Smoothened antagonists for hair inhibition

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 16, 2010, Pages 4932-4935

  Li, Jie Jack ^a,b   Shanmugasundaram, Veerabahu ^a   Reddy, Satya ^a   Fleischer, Laura L ^a   Wang, Zenquan ^a   Smith, Yvonne ^a   Harter, William G ^a   Yue, Wen Song ^a   Swaroop, Manju ^a   Li, Ling ^a   Ji, Christy Xiaodong ^a   Dettling, Danielle ^a   Osak, Bella ^a   Fitzgerald, Laura R ^a   Conradi, Robert ^a  

^a PFIZER INC   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

Aminomethylpyrazoles; Hair; Photo irritation; Smoothened antagonists

Indexed keywords

AMINOMETHYLPYRAZOLE DERIVATIVE; EFLORNITHINE; PYRAZOLE DERIVATIVE; SMOOTHENED PROTEIN; UNCLASSIFIED DRUG; AZETIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG SELECTIVITY; DRUG SYNTHESIS; GROWTH STIMULATION; HAIR GROWTH; IC 50; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; ANIMAL; CHEMISTRY; DRUG EFFECTS; GROWTH, DEVELOPMENT AND AGING; HAIR; KNOCKOUT MOUSE; SYNTHESIS;

ANIMALS; AZETIDINES; EFLORNITHINE; HAIR; MICE; MICE, KNOCKOUT; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77955415312     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.06.033     Document Type: Article

References (28)

1. E.B. Lewis Nature 276 1978 565
2. C. Nüsslein-Volhard, and E. Wieschaus Nature 287 1980 795
3. For a review, see: P.W. Ingham EMBO J. 17 1998 3505
4. For a review, see: G.V. Borzillo, and B. Lippa Curr. Top. Med. Chem. 5 2005 147
5. J.K. Chen, J. Taipale, M.K. Cooper, and P.A. Beachy Genes Dev. 16 2002 2743
6. M.R. Tremblay, A. Lescarbeau, M.J. Grogan, E. Tan, G. Lin, and B.C. Austad J. Med. Chem. 52 2009 4400
7. K.D. Robarge, S.A. Brunton, G.M. Castanedo, Y. Cui, M.S. Dina, and R. Goldsmith Bioorg. Med. Chem. Lett. 19 2009 5576
8. J.K. Chen, J. Taipale, K.E. Young, T. Maiti, and P.A. Beachy Proc. Natl. Acad. Sci. U.S.A. 99 2002 14071
9. For a review, see: A. Dlugosz J. Clin. Invest. 104 1999 851
10. P. Mill, R. Mo, H. Fu, M. Grachtchouk, P.C.W. Kim, A.A. Dlugosz, and C.C. Hui Genes Dev. 17 2003 282
11. A.E. Oro, and K. Higgins Dev. Biol. 255 2003 238
12. A. Brancaccio, A. Minichiello, M. Grachtchouk, D. Antonini, H. Sheng, R. Parlato, N. Dathan, A.A. Dlugosz, and C. Missero Hum. Mol. Genet. 13 2004 2595
13. M.E. Hutchin, M.S.T. Kariapper, M. Grachtchouk, A. Wang, L. Wei, D. Cummings, J. Liu, L.E. Michael, A. Glick, and A.A. Dlugosz Genes Dev. 19 2005 214
14. T. Sagai, H. Masuya, M. Tamura, K. Shimizu, Y. Yada, S. Wakana, Y. Gondo, T. Noda, and T. Shiroishi Mamm. Genome 15 2004 23
15. R.D. Paladini, J. Saleh, C. Qian, G.-X. Xu, and L.L. Rubin J. Invest. Dermatol. 125 2005 638
16. J. Jackson, J.J. Caro, G. Caro, F. Garfield, F. Huber, W. Zhou, C.-S. Lin, D. Shander, and K. Schrode Int. J. Dermatol. 46 2007 976
17. C3H/HeN mouse hair growth model: J. Jiang, R. Tsuboi, Y. Kojima, and H. Ogawa Dermatology 32 2005 243
18. B. Osak, and L.R. Fitzgerald Assay Drug Dev. Technol. 5 2007 785
19. 50.
20. P.R. Ortiz de Montellano, O. Augusto, F. Viola, and K.L. Kunze J. Biol. Chem. 258 1983 8623
21. B. Kalyanaraman, and B.K. Sinha Environ. Health Perspect. 64 1985 179
22. S.D. Nelson J. Med. Chem. 25 1982 753
23. A.J. Streeter, and J.A. Timbrell Drug Metab. Dispos. 11 1983 179
24. J.A. Timbrell Drug Metab. Rev. 10 1979 125
25. R.A. Prough, M.W. Coomes, S.W. Cummings, and P. Wiebkin Adv. Exp. Med. Biol. 136B 1982 983
26. C. Nam, S. An, E. Lee, S. Moon, J. Kang, and I. Chang ATLA, Altern. Lab. Anim. 32 2004 693
27. Spielmann, H.; Presented at Alternatives to Animal Testing II, Proceedings of the Second International Scientific Conference, Brussels, 1999, 15.
28. Franz diffusion chambers: C. Antille, C. Tran, O. Sorg, and J.-H. Saurat Exp. Dermatol. 13 2004 558