Panax ginseng reduces oxidative stress and restores antioxidant capacity in aged rats

Nutrition Research

Volumn 32, Issue 9, 2012, Pages 718-726

  Ramesh, Thiyagarajan ^a   Kim, Sung Won ^a   Hwang, Seock Yeon ^b   Sohn, Sang Hyun ^a   Yoo, Sung Kwang ^a   Kim, Si Kwan ^a  

^a Konkuk University   (South Korea)

^b Daejeon University   (South Korea)

Author keywords

Aging; Antioxidants; Lipid peroxidation; Oxidative stress; Panax ginseng nutrients; Rats

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA TOCOPHEROL; ASCORBIC ACID; ASPARTATE AMINOTRANSFERASE; CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; CREATININE; GINSENG EXTRACT; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; MALONALDEHYDE; NITROGEN; SUPEROXIDE DISMUTASE; UREA;

AGING; ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIET SUPPLEMENTATION; FOOD INTAKE; LIPID PEROXIDATION; MALE; NONHUMAN; OUTCOME ASSESSMENT; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; RISK REDUCTION; UREA NITROGEN BLOOD LEVEL;

AGING; ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; CATALASE; DIET; DIETARY SUPPLEMENTS; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; LIPID PEROXIDATION; MALE; OXIDATIVE STRESS; PANAX; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE; VITAMIN E;

EID: 84867765388     PISSN: 02715317     EISSN: 18790739     Source Type: Journal    
DOI: 10.1016/j.nutres.2012.08.005     Document Type: Article

References (42)

1. Hwang S.Y., Sohn S.H., Wee J.J., Yang J.B., Kyung J.S., Kwak Y.S., et al. Panax ginseng improves senile testicular function in rats. J Ginseng Res 2010, 34:327-335.
2. Heo J.H., Lee S.T., Oh M.J., Park H.J., Shim J.Y., Chu K., et al. Improvement of cognitive deficit in Alzheimer's disease patients by long term treatment with Korean red ginseng. J Ginseng Res 2011, 35:457-461.
3. Li T.S.C., Mazza G., Cottrell A.C., Gao L. Ginsenosides in roots and leaves of American ginseng. J Agric Food Chem 1996, 44:717-720.
4. Lau A., Seo B., Woo S., Koh H. High-performance liquid chromatographic method with quantitative comparisons of whole chromatograms of raw and steamed Panax notoginseng. J Chromatogr A 2004, 1057:141-149.
5. Kim N.D. Pharmacologic effect of red ginseng. J Ginseng Res 2001, 25:2-10.
6. Sun B.S., Gu L.J., Fang Z.M., Wang C.Y., Wang Z., Lee M.R., et al. Simultaneous quantification of 19 ginsenosides in black ginseng developed from Panax ginseng by HPLC-ELSD. J Pharm Biomed Anal 2009, 50:15-22.
7. Park J.D. Recent studies on the chemical constituents of Korean ginseng (Panax ginseng C.A. Meyer). J Ginseng Sci 1996, 20:389-415.
8. Kim W.Y., Kim J.M., Han S.B., Lee S.K., Kim N.D., Park M.K., et al. Steaming of ginseng at high temperature enhances biological activity. J Nat Prod 2000, 63:1702-1704.
9. Kwon J.H., Belanger J.M.R., Sigouin M., Lanthier J., Willemot C., Par J.R.J. Chemical constituents of Panax ginseng exposed to γ-irradiation. J Agric Food Chem 1990, 38:830-834.
10. Woo Y.A., Cho C.H., Kim H.J., Yang J.S., Seong K.Y. Classification of cultivation area of ginseng by near infrared spectroscopy and ICP-AES. Microchem J 2002, 73:299-306.
11. Choi M.K., Kang M.H., Kim M.H. The analysis of copper, selenium, and molybdenum contents in frequently consumed foods and an estimation of their daily intake in Korean adults. Biol Trace Elem Res 2009, 128:104-117.
12. Harman D. Aging: a theory based on free radical, and radiation chemistry. J Gerontol 1956, 11:298-300.
13. Yu B.P., Chung H.Y. Oxidative stress and vascular aging. Diabetes Res Clin Pract 2001, 54:S73-S80.
14. Kim C.H., Park D.H., Chung A., Zou Y., Jung K.J., Sung B.K., et al. Proteomic analysis of post-mitochondrial fractions of young and old rat kidney. Exp Geront 2004, 39:1155-1168.
15. Arivazhagan P., Thilakavathy T., Panneerselvam C. Antioxidant lipoate and tissue antioxidants in aged rats. J Nutr Biochem 2000, 11:122-127.
16. Senthilmohan S.T., Zhang J., Stanley R.A. Effects of flavonoid extract Enzogenol® with vitamin C on protein oxidation and DNA damage in older human subjects. Nutr Res 2003, 23:1199-1210.
17. Guo C., Wei J., Yang J., Xu J., Pang W., Jiang Y. Pomegranate juice is potentially better than apple juice in improving antioxidant function in elderly subjects. Nutr Res 2008, 28:72-77.
18. Council of Europe European pharmacopoeia, 5th edn. European Directorate for the Quality of Medicines & HealthCare 2005, S5.1:2935-2936.
19. Ohkawa H., Ohishi N., Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979, 95:351-358.
20. Marklund S., Marklund G. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 1974, 47:469-474.
21. Sinha A.K. Colorimetric assay of catalase. Anal Biochem 1972, 47:389-394.
22. Rotruck J.T., Pope A.L., Ganther H.E., Swanson A.B., Hafeman D.G., Hoekstra W.G. Selenium: biochemical role as a component of glutathione peroxidase. Science 1973, 179:588-590.
23. Mize C.E., Langdon R.G. Hepatic glutathione reductase. I. Purification and general kinetic properties. J Biol Chem 1962, 237:1589-1595.
24. Habig W.H., Pabst M.J., Jakoby W.B. Glutathione-S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem 1974, 249:7130-7139.
25. Beutler E., Duron O., Kelly B.M. Improved method for the determination of blood glutathione. J Lab Clin Med 1963, 61:882-888.
26. Omaye S.T., Turnbull J.D., Sauberlich H.E. Selected methods for the determination of ascorbic acid in animal cells, tissues, and fluids. Methods Enzymol 1979, 62:3-11.
27. Varley H., Gowenlock A.H., Bell M. Practical clinical biochemistry: hormones, vitamins, drugs and poisons. Vol II, 5th edn 1976, 222-223. William Heinemann Medical Books Ltd., London.
28. Plaa G.L., Witschi H. Chemical, drugs and lipid peroxidation. Ann Rev Pharmacol Toxicol 1976, 15:125-141.
29. Sohal R.S., Arnold L., Orr W.C. Effect of age on superoxide dismutase, catalase, glutathione reductase, inorganic peroxides, TBA-reactive material, GSH/GSSG, NADPH/NADP+ and NADH/NAD+ in Drosophila melanogaster. Mech Ageing Dev 1990, 56:223-235.
30. Aydin A.F., Kucukgergin C., Ozdemirler-Erata G., Kocak-Toker N., Uysal M. The effect of carnosine treatment on prooxidant-antioxidant balance in liver, heart and brain tissues of male aged rats. Biogerontology 2010, 11:103-109.
31. Jayakumar T., Thomas P.A., Geraldine P. Protective effect of an extract of the oyster mushroom, Pleurotus ostreatus, on antioxidants of major organs of aged rats. Exp Gerontol 2007, 42:183-191.
32. Senthil Kumaran V., Arulmathi K., Srividhya R., Kalaiselvi P. Repletion of antioxidant status by EGCG and retardation of oxidative damage induced macromolecular anomalies in aged rats. Exp Gerontol 2008, 43:176-183.
33. Kumaran V.S., Arulmathi K., Kalaiselvi P. Senescence mediated redox imbalance in cardiac tissue: antioxidant rejuvenating potential of green tea extract. Nutrition 2009, 25:847-854.
34. Ramesh T., Kim S.W., Sung J.H., Hwang S.Y., Sohn S.H., Yoo S.K., Kim S.K. Effect of fermented Panax ginseng extract (GINST) on oxidative stress and antioxidant activities in major organs of aged rats. Exp Gerontol 2012, 47:77-84.
35. 1-induced hepatotoxicity in rat. J Ginseng Res 2011, 35:243-249.
36. Hashimoto K., Takasaki W., Sato I., Tsuda S. DNA damage measured by comet assay and 8-OH-dG formation related to blood chemical analyses in aged rats. J Toxicol Sci 2007, 32:249-259.
37. Yokozawa T., Kim H.Y., Kim H.J., Tanaka T., Sugino H., Okubo T., et al. Amla (Emblica officinalis Gaertn.) attenuates age-related renal dysfunction by oxidative stress. J Agric Food Chem 2007, 55:7744-7752.
38. Beckman J.S., Estevez A.G., Crow J.P., Barbeito L. Superoxide dismutase and the death of motoneurons in ALS. Trends Neurosci 2001, 24:S15-S20.
39. Tupe R.S., Tupe S.G., Tarwadi K.V., Agte V.V. Effect of different dietary zinc levels on hepatic antioxidant and micronutrients indices under oxidative stress conditions. Metab Clin Ex 2010, 59:1603-1611.
40. Shaheen A.A., El-Fattah A.A.A. Effect of dietary zinc on lipid peroxidation, glutathione, protein thiols levels and superoxide dismutase activity in rat tissues. Int J Biochem Cell Biol 1995, 27:89-95.
41. Savarino L., Granchi D., Ciapetti G., Cenni E., Ravaglia G., Forti P., et al. Serum concentrations of zinc and selenium in elderly people: results in healthy nonagenarians/centenarians. Exp Gerontol 2001, 36:327-339.
42. Nandi D., Patra R.C., Swarup D. Effect of cysteine, methionine, ascorbic acid and thiamine on arsenic-induced oxidative stress and biochemical alterations in rats. Toxicology 2005, 211:26-35.