ASB16165, a novel inhibitor for phosphodiesterase 7A (PDE7A), suppresses IL-12-induced IFN-γ production by mouse activated T lymphocytes

Immunology Letters

Volumn 122, Issue 2, 2009, Pages 193-197

  Kadoshima Yamaoka, Kumiko ^a   Murakawa, Masao ^a   Goto, Megumi ^a   Tanaka, Yoshitaka ^a   Inoue, Hidekazu ^a   Murafuji, Hidenobu ^a   Nagahira, Asako ^a   Hayashi, Yasuhiro ^a   Nagahira, Kazuhiro ^a   Miura, Kenju ^a   Nakatsuka, Takashi ^a   Chamoto, Kenji ^b   Fukuda, Yoshiaki ^a   Nishimura, Takashi ^b  

^a DAIICHI SANKYO CO   (Japan)

^b Institute for Genetic Medicine   (Japan)

Author keywords

cAMP; Interferon (IFN ); Interleukin 12 (IL 12); Phosphodiesterase 7 (PDE7); T lymphoblast

Indexed keywords

1 CYCLOHEXYL N [6 (4 HYDROXY 1 PIPERIDINYL) 3 PYRIDINYL] 3 METHYL 1H THIENO[2,3 C]PYRAZOLE 5 CARBOXAMIDE; ASB 16165; BUCLADESINE; CD3 ANTIBODY; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; FORSKOLIN; GAMMA INTERFERON; INTERLEUKIN 12; PHOSPHODIESTERASE VII INHIBITOR; ROLIPRAM; TACROLIMUS; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CYTOKINE PRODUCTION; DRUG EFFECT; IC 50; IMMUNOSTIMULATION; INTERFERON PRODUCTION; LYMPHOCYTE FUNCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; SPLEEN CELL; T LYMPHOBLAST; T LYMPHOCYTE ACTIVATION;

8-BROMO CYCLIC ADENOSINE MONOPHOSPHATE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD3; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 7; INTERFERON-GAMMA; INTERLEUKIN-12; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; PYRAZOLES; ROLIPRAM; T-LYMPHOCYTES; THIONUCLEOTIDES; THIOPHENES;

EID: 61849162798     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imlet.2009.01.004     Document Type: Article

References (23)

1. Mehats C., Andersen C.B., Filopanti M., Jin S.L., and Conti M. Cyclic nucleotide phosphodiesterases and their role in endocrine cell signaling. Trends Endocrinol Metab 13 (2002) 29-35
2. Conti M., and Beavo J. Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling. Annu Rev Biochem 76 (2007) 481-511
3. Michaeli T., Bloom T.J., Martins T., Loughney K., Ferguson K., Riggs M., et al. Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiae. J Biol Chem 268 (1993) 12925-12932
4. Smith S.J., Brookes-Fazakerley S., Donnelly L.E., Barnes P.J., Barnette M.S., and Giembycz M.A. Ubiquitous expression of phosphodiesterase 7A in human proinflammatory and immune cells. Am J Physiol Lung Cell Mol Physiol 284 (2003) L279-289
5. Bloom T.J., and Beavo J.A. Identification and tissue-specific expression of PDE7 phosphodiesterase splice variants. Proc Natl Acad Sci USA 93 (1996) 14188-14192
6. Han P., Zhu X., and Michaeli T. Alternative splicing of the high affinity cAMP-specific phosphodiesterase (PDE7A) mRNA in human skeletal muscle and heart. J Biol Chem 272 (1997) 16152-16157
7. Lugnier C. Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the development of specific therapeutic agents. Pharmacol Ther 109 (2006) 366-398
8. Gardner C., Robas N., Cawkill D., and Fidock M. Cloning and characterization of the human and mouse PDE7B, a novel cAMP-specific cyclic nucleotide phosphodiesterase. Biochem Biophys Res Commun 272 (2000) 186-192
9. Hetman J.M., Soderling S.H., Glavas N.A., and Beavo J.A. Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase. Proc Natl Acad Sci USA 97 (2000) 472-476
10. Li L., Yee C., and Beavo J.A. CD3- and CD28-dependent induction of PDE7 required for T cell activation. Science 283 (1999) 848-851
11. Yang G., McIntyre K.W., Townsend R.M., Shen H.H., Pitts W.J., Dodd J.H., et al. Phosphodiesterase 7A-deficient mice have functional T cells. J Immunol 171 (2003) 6414-6420
12. Thompson W.J., Ross C.P., Pledger W.J., Strada S.J., Banner R.L., and Hersh E.M. Cyclic adenosine 3′:5′-monophosphate phosphodiesterase Distinct forms in human lymphocytes and monocytes. J Biol Chem 251 (1976) 4922-4929
13. Verghese M.W., McConnell R.T., Lenhard J.M., Hamacher L., and Jin S.L. Regulation of distinct cyclic AMP-specific phosphodiesterase (phosphodiesterase type 4) isozymes in human monocytic cells. Mol Pharmacol 47 (1995) 1164-1171
14. Dickensheets H.L., Freeman S.L., and Donnelly R.P. Interleukin-12 differentially regulates expression of IFN-gamma and interleukin-2 in human T lymphoblasts. J Interferon Cytokine Res 20 (2000) 897-905
15. Thierfelder W.E., van Deursen J.M., Yamamoto K., Tripp R.A., Sarawar S.R., Carson R.T., et al. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature 382 (1996) 171-174
16. Kaplan M.H., Sun Y.L., Hoey T., and Grusby M.J. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 382 (1996) 174-177
17. Liu L., Yen J.H., and Ganea D. A novel VIP signaling pathway in T cells cAMP → protein tyrosine phosphatase (SHP-2?) → JAK2/STAT4 → Th1 differentiation. Peptides 28 (2007) 1814-1824
18. Nakata A., Ogawa K., Sasaki T., Koyama N., Wada K., Kotera J., et al. Potential role of phosphodiesterase 7 in human T cell function: comparative effects of two phosphodiesterase inhibitors. Clin Exp Immunol 128 (2002) 460-466
19. Jones N.A., Leport M., Holand T., Vos T., Morgan M., Fink M., et al. Phosphodiesterase (PDE) 7 in inflammatory cells from patients with asthma and COPD. Pulm Pharmacol Ther 20 (2007) 60-68
20. Smith S.J., Cieslinski L.B., Newton R., Donnelly L.E., Fenwick P.S., Nicholson A.G., et al. Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a selective inhibitor of phosphodiesterase 7: in vitro studies in human monocytes, lung macrophages, and CD8+ T-lymphocytes. Mol Pharmacol 66 (2004) 1679-1689
21. Nueda A., Garcia-Roger N., Domenech T., Godessart N., Cardenas A., Santamaria-Babi L.F., et al. Phosphodiesterase 7A1 is expressed in human CD4+ naive T cells at higher levels than in CD4+ memory cells and is not required during their CD3/CD28-dependent activation. Cell Immunol 242 (2006) 31-38
22. Kusaba H., Ghosh P., Derin R., Buchholz M., Sasaki C., Madara K., et al. Interleukin-12-induced interferon-gamma production by human peripheral blood T cells is regulated by mammalian target of rapamycin (mTOR). J Biol Chem 280 (2005) 1037-1043
23. Wittmann M., Killig C., Bruder M., Gutzmer R., and Werfel T. Critical involvement of IL-12 in IFN-gamma induction by calcineurin antagonists in activated human lymphocytes. J Leukoc Biol 80 (2006) 75-86