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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 9, 2012, Pages 3223-3228

Isothiazole and isoxazole fused pyrimidones as PDE7 inhibitors: SAR and pharmacokinetic evaluation

(7) Banerjee, Abhisek a Yadav, Pravin S a Bajpai, Malini a Sangana, Ramachandra Rao a Gullapalli, Srinivas a Gudi, Girish S a Gharat, Laxmikant A a

a Glenmark Pharmaceuticals Limited (India)

Author keywords

CNS penetration; Isothiazolopyrimidone; Isoxazolopyrimidone; Parkinson's disease; Phosphodiesterase 7 inhibitors

Indexed keywords

ISOTHIAZOLE DERIVATIVE; ISOXAZOLE; PHOSPHODIESTERASE; PHOSPHODIESTERASE 10A; PHOSPHODIESTERASE 11A; PHOSPHODIESTERASE 1A; PHOSPHODIESTERASE 2A; PHOSPHODIESTERASE 3A; PHOSPHODIESTERASE 4D; PHOSPHODIESTERASE 5A; PHOSPHODIESTERASE 8A1; PHOSPHODIESTERASE 9A2; PHOSPHODIESTERASE VII; PHOSPHODIESTERASE VII INHIBITOR; PHOSPHODIESTERASE VIIA; PHOSPHODIESTERASE VIIB; PYRIMIDINONE DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CENTRAL NERVOUS SYSTEM; CYANATION; CYCLIZATION; DRUG METABOLISM; DRUG PENETRATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HECK REACTION; HUMAN; IC 50; LIVER MICROSOME; MALE; MAXIMUM PLASMA CONCENTRATION; METHYLATION; MITSUNOBU REACTION; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; SUZUKI REACTION; TIME TO MAXIMUM PLASMA CONCENTRATION;

CENTRAL NERVOUS SYSTEM; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 7; HUMANS; ISOXAZOLES; PARKINSON DISEASE; PHARMACOKINETICS; PHOSPHODIESTERASE INHIBITORS; PYRIMIDINONES; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 84859865682 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.03.025 Document Type: Article

Times cited : (19)

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