Panax ginseng improves senile testicular function in rats

Journal of Ginseng Research

Volumn 34, Issue 4, 2010, Pages 327-335

  Hwang, Seock Yeon ^a   Sohn, Sang Hyun ^b   Wee, Jae Joon ^c   Yang, Jin Bae ^a   Kyung, Jong Soo ^c   Kwak, Yi Seong ^c   Kim, Sung Won ^b   Kim, Si Kwan ^b  

^a Daejeon University   (South Korea)

^b Konkuk University   (South Korea)

^c Korea Ginseng Corporation   (South Korea)

Author keywords

Aging; Crude saponin; Red ginseng; Sperm quality; Spermatogenesis

Indexed keywords

ANIMALIA; CAVIA; PANAX GINSENG; RATTUS;

EID: 79951802858     PISSN: 12268453     EISSN: None     Source Type: Journal    
DOI: 10.5142/jgr.2010.34.4.327     Document Type: Article

References (34)

1. Neaves WB, Johnson L, Porter JC, Parker CR Jr, Petty CS. Leydig cell numbers, daily sperm production, and serum gonadotropin levels in aging men. J Clin Endocrinol Metab 1984;59:756-763. (Pubitemid 14012503)
2. Johnson L, Petty CS, Neaves WB. Influence of age on sperm production and testicular weights in men. J Reprod Fertil 1984;70:211-218. (Pubitemid 14223139)
3. Holstein AF. Spermatogenesis in the aged-a borderland between normal and pathologic anatomy. Urologe A 1986;25:130-137.
4. Gray A, Feldman HA, McKinlay JB, Longcope C. Age, disease, and changing sex hormone levels in middle-aged men: results of the Massachusetts Male Aging Study. J Clin Endocrinol Metab 1991;73:1016-1025. (Pubitemid 21901140)
5. Noguchi J, Yoshida M, Ikadai H, Imamichi T, Watanabe G, Taya K. Age-related changes in blood concentrations of FSH, LH and testosterone and testicular morphology in a new rat sterile mutant with hereditary aspermia. J Reprod Fertil 1993;97:433-439. (Pubitemid 23127679)
6. Tenover JS, McLachlan RI, Dahl KD, Burger HG, De Kretser DM, Bremner WJ. Decreased serum inhibin levels in normal elderly men: evidence for a decline in Sertoli cell function with aging. J Clin Endocrinol Metab 1988;67:455-459.
7. Plas E, Berger P, Hermann M, Pflüger H. Effects of aging on male fertility? Exp Gerontol 2000;35:543-551.
8. Corona G, Razzoli E, Forti G, Maggi M. The use of phosphodiesterase 5 inhibitors with concomitant medications. J Endocrinol Invest 2008;31:799-808.
9. Sivalingam S, Hashim H, Schwaibold H. An overview of the diagnosis and treatment of erectile dysfunction. Drugs 2006;66:2339-2355. (Pubitemid 46072446)
10. Costabile RA, Mammen T, Hwang K. An overview and expert opinion on the use of alprostadil in the treatment of sexual dysfunction. Expert Opin Pharmacother 2008;9:1421-1429. (Pubitemid 351877525)
11. van Dijk MM, De La Rosette JJ, Michel MC. Effects of alpha (1)-adrenoceptor antagonists on male sexual function. Drugs 2006;66:287-301. (Pubitemid 46291765)
12. Becker AJ, Stief CG, Schultheiss D, Truss MC, Jonas U. Pharmacological therapy of erectile dysfunction. Urologe A 1998;37:503-508.
13. Yuan HD, Shin EJ, Chung SH. Anti-diabetic effect and mechanism of Korean red ginseng in C57BL/KsJ db/db mice. J Ginseng Res 2008;32:187-193.
14. Qureshi AA, Abuirmeileh N, Din ZZ, Ahmad Y, Burger WC, Elson CE. Suppression of cholesterogenesis and reduction of LDL cholesterol by dietary ginseng and its fractions in chicken liver. Atherosclerosis 1983;48:81-94. (Pubitemid 13056703)
15. Choi HK, Choi YD, Adaikan PG, Jiang Y. Effectiveness of Korea red ginseng in erectile dysfunction-multi-national approach. J Ginseng Res 1999;23:247-256.
16. Sung H, Kang SM, Lee MS, Kim TG, Cho YK. Korean red ginseng slows depletion of CD4 T cells in human immunodeficiency virus type 1-infected patients. Clin Diagn Lab Immunol 2005;12:497-501. (Pubitemid 41175316)
17. Yun TK, Yun YS, Han IW. Anticarcinogenic effect of longterm oral administration of red ginseng on newborn mice exposed to various chemical carcinogens. Cancer Detect Prev 1983;6:515-525.
18. Kim HS, Jung MW, Jang CG, Park WK, Oh KW. Effects of ginseng total saponin on stress-induced analgesia. Korean J Ginseng Sci 1993;17:22-28.
19. Kim W, Hwang S, Lee H, Song H, Kim S. Panax ginseng protects the testis against 2, 3, 7, 8-tetrachlorodibenzo-pdioxin induced testicular damage in guinea pigs. BJU Int 1999;83:842-849. (Pubitemid 29224410)
20. Hwang SY, Kim WJ, Wee JJ, Choi JS, Kim SK. Panax ginseng improves survival and sperm quality in guinea pigs exposed to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin. BJU Int 2004;94:663-668.
21. Kim SK, Kwak YS, Kim SW, Hwang SY, Ko YS, Yoo CM. Improved method for the preparation of crude ginseng saponin. J Ginseng Res 1998;22:155-160.
22. Gaedcke F, Steinhoff B, Blasius H. Herbal medicinal products: scientific and regulatory basis for development, quality assurance and marketing authorisation. London: CRC Press, 2003.
23. Hankinson O. Role of coactivators in transcriptional activation by the aryl hydrocarbon receptor. Arch Biochem Biophys 2005;433:379-386. (Pubitemid 39592792)
24. Russell LD, Ettlin RA, Hikim AP, Clegg ED. The classification and timing of spermatogenesis. In:. Russell LD, Ettlin RA, Hikim AP, Clegg ED (Eds.). Histological and histopathological evaluation of the testis. Clearwater: Cache River Press, 1990.
25. Johnsen SG. Testicular biopsy score count-a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males. Hormones 1970;1:2-25.
26. Ernst E, Pittler MH. Yohimbine for erectile dysfunction: a systematic review and meta-analysis of randomized clinical trials. J Urol 1998;159:433-436. (Pubitemid 28049250)
27. Drewes SE, Horn MM, Munro OQ, Dhlamini JT, Meyer JJ, Rakuambo NC. Pyrano-isoflavones with erectile-dysfunction activity from Eriosema kraussianum. Phytochemistry 2002;59:739-747. (Pubitemid 34269947)
28. Chiou WF, Chen J, Chen CF. Relaxation of corpus cavernosum and raised intracavernous pressure by berberine in rabbit. Br J Pharmacol 1998;125:1677-1684. (Pubitemid 29000814)
29. Zaher TF. Papaverine plus prostaglandin E1 versus prostaglandin E1 alone for intracorporeal injection therapy. Int Urol Nephrol 1998;30:193-196. (Pubitemid 28459641)
30. Mulhall JP, Daller M, Traish AM, Gupta S, Park K, Salimpour P, Payton TR, Krane RJ, Goldstein I. Intracavernosal forskolin: role in management of vasculogenic impotence resistant to standard 3-agent pharmacotherapy. J Urol 1997;158:1752-1758.
31. Chen X, Lee TJ. Ginsenosides-induced nitric oxide-mediated relaxation of the rabbit corpus cavernosum. Br J Pharmacol 1995;115:15-18.
32. Choi HK, Seong DH, Rha KH. Clinical efficacy of Korean red ginseng for erectile dysfunction. Int J Impot Res 1995;7:181-186.
33. Fahim MS, Fahim Z, Harman JM, Clevenger TE, Mullins W, Hafez ES. Effect of Panax ginseng on testosterone level and prostate in male rats. Arch Androl 1982;8:261-263. (Pubitemid 12057162)
34. Ford WC, North K, Taylor H, Farrow A, Hull MG, Golding J. Increasing paternal age is associated with delayed conception in a large population of fertile couples: evidence for declining fecundity in older men. The ALSPAC Study Team (Avon Longitudinal Study of Pregnancy and Childhood). Hum Reprod 2000;15:1703-1708. (Pubitemid 30636056)