Ectodomain shedding of EGFR ligands and TNFR1 dictates hepatocyte apoptosis during fulminant hepatitis in mice

Journal of Clinical Investigation

Volumn 120, Issue 8, 2010, Pages 2731-2744

  Murthy, Aditya ^a   Defamie, Virginie ^a   Smookler, David S ^a   Di Grappa, Marco A ^a   Horiuchi, Keisuke ^b   Federici, Massimo ^c   Sibilia, Maria ^d   Blobel, Carl P ^e   Khokha, Rama ^a  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b KEIO UNIVERSITY   (Japan)

^c UNIVERSITY OF ROME TOR VERGATA   (Italy)

^d MEDICAL UNIVERSITY OF VIENNA   (Austria)

^e WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

A DISINTEGRIN AND METALLOPROTEASE PROTEIN 17; ADAM PROTEIN; AMPHIREGULIN; DEATH RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; LIGAND; TISSUE INHIBITOR OF METALLOPROTEINASE 3; TRANSFORMING GROWTH FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1; UNCLASSIFIED DRUG;

ACUTE STRESS; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME REGULATION; HEPATITIS; LIVER CELL; LIVER FAILURE; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SIGNAL TRANSDUCTION;

ADAM PROTEINS; ANIMALS; ANTIGENS, CD95; APOPTOSIS; CELLS, CULTURED; CYTOPROTECTION; DRUG-INDUCED LIVER INJURY; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HEPATOCYTES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIVER FAILURE, ACUTE; MALE; MICE; MICE, INBRED C57BL; NF-KAPPA B; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; SIGNAL TRANSDUCTION; TISSUE INHIBITOR OF METALLOPROTEINASE-3;

EID: 77955284154     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI42686     Document Type: Article

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