F.³ Dillman, K.S.⁴ Menniti, F.S.⁵

40
- 74049158987
- A.B. Burgin, O.T. Magnusson, J. Singh, P. Witte, B.L. Staker, J.M. Bjornsson, M. Thorsteinsdottir, S. Hrafnsdottir, T. Hagen, A.S. Kiselyov, L.J. Stewart, and M.E. Gurney Nat. Biotechnol. 28 2010 63
- (2010) Nat. Biotechnol. , vol.28 , pp. 63
- Burgin, A.B.¹ Magnusson, O.T.² Singh, J.³ Witte, P.⁴ Staker, B.L.⁵ Bjornsson, J.M.⁶ Thorsteinsdottir, M.⁷ Hrafnsdottir, S.⁸ Hagen, T.⁹ Kiselyov, A.S.¹⁰ Stewart, L.J.¹¹ Gurney, M.E.¹²

41
- 33749059769
- J. Bingham, S. Sudarsanam, and S. Srinivasan Biochem. Biophys. Res. Commun. 350 2006 25
- (2006) Biochem. Biophys. Res. Commun. , vol.350 , pp. 25
- Bingham, J.¹ Sudarsanam, S.² Srinivasan, S.³

42
- 0141425593
- P. Wang, P. Wu, R.W. Egan, and M. Billah Gene 314 2003 15
- (2003) Gene , vol.314 , pp. 15
- Wang, P.¹ Wu, P.² Egan, R.W.³ Billah, M.⁴

43
- 0037436281
- C. Rentero, A. Monfort, and P. Puigdomenech Biochem. Biophys. Res. Commun. 301 2003 686
- (2003) Biochem. Biophys. Res. Commun. , vol.301 , pp. 686
- Rentero, C.¹ Monfort, A.² Puigdomenech, P.³

44
- 21744442922
- W. Richter, S.-L.C. Jin, and M. Conti Biochem. J. 388 2005 803
- (2005) Biochem. J. , vol.388 , pp. 803
- Richter, W.¹ Jin, S.-L.C.² Conti, M.³

45
- 84867852661
- S.H. Francis, M. Conti, M.D. Houslay, Springer Berlin
- J.E. Schultz, T. Dunkern, and E. Gawlitta-Gorka S.H. Francis, M. Conti, M.D. Houslay, Phosphodiesterases as Drug Targets 2011 Springer Berlin
- (2011) Phosphodiesterases As Drug Targets
- Schultz, J.E.¹ Dunkern, T.² Gawlitta-Gorka, E.³

46
- 84857743319
- J.W. Scannell, A. Blanckley, H. Boldon, and B. Warrington Nat. Rev. Drug Discov. 11 2012 191
- (2012) Nat. Rev. Drug Discov. , vol.11 , pp. 191
- Scannell, J.W.¹ Blanckley, A.² Boldon, H.³ Warrington, B.⁴

47
- 79959929769
- D.C. Swinney, and J. Anthony Nat. Rev. Drug Discov. 10 2011 507
- (2011) Nat. Rev. Drug Discov. , vol.10 , pp. 507
- Swinney, D.C.¹ Anthony, J.²

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.