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Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 22, 2011, Pages 6652-6656

Synthesis and structure-activity relationship studies of dihydronaphthyridinediones as a novel structural class of potent and selective PDE7 inhibitors

(5) Gewald, Rainer a Rueger, Carla a Grunwald, Christian a Egerland, Ute a Hoefgen, Norbert a

a Biocrea GmbH (Germany)

Author keywords

Dihydronaphthyridinedione; Molecular docking; PDE7 inhibitor; Phosphodiesterase; Structure activity relationship

Indexed keywords

DIHYDRONAPHTHYRIDINEDIONE DERIVATIVE; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE VII INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG SELECTIVITY; DRUG STABILITY; DRUG SYNTHESIS; HYDROGEN BOND; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION;

ANIMALS; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 7; ENZYME INHIBITORS; HUMANS; MODELS, MOLECULAR; NAPHTHYRIDINES; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80054760374 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2011.09.065 Document Type: Article

Times cited : (18)

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