A role for cGMP in inducible nitric-oxide synthase (iNOS)-induced tumor necrosis factor (TNF) α-converting enzyme (TACE/ADAM17) activation, translocation,and TNF receptor 1 (TNFR1) shedding in hepatocytes

Journal of Biological Chemistry

Volumn 287, Issue 43, 2012, Pages 35887-35898

  Chanthaphavong, R Savanh ^a   Loughran, Patricia A ^a   Lee, Tiffany Y S ^a   Scott, Melanie J ^a   Billiar, Timothy R ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONVERTING ENZYME; DEATH-INDUCING SIGNALING COMPLEXES; HEPATOCYTES; HEPATOPROTECTIVE; IN-VITRO; INDUCED APOPTOSIS; INDUCIBLE NITRIC OXIDE SYNTHASE (INOS); TUMOR NECROSIS FACTORS; UP-REGULATION;

GLYCOPROTEINS; MACROPHAGES; NITRIC OXIDE; PHOSPHORYLATION;

ENZYMES;

CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; INDUCIBLE NITRIC OXIDE SYNTHASE; IRHOM2 PROTEIN; LIPOPOLYSACCHARIDE; NITRIC OXIDE; PROTEINASE; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; TUMOR NECROSIS FACTOR RECEPTOR 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL PROTECTION; CELL SURFACE; COMPLEX FORMATION; CONTROLLED STUDY; LIVER CELL; LIVER PROTECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; UPREGULATION;

ADAM PROTEINS; ANIMALS; CARRIER PROTEINS; CELLS, CULTURED; CYCLIC GMP; ENZYME ACTIVATION; HEPATOCYTES; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, KNOCKOUT; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PHOSPHORYLATION; PROTEIN TRANSPORT; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 84867818285     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.365171     Document Type: Article

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