Identification of potent pyrimidine inhibitors of phosphodiesterase 7 (PDE7) and their ability to inhibit T cell proliferation

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 7, 2009, Pages 1935-1938

  Guo, Junqing ^a   Watson, Andrew ^a   Kempson, James ^a   Carlsen, Marianne ^a   Barbosa, Joseph ^a   Stebbins, Karen ^a   Lee, Deborah ^a   Dodd, John ^a   Nadler, Steven G ^a   McKinnon, Murray ^a   Barrish, Joel ^a   Pitts, William J ^a  

^a BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

Author keywords

Phosphodiesterase 7; Pyrimidine; T cell

Indexed keywords

PHOSPHODIESTERASE VII INHIBITOR; PYRIMIDINE ANTAGONIST;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; T LYMPHOCYTE ACTIVATION;

ANIMALS; CELL PROLIFERATION; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 7; GENE KNOCKOUT TECHNIQUES; MICE; PHOSPHODIESTERASE INHIBITORS; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTES;

EID: 61849084263     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.02.060     Document Type: Article

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