Profiling human phosphodiesterase genes and splice isoforms

Biochemical and Biophysical Research Communications

Volumn 350, Issue 1, 2006, Pages 25-32

  Bingham, Jonathan ^a   Sudarsanam, Sucha ^b   Srinivasan, Subha ^a  

^a Jivan Biologics Inc   (United States)

^b Emiliem Inc   (United States)

Author keywords

Array; Expression; Gene; Isoform; Microarray; PDE; Phosphodiesterase; Profile; Splice variant; Splicing

Indexed keywords

ISOENZYME; PHOSPHODIESTERASE; PHOSPHODIESTERASE 10A; PHOSPHODIESTERASE 11A; PHOSPHODIESTERASE 1A; PHOSPHODIESTERASE 1C; PHOSPHODIESTERASE 2A; PHOSPHODIESTERASE 4B; PHOSPHODIESTERASE 4C; PHOSPHODIESTERASE 4D; PHOSPHODIESTERASE 5A; PHOSPHODIESTERASE 7A; PHOSPHODIESTERASE 8A; PHOSPHODIESTERASE 8B; PHOSPHODIESTERASE 9A; UNCLASSIFIED DRUG;

ALTERNATIVE RNA SPLICING; ARTICLE; CONTROLLED STUDY; DNA MICROARRAY; DNA PROBE; EXON; EXPRESSED SEQUENCE TAG; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENETIC TRANSCRIPTION; HUMAN; HUMAN TISSUE; MALE; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; SKELETAL MUSCLE; UNINDEXED SEQUENCE;

1-METHYL-3-ISOBUTYLXANTHINE; ALTERNATIVE SPLICING; CALCIUM; CALMODULIN; CYCLIC AMP; CYCLIC GMP; ENZYME ACTIVATION; EXONS; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMANS; ISOENZYMES; PHOSPHORIC DIESTER HYDROLASES; SENSITIVITY AND SPECIFICITY;

EID: 33749059769     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.08.180     Document Type: Article

References (33)

1. Rena G., Begg F., Ross A., MacKenzie C., McPhee I., Campbell L., Huston E., Sullivan M., and Houslay M.D. Molecular cloning, genomic positioning, promoter identification, and characterization of the novel cyclic amp-specific phosphodiesterase PDE4A10. Mol. Pharmacol. 59 5 (2001) 996-1011
2. Wang P., Wu P., Egan R.W., and Billah M.M. Identification and characterization of a new human type 9 cGMP-specific phosphodiesterase splice variant (PDE9A5). Differential tissue distribution and subcellular localization of PDE9A variants. Gene 314 (2003) 15-27
3. Hansen G., et al. Absence of muscarinic cholinergic airway responses in mice deficient in the cyclic nucleotide phosphodiesterase PDE4D. Proc. Natl. Acad. Sci. USA 97 12 (2000) 6751-6756
4. Okada S., Ohshima K., and Mori M. Phosphodiesterase 3 (PDE3) attenuates insulin secretion from the human pancreas: a specific PDE3 inhibitor improves insulin secretion in type II diabetes mellitus. Endocr. J. 49 5 (2002) 581-582
5. Masciarelli S., et al. Cyclic nucleotide phosphodiesterase 3A-deficient mice as a model of female infertility. J. Clin. Invest. 114 2 (2004) 196-205
6. Zhang H.T., Huang Y., Jin S.L., Frith S.A., Suvarna N., Conti M., and O'Donnell J.M. Antidepressant-like profile and reduced sensitivity to rolipram in mice deficient in the PDE4D phosphodiesterase enzyme. Neuropsychopharmacology 27 4 (2002) 587-595
7. Gibson L.C., Hastings S., McPhee I., Clayton R.A., Darroch C.E., Mackenzie A., Mackenzie F.L., Nagasawa M., Stevens P.A., and Mackenzie S.J. Abstract: the inhibitory profile of Ibudilast against the human phosphodiesterase enzyme family. Eur. J. Pharmacol. 538 1-3 (2006) 39-42
8. Giembycz M.A. Phosphodiesterase-4: selective and dual-specificity inhibitors for the therapy and chronic obstructive pulmonary disease. Proc. American Thoracic Soc. 2 (2005) 326-333
9. Clark T.A., Sungnet C., and Ares Jr. M. Genomewide analysis of mRNA processing in yeast using splicing-specific microarrays. Science 296 5569 (2002) 907-910
10. J.M. Johnson, J. Castle, P. Garrett-Engele, P.M. Loerch, Z. Kan, C.D. Armour, R. Santos, E.E. Schadt, R. Stoughton, D.D. Shoemaker, Rosetta (Merck) Splicing Experiment, Chip 1 of 5, 2003.
11. Packer J., and David P.-S. Drug target database: knowledge management exemplified through a gene family approach. BioFocus plc. (2002)
12. 2+/calmodulin-dependent phosphodiesterase PDE1A novel splice variants, their specific expresion, genomic organization, and chromosomal localization. Biochim. Biophys. Acta 1517 2 (2001) 278-287
13. Loughney K., Hill T., Florio V.A., Uher L., Rosman G.J., Wolda S.L., Jones B.A., Howard M.L., McAllister-Lucas L.M., Sonnenburg W.K., Francis S.H., Corbin J.D., Beavo J.A., and Ferguson K. Isolation and characterization of cDNAs encoding PDE5A, a human cGMP-binding, cGMP-specific 3′,5′-cyclic nucleotide phosphodiesterase. Gene 216 1 (1998) 139-147
14. 2+/calmodulin-stimulated phosphodiesterase (PDE1A). Cell Signal 11 7 (1999) 535-544
15. Yan C., et al. Stage and cell-specific expression of calmodulin-dependent phosphodiesterases in mouse testis. Biol. Reprod. 64 6 (2001) 1746-1754
16. Fidock M., Miller M., and Lanfear J. Isolation and differential tissue distribution of two human cDNAs encoding PDE1 splice variants. Neuroendocrinology 68 6 (1998) 365-373
17. Kostic M.M., Erdogan S., Rena G., Borchert G., Hoch B., Bartel S., Scotland G., Huston E., Houslay M.D., and Krause E.G. Abstract Altered expression of PDE1 and PDE4 cyclic nucleotide phosphodiesterase isoforms in 7-oxo-prostacyclin-preconditioned rat heart. J. Mol. Cell Cardiol. 29 11 (1997) 3135-3146
18. Yan C., Zhao A., Bentley J.K., and Beavo J.A. The calmodulin-dependent phosphodiesterase gene PDE1C encodes several functionally different splice variants in a tissue-specific manner. J. Biol. Chem. 11271 41 (1996) 25699-25706
19. Iffland A., Kohls D., Low S., Luan J., Zhang Y., Kothe M., Cao Q., Kamath A.V., Ding Y.H., and Ellenberger T. Structural determinants for inhibitor specificity and selectivity in PDE2A using the wheat germ in vitro translation system. Biochemistry 44 23 (2005) 8312-8325
20. Sadhu K., Hensley K., Florio V.A., and Wolda S.L. Differential expression of the cyclic GMP-stimulated phosphodiesterase PDE2A in human venous and capillary endothelial cells. J. Histochem. Cytochem. 47 7 (1999) 895-906
21. O'Donnell J., and Zhang H. Antidepressant effects of inhibitors of cAMP phosphodiesterases (PDE4). Trends Pharmacol. Sci. 25 3 (2004) 158-163
22. Obernolte R., Ratzliff J., Baecker P.A., Daniels D.V., Zuppan P., Jarnagin K., and Shelton E.R. Multiple splice variants of phosphodiesterase PDE4C cloned from human lung and testis. Biochim. Biophys. Acta 1353 3 (1997) 287-297
23. Yanaka N., Kotera J., Ohtsuka A., Akatsuka H., Imai Y., Michibata H., Fujishige K., Kawai E., Takebayashi S., Okumura K., and Omori K. Expression, structure and chromosomal localization of the human cGMP-binding cGMP-specific phosphodiesterase PDE5A gene. Eur. J. Biochem. 255 2 (1998) 391-399
24. Han P., Zhu X., and Michaeli T. J. biol. Chem. 272 26 (1997) 16152-16157
25. Wang P., Wu P., Egan R.W., and Billah M.M. Cloning, characterization, and tissue distribution of mouse phosphodiesterase 7A1. Biochem. Biophys. Res. Commun. 276 3 (2000) 1271-1277
26. Hetman J.M., Soderling S., Glavas N.A., and Beavo J.A. Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase. Proc. Natl. Acad. Sci. USA 97 1 (2000) 472-476
27. Sasaki T., Kotera J., Yuasa K., and Omori K. Identification of human PDE7B, a cAMP-specific phosphodiesterase. Biochem. Biophys. Res. Commun. 271 3 (2000) 575-583
28. Hayashi M., Matsushima K., Ohashi H., Tsunoda H., Murase S., Kawarada Y., and Tanaka T. Molecular cloning and characterization of human PDE8B, a novel thyroid-specific isozyme of 3′,5′-cyclic nucleotide phosphodiesterase. Biochem. Biophys. Res. Commun. 250 3 (1998) 751-756
29. Hayashi M., Shimada Y., Nishimura Y., Hama T., and Tanaka T. Genomic organization, chromosomal localization, and alternative splicing of the human phosphodiesterase 8B gene. Biochem. Biophys. Res. Commun. 29 5 (2002) 1253-1258
30. Rentero C., Monfort A., and Puigdomenech P. Identification and distribution of different mRNA variants produced by differential splicing in the human phosphodiesterase 9A gene. Biochem. Biophys. Res. Commun. 301 3 (2003) 686-692
31. Fujishige K., Kotera J., and Omori K. Striatum- and testis-specific phosphodiesterase PDE10A isolation and characterization of a rat PDE10A. Eur. J. Biochem. 266 3 (1999) 1118-1127
32. Soderling S.H., Bayuga S., and Beavo J.A. Isolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A. Proc. Natl. Acad. Sci. USA 96 12 (1999) 7071-7076
33. Fawcett L., Baxendale R., Stacey P., McGrouther C., Harrow I., Soderling S., Hetman J., Beavo J.A., and Phillips S.C. Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A. Proc. Natl. Acad. Sci. USA 97 7 (2000) 3702-3707