Inhibition of β-amyloid toxicity by short peptides containing N-methyl amino acids

Journal of Peptide Research

Volumn 63, Issue 3, 2004, Pages 324-328

  Cruz, M ^a   Tusell, J M ^b   Grillo Bosch, D ^a   Albericio, F ^a,c   Serratosa, J ^a,b   Rabanal, F ^c   Giralt, E ^a,c  

^a INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Spain)

^b INST D INVESTIGACIONS B   (Spain)

^c UNIVERSITY OF BARCELONA   (Spain)

Author keywords

amyloid protein; Alzheimer's disease; Cytotoxicity inhibition; N methyl peptides

Indexed keywords

AMYLOID BETA PROTEIN; LYSYLLYSYLLEUCYLNORMETHYLVALYLPHENYLALANYLPHENYLALANYLALANINAMIDE; LYSYLLYSYLLEUCYLVALYLNORMETHYLPHENYLALANYLPHENYLALANYLALANINAMIDE; LYSYLLYSYLLEUCYLVALYLPHENYLALANYLNORMETHYLPHENYLALANYLALANINAMIDE; LYSYLLYSYLLEUCYLVALYLPHENYLALANYLPHENYLALANYLNORMETHYLALANINAMIDE; LYSYLLYSYLNORMETHYLLEUCYLVALYLPHENYLALANYLPHENYLALANYLALANINAMIDE; PEPTIDE DERIVATIVE; PHENYLALANINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL LINE; CELL PROTECTION; CELL VIABILITY; CYTOTOXICITY; DRUG EFFECT; HYDROPHOBICITY; NONHUMAN; PRIORITY JOURNAL; RAT; STATISTICAL SIGNIFICANCE; STUDENT T TEST;

ALZHEIMER DISEASE; AMINO ACIDS; AMYLOID BETA-PROTEIN; ANIMALS; BIOLOGICAL ASSAY; CELL SURVIVAL; FORMAZANS; PC12 CELLS; PEPTIDES; RATS; TETRAZOLIUM SALTS;

ANIMALIA;

EID: 1942470038     PISSN: 1397002X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-3011.2004.00156.x     Document Type: Article

References (15)

1. Wolfe, M.S. (2002) Therapeutic strategies for Alzheimer's disease. Nat. Rev. Drug Discov. 1, 859-866.
2. Hardy, J. & Selkoe, D.J. (2002) The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297, 353-356.
3. Tjernberg, L.O., Näslund, J., Lindqvist, F., Johansson, J., Karlström, A.R., Thyberg, J., Terenius, L. & Nordstedt, C. (1996) Arrest of β-amyloid fibril formation by a pentapeptide ligand. J. Biol. Chem. 271, 8545-8548.
4. Soto, C., Sigurdsson, E.M., Morelli, L., Kumar, R.A., Castaño, E.M. & Frangione, B. (1998) β-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapy. Nat. Med. 4, 822-838.
5. Hughes, E., Burke, R.M. & Doig, A.J. (2000) Inhibition of toxicity in the β-amyloid peptide fragment β(25-35) using N-methylated derivatives. J. Biol. Chem. 275, 25109-25115.
6. Gordon, D.J., Sciarretta, K.L. & Meredith, S.C. (2001) Inhibition of β-amyloid(40) fibrillogenesis and disassembly of β-amyloid(40) fibrils by short amyloid congeners containing N-methyl amino acids at alternate residues. Biochemistry 40, 8237-8245.
7. Gordon, D.J., Tappe, R. & Meredith, S.C. (2002) Design and characterization of a membrane permeable N-methyl amino acid-containing peptide that inhibits Aβ1-40 fibrillogenesis. J. Pept. Res. 60, 37-55.
8. Kapurniotu, A., Schmauder, A. & Tenidis, K. (2002) Structure-based design and study of non-amyoidogenic, double methylated IAPP amyloid core sequences as inhibitors of IAPP amyloid formation and cytotoxicity. J. Mol. Biol. 315, 339-350.
9. Varadarajan, S., Kanski, J., Aksenova, M., Lauderback, C. & Butterfield, D.A. (2001) Different mechanisms of oxidative stress and neurotoxicity for Alzheimer's Aβ(1-42) and Aβ(25-35). J. Am. Chem. Soc. 123, 5625-5631.
10. Rabanal, F., Tusell, J.M., Sastre, L.L., Quintero, M.R., Cruz, M., Grillo, D., Pons, M., Albericio, F., Serratosa, J. & Giralt, E. (2002) Structural, kinetic and cytotoxic aspects of 12-28 β-amyloid protein fragment: a reappraisal. J. Pept. Sci. 8, 578-588.
11. Walsh, D.M., Klyubin, I., Fadeeva, J.V., Cullen, W.K., Anwyl, R., Wolfe, M.S., Rowan, M.J. & Selkoe, D.J. (2002) Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long term potentiation in vivo. Nature 416, 535-539.
12. Bucciantini, M., Giannoni, E., Chiti, F., Baroni, F., Formigli, L., Zurdo, J., Taffei, N., Ramponi, G., Dobson, C.M. & Stefani, M. (2002) Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases. Nature 416, 507-511.
13. Madder, A., Farcy, N., Hosten, N.G.C., De Muynck, H., De Clercq, P.J., Barry, J. & Davis, A.P. (1999) A novel sensitive colorimetric assay for visual detection of solid-phase bound Amines. Eur. J. Org. Chem. 1, 2787-2791.
14. Zagorski, M.G., Yang, J., Shao, H., Ma, K., Zeng, H. & Hong, A. (1999) Methodological and chemical factors affecting amyloid β peptide amyloidogenicity. Meth. Enzymol. 309, 189-235.
15. Hansen, M.B., Nielsen, S.E. & Berg, K. (1989) Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J. Immunol. Methods 119, 203-210.