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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 5, 2012, Pages 1944-1948

Discovery of 4-hydroxy-1,6-naphthyridine-3-carbonitrile derivatives as novel PDE10A inhibitors

(9) Bauer, Udo a Giordanetto, Fabrizio a Bauer, Martin a O'Mahony, Gavin a Johansson, Kjell E a Knecht, Wolfgang a Hartleib Geschwindner, Judith a Carlsson, Eva Töppner a Enroth, Cristofer b

a ASTRAZENECA R AND D (Sweden)

b Department of Natural Sciences (Sweden)

Author keywords

Enzyme inhibitor; Hit to lead; Naphthyridine; PDE10A; Phosphodiesterase

Indexed keywords

4 HYDROXY 1,6 NAPHTHYRIDINE 3 CARBONITRILE DERIVATIVE; LIGAND; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE IX A INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; LIPOPHILICITY; MOLECULAR INTERACTION; X RAY CRYSTALLOGRAPHY;

ANTIPSYCHOTIC AGENTS; HUMANS; MODELS, MOLECULAR; NAPHTHYRIDINES; NITRILES; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84857355907 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.01.046 Document Type: Article

Times cited : (28)

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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.